Cited by 278Coffee research and impactsSleep and related disordersSleep and Wakefulness Research

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A Genetic Variation in the Adenosine A2A Receptor Gene (ADORA2A) Contributes to Individual Sensitivity to Caffeine Effects on Sleep

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Rétey, J V, Adam, M, Khatami, R, Luhmann, U F O, Jung, H H, Berger, W, Landolt, H-P·2007·Clinical Pharmacology & Therapeutics

DOI 10.1038/sj.clpt.6100102

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Abstract

Caffeine is the most widely used stimulant in Western countries. Some people voluntarily reduce caffeine consumption because it impairs the quality of their sleep. Studies in mice revealed that the disruption of sleep after caffeine is mediated by blockade of adenosine A2A receptors. Here we show in humans that (1) habitual caffeine consumption is associated with reduced sleep quality in self-rated caffeine-sensitive individuals, but not in caffeine-insensitive individuals; (2) the distribution of distinct c.1083T>C genotypes of the adenosine A2A receptor gene (ADORA2A) differs between caffeine-sensitive and -insensitive adults; and (3) the ADORA2A c.1083T>C genotype determines how closely the caffeine-induced changes in brain electrical activity during sleep resemble the alterations observed in patients with insomnia. These data demonstrate a role of adenosine A2A receptors for sleep in humans, and suggest that a common variation in ADORA2A contributes to subjective and objective responses to caffeine on sleep.

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Authors: Rétey, J. V., Adam, M., Khatami, R., Luhmann, U. F. O., Jung, H. H., Berger, W., & Landolt, H.-P.
Affiliations: University of Zurich (CH)
University Hospital Zurich (CH)
Corresponding author: Landolt, H-P
ORCID: Adam, M
Khatami, R
Luhmann, U F O
Jung, H H
Berger, W
Landolt, H-P
Venue: Clinical Pharmacology & Therapeutics
Publisher: Wiley
Published: 2007-02-28
Volume: 81
Issue: 5
Pages: 692-698
ISSN: 0009-9236 (ISSN-L)
1532-6535
DOI: 10.1038/sj.clpt.6100102
OpenAlex: W2035474281
Cited by: 278
References: 48
Citations by year: 2026: 11 · 2025: 11 · 2024: 12 · 2023: 14 · 2022: 8 · 2021: 12 · 2020: 22 · 2019: 17 · 2018: 13 · 2017: 13 · 2016: 16 · 2015: 17 · 2014: 14 · 2013: 10 · 2012: 26
FWCI: 9.75
Type: journal article
Language: en
Open access: green
doi.org
Locations: Clinical Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
UCL Discovery (University College London) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich)
Funders: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Topics: Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: caffeine, adenosine A2A receptor, caffeine sensitivity, sleep quality, genetic variation, insomnia, habitual caffeine consumption
MeSH terms: Adult, Aged, Alleles, Central Nervous System Stimulants, Caffeine, Data Interpretation, Statistical, DNA, Electroencephalography, Female, Genotype, Humans, Male, Middle Aged, Surveys and Questionnaires, Sleep, Genetic Variation, Polysomnography, Reverse Transcriptase Polymerase Chain Reaction, Internet, Receptor, Adenosine A2A

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A Genetic Variation in the Adenosine A2A Receptor Gene (ADORA2A) Contributes to Individual Sensitivity to Caffeine Effects on Sleep

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