Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes
Open accessAbstract
Interleukin 10 (IL-10), originally identified as a TH2 helper T-cell product able to inhibit cytokine production by TH1 cells, is highly homologous to BCRF1 (viral IL-10), an open reading frame in the Epstein-Barr virus genome. Here, we show that human and viral IL-10 stimulate DNA replication of B lymphocytes activated either via their antigen receptor or via their CD40 antigen. IL-4 and IL-10 display additive effects and induce a strong increase in the number of viable cells. Moreover, IL-10 induces activated B cells to secrete large amounts of IgG, IgA, and IgM, and the combination of IL-10 and IL-4 results in the secretion of the four immunoglobulin isotypes. Thus, IL-10 may play an important role in the amplification of humoral responses.
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IL-10 inhibits IFN-γ production by Th1 and NK cells.
“Of particular interest is that IL-10 inhibits the production of IFN-γ by Th1 and NK cells, and induces the growth, differentiation, and secretion of IgGs by B cells (61, 62).”
From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [62]
IL-10 induces the growth, differentiation, and secretion of IgGs by B cells.
“Of particular interest is that IL-10 inhibits the production of IFN-γ by Th1 and NK cells, and induces the growth, differentiation, and secretion of IgGs by B cells (61, 62).”
From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [62]
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- Authors
- Rousset, F., Garcia, E., Defrance, T., Péronne, C., Vezzio, N., Hsu, D. H., Kastelein, R., Moore, K. W., & Banchereau, J.
- Affiliations
- Schering-Plough, Laboratory for Immunological Research, Dardilly, France.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1992-03
- Volume
- 89
- Issue
- 5
- Pages
- 1890-1893
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC48559
- OpenAlex
- W2036072927
- Cited by
- 1,238
- References
- 0
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 11 · 2023: 17 · 2022: 35 · 2021: 18 · 2020: 36 · 2019: 21 · 2018: 18 · 2017: 18 · 2016: 28 · 2015: 27 · 2014: 43 · 2013: 37 · 2012: 36
- FWCI
- 23.36
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- IL-10, B cell activation, Epstein-Barr virus, viral IL-10, IL-4, CD40 signaling, B cell proliferation, immunoglobulin secretion, humoral immune response, DNA replication, antibody isotypes
- MeSH terms
- Antibody Formation, Antigens, Differentiation, B-Lymphocyte, B-Lymphocytes, Cell Differentiation, Cell Division, Cells, Cultured, DNA, Humans, Lymphocyte Activation, Receptors, Antigen, B-Cell, Recombinant Proteins, Viral Proteins, Antigens, CD, Interleukin-4, Interleukin-10, CD40 Antigens, In Vitro Techniques
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