The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
Regulating mammalian checkpoints through Cdc25 inactivation
Open accessAbstract
Precise monitoring of DNA replication and chromosome segregation ensures that there is accurate transmission of genetic information from a cell to its daughters. Eukaryotic cells have developed a complex network of checkpoint pathways that sense DNA lesions and defects in chromosome segregation, spindle assembly and the centrosome cycle, leading to an inhibition of cell‐cycle progression for the time required to remove the defect and thus preventing genomic instability. The activation of checkpoints that are responsive to DNA damage or incomplete DNA replication ultimately results in the inhibition of cyclin‐dependent kinases. This review focuses on our understanding of the biochemical mechanisms that specifically inactivate Cdc25 (cell division cycle 25) phosphatases to achieve this. The evidence for links between checkpoint deregulation and oncogenesis is discussed.
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Cited by
Cell-cycle checkpoints and cancer
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Checking on DNA damage in S phase
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SCFβ-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase
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Metadata
- Authors
- Donzelli, M., & Draetta, G. F.
- Venue
- EMBO reports
- Published
- 2003-07
- Volume
- 4
- Issue
- 7
- Pages
- 671-677
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2108979392
- Cited by
- 438
- References
- 69
- FWCI
- 7.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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