Checking on DNA damage in S phase

Genome maintenance mechanisms for preventing cancer

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

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The DNA damage response: putting checkpoints in perspective

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Checkpoints: Controls That Ensure the Order of Cell Cycle Events

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Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

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ATM and related protein kinases: safeguarding genome integrity

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Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

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Cell cycle checkpoint signaling through the ATM and ATR kinases

Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966 · see citing works

Cancer Susceptibility and the Functions of BRCA1 and BRCA2

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Chk1 is an essential kinase that is regulated by Atr and required for the G ₂ /M DNA damage checkpoint

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Chk1 and Chk2 kinases in checkpoint control and cancer

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F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

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The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

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Requirement of the MRN complex for ATM activation by DNA damage

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Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

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ATR and ATRIP: Partners in Checkpoint Signaling

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<i>ATR</i> disruption leads to chromosomal fragmentation and early embryonic lethality

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Molecular views of recombination proteins and their control

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Replicon Clusters Are Stable Units of Chromosome Structure: Evidence That Nuclear Organization Contributes to the Efficient Activation and Propagation of S Phase in Human Cells

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MDC1 is a mediator of the mammalian DNA damage checkpoint

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The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling

D'Amours, D., & Jackson, S. P. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm805 · Cited by 874 · see citing works

The BRCT Domain Is a Phospho-Protein Binding Domain

Yu, X., Chini, C. C. S., He, M., Mer, G., & Chen, J. (2003) · Science · doi:10.1126/science.1088753 · Cited by 862 · see citing works

A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome

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Radiosensitivity in ataxia-telangiectasia: a new explanation.

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Rapid Destruction of Human Cdc25A in Response to DNA Damage

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Toward Maintaining the Genome: DNA Damage and Replication Checkpoints

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Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2004) · Science · doi:10.1126/science.1091496 · Cited by 762 · see citing works

The DNA replication checkpoint response stabilizes stalled replication forks

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The F-box protein family.

Kipreos, E. T., & Pagano, M. (2000) · Genome biology · doi:10.1186/gb-2000-1-5-reviews3002 · Cited by 743 · see citing works

Interfaces Between the Detection, Signaling, and Repair of DNA Damage

Rouse, J. W., & Jackson, S. P. (2002) · Science · doi:10.1126/science.1074740 · Cited by 688 · see citing works

Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint

Tercero, J. A., & Diffley, J. F. X. (2001) · Nature · doi:10.1038/35087607 · Cited by 667 · see citing works

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

Manke, I. A., Lowery, D. M., Nguyen, A., & Yaffe, M. B. (2003) · Science · doi:10.1126/science.1088877 · Cited by 651 · see citing works

DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1

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Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damagePreprint

Kim, S., Xu, B., & Kastan, M. B. (2002) · Genes & Development · doi:10.1101/gad.970602 · Cited by 581 · see citing works

53BP1, a Mediator of the DNA Damage Checkpoint

Wang, B., Matsuoka, S., Carpenter, P. B., & Elledge, S. J. (2002) · Science · doi:10.1126/science.1076182 · Cited by 578 · see citing works

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A

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Involvement of Brca1 in S-Phase and G 2 -Phase Checkpoints after Ionizing Irradiation

Xu, B., Kim, S., & Kastan, M. B. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3445-3450.2001 · Cited by 540 · see citing works

Overexpression of a kinase‐inactive ATR protein causes sensitivity to DNA‐damaging agents and defects in cell cycle checkpoints

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Phosphorylation of SMC1 is a critical downstream event in the ATM–NBS1–BRCA1 pathwayPreprint

Kitagawa, R., Bakkenist, C. J., McKinnon, P. J., & Kastan, M. B. (2004) · Genes & Development · doi:10.1101/gad.1200304 · Cited by 528 · see citing works

Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: Evidence for multiple roles of mitotic cyclins

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MDC1 is required for the intra-S-phase DNA damage checkpoint

Goldberg, M., Stucki, M., Falck, J., D'Amours, D., Rahman, D., Pappin, D., Bartek, J., & Jackson, S. P. (2003) · Nature · doi:10.1038/nature01445 · Cited by 506 · see citing works

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpointPreprint

Yazdi, P. T., Wang, Y., Zhao, S., Patel, N., Lee, E. Y.-H. P., & Qin, J. (2002) · Genes & Development · doi:10.1101/gad.970702 · Cited by 505 · see citing works

The Mre11 complex is required for ATM activation and the G2/M checkpoint

Carson, C. T., Schwartz, R. A., Stracker, T. H., Lilley, C. E., Lee, D. V., & Weitzman, M. D. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg630 · Cited by 502 · see citing works

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatinPreprint

Zou, L., Cortez, D., & Elledge, S. J. (2002) · Genes & Development · doi:10.1101/gad.950302 · Cited by 498 · see citing works

Aberrant cell cycle checkpoint function and early embryonic death in Chk1−/− micePreprint

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Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage.

