Rationale for phosphodiesterase 5 inhibitor use post-radical prostatectomy: experimental and clinical review

Rambhatla, A; Kovanecz, I; Ferrini, M; Gonzalez-Cadavid, N F; Rajfer, J

doi:10.1038/sj.ijir.3901588

Cited by 51Sexual function and dysfunction studiesUrological Disorders and TreatmentsUrinary Bladder and Prostate Research

Rationale for phosphodiesterase 5 inhibitor use post-radical prostatectomy: experimental and clinical review

Rambhatla, A, Kovanecz, I, Ferrini, M, Gonzalez-Cadavid, N F, Rajfer, J·2008·International Journal of Impotence Research

DOI 10.1038/sj.ijir.3901588

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Abstract

Erectile dysfunction (ED) is a common complication after radical prostatectomy and results from trauma sustained by the cavernosal nerves. This is a major concern for patients and often affects treatment decisions. The likely mechanism for post-prostatectomy ED is through corporal veno-occlusive dysfunction. There is an increasing amount of evidence to suggest that phosphodiesterase 5 inhibitors (PDE5 inhibitors), when given on a continuous long-term basis, can help to prevent and reverse ED after surgery. In this review article we will examine the pathophysiology of post-prostatectomy ED and discuss the experimental and available clinical evidence for administering PDE5 inhibitors after prostatectomy.

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Authors: Rambhatla, A., Kovanecz, I., Ferrini, M., Gonzalez-Cadavid, N. F., & Rajfer, J.
Affiliations: Harbor–UCLA Medical Center (US)
The Lundquist Institute (US)
University of California, Los Angeles (US)
Corresponding author: Rajfer, J
ORCID: Rambhatla, A
Kovanecz, I
Ferrini, M
Venue: International Journal of Impotence Research
Publisher: Springer Science and Business Media LLC
Published: 2007-08-02
Volume: 20
Issue: 1
Pages: 30-34
ISSN: 0955-9930 (ISSN-L)
1476-5489
DOI: 10.1038/sj.ijir.3901588
OpenAlex: W2158072358
Cited by: 51
References: 40
Citations by year: 2025: 1 · 2022: 1 · 2021: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 5 · 2013: 2 · 2012: 2
FWCI: 0.89
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: International Journal of Impotence Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
Health Sciences › Medicine › Urology › Urological Disorders and Treatments
Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
Keywords: phosphodiesterase-5 inhibitors, erectile dysfunction, radical prostatectomy, post-prostatectomy erectile dysfunction
MeSH terms: Humans, Erectile Dysfunction, Male, Penile Erection, Penis, Phosphodiesterase Inhibitors, Prostatectomy, Treatment Outcome, Cyclic Nucleotide Phosphodiesterases, Type 5

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Rationale for phosphodiesterase 5 inhibitor use post-radical prostatectomy: experimental and clinical review

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