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Cited by 149Hematopoietic Stem Cell TransplantationRenal Transplantation Outcomes and TreatmentsEffects of Radiation Exposure

Chronic kidney disease in long-term survivors of hematopoietic cell transplant

Hingorani, S, Guthrie, K A, Schoch, G, Weiss, N S, McDonald, G B·2007·Bone Marrow Transplantation
DOI 10.1038/sj.bmt.1705573
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Abstract

We conducted a cohort study to identify risk factors of chronic kidney disease (CKD) among long-term survivors of hematopoietic cell transplant (HCT). We studied 1635 patients transplanted at the Fred Hutchinson Cancer Research Center (FHCRC) between 1991 and 2002, who survived to day +131 after transplant and had serum creatinine measured on at least two occasions after day +131. CKD was defined as a glomerular filtration rate < 60 ml/min/m(2) on two occasions separated by at least 30 days between days 100 and 540 post transplant. Cox regression models estimated hazard ratios (HRs) describing associations between demographic data, clinical variables and the risk of developing CKD. A total of 376 patients (23%) developed CKD at a median of 191 days post transplant (range 131-516 days). An increased risk of CKD was associated with acute renal failure (ARF) (HR=1.7, 95% confidence interval (CI) 1.3-2.1), acute graft-vs-host disease (aGVHD) grade II (HR=2.0, 95% CI 1.4-2.9) and grades III/IV (HR=3.1, 95% CI 2.1-4.6) and chronic GVHD (HR=1.8, 95% CI 1.4-2.2). Total body irradiation (TBI) (HR=1.0, 95% CI 0.8-1.3) was not associated with an increased risk of CKD. CKD is relatively common among survivors of HCT. The presence of ARF and GVHD, but not receipt of TBI, appears to be associated with the occurrence of CKD.

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  • Transplantation of bone marrow, gut microbiota or kidney has been demonstrated to induce disorders not only in the organs of the proposed brain-gut-kidney axis but also in the interconnected pathways of this axis.

    “Consistent with our hypothesis, transplantation of bone marrow15,122, gut microbiota90 or kidney204 has been demonstrated to induce disorders not only in the organs of the proposed brain-gut-kidney axis but also in the interconnected pathways of this axis.”

    From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [122]

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Authors
Hingorani, S., Guthrie, K. A., Schoch, G., Weiss, N. S., & McDonald, G. B.
Affiliations
University of Washington (US)
Corresponding author
Hingorani, S
ORCID
Venue
Bone Marrow Transplantation
Publisher
Springer Science and Business Media LLC
Published
2007-02
Volume
39
Issue
4
Pages
223-229
ISSN
  • 0268-3369 (ISSN-L)
  • 1476-5365
DOI
10.1038/sj.bmt.1705573
OpenAlex
W1999165120
Cited by
149
References
46
Citations by year
2026: 2 · 2025: 4 · 2024: 2 · 2023: 8 · 2022: 14 · 2021: 10 · 2020: 9 · 2019: 6 · 2018: 8 · 2017: 6 · 2016: 3 · 2015: 11 · 2014: 8 · 2013: 12 · 2012: 8
FWCI
6.39
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Bone Marrow Transplantation (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Society of Nephrology
  • National Cancer Institute (CA18029, CA 15704+, P30CA015704, P01CA018029)
  • National Institute of Diabetes and Digestive and Kidney Diseases (K23DK063038)
Topics
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Keywords
chronic kidney disease, hematopoietic stem cell transplantation, long-term transplant survivors, acute kidney injury, graft-versus-host disease, chronic graft-versus-host disease, total body irradiation, risk factors, glomerular filtration rate
MeSH terms
Adolescent, Adult, Aged, Child, Child, Preschool, Female, Glomerular Filtration Rate, Graft vs Host Disease, Humans, Infant, Male, Middle Aged, Retrospective Studies, Risk Factors, Whole-Body Irradiation, Cohort Studies, Proportional Hazards Models, Survivors, Hematopoietic Stem Cell Transplantation, Renal Insufficiency, Chronic, Acute Kidney Injury

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