The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Differential regulation of interleukin-10 production by genetic and environmental factors – a twin study
Abstract
Interleukin-10 (IL-10) has a critical role in the regulation of immune responses. The relative contribution of genetic and environmental factors to IL-10 production is under debate. We performed a twin study in 246 monozygotic and dizygotic twins to assess the heritability of IL-10 production after LPS stimulation in whole blood. In addition, the influence of promoter single nucleotide polymorphisms (-1082, -819 and -592) on transcriptional activity and their binding to nuclear factors was studied in luciferase reporter gene and electrophoretic mobility shift assays. IL-10 production showed a genetic determination with a heritability of 0.5. Decreasing body mass index (BMI), smoking and female gender lead to decreased IL-10 production. In monocytes, the -1082A allele showed higher binding affinity to the transcription factor PU.1 resulting in decreased transcriptional activity of -1082A promoter haplotypes. Genetic determination of IL-10 secretion is probably lower than that previously reported. Fifty percent of the observed variability explained by genetic factors. Female individuals produce less IL-10 than male subjects. Environmental factors like smoking and decreasing BMI exert suppressing effects on IL-10 production. Although the -1082A allele shows higher binding affinity to the PU.1 transcription factor and lower transcriptional activity, this polymorphism probably explains only a small fraction of the observed heritability.
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“PU.1 is a transcription repressor that interacts with the Il10 promoter27,28.”
From The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance (2009) · cites this paper as [27]
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Cites
IL-10 inhibits cytokine production by activated macrophages
Fiorentino, D. F., Zlotnik, A., Mosmann, T. R., Howard, M., & O’Garra, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.11.3815 · Cited by 2,888
AN INVESTIGATION OF POLYMORPHISM IN THE INTERLEUKIN‐10 GENE PROMOTER
Turner, D. M., Williams, D. M., Sankaran, D., Lazarus, M. N., Sinnott, P. J., & Hutchinson, I. V. (1997) · European Journal of Immunogenetics · doi:10.1111/j.1365-2370.1997.tb00001.x · Cited by 1,706
Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes
Rousset, F., Garcia, E., Defrance, T., Péronne, C., Vezzio, N., Hsu, D. H., Kastelein, R., Moore, K. W., & Banchereau, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1890 · Cited by 1,238
Human Genetics. Problems and Approaches.
(1980) · Annals of Internal Medicine · doi:10.7326/0003-4819-93-1-163_3 · Cited by 990
Cytokine gene polymorphism in human disease: on-line databases
Bidwell, J. L., Keen, L. J., Gallagher, G. E., Kimberly, R. P., Huizinga, T. W. J., McDermott, M., Oksenberg, J. R., McNicholl, J., Pociot, F., Hardt, C., et al. (1999) · Genes and Immunity · doi:10.1038/sj.gene.6363645 · Cited by 805
Genetic control of the circulating concentration of transforming growth factor type beta1
Grainger, D. J. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.1.93 · Cited by 754
Llorente, L., Zou, W., Lévy, Y., Richaud‐Patín, Y., Wijdenes, J., Alcocer-Varela, J. C., Morel-Fourrier, B., Brouet, J. C., Alarcón-Segovia, D., Galanaud, P., et al. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.3.839 · Cited by 540
Properties and Functions of Interleukin-10
Mosman, T. R. (1994) · Advances in immunology · doi:10.1016/s0065-2776(08)60449-6 · Cited by 495
