Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling

Wilson, Nicholas S; Young, Louise J; Kupresanin, Fiona; Naik, Shalin H; Vremec, David; Heath, William R; Akira, Shizuo; Shortman, Ken; Boyle, Jeff; Maraskovsky, Eugene; Belz, Gabrielle T; Villadangos, José A

doi:10.1038/sj.icb.7100125

Cited by 102Immunotherapy and Immune ResponsesImmune Response and InflammationT-cell and B-cell Immunology

Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling

Wilson, Nicholas S, Young, Louise J, Kupresanin, Fiona, Naik, Shalin H, Vremec, David, Heath, William R, Akira, Shizuo, Shortman, Ken +4 more·2008·Immunology & Cell Biology

DOI 10.1038/sj.icb.7100125

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Abstract

Dendritic cells (DCs) play major roles in immunosurveillance. In peripheral tissues, 'immature' DCs are dedicated to capturing antigens. Detection of pathogens through Toll-like receptors (TLRs) triggers DC migration to the lymph nodes (LNs), where they acquire a 'mature' phenotype specialized at presenting antigens. However, DCs migrate from tissues and mature even in the absence of overt infections. This has been attributed to detection of commensal flora in the skin, the gut or other peripheral tissues in the steady state. To test this assumption, we have analyzed the DCs contained in the lymphoid organs of germ-free mice and of mice lacking the TLR adapter molecules, MyD88 and TRIF. We show that the proportion and expression of maturation markers in DC immigrants in the LNs of these mice are similar to those in normal mice. These results suggest that DC migration from tissues, followed by their phenotypic maturation, is regulated in the steady state by an inherent program of DC differentiation or by the release of low levels of inflammatory signals from normal tissues.

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There were no differences in dendritic cell proportions in spleen, tumor-draining or inguinal lymph nodes between SPF and GF mice that were naive or tumor-bearing.
“Of note, we did not observe differences in DC proportions in the spleen, tumor-draining or inguinal lymph nodes from SPF and GF mice that were either naive or tumor-bearing (Figures S2D and S2E), agreeing with previous reports (Ganal et al., 2012; Wilson et al., 2008).”
From Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment (2021) · cites this paper as Wilson et al., 2008

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Authors: Wilson, N. S., Young, L. J., Kupresanin, F., Naik, S. H., Vremec, D., Heath, W. R., Akira, S., Shortman, K., Boyle, J., Maraskovsky, E., Belz, G. T., & Villadangos, J. A.
Affiliations: Genentech (US)
Walter and Eliza Hall Institute of Medical Research (AU)
Research Institute for Microbial Diseases, The University of Osaka (JP)
CSL (Australia) (AU)
The Walter and Eliza Hall Institute of Medical Research Parkville Victoria Australia
Corresponding author: Belz, Gabrielle T
ORCID: Wilson, Nicholas S
Naik, Shalin H
Heath, William R
Akira, Shizuo
Shortman, Ken
Maraskovsky, Eugene
Belz, Gabrielle T
Venue: Immunology & Cell Biology
Publisher: Wiley
Published: 2007-11-20
Volume: 86
Issue: 2
Pages: 200-205
ISSN: 0004-945X (ISSN-L)
0818-9641
1440-1711
DOI: 10.1038/sj.icb.7100125
OpenAlex: W1969532079
Cited by: 102
References: 38
Citations by year: 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 6 · 2017: 10 · 2016: 5 · 2015: 8 · 2014: 7 · 2013: 9 · 2012: 8
FWCI: 2.85
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Immunology and Cell Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Health and Medical Research Council of Australia
University of Melbourne Research Scholarship
Leukemia and Lymphoma Society Scholarship
Wellcome Trust Senior Overseas Fellowship
Howard Hughes Medical Institute International Fellowships
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: dendritic cells, dendritic cell migration, dendritic cell maturation, Toll-like receptors, MyD88, TRIF, germ-free mice, lymph nodes, steady-state immunity, commensal microbiota, inflammatory signals
MeSH terms: Animals, Bacteria, Cell Movement, Dendritic Cells, Germ-Free Life, Mice, Inbred C57BL, Signal Transduction, Adaptor Proteins, Vesicular Transport, Toll-Like Receptors, Mice, Myeloid Differentiation Factor 88

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Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling

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