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Characteristics of a human cell line transformed by DNA from human adenovirus type 5

Graham, F. L., Russell, W. C., Smiley, J., & Nairn, R. (1977) · Journal of General Virology · doi:10.1099/0022-1317-36-1-59 · Cited by 4,793

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741

A novel cationic liposome reagent for efficient transfection of mammalian cells

Gao, X., & Huang, L. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91366-k · Cited by 847

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Lee, E. R., Marshall, J., Siegel, C., Jiang, C., Yew, N. S., Nichols, M., Nietupski, J. B., Ziegler, R. J., Lane, M. B., Wang, K. X., et al. (1996) · Human Gene Therapy · doi:10.1089/hum.1996.7.14-1701 · Cited by 443

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Newell-Price, J. D. C., Clark, A. J. L., & King, P. (2000) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(00)00248-4 · Cited by 330

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Qin, L., Ding, Y., Pahud, D. R., Chang, E., Imperiale, M. J., & Bromberg, J. S. (1997) · Human Gene Therapy · doi:10.1089/hum.1997.8.17-2019 · Cited by 315

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Spencer, V. A., & Davie, J. (1999) · Gene · doi:10.1016/s0378-1119(99)00405-9 · Cited by 306

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Löser, P., Jennings, G. S., Strauss, M., & Sandig, V. (1998) · Journal of Virology · doi:10.1128/jvi.72.1.180-190.1998 · Cited by 277

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Uetsuki, T., Naito, A., Nagata, S., & Kaziro, Y. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83619-5 · Cited by 272

Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies.

Carvalho, T., Seeler, J.-S., Öhman, K., Jordan, P., Pettersson, U., Akusjärvi, G., Carmo‐Fonseca, M., & Dejean, A. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.1.45 · Cited by 267

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Magin-Lachmann, C., Kotzamanis, G., D’Aiuto, L., Wagner, E., & Huxley, C. M. (2003) · BMC Biotechnology · doi:10.1186/1472-6750-3-2 · Cited by 35

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Jones, S., Gill, D. R., & Hyde, S. C. (2007) · Journal of Virology · doi:10.1128/jvi.01010-07 · Cited by 32

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Young, J. L., Zimmer, W. E., & Dean, D. A. (2008) · Experimental Biology and Medicine · doi:10.3181/0712-rm-331 · Cited by 31

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Byun, H., Suh, D., Jeong, Y., Wee, H. S., Kim, J. M., Kim, W., Ko, J. J., Kim, J., Lee, Y., & Oh, Y. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.04.155 · Cited by 29

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Sclimenti, C. R., Neviaser, A. S., Baba, E. J., Meuse, L. A., Kay, M. A., & Calos, M. P. (2003) · Biotechnology Progress · doi:10.1021/bp0200907 · Cited by 28

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Dagnæs‐Hansen, F., Holst, H., Lindhard, M. S., Vorup‐Jensen, T., Flyvbjerg, A., Jensen, U. B., & Jensen, T. G. (2002) · Journal of Molecular Medicine · doi:10.1007/s00109-002-0371-1 · Cited by 28

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Chyung, Y. H., Peng, P. D., & Kay, M. A. (2003) · Human Gene Therapy · doi:10.1089/104303403767740795 · Cited by 6

Optimizing approaches for targeted integration of transgenic cassettes by integrase-mediated cassette exchange in mouse and human stem cells

Rath, P., Krämer, P., Biggs, D., Preece, C., Hortin, N., Diaz, R., Perez‐Alcantara, M., Li, X., Bolard, A., Beer, N. L., et al. (2025) · Stem Cells · doi:10.1093/stmcls/sxae092 · Cited by 7

Lentivirus vector driven by polybiquitin C promoter without woodchuck posttranscriptional regulatory element and central polypurine tract generates low level and short-lived reporter gene expression

Ngai, S. C., Rosli, R., Nordin, N., Veerakumarasivam, A., & Abdullah, S. (2012) · Gene · doi:10.1016/j.gene.2012.01.071 · Cited by 5

Identification of Biomarker and Co-Regulatory Motifs in Lung Adenocarcinoma Based on Differential Interactions

Zhao, N., Liu, Y., Chang, Z., Li, K., Zhang, R., Zhou, Y., Qiu, F., Han, X., & Xu, Y. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139165 · Cited by 4

A Self-Augmenting Gene Expression Cassette for Enhanced and Sustained Transgene Expression in the Presence of Proinflammatory Cytokines

Luo, P., Reed, B. D., Tsang, T. C., Harris, D. T., & Flavell, R. A. (2006) · DNA and Cell Biology · doi:10.1089/dna.2006.25.659 · Cited by 4

New Genetic and Pharmacological Treatments for Cystic Fibrosis

Conese, M., Romano, M., Furnari, M. L., Copreni, E., Fino, I. D., Pardo, F., & Galietta, L. J. V. (2009) · Current Pediatric Reviews · doi:10.2174/157339609787587555 · Cited by 3

Eliminating bacteria backbone of naked DNA enhanced hFIX expression and reduced inflammatory response in mice

Zhu, H.-Z., Chen, H., Feng, D., Shen, Q., Xue, J., & Jia, W. W.-G. (2008) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2008.02.006 · Cited by 3

Combination of optison with ultrasound and electroporation increases albumin and thrompoietin transgene expression whilst elongation factor promoter prolongs its duration

