A Genetic Variation in the Adenosine A2A Receptor Gene (ADORA2A) Contributes to Individual Sensitivity to Caffeine Effects on Sleep

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A genetic variation in the adenosine A2A receptor gene contributes to variability in oscillatory alpha power in wake and sleep EEG and A1 adenosine receptor availability in the human brain

Tichelman, N. L., Foerges, A. L., Elmenhorst, E., Lange, D., Hennecke, E., Baur, D. M., Beer, S., Kroll, T., Neumaier, B., Bauer, A., et al. (2023) · NeuroImage · doi:10.1016/j.neuroimage.2023.120345 · Cited by 10

Sleep hygiene and the prevention of chronic insomnia

Ellis, J. G., & Allen, S. F. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815373-4.00011-3 · Cited by 9

Sleep Quality and Duration in Children That Consume Caffeine: Impact of Dose and Genetic Variation in ADORA2A and CYP1A

Jessel, C. D., Narang, A., Zuberi, R., & Bousman, C. (2023) · Genes · doi:10.3390/genes14020289 · Cited by 7

Association between adenosine receptor gene polymorphism and response to caffeine citrate treatment in apnea of prematurity; An Egyptian single-center study

Mokhtar, W. A., Fawzy, A., Allam, R. M., Zidan, N., & Hamed, M. S. (2018) · Egyptian Pediatric Association Gazette · doi:10.1016/j.epag.2018.09.001 · Cited by 7

Habitual coffee intake shapes the gut microbiome and modifies host physiology and cognition

Boscaini, S., Bastiaanssen, T. F. S., Moloney, G. M., Bergamo, F., Zeraik, L., O'Leary, C., Ferri, A., Irfan, M., van der Rhee, M., Lindemann, T. I. F., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-71264-8 · Cited by 9

Concentration–effect relationships of plasma caffeine on EEG delta power and cardiac autonomic activity during human sleep

Baur, D. M., Dornbierer, D., & Landolt, H. (2024) · Journal of Sleep Research · doi:10.1111/jsr.14140 · Cited by 6

The effect of caffeine abstinence on sleep among habitual caffeine users with poor sleep

Irish, L. A., Mead, M. P., Cao, L., Veronda, A. C., & Crosby, R. D. (2020) · Journal of Sleep Research · doi:10.1111/jsr.13048 · Cited by 7

Caffeine Consumption, Psychological Distress, and Insomnia in a Cohort of Individuals with Depression

McIntosh, H. A., Borgas, A. J., Aouira, N., Mitchell, B. L., Crouse, J. J., Medland, S. E., Hickie, I. B., Wray, N. R., Martin, N. G., Middeldorp, C. M., et al. (2025) · Complex Psychiatry · doi:10.1159/000545393 · Cited by 5

WS0701

Bai, X., Zhang, X., Zhang, Y., Wu, S., Hao, L.-H., Liu, R., Huang, Z., Zhang, W., Sun, Z.-M., & Du, G. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000075 · Cited by 5

Caffeine-Containing Energy Drinks/Shots

Gurley, B. J., Kingston, R., & Thomas, S. L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805413-0.00026-0 · Cited by 5

The Highs and Lows of Caffeine Intake in New Zealand Children

Ali, A., Wham, C. A., Wolber, F. M., Dickens, M., O’Keeffe, K., Thunders, M. C., Thomas, J., Starck, C. S., & Rutherfurd-Markwick, K. J. (2018) · Journal of Caffeine and Adenosine Research · doi:10.1089/caff.2017.0035 · Cited by 6

The Treatment of Dually Diagnosed Individuals with Sleep Disturbances and Intellectual Disabilities

McPherson, P., Kaushal, M., & Kothapalli, V. (2020) · Autism and child psychopathology series · doi:10.1007/978-3-030-46835-4_36 · Cited by 6

"No Thanks, Coffee Keeps Me Awake": Individual Caffeine Sensitivity Depends on ADORA2A Genotype Commentary on Byrne et al. A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor. SLEEP 2012;35:967-975.

Landolt, H. (2012)

Individuelle Koffeinempfindlichkeit: Implikationen für eine personalisierte Schlafmedizin?

Landolt, H. (2016) · Praxis · doi:10.1024/1661-8157/a002352

Importance des différences interindividuelles de sensibilité à la caféine en médecine du sommeil – Rôles de l’adénosine et de la dopamine

Landolt, H. (2016) · Médecine du Sommeil · doi:10.1016/j.msom.2016.09.003

The Impact of Genetic Variations in ADORA2A in the Association between Caffeine Consumption and Sleep

Erblang, M., Drogou, C., Gomez-Mérino, D., Metlaine, A., Boland, A., Deleuze, J., Thomas, C., Sauvet, F., & Chennaoui, M. (2019) · Genes · doi:10.3390/genes10121021 · Cited by 52

The association between caffeine consumption and objective sleep variables is dependent on ADORA2A c.1083T>C genotypes

Nunes, R. A., Mazzotti, D. R., Hirotsu, C., Andersen, M. L., Tufik, S. B., & Bittencourt, L. (2016) · Sleep Medicine · doi:10.1016/j.sleep.2016.06.038 · Cited by 27