Interleukin 10 secretion in relation to human IL-10 locus haplotypes
Eskdale, J., Gallagher, G. E., Verweij, C. L., Keijsers, V., Westendorp, R. G. J., & Huizinga, T. W. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9465 · Cited by 466
Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1
Zhang, P., Behre, G., Pan, J., Iwama, A., Wara-aswapati, N., Radomska, H. S., Auron, P. E., Tenen, D. G., & Sun, Z. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.15.8705 · Cited by 459
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Li, X., Huang, Z., Hu, Y., Niu, Y., & Cai, J. (2020) · Journal of Immunology Research · doi:10.1155/2020/9382609 · Cited by 3
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Zhang, T., Wang, M., Pan, L., Ding, W., Wang, J., Yang, L., Liu, M., Li, W., & Yan, Z. (2007) · Twin Research and Human Genetics · doi:10.1375/twin.10.3.496 · Cited by 3
Shu, C., Wang, J., He, Y., Song, T., Chen, Z., Tang, S., & Tang, X. (2015) · Europe PMC (PubMed Central) · Cited by 3
Farias, M. G., dos Santos, C. A., Paz, A. A., & Daudt, L. E. (2024) · Transplant Immunology · doi:10.1016/j.trim.2024.102002 · Cited by 2
Saas, P., Courivaud, C., Bamoulid, J., Garnache‐Ottou, F., Seillès, E., & Ducloux, D. (2008) · Annales Pharmaceutiques Françaises · doi:10.1016/j.pharma.2008.03.004 · Cited by 2
Rai, H., & Sinha, N. (2017) · Exploratory Research and Hypothesis in Medicine · doi:10.14218/erhm.2016.00010 · Cited by 2
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Bubeshka, D. A., Snezhitskiy, V. А., & Степуро, Т. Л. (2017) · Vestnik of Vitebsk State Medical University · doi:10.22263/2312-4156.2017.2.70 · Cited by 1
Bratosiewicz‐Wąsik, J., & Wąsik, T. J. (2024) · Human Immunology · doi:10.1016/j.humimm.2024.111086 · Cited by 1
Wood, M. J. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i48.9366 · Cited by 1
The association between the interleukin-10 gene polymorphism (-1082 G/A) and allergic diseases.
Bocșan, I. C., Muntean, A. G., & Buzoianu, A. D. (2015) · Cited by 1
Dabitao, D., Dembélé, M., Urbanowski, M. E., Kone, B., Wague, M., Coulibaly, N., Sarro, Y. D. S., Baya, B., Goita, D., Dao, S., et al. (2020) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2020.0140 · Cited by 1
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Munro, S. K. (2013) · ResearchSpace (University of Auckland) · Cited by 1
Allergies et hypersensibilités aux médicaments. Facteurs de risque
Demoly, P. M., Guglielmi, P., & Guglielmi, L. (2006) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/s0001-4079(19)33172-3 · Cited by 1
Host Genetic Susceptibility to Infection
Ladhani, S. N., & Booy, R. (2008) · Springer eBooks · doi:10.1007/978-1-84628-917-0_9 · Cited by 1
Lung Cancer Susceptibility and Risk Assessment Models
Wu, X., Yang, H., Lin, J., & Spitz, M. R. (2008) · Lung Cancer · doi:10.1002/9780470696330.ch3 · Cited by 1
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Cardinal, P., Rieppi, G., & Bengochea, M. (2011) · Revista Médica del Uruguay
Woodward, E. (2011) · Murdoch University Research Portal
Liu, S., Zhang, K., Yin, C., Han, L., Sun, Y., Ren, W., Chu, N., & Li, C. (2012) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2011.0314
Mulholland, C. V. (2012) · Research Commons (University of Waikato)
Medhat, E. (2014) · Journal of Advances in Medicine and Medical Research · doi:10.9734/bjmmr/2014/11022
Duncan, D. D., Tiberio, L., & Eldridge, J. H. (2004) · Infection and Immunity · doi:10.1128/iai.72.7.4282-4285.2004
Functional analysis of the -1087 single nucleotide polymorphism in the IL-10 promoter region.
