Cited by 120Acute Ischemic Stroke ManagementNeuroprotection in Cerebral IschemiaProtease and Inhibitor Mechanisms

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Minocycline Protects against Permanent Cerebral Ischemia in Wild Type but Not in Matrix Metalloprotease-9-Deficient Mice

Open access

Koistinaho, Milla, Malm, Tarja M, Kettunen, Mikko I, Goldsteins, Gundars, Starckx, Sofie, Kauppinen, Risto A, Opdenakker, Ghislain, Koistinaho, Jari·2005·Journal of Cerebral Blood Flow & Metabolism

DOI 10.1038/sj.jcbfm.9600040

Open this paper in CoChat — free account Open PDF

Abstract

Minocycline is protective in models of transient middle cerebral artery occlusion (MCAO). We studied whether minocycline and doxycycline, another tetracycline derivative, provide protection in permanent MCAO. Because minocycline inhibits matrix metalloprotease-9 (MMP-9), we also compared minocycline's protective effect in wild type (wt) and MMP-9 knock-out (ko) mice. Wt FVB/N, Balb/C, and two lines of MMP-9 ko and their wt C57Bl/6 control mice were subjected to 24- or 72-hour permanent MCAO. Drug administration was started either 12 hours before or 2 hours after the onset of MCAO. Infarct size was determined by triphenyltetrazolium staining or T2-weighted MRI. Zymography was used to study the expression of MMPs. In wt strains, tetracycline treatments started before MCAO reduced the infarct size by 25% to 50%, whereas the treatment started after MCAO was not protective. Minocycline inhibited ischemia-provoked pro-MMP-9 induction in wt mice, but was not protective in MMP-9 ko mice. Pro-MMP-2 was induced by MCAO in wt and MMP-9 ko mice. MCAO-induced pro-MMP-2 was downregulated by minocycline treatment in wt mice but remained in MMP-9 ko mice at the same level as in saline-treated wt mice. Tetracyclines are protective in permanent MCAO when the treatment is started before the insult. Minocycline may provide protection by interfering with MMPs.

Integrity signals

Registry

Crossref · 10.1038/sj.jcbfm.9600040

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
Zhu, S., Stavrovskaya, I. G., Drozda, M., Kim, B. Y. S., Ona, V. O., Li, M., Sarang, S. S., Liu, A. S., Hartley, D. M., Wu, D. C., et al. (2002) · Nature · doi:10.1038/417074a · Cited by 1,069
Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease
Chen, M., Ona, V. O., Li, M., Ferrante, R. J., Fink, K., Zhu, S., Bian, J., Guo, L., Farrell, L. A., Hersch, S. M., et al. (2000) · Nature Medicine · doi:10.1038/77528 · Cited by 1,060
A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window
Yrjänheikki, J., Kauppinen, T. M., Keinänen, R., Goldsteins, G., Chan, P. H., & Koıstınaho, J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13496 · Cited by 1,040
Self-citation
Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia
Yrjänheikki, J., Keinänen, R., Pellikka, M., Hökfelt, T., & Koistinaho, J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15769 · Cited by 1,006
Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia
Tikka, T., Fiebich, B. L., Goldsteins, G., Keinänen, R., & Koistinaho, J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02580.2001 · Cited by 958
Self-citation
Biochemistry and Molecular Biology of Gelatinase B or Matrix Metalloproteinase-9 (MMP-9)
den Steen, P. E. V., Dubois, B., Nelissen, I., Rudd, P., Dwek, R., & Opdenakker, G. (2002) · Critical reviews in biochemistry and molecular biology · doi:10.1080/10409230290771546 · Cited by 948
Self-citation
Inflammatory Mediators and Stroke: New Opportunities for Novel Therapeutics
Barone, F. C., & Feuerstein, G. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199908000-00001 · Cited by 924
Matrix Metalloproteinases and TIMPs Are Associated With Blood-Brain Barrier Opening After Reperfusion in Rat Brain
Rosenberg, G. A., Estrada, E. Y., & Dencoff, J. E. (1998) · Stroke · doi:10.1161/01.str.29.10.2189 · Cited by 861
Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction
Ducharme, A., Frantz, S., Aikawa, M., Aïkawa, E., Lindsey, M. L., Rohde, L. E. P., Schöen, F. J., Kelly, R. A., Werb, Z., Libby, P., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8768 · Cited by 814
Minocycline Prevents Nigrostriatal Dopaminergic Neurodegeneration in the MPTP Model of Parkinson’s Disease
Du, Y., Ma, Z., Lin, S., Dodel, R. C., Gao, F., Bales, K. R., Triarhou, L. C., Chernet, E., Perry, K. W., Nelson, D. L. G., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251341998 · Cited by 789
Matrix Metalloproteinase Expression Increases After Cerebral Focal Ischemia in Rats
Romanic, A. M., White, R. F., Arleth, A. J., Ohlstein, E. H., & Barone, F. C. (1998) · Stroke · doi:10.1161/01.str.29.5.1020 · Cited by 740
Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats.
Lin, T., He, Y. Y., Wu, G., Khan, M., & Hsu, C. Y. (1993) · Stroke · doi:10.1161/01.str.24.1.117 · Cited by 723
Tetracyclines Inhibit Connective Tissue Breakdown by Multiple Non-Antimicrobial Mechanisms
Golub, L. M., Lee, H. M., RYAN, M. E., Giannobile, W. V., Payne, J. B., & Sorsa, T. A. (1998) · Advances in Dental Research · doi:10.1177/08959374980120010501 · Cited by 690
Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase.
Hibbs, M. S., Hasty, K. A., Seyer, J. M., Kang, A. H., & Mainardi, C. L. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89580-1 · Cited by 613
Role for Matrix Metalloproteinase 9 after Focal Cerebral Ischemia: Effects of Gene Knockout and Enzyme Inhibition with BB-94
Asahi, M., Asahi, K., Jung, J., del Zoppo, G. J., Fini, M. E., & Lo, E. H. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200012000-00007 · Cited by 610
Cerebral Microvessel Responses to Focal Ischemia
del Zoppo, G. J., & Mabuchi, T. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000078322.96027.78 · Cited by 601
Minocycline Provides Neuroprotection Against N -Methyl- d