Overview of management of atrial fibrillation in symptomatic elderly patients: pharmacologic therapy versus AV node ablation
Abstract
Atrial fibrillation is an abnormal heart rhythm affecting the upper chambers of the heart in which uncoordinated electrical depolarizations lead to ineffective contractions. Approximately five million patients in the US have atrial fibrillation, and this number is expected to double to 10 million over the next 30 years. Advancing age is a major risk factor for the development of atrial fibrillation; new cases of atrial fibrillation are diagnosed in men over age 80 at the rate of 2% per year. Although several drugs are available for management of atrial fibrillation, the efficacy of these drugs may be limited in elderly patients. In this review, we provide an overview of management of atrial fibrillation, with special emphasis on pharmacologic therapy versus arteriovenous (AV) node ablation in symptomatic elderly patients.
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AV node ablation and pacing does not worsen LV function and may even improve LVEF in selected patients.
“The procedure does not worsen LV function 567 and may even improve LVEF in selected patients.[568][569][570]”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [568]
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- Authors
- Bradley, D. J., & Shen, W.-K.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Shen, W-K
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2007-02
- Volume
- 81
- Issue
- 2
- Pages
- 284-287
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W2062685615
- Cited by
- 20
- References
- 20
- Citations by year
- 2024: 3 · 2022: 1 · 2021: 5 · 2020: 1 · 2018: 1 · 2016: 3 · 2012: 1
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Keywords
- atrial fibrillation, elderly patients, pharmacotherapy, AV node ablation, antiarrhythmic drugs, symptomatic atrial fibrillation, atrial fibrillation incidence
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Atrial Fibrillation, Atrioventricular Node, Humans, Practice Patterns, Physicians', Practice Guidelines as Topic
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