Larsson, L. (2010) · Gothenburg University Publications Electronic Archive (Gothenburg University)
ASSOCIATION OF CYTOKINE GENE POLYMORPHISMS WITH ATOPIC DERMATITIS
Vashina, G., Miteva, L. D., Hristakieva, E., & Stanilova, S. A. (2010)
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Ryckman, K. K. (2009)
Buziashvili, Y. I., Кокшенева, И. В., Abukov, S. T., & Sandukhadze, B. R. (2016) · Russian Journal of Cardiology and Cardiovascular Surgery · doi:10.17116/kardio20169113-19
Galdame, O., Fainboim, L., Muñoz, A., Paladino, N., Fainboim, H. A., & Theiler, G. (2013)
Krasnova, T. N., Иваницкий, Л. В., Korogodina, A. D., Борисов, Е. Н., Mukhin, N. A., Викторовна, Н. Н., Novikov, P. I., Samokhodskaya, L. M., & Kamalov, A. A. (2015) · CyberLeninK (CyberLeninka)
IL-10(-1082 G/A) Gene Polymorphism in Iraqi Patients with Scabies
Hadi, A. A. (2020) · Medico-Legal Update · doi:10.37506/mlu.v20i3.1592
Делегация университета им. Коменского из Братиславы, Словакия, посетила ВГМУ
(2017) · Vestnik of Vitebsk State Medical University · doi:10.22263/2312-4156.2017.2
Fazeli, Z., Abdollahimajd, F., Atazadeh, F., Karimi, M., Alikhani, A., Aryan, A., & Asadi, K. (2022) · Gene Reports · doi:10.1016/j.genrep.2022.101677
Khalek, E. R. A., Hassan, T., Latif, W. A., Yousef, H. M., & Ahmed, A. A. R. (2022) · The Egyptian Journal of Hospital Medicine · doi:10.21608/ejhm.2022.270808
Peran Polimorfisme Promotor Gen Interleukin-10 pada Penyakit Kusta: Tinjauan Sistematik
Oktariana, D., Saleh, I., Hafy, Z., & Liberty, I. A. (2023) · Journal Of The Indonesian Medical Association · doi:10.47830/jinma-vol.73.1-2023-816
de Azevedo, A. R. A., Bezerra, M. C. S., Silva, A. D. M., Constantino, T. D. S., Cândido, L. E. D. V., & Silva, P. C. V. (2023) · International Journal of Health Science · doi:10.22533/at.ed.1593422302062
de Oliveira, J. N., Fernandes, C. Y. M., de Godoy, S. M., Frantine‐Silva, W., Cassela, P. L. C. S., Trigo, G. L., Lozovoy, M. A. B., Tano, Z. N., Simão, A. N. C., & de Oliveira, K. B. (2025) · Human Immunology · doi:10.1016/j.humimm.2025.111261
Anciuc-Crauciuc, M., Crauciuc, A., Tripon, F., Simon, M., Cucerea, M., & Bănescu, C. V. (2025) · Diagnostics · doi:10.3390/diagnostics15172259
Menon, S. (2011) · University of Birmingham Institutional Research Archive (University of Birmingham)
Karami, P., Mokari, S., Alikhani, M. Y., Kazemi, S., Mirzaei, M., Soltanian, A., Ahmadyousefi, M., Dehdar, F., Haghi, A. R., & Azizi, E. (2026) · BMC Gastroenterology · doi:10.1186/s12876-026-05054-3
Metadata
- Authors
- Reuss, E., Fimmers, R., Kruger, A., Becker, C., Rittner, C., & Höhler, T.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- University of Bonn (DE)
- Corresponding author
- Höhler, T
- ORCID
- Becker, C
- Venue
- Genes & Immunity
- Published
- 2002-11-01
- Volume
- 3
- Issue
- 7
- Pages
- 407-413
- ISSN
- 1466-4879 (ISSN-L)
- 1476-5470
- OpenAlex
- W1985776841
- Cited by
- 247
- References
- 36
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 7 · 2021: 4 · 2020: 7 · 2019: 3 · 2018: 10 · 2017: 9 · 2016: 8 · 2015: 17 · 2014: 14 · 2013: 10 · 2012: 16
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Genes and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- IL-10, IL-10 production, heritability, genetic factors, environmental factors, monozygotic twins, dizygotic twins, promoter polymorphism, transcriptional activity, smoking, body mass index, sex differences, monocytes, lipopolysaccharide stimulation
- MeSH terms
- Binding Sites, Cell Line, DNA, Female, Gene Expression Regulation, Humans, Male, Monocytes, Promoter Regions, Genetic, Transcription Factors, Interleukin-10, Genes, Reporter, Twin Studies as Topic, Polymorphism, Single Nucleotide, Electrophoretic Mobility Shift Assay, In Vitro Techniques
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