The DOI matches its Crossref record; 44 of the 45 references it cites were found in a registry or an index.
Control of neuronal branching by the death receptor CD95 (Fas/Apo-1)
Abstract
The CD95 (Apo-1/Fas)/CD95 ligand (CD95L) system is best characterized as a trigger of apoptosis. Nevertheless, despite broad expression of CD95L and CD95 in the developing brain, absence of functional CD95 (lpr mice) or CD95L (gld mice) does not alter neuronal numbers. Here, we report that in embryonic hippocampal and cortical neurons in vivo and in vitro CD95L does not induce apoptosis. Triggering of CD95 in cultured immature neurons substantially increases neurite branches by promoting their formation. The branching increase occurs in a caspase-independent and death domain-dependent manner and is paralleled by an increase in the nonphosphorylated form of Tau. Most importantly, lpr and gld mutants exhibit a reduced number of dendritic branches in vivo at the time when synapse formation takes place. These data reveal a novel function for the CD95 system and add to the picture of guidance molecules in the developing brain.
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“In embryonic hippocampal and cortical neurons, activation of CD95 stimulated neurite branching, which occurred in a caspase-independent and death-domain-dependent manner and was paralleled by an increase in non-phosphorylated Tau.98”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [98]
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Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
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Two CD95 (APO‐1/Fas) signaling pathways
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Self-citationTumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.
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Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene Delivery
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FLICE is activated by association with the CD95 death‐inducing signaling complex (DISC)
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1 of the 45 references couldn’t be matched to a known paper.
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- Denburg JA, Carbotte RM and Denburg SD (1987) Neuronal antibodies and cognitive function in systemic lupus erythematosus. Neurology 37: 464–467 · DOI
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Life and death in peripheral T cells
Krammer, P. H., Arnold, R., & Lavrik, I. N. (2007) · Nature reviews. Immunology · doi:10.1038/nri2115 · Cited by 668
Self-citationThe TNF Family of Ligands and Receptors: Communication Modules in the Immune System and Beyond
Dostert, C., Grusdat, M., Letellier, E., & Brenner, D. (2018) · Physiological Reviews · doi:10.1152/physrev.00045.2017 · Cited by 529
The CD95 Receptor: Apoptosis Revisited
Peter, M. E., Budd, R. C., Desbarats, J., Hedrick, S. Μ., Hueber, A., Newell, M. K., Owen, L. B., Pope, R. M., Tschopp, J. F., Wajant, H., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.031 · Cited by 396
The role of CD95 and CD95 ligand in cancer
Peter, M. E., Hadji, A., Murmann, A. E., Brockway, S., Putzbach, W., Pattanayak, A., & Ceppi, P. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.3 · Cited by 368
Regulation of CD95/Fas signaling at the DISC
Lavrik, I. N., & Krammer, P. H. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.155 · Cited by 376
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Metadata
- Authors
- Zuliani, C., Kleber, S., Klussmann, S., Wenger, T., Kenzelmann, M., Schreglmann, N., Martinez, A., del Rio, J. A., Soriano, E., Vodrazka, P., Kuner, R., Groene, H.-J., Herr, I., Krammer, P. H., & Martin-Villalba, A.
- Affiliations
- German Cancer Research Center (DE)
- Parc Científic de Barcelona (ES)
- Heidelberg University (DE)
- Venue
- Cell Death & Differentiation
- Published
- 2005-07-08
- Volume
- 13
- Issue
- 1
- Pages
- 31-40
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- OpenAlex
- W1994416984
- Cited by
- 117
- References
- 45
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 5 · 2015: 9 · 2014: 5 · 2013: 9 · 2012: 7
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Death and Differentiation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SFB405)
- Ministerio de Ciencia y Tecnología
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- Fas, Fas ligand, neuronal branching, neurite branching, dendritic branching, lpr mice, gld mice, death domain, tau phosphorylation, synaptogenesis, hippocampal neurons, cortical neurons, neuronal development, guidance molecules
- MeSH terms
- Animals, Cell Differentiation, Cells, Cultured, Hippocampus, Membrane Glycoproteins, Mice, Inbred CBA, Mice, Mutant Strains, Neuronal Plasticity, Neurons, Transcription Factors, Signal Transduction, Neurites, Apoptosis, fas Receptor, Caspases, Tumor Necrosis Factors, Mice, Fas Ligand Protein
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