Interleukin-7 induced facilitation of immunological reconstitution of sublethally irradiated mice following treatment with alloreactive spleen cells in a murine model of B-cell leukemia/lymphoma (BCL1).
Abstract
Interleukin-7 (IL-7) plays a key role in maturation and function of both T and B cells. We investigate the potential use of recombinant human IL-7 for facilitation of graft-versus-leukemia (GVL) effects mediated by T cells following transplantation in a murine model. Administration of IL-7 in vivo to allogeneic-transplanted mice improved disease-free survival: 67% of mice treated with IL-7 remained alive and disease free for more than 60 days, in comparison to 17% of the controls (P<0.05). Similar results were obtained when C57BL/6 spleen cells sensitized against irradiated B-cell leukemia (BCL(1)) cells in the presence of IL-7 were transplanted to F(1) mice, followed by IL-7 treatment in vivo. Of the BALB/c mice that received spleen cells from F(1) mice treated with IL-7 following transplantation of C57BL/6 spleen cells sensitized with irradiated BCL(1) in the presence of IL-7, only 29% developed leukemia, as compared to 79% in the control group (P<0.05). Mice treated with IL-7 showed increased splenic and thymic cellularity and improved T cell-dependent proliferative responses compared to the controls (P<0.05). IL-7 may provide a novel tool to enhance immune reconstitution following transplantation of mismatched stem cells and for enhancement of GVL effects mediated by alloreactive lymphocytes.
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The BCL-1 cell line is highly sensitive to glucocorticoids, with an in vitro growth inhibition (GI50) in the nanomolar range (~4.2 nM).
“The BCL-1 cell line [53] is characterized by its high sensitivity to GCs, having an in vitro growth inhibition (GI50) in the nanomolar range (∼4.2 nM).”
From Fabrication Principles and Their Contribution to the Superior In Vivo Therapeutic Efficacy of Nano-Liposomes Remote Loaded with Glucocorticoids (2011) · cites this paper as [53]
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Self-citation
- Authors
- Abdul-Hai, A., Weiss, L., Ben-Yehuda, A., Ergas, D., Shapira, M. Y., & Slavin, S.
- Affiliations
- Hadassah Medical Center (IL)
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Slavin, S
- Venue
- Bone Marrow Transplantation
- Published
- 2007-08-20
- Volume
- 40
- Issue
- 9
- Pages
- 881-889
- ISSN
- 0268-3369 (ISSN-L)
- 1476-5365
- OpenAlex
- W2081212839
- Cited by
- 9
- References
- 22
- Citations by year
- 2025: 1 · 2017: 1 · 2015: 1
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bone Marrow Transplantation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- IL-7, graft-versus-leukemia effect, BCL1, sublethal irradiation, immune reconstitution, T cell proliferation
- MeSH terms
- Animals, Disease Models, Animal, Humans, Immune System, Mice, Inbred Strains, Regeneration, Spleen, Transplantation, Homologous, Leukemia, B-Cell, Interleukin-7, Lymphoma, B-Cell, Cell Transplantation, Disease-Free Survival, Adoptive Transfer, Graft vs Leukemia Effect, Mice
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