Inducible heat shock protein 70 kD and inducible nitric oxide synthase in hemorrhage/resuscitation-induced injury
Open accessAbstract
Inducible head shock protein 70 kD (HSP-70i) has been shown to protect cells, tissues, and organs from harmful assaults in vivo and in vitro experimental models. Hemorrhagic shock followed by resuscitation is the principal cause of death among trauma patients and soldiers in the battlefield. Although the underlying mechanisms are still not fully understood, it has been shown that nitric oxide (NO) overproduction and inducible nitric oxide synthase (iNOS) overexpression play important roles in producing injury caused by hemorrhagic shock including increases in polymorphonuclear neutrophils (PMN) infiltration to injured tissues and leukotriene B(4) (LTB(4)) generation. Moreover, transcription factors responsible for iNOS expression are also altered by hemorrhage and resuscitation. It has been evident that either up-regulation of HSP-70i or down-regulation of iNOS can limit tissue injury caused by ischemia/reperfusion or hemorrhage/resuscitation. In our laboratory, geldanamycin, a member of ansamycin family, has been shown to induce HSP- 70i overexpression and then subsequently to inhibit iNOS expression, to reduce cellular caspase-3 activity, and to preserve cellular ATP levels. HSP-70i is found to couple to iNOS and its transcription factor. Therefore, the complex formation between HSP-70i and iNOS may be a novel mechanism for protection from hemorrhage/resuscitation-induced injury.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
HSPA8 was significantly co-expressed with integrin alpha V, annexin I and other ECM components.
“Also, the heat shock protein 8 (HSPA8), a surface marker for the undifferentiated cellular state expressed on the surface of human embryonic stem cells [39], performs an important role in the repair processes following harmful tissular assaults (for example, hemorrhage or local ischemia) [40], and was found to be significantly co-expressed with integrin alpha V, annexin I and other ECM components.”
From Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity (2008) · cites this paper as [40]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.
Xie, Q. W., Kashiwabara, Y., & Nathan, C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37600-7 · Cited by 2,212 · see citing works
Regulation of biosynthesis of nitric oxide.
Nathan, C., & Xie, Q. W. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36703-0 · Cited by 1,669 · see citing works
Nitric Oxide Synthases: Properties and Catalytic Mechanism
Griffith, O. W., & Stuehr, D. J. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.003423 · Cited by 1,311 · see citing works
Heat Shock Protein 70 kDa Molecular Biology, Biochemistry, and Physiology
Kiang, J. G. (1998) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00028-x · Cited by 1,164 · see citing works
Self-citationThe Causes of Death in Conventional Land Warfare: Implications for Combat Casualty Care Research
Bellamy, R. F. (1984) · Military Medicine · doi:10.1093/milmed/149.2.55 · Cited by 732 · see citing works
Hierholzer, C., Harbrecht, B. G., Menezes, J. M., Kane, J., MacMicking, J. D., Nathan, C., Peitzman, A. B., Billiar, T. R., & Tweardy, D. J. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.6.917 · Cited by 471 · see citing works
L-N6-(1-Iminoethyl)lysine: A Selective Inhibitor of Inducible Nitric Oxide Synthase
Moore, W. M., Webber, R. K., Jerome, G. M., Tjoeng, F. S., Misko, T. P., & Currie, M. G. (1994) · Journal of Medicinal Chemistry · doi:10.1021/jm00049a007 · Cited by 458 · see citing works
Baue, A. E., Durham, R. M., & Faist, E. (1998) · Shock · doi:10.1097/00024382-199808000-00001 · Cited by 447 · see citing works
Taylor, B. S., de Vera, M. E., Ganster, R. W., Wang, Q., Shapiro, R. A., Morris, S. M., Billiar, T. R., & Geller, D. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.24.15148 · Cited by 413 · see citing works
Ren, M., Leng, Y., Jeong, M. R., Leeds, P. R., & Chuang, D. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02406.x · Cited by 378 · see citing works
Nakai, A., Tanabe, M., Kawazoe, Y., Inazawa, J., Morimoto, R. I., & Nagata, K. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.1.469 · Cited by 351 · see citing works
Marks-Kończalik, J., Chu, S. C., & Moss, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.35.22201 · Cited by 311 · see citing works
Nitric oxide synthases: targets for therapeutic strategies in neurological diseases
Chabrier, P. E., Demerlé-Pallardy, C., & Auguet, M. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050353 · Cited by 215 · see citing works
Progress in the Development of Selective Nitric Oxide Synthase (NOS) Inhibitors
