The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Ku recruits XLF to DNA double‐strand breaks
Open accessAbstract
XRCC4‐like factor (XLF)—also known as Cernunnos—has recently been shown to be involved in non‐homologous end‐joining (NHEJ), which is the main pathway for the repair of DNA double‐strand breaks (DSBs) in mammalian cells. XLF is likely to enhance NHEJ by stimulating XRCC4–ligase IV‐mediated joining of DSBs. Here, we report mechanistic details of XLF recruitment to DSBs. Live cell imaging combined with laser micro‐irradiation showed that XLF is an early responder to DSBs and that Ku is essential for XLF recruitment to DSBs. Biochemical analysis showed that Ku–XLF interaction occurs on DNA and that Ku stimulates XLF binding to DNA. Unexpectedly, XRCC4 is dispensable for XLF recruitment to DSBs, although photobleaching analysis showed that XRCC4 stabilizes the binding of XLF to DSBs. Our observations showed the direct involvement of XLF in the dynamic assembly of the NHEJ machinery and provide mechanistic insights into DSB recognition.
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Cites
Callebaut, I., Malivert, L., Fischer, A., Mornon, J.-P., Revy, P., & de Villartay, J.-P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.c500473200 · Cited by 130
Cited by
Mechanisms of DNA damage, repair, and mutagenesis
Chatterjee, N., & Walker, G. C. (2017) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22087 · Cited by 2,039
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
Polo, S. E., & Jackson, S. P. (2011) · Genes & Development · doi:10.1101/gad.2021311 · Cited by 1,092
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
Mahaney, B. L., Meek, K., & Lees-Miller, S. P. (2009) · Biochemical Journal · doi:10.1042/bj20080413 · Cited by 717
Moyal, L., Lerenthal, Y., Gana-Weisz, M., Mass, G., So, S., Wang, S.-Y., Eppink, B., Chung, Y. M., Shalev, G., Shema, E., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.02.015 · Cited by 403
Self-citationThompson, L. H. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.06.002 · Cited by 357
Metadata
- Authors
- Yano, K., Morotomi‐Yano, K., Wang, S., Uematsu, N., Lee, K., Asaithamby, A., Weterings, E., & Chen, D. J.
- Venue
- EMBO reports
- Published
- 2007-12-07
- Volume
- 9
- Issue
- 1
- Pages
- 91-96
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2085422820
- Cited by
- 193
- References
- 1
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yano, K., Morotomi‐Yano, K., Wang, S., Uematsu, N., Lee, K., Asaithamby, A., Weterings, E., & Chen, D. J. (2008). Ku recruits XLF to DNA double‐strand breaks. EMBO reports. https://doi.org/10.1038/sj.embor.7401137
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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