Lukas, C., Falck, J., Bartkova, J., Bartek, J., & Lukas, J. (2003) · Nature Cell Biology · doi:10.1038/ncb945 · Cited by 474 · see citing works

Pathways governing G1/S transition and their response to DNA damage

Bartek, J. J., & Lukas, J. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02114-7 · Cited by 467 · see citing works

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G 2 checkpoints

Zhao, H., Watkins, J. L., & Piwnica-Worms, H. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182557299 · Cited by 459 · see citing works

Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage

Busino, L., Donzelli, M., Chiesa, M., Guardavaccaro, D., Ganoth, D., Valerio Dorrello, N., Hershko, A., Pagano, M., & Draetta, G. F. (2003) · Nature · doi:10.1038/nature02082 · Cited by 447 · see citing works

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

de Klein, A., Muijtjens, M., van Os, R. P., Verhoeven, Y., Smit, B., Carr, A. M., Lehmann, A. R., & Hoeijmakers, J. H. J. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00447-4 · Cited by 437 · see citing works

Regulating mammalian checkpoints through Cdc25 inactivation

Donzelli, M., & Draetta, G. F. (2003) · EMBO Reports · doi:10.1038/sj.embor.embor887 · Cited by 435 · see citing works

Chk2‐deficient mice exhibit radioresistance and defective p53‐mediated transcription

Takai, H., Naka, K., Okada, Y., Watanabe, M., Harada, N., Saito, S., Anderson, C. W., Appella, E., Nakanishi, M., Suzuki, H., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf506 · Cited by 435 · see citing works

Claspin, a Novel Protein Required for the Activation of Chk1 during a DNA Replication Checkpoint Response in Xenopus Egg Extracts

Kumagai, A., & Dunphy, W. G. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00092-4 · Cited by 430 · see citing works

p53 Binding Protein 53BP1 Is Required for DNA Damage Responses and Tumor Suppression in Mice

Ward, I. M., Minn, K. T., van Deursen, J., & Chen, J. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.7.2556-2563.2003 · Cited by 412 · see citing works

Chk2 Is a Tumor Suppressor That Regulates Apoptosis in both an Ataxia Telangiectasia Mutated (ATM)-Dependent and an ATM-Independent Manner

Hirao, A., Cheung, A., Duncan, G. S., Girard, P.-M., Elia, A., Wakeham, A. C., Okada, H., Sarkissian, T., Wong, J. A., Sakai, T., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.18.6521-6532.2002 · Cited by 404 · see citing works

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

DiTullio, R. A., Mochan, T. A., Venere, M., Bártková, J., Sehested, M., Bártek, J., & Halazonetis, T. D. (2002) · Nature Cell Biology · doi:10.1038/ncb892 · Cited by 399 · see citing works

The DNA damage-dependent intra–S phase checkpoint is regulated by parallel pathways

Falck, J., Petrini, J. H. J., Williams, B. R., Lukas, J., & Bartek, J. (2002) · Nature Genetics · doi:10.1038/ng845 · Cited by 392 · see citing works

Targeting the checkpoint kinases: chemosensitization versus chemoprotection

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Mdc1 couples DNA double‐strand break recognition by Nbs1 with its H2AX‐dependent chromatin retention

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ATR and ATM regulate the timing of DNA replication origin firing

Shechter, D., Costanzo, V., & Gautier, J. (2004) · Nature Cell Biology · doi:10.1038/ncb1145 · Cited by 383 · see citing works

Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae

Myung, K., Chen, C. C., & Kolodner, R. (2001) · Nature · doi:10.1038/35082608 · Cited by 369 · see citing works

An ATR- and Cdc7-Dependent DNA Damage Checkpoint that Inhibits Initiation of DNA Replication

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Action of DNA Repair Endonuclease ERCC1/XPF in Living Cells

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Checking on the fork: the DNA-replication stress-response pathway

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SCF^β-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