Saleron, L., Sorrenti, V., Giacomo, C. D., Romeo, G., & SIRACUSA, M. A. (2002) · Current Pharmaceutical Design · doi:10.2174/1381612023396375 · Cited by 214 · see citing works
Ren, M., Senatorov, V. V., Chen, R., & Chuang, D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0937423100 · Cited by 206 · see citing works
Morimoto, R. I., Kroeger, P. E., & Cotto, J. J. (1996) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-9088-5_10 · Cited by 167 · see citing works
The Cytokine Responsive Vascular Smooth Muscle Cell Enhancer of Inducible Nitric Oxide Synthase
Spink, J. M., Cohen, J., & Evans, T. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.49.29541 · Cited by 162 · see citing works
Trost, S. U., Omens, J. H., Karlon, W. J., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci265 · Cited by 143 · see citing works
Molecular mechanisms in the early phase of hemorrhagic shock
Hierholzer, C., & Billiar, T. R. (2001) · Langenbeck s Archives of Surgery · doi:10.1007/s004230100242 · Cited by 141 · see citing works
Induction of heat-shock protein 72 protects against ischemia/reperfusion in rat small intestine
Stojadinovic, A., Kiang, J. G., Smallridge, R. C., et al. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90339-9 · Cited by 132 · see citing works
Self-citationSato, M., Maulik, N., & Das, D. K. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02911.x · Cited by 116 · see citing works
Fonager, J., Beedholm, R., Clark, B. F. C., & Rattan, S. I. S. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00128-6 · Cited by 114 · see citing works
He, H., Soncin, F., Grammatikakis, N., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304663200 · Cited by 111 · see citing works
Kroeger, P. E., Sarge, K. D., & Morimoto, R. I. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.6.3370-3383.1993 · Cited by 108 · see citing works
Kim, H. R., Kang, H. S., & Kim, H. D. (1999) · IUBMB Life · doi:10.1080/713803536 · Cited by 107 · see citing works
Morris, S., Cumming, D. V. E., Latchman, D. S., et al. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118468 · Cited by 96 · see citing works
Calabrese, V., Testa, G., Ravagna, A., Bates, T. E., & Stella, A. M. G. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2311 · Cited by 93 · see citing works
Recovery of hepatocellular ATP and “pericentral apoptosis” after hemorrhage and resuscitation
Paxian, M., Bauer, I., Rensing, H., et al. (2003) · The FASEB Journal · doi:10.1096/fj.02-0624com · Cited by 93 · see citing works
Meng, X., & Harken, A. H. (2002) · Shock · doi:10.1097/00024382-200205000-00001 · Cited by 81 · see citing works
Kiang, J. G., McKinney, L. C., & Gallin, E. K. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.259.5.c727 · Cited by 79 · see citing works
Self-citationLoss of PKC-δ alters cardiac metabolism
Mayr, M., Chung, Y., Mayr, U., McGregor, E., Troy, H., Baier, G., Leitges, M., Dunn, M. J., Griffiths, J. R., & Xu, Q. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00877.2003 · Cited by 77 · see citing works
HSP-72 synthesis is promoted by increase in [Ca2+]i or activation of G proteins but not pHi or cAMP
Kiang, J. G., Carr, F. E., Burns, M. R., & McClain, D. E. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.267.1.c104 · Cited by 75 · see citing works
Self-citationWarke, V. G., Nambiar, M. P., Krishnan, S. K., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300787200 · Cited by 75 · see citing works
Collins, J. L., Vodovotz, Y., Hierholzer, C., et al. (2003) · Shock · doi:10.1097/00024382-200302000-00005 · Cited by 67 · see citing works
Rajnik, M., Salkowski, C. A., Thomas, K. E., Li, Y., Rollwagen, F. M., & Vogel, S. N. (2002) · Shock · doi:10.1097/00024382-200204000-00015 · Cited by 62 · see citing works
Kiang, J. G., Koenig, M. L., & Smallridge, R. C. (1992) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1992.263.1.c30 · Cited by 62 · see citing works
Self-citationDing, X. Z., Smallridge, R. C., Galloway, R. J., et al. (1996) · Journal of Investigative Medicine · doi:10.1177/108155899604400407 · Cited by 62 · see citing works
Conde, A. G., Lau, S. S., DILLMANN, W. H., et al. (1997) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1997.0431 · Cited by 56 · see citing works
Papaconstantinou, A. D., Brown, K. M., Noren, B., et al. (2003) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.10044 · Cited by 55 · see citing works
Pittet, J., Lu, L. N., Geiser, T., et al. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.013102 · Cited by 51 · see citing works
cDNA array analysis of gene expression following hemorrhagic shock and resuscitation in rats
Alam, H. B., Stegalkina, S. S., Rhee, P., & Koustova, E. (2002) · Resuscitation · doi:10.1016/s0300-9572(02)00095-3 · Cited by 51 · see citing works
Kiang, J. G., Bowman, P. D., Wu, B. W., et al. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00194.2004 · Cited by 49 · see citing works
Self-citationMizushima, Y., Wang, P., Jarrar, D., et al. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.2.r352 · Cited by 46 · see citing works
Kiang, J. G., Ding, X. Z., & McClain, D. E. (1998) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1997.8364 · Cited by 45 · see citing works
Self-citationJones, D. T., Addison, E., North, J. M., et al. (2003) · Blood · doi:10.1182/blood-2003-05-1603 · Cited by 44 · see citing works
Murphy, P. G., Sharp, A. J., Shin, J. Y., et al. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10139 · Cited by 43 · see citing works
Transglutaminase catalyzes differential crosslinking of small heat shock proteins and amyloid‐β
Boros, S., Kamps, B., Wunderink, L., et al. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.08.062 · Cited by 39 · see citing works
How Shall We Train for Combat Casualty Care?
Bellamy, R. F. (1987) · Military Medicine · doi:10.1093/milmed/152.12.617 · Cited by 35 · see citing works
Ethyl pyruvate: a novel treatment for sepsis and shock.
Fink, M. (2004) · PubMed · Cited by 34 · see citing works
The Use of Insulin and Glucose during Resuscitation from Hemorrhagic Shock Increases Hepatic ATP
Chang, C. G., Way, C. W. V., Dhar, A., et al. (2000) · Journal of Surgical Research · doi:10.1006/jsre.2000.5857 · Cited by 34 · see citing works
Kiang, J. G., Wu, Y. Y., & Lin, M. (1991) · Biochemical Journal · doi:10.1042/bj2760683 · Cited by 34 · see citing works
Self-citationCellular Energetics in Hemorrhagic Shock: Restoring Adenosine Triphosphate to the Cells
Way, C. W. V., Dhar, A., Morrison, D. C., et al. (2003) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/01.ta.0000047226.36678.ee · Cited by 34 · see citing works
Regulation of heat shock protein 72 kDa and 90 kDa in human breast cancer MDA-MB-231 cells
Kiang, J. G., Gist, I. D., & Tsokos, G. C. (2000) · Molecular and Cellular Biochemistry · doi:10.1023/a:1007016822939 · Cited by 31 · see citing works
Self-citationMeng, X., Banerjee, A. M., Ao, L., Meldrum, D. R., Cain, B. S., Shames, B. D., & Harken, A. H. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09226.x · Cited by 29 · see citing works
Kiang, J. G., Gist, I. D., & Tsokos, G. C. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.14.1571 · Cited by 27 · see citing works
Self-citationAdenosine triphosphate–magnesium chloride: relevance for intensive care
Nalos, M., Asfar, P., Ichaï, C., et al. (2003) · Intensive Care Medicine · doi:10.1007/s00134-002-1550-9 · Cited by 26 · see citing works
NaCN-induced chemical hypoxia is associated with altered gene expression
Kiang, J. G., Warke, V. G., & Tsokos, G. C. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1027363900317 · Cited by 26 · see citing works
Self-citationSaika, M., Ueyama, T., & Senba, E. (2000) · Digestive Diseases and Sciences · doi:10.1023/a:1005615714451 · Cited by 26 · see citing works
Jg, K., Xz, D., & McClain, D. E. (1996) · PubMed · Cited by 24 · see citing works
Sec-dependent protein export and the involvement of the molecular chaperone SecB
Kim, J., & Kendall, D. A. (2000) · Cell Stress and Chaperones · doi:10.1379/1466-1268(2000)005 · Cited by 23 · see citing works
Tunici, P., Schiaffonati, L., Rabellotti, E., et al. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04084.x · Cited by 23 · see citing works
Briant, D. J., Ohan, N. W., & Heikkila, J. J. (1997) · Biochemistry and Cell Biology · doi:10.1139/o97-071 · Cited by 23 · see citing works
Kiang, J. G., Gist, I. D., & Tsokos, G. C. (1997) · PubMed · Cited by 20 · see citing works
Self-citationCarter, Y., Liu, G., Yang, J., et al. (2003) · Surgical Infections · doi:10.1089/109629603764655245 · Cited by 19 · see citing works
Kiang, J. G., Gist, I. D., & Tsokos, G. C. (1999) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006946329581 · Cited by 18 · see citing works
Self-citationKiang, J. G., Lu, X., Tabaku, L., Bentley, T. B., Atkins, J. L., & Tsokos, G. C. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00858.2004 · Cited by 16 · see citing works
Self-citationGenistein inhibits herbimycin A-induced overexpression of inducible heat shock protein 70 kDa
Kiang, J. G. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1022836616452 · Cited by 14 · see citing works
Self-citationHerbimycin A attenuates apoptosis during heat stress in rats
Sachidhanandam, S., Lu, J., Low, K. S. Y., et al. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01997-6 · Cited by 13 · see citing works
Combat Medicine: Basic and Clinical Research in Military, Trauma, and Emergency Medicine
Hoff, W. S. (2004) · Current Surgery · doi:10.1016/j.cursur.2003.11.011 · Cited by 11 · see citing works
ATP depletion and replenishment in hemorrhagic shock.
Ih, C., Planer, G. J., Mm, S., et al. (1973) · PubMed · Cited by 11 · see citing works
Kiang, J. G., & Koenig, M. L. (1996) · Journal of Investigative Medicine · doi:10.1177/108155899604400611 · Cited by 9 · see citing works
Self-citationShea‐Donohue, T., Anderson, J., & Swiecki, C. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-407-8_9 · Cited by 7 · see citing works
Heat shock protein (HSP72) and p38 MAPK involvement in sublethal hemorrhage (SLH)-induced tolerance
Carter, Y., Liu, G., Stephens, W. B., et al. (2003) · Journal of Surgical Research · doi:10.1016/s0022-4804(03)00080-5 · Cited by 7 · see citing works
Hemorrhagic Shock and Resuscitation
Rhee, P., Alam, H. B., & Ling, G. S. F. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-407-8_8 · Cited by 4 · see citing works
Kianq, J. G., Lu, X., Tabaku, L., et al. (2004) · Shock · doi:10.1097/00024382-200406002-00129 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Henegar, C., Tordjman, J., Achard, V., Lacasa, D., Cremer, I., Guerre-Millo, M., Poitou, C., Basdevant, A., Stich, V., Viguerie, N., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-1-r14 · Cited by 471 · see citing works
Filipović, D., Todorović, N., Bernardi, R. E., & Gass, P. (2017) · Brain Structure and Function · doi:10.1007/s00429-016-1218-9 · Cited by 138 · see citing works
Di Domenico, F., Di Domenico, F., Perluigi, M., Foppoli, C., Blarzino, C., Coccia, R., De Marco, F., Butterfield, D. A., & Cini, C. (2009) · Free Radical Research · doi:10.1080/10715760902777329 · Cited by 41 · see citing works
- Authors
- KIANG, J. G.
- Affiliations
- Uniformed Services University of the Health Sciences (US)
- Corresponding author
- KIANG, Juliann G
- ORCID
- KIANG, Juliann G
- Venue
- Cell Research
- Published
- 2004-12
- Volume
- 14
- Issue
- 6
- Pages
- 450-459
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- OpenAlex
- W2049047452
- Cited by
- 63
- References
- 75
- Citations by year
- 2025: 2 · 2022: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 2 · 2015: 6 · 2014: 5 · 2013: 4 · 2012: 3
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- green
- zenodo.org
- Licence
- public-domain
- www.springer.com/tdm (tdm)
- Locations
- Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, public-domain)
- Funders
- U.S. Department of Defense
- Uniformed Services University of the Health Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
- Health Sciences › Medicine › Emergency Medicine › Cardiac Arrest and Resuscitation
- Keywords
- HSP70, inducible nitric oxide synthase, hemorrhagic shock, resuscitation, nitric oxide, ischemia-reperfusion injury, geldanamycin, ansamycins, caspase-3, neutrophil infiltration, leukotriene B4, transcription factors, trauma (physical injury)
- MeSH terms
- Animals, Enzyme Activation, Humans, Nitric Oxide, Resuscitation, Shock, Hemorrhagic, Wounds and Injuries, HSP70 Heat-Shock Proteins, Nitric Oxide Synthase, Nitric Oxide Synthase Type II
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
