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Cited by 117Cell death mechanisms and regulationAxon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanisms

The DOI matches its Crossref record; 44 of the 45 references it cites were found in a registry or an index.

Control of neuronal branching by the death receptor CD95 (Fas/Apo-1)

Zuliani, C, Kleber, S, Klussmann, S, Wenger, T, Kenzelmann, M, Schreglmann, N, Martinez, A, del Rio, J A, Soriano, E, Vodrazka, P, Kuner, R, Groene, H-J, Herr, I, Krammer, P H, Martin-Villalba, A·2006·Cell Death & Differentiation
DOI 10.1038/sj.cdd.4401720
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Abstract

The CD95 (Apo-1/Fas)/CD95 ligand (CD95L) system is best characterized as a trigger of apoptosis. Nevertheless, despite broad expression of CD95L and CD95 in the developing brain, absence of functional CD95 (lpr mice) or CD95L (gld mice) does not alter neuronal numbers. Here, we report that in embryonic hippocampal and cortical neurons in vivo and in vitro CD95L does not induce apoptosis. Triggering of CD95 in cultured immature neurons substantially increases neurite branches by promoting their formation. The branching increase occurs in a caspase-independent and death domain-dependent manner and is paralleled by an increase in the nonphosphorylated form of Tau. Most importantly, lpr and gld mutants exhibit a reduced number of dendritic branches in vivo at the time when synapse formation takes place. These data reveal a novel function for the CD95 system and add to the picture of guidance molecules in the developing brain.

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Crossref · 10.1038/sj.cdd.4401720

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Research works printed but not linked: 1

  1. Denburg JA, Carbotte RM and Denburg SD (1987) Neuronal antibodies and cognitive function in systemic lupus erythematosus. Neurology 37: 464–467 · DOI

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Metadata

Authors
Zuliani, C., Kleber, S., Klussmann, S., Wenger, T., Kenzelmann, M., Schreglmann, N., Martinez, A., del Rio, J. A., Soriano, E., Vodrazka, P., Kuner, R., Groene, H.-J., Herr, I., Krammer, P. H., & Martin-Villalba, A.
Affiliations
  • German Cancer Research Center (DE)
  • Parc Científic de Barcelona (ES)
  • Heidelberg University (DE)
ORCID
Venue
Cell Death & Differentiation
Publisher
Springer Science and Business Media LLC
Published
2005-07-08
Volume
13
Issue
1
Pages
31-40
ISSN
  • 1350-9047 (ISSN-L)
  • 1476-5403
DOI
10.1038/sj.cdd.4401720
OpenAlex
W1994416984
Cited by
117
References
45
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 5 · 2015: 9 · 2014: 5 · 2013: 9 · 2012: 7
FWCI
4.14
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Cell Death and Differentiation (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Deutsche Forschungsgemeinschaft (SFB405)
  • Ministerio de Ciencia y Tecnología
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
Fas, Fas ligand, neuronal branching, neurite branching, dendritic branching, lpr mice, gld mice, death domain, tau phosphorylation, synaptogenesis, hippocampal neurons, cortical neurons, neuronal development, guidance molecules
MeSH terms
Animals, Cell Differentiation, Cells, Cultured, Hippocampus, Membrane Glycoproteins, Mice, Inbred CBA, Mice, Mutant Strains, Neuronal Plasticity, Neurons, Transcription Factors, Signal Transduction, Neurites, Apoptosis, fas Receptor, Caspases, Tumor Necrosis Factors, Mice, Fas Ligand Protein

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