CoChat
Sign Up
Cited by 229Muscle Physiology and DisordersAdipose Tissue and MetabolismDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Fat content in individual muscle fibers of lean and obese subjects.

Malenfant, P, Joanisse, DR, Thériault, R, Goodpaster, BH, Kelley, DE, Simoneau, J-A·2001·International Journal of Obesity
DOI 10.1038/sj.ijo.0801733
Open this paper in CoChat — free account

Abstract

Objective To examine skeletal muscle intracellular triglyceride concentration in different fiber types in relation to obesity.Design Skeletal muscle fiber type distribution and intracellular lipid content were measured in vastus lateralis samples obtained by needle biopsy from lean and obese individuals.Subjects Seven lean controls (body mass index (BMI) 23.0+/-3.3 kg/m(2); mean+/-s.d.) and 14 obese (BMI 33.7+/-2.7 kg/m(2)) individuals; both groups included comparable proportions of men and women.Measurements Samples were histochemically stained for the identification of muscle fiber types (myosin ATPase) and intracellular lipid aggregates (oil red O dye). The number and size of fat aggregates as well as their concentration within type I, IIA and IIB muscle fiber types were measured. The cellular distribution of the lipid aggregates was also examined.Results The size of fat aggregates was not affected by obesity but the number of lipid droplets within muscle fibers was twice as abundant in obese compared to lean individuals. This was seen in type I (298+/-135 vs 129+/-75; obese vs lean, P<0.05), IIA (132+/-67 vs 79+/-29; P<0.05), and IIB (103+/-63 vs 51+/-13; P<0.05) muscle fibers. A more central distribution of lipid droplets was observed in muscle fibers of obese compared to lean subjects (27.2+/-5.7 vs 19.7+/-6.4%; P<0.05).Conclusion The higher number of lipid aggregates and the disposition to a greater central distribution in all fiber types in obesity indicate important changes in lipid metabolism and/or storage that are fiber type-independent.

Overview

Integrity signals

Registry

Crossref · 10.1038/sj.ijo.0801733

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 31 references

Research works printed but not linked: 1

  1. Simoneau JA, Kelley DE . Skeletal muscle and obesity. In: Bray GA, Bouchard C, James WPT (eds). Handbook of obesity Marcel Dekker: New York 1998 539–553.

Cited by

Sorted by citations

Items 101–200 of 229

Related

See all

Metadata

Authors
Malenfant, P., Joanisse, D., Thériault, R., Goodpaster, B., Kelley, D., & Simoneau, J.-A.
Affiliations
  • Université Laval (CA)
  • University of Pittsburgh (US)
Corresponding author
Kelley, DE
ORCID
Thériault, R
Venue
International Journal of Obesity
Publisher
Springer Science and Business Media LLC
Published
2001-09
Volume
25
Issue
9
Pages
1316-1321
ISSN
  • 0307-0565 (ISSN-L)
  • 1476-5497
DOI
10.1038/sj.ijo.0801733
OpenAlex
W2089177804
Cited by
227
References
31
Citations by year
2026: 1 · 2025: 8 · 2024: 8 · 2023: 4 · 2022: 9 · 2021: 8 · 2020: 11 · 2019: 9 · 2018: 8 · 2017: 9 · 2016: 8 · 2015: 10 · 2014: 10 · 2013: 8 · 2012: 16
FWCI
2.91
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • International Journal of Obesity (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK049200, R01 DK49200-03)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
obesity, skeletal muscle, intracellular triglycerides, lipid droplets, muscle fiber type, vastus lateralis, lipid metabolism, fat deposition, myosin ATPase histochemistry, Oil Red O staining
MeSH terms
Adult, Azo Compounds, Biopsy, Needle, Coloring Agents, Female, Histocytochemistry, Humans, Male, Myosins, Obesity, Triglycerides, Muscle, Skeletal, Muscle Fibers, Skeletal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review