Habib, N. A., Havlík, R., Jiao, L., Kiri, A., Jensen, S. L., Nicholls, J. P., Sarraf, C., Goldspink, G., Davies, A., Slavík, L., et al. (2004) · WestminsterResearch (University of Westminster) · Cited by 3

Development of CpG‐Depleted CFTR Plasmid‐Based Nanoparticles for Nonviral Gene Therapy in Lung Cystic Fibrosis Disease

Qiu, B., Lorino, M., Li, Y., He, Z., Wang, X., Wang, W., & Lara‐Sáez, I. (2026) · The Journal of Gene Medicine · doi:10.1002/jgm.70087 · Cited by 2

Promoting Gene Therapy: Expression Systems for Iransgenes and Post-transcriptional Gene Silencing

Unwalla, H. J., & Rossi, J. J. (2006) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2006.10648079 · Cited by 2

Gene therapy for cystic fibrosis lung disease

Jones, S., Gill, D. R., & Hyde, S. C. (2010) · Springer eBooks · doi:10.1007/978-3-0346-0165-8_4 · Cited by 2

Nonionic Amphiphilic Block Copolymers Promote Gene Transfer to the Lung

Desigaux, L., Gourden, C., Bello-Roufaı̈, M., Richard, P., Oudrhiri, N., Lehn, P., Escande, D., Pollard, H., & Pitard, B. (2005) · Human Gene Therapy · doi:10.1089/hum.2005.16.ft-82 · Cited by 2

Fine-tuned phenylboronic acid polymer assembly with tannic acid enables adeno-associated virus to evade and suppress neutralizing antibody responses

Xiao, Y., Honda, Y., Matsudaira, N., Kinoh, H., Shen, X., Haochen, G., Hayashita-Kinoh, H., Gao, S., Awaad, A., Miura, Y., et al. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.114844 · Cited by 1

AAV9‐ DARS2 Gene Therapy Rescues Phenotype in Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation Patient Cells and Neuronal Dars2 Deficient Mice

Garofolo, I., Lindsay, B. D., Liang, Y., Ratajczak, B., Janowski, M., Walczak, P., Fatemi, A. S., & Nemeth, C. L. (2025) · Annals of Neurology · doi:10.1002/ana.78037 · Cited by 1

Gene Therapy for Lung Diseases

Alton, E. W. F. W., Davies, J. C., & Geddes, D. M. (2006) · Humana Press eBooks · doi:10.1007/978-1-59259-963-9_28 · Cited by 1

Recombinant protein expression in mammalian cells

Joshi, M., Verma, P., Mago, P., Agrawal, Y., Gunwal, I., Khurana, S., Tanwar, J., Yadav, U., & Yadav, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-98388-4.00008-3 · Cited by 1

Production of lentivirus carrying green fluorescent protein with different promoters for in vitro gene transfer

Ngai, S. C., Ramasamy, R., & Abdullah, S. (2012) · Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) · Cited by 1

Identification of ebola glycoprotein mutants that exhibit increased transduction efficiency

Sandersfeld, L. M. (2009) · doi:10.17077/etd.7awu17s3

Gene Electrotransfer to Lung

Dean, D. A. (2011) · Springer eBooks · doi:10.1007/978-1-4419-8363-3_15

Utilizing Minicircle Vectors for the Episomal Modification of Cells

Argyros, O., Wong, S., Coutelle, C. C., & Harbottle, R. P. (2013) · Wiley eBooks · doi:10.1002/9783527670420.ch7

Characterization and applications in muscle of a Minicircle vector for Nonviral gene therapy

Stenler, S. (2015) · Figshare

FUNCTIONAL ANALYSIS OF 5'-FLANKING REGION OF CYTOCHROME P450 GENES THROUGH MOLECULAR CLONING AND TRANSFECTION IN VITRO AND IN VIVO

Al-Dosari, M. S. (2005) · D-Scholarship@Pitt (University of Pittsburgh)

Detection of plasmid DNA vectors following gene transfer to the murine airways

Pringle, I. A., Raman, S., Sharp, W. W., Cheng, S. H., Hyde, S. C., & Gill, D. R. (2005) · Gene Therapy · doi:10.1038/sj.gt.3302518 · Cited by 41

An investigation into persistent transgene expression from plasmid vectors in the lung

de Oliveira, C. A. L. (2016) · Oxford University Research Archive (ORA) (University of Oxford) · doi:10.5287/ora-mqy9rn8xj

High and Sustained Transgene Expression in Vivo from Plasmid Vectors Containing a Hybrid Ubiquitin Promoter

Yew, N. S., Przybylska, M., Ziegler, R. J., Liu, D., & Cheng, S. H. (2001) · Molecular Therapy · doi:10.1006/mthe.2001.0415 · Cited by 132

Transgene sequences free of CG dinucleotides lead to high level, long-term expression in the lung independent of plasmid backbone design

Bazzani, R. P., Pringle, I. A., Connolly, M. M., Davies, L. A., Jones, S., Schleef, M., Hyde, S. C., & Gill, D. R. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.03.029 · Cited by 16

Increased Duration of Transgene Expression in the Lung with Plasmid DNA Vectors Harboring Adenovirus E4 Open Reading Frame 3

Yew, N. S., Marshall, J., Przybylska, M., Wysokenski, D. M., Ziegler, R. J., Rafter, P. W., Li, C. Q., Armentano, D., & Cheng, S. H. (1999) · Human Gene Therapy · doi:10.1089/10430349950017518 · Cited by 23