Jin, J., Shirogane, T., Xu, L., Nalepa, G., Qin, J., Elledge, S. J., & Harper, J. W. (2003) · Genes &amp; Development · doi:10.1101/gad.1157503 · Cited by 340 · see citing works

The cellular response to DNA double-strand breaks: defining the sensors and mediators

Petrini, J. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00170-3 · Cited by 339 · see citing works

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

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Suppression of Spontaneous Chromosomal Rearrangements by S Phase Checkpoint Functions in Saccharomyces cerevisiae

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Regulation of G2/M events by Cdc25A through phosphorylation‐dependent modulation of its stability

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ATM: Genome stability, neuronal development, and cancer cross paths

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Spatial and Temporal Dynamics of DNA Replication Sites in Mammalian Cells

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ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanismPreprint

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Interaction of FANCD2 and NBS1 in the DNA damage response

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Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage

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Visualization of Altered Replication Dynamics after DNA Damage in Human Cells

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The DNA crosslink‐induced S‐phase checkpoint depends on ATR–CHK1 and ATR–NBS1–FANCD2 pathways

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ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phasePreprint

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The mismatch repair system is required for S-phase checkpoint activation

Brown, K. D., Rathi, A., Kamath, R., Beardsley, D. I., Zhan, Q., Mannino, J. L., & Baskaran, R. (2003) · Nature Genetics · doi:10.1038/ng1052 · Cited by 206 · see citing works

Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis

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Claspin, a Chk1-Regulatory Protein, Monitors DNA Replication on Chromatin Independently of RPA, ATR, and Rad17

Lee, J., Kumagai, A., & Dunphy, W. G. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00045-5 · Cited by 199 · see citing works

Distinct Functional Domains of Nibrin Mediate Mre11 Binding, Focus Formation, and Nuclear Localization

Desai-Mehta, A., Cerosaletti, K. M., & Concannon, P. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.6.2184-2191.2001 · Cited by 196 · see citing works

53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage.

Mochan, T. A., Venere, M., DiTullio, R. A., & Halazonetis, T. D. (2003) · PubMed · Cited by 194 · see citing works

Dual mode of degradation of Cdc25 A phosphatase

Donzelli, M., Squatrito, M., Ganoth, D., Hershko, A., Pagano, M., & Draetta, G. F. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf491 · Cited by 194 · see citing works

Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex

Grenon, M., Gilbert, C., & Lowndes, N. F. (2001) · Nature Cell Biology · doi:10.1038/ncb0901-844 · Cited by 184 · see citing works

Phosphorylation of Histone H2B at DNA Double-Strand Breaks

Fernández-Capetillo, Ó., Allis, C. D., & Nussenzweig, A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20032247 · Cited by 182 · see citing works

Reconstitution of an ATM-Dependent Checkpoint that Inhibits Chromosomal DNA Replication following DNA Damage

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Requirement of protein phosphatase 5 in DNA-damage-induced ATM activationPreprint

Ali, A., Zhang, J., Bao, S., Liu, I., Otterness, D. M., Dean, N. M., Abraham, R. T., & Wang, X.-F. (2004) · Genes & Development · doi:10.1101/gad.1176004 · Cited by 170 · see citing works

Human Tousled like kinases are targeted by an ATM‐ and Chk1‐dependent DNA damage checkpoint

Groth, A., Lukáš, J., Nigg, E. A., Silljé, H. H. W., Wernstedt, C., Bartek, J. J., & Hansen, K. H. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg151 · Cited by 166 · see citing works

DNA damage stabilizes interaction of CSB with the transcription elongation machinery

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Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesis

Dimitrova, D. S., & Gilbert, D. M. (2000) · Nature Cell Biology · doi:10.1038/35036309 · Cited by 160 · see citing works

The many functions of smc proteins in chromosome dynamics

Jessberger, R. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm930 · Cited by 159 · see citing works

Control of Replication Origin Density and Firing Time in Xenopus Egg Extracts

Marheineke, K., & Hyrien, O. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401574200 · Cited by 152 · see citing works

The SCF Ubiquitin Ligase

Jackson, P. K., & Eldridge, A. G. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00538-5 · Cited by 152 · see citing works

Xeroderma pigmentosum group A protein loads as a separate factor onto DNA lesions

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Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae

Myung, K., & Kolodner, R. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.062702199 · Cited by 143 · see citing works

DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology.

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Mediator of DNA Damage Checkpoint Protein 1 Regulates BRCA1 Localization and Phosphorylation in DNA Damage Checkpoint Control

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