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The role of glutathione in disulphide bond formation and endoplasmic‐reticulum‐generated oxidative stress
Open accessAbstract
Glutathione is a ubiquitous molecule found in all parts of the cell where it fulfils a range of functions from detoxification to protection from oxidative damage. It provides the main redox buffer for cells and as such has been implicated in the formation of native disulphide bonds. However, the discovery of the enzyme Ero1 has called into question the exact role of glutathione in this process. In this review, we discuss the arguments for and against a role for glutathione in facilitating disulphide‐bond formation and consider its role in protecting the cell from endoplasmic‐reticulum‐generated oxidative stress.
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Citations
Cites
Oxidized Redox State of Glutathione in the Endoplasmic Reticulum
Hwang, C., Sinskey, A. J., & Lodish, H. F. (1992) · Science · doi:10.1126/science.1523409 · Cited by 1,968
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Hasanuzzaman, M., Bhuyan, M. H. M., Zulfiqar, F., Raza, A., Mohsin, S., Mahmud, J., Fujita, M., & Fotopoulos, V. (2020) · Antioxidants · doi:10.3390/antiox9080681 · Cited by 3,096
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Forman, H. J., Maiorino, M., & Ursini, F. (2010) · Biochemistry · doi:10.1021/bi9020378 · Cited by 827
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Zhuang, J., Gordon, M. R., Ventura, J., Li, L., & Thayumanavan, S. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60094g · Cited by 621
Metadata
- Authors
- Chakravarthi, S., Jessop, C. E., & Bulleid, N. J.
- Venue
- EMBO reports
- Published
- 2006-03
- Volume
- 7
- Issue
- 3
- Pages
- 271-275
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2146774140
- Cited by
- 463
- References
- 1
- FWCI
- 7.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Chakravarthi, S., Jessop, C. E., & Bulleid, N. J. (2006). The role of glutathione in disulphide bond formation and endoplasmic‐reticulum‐generated oxidative stress. EMBO reports. https://doi.org/10.1038/sj.embor.7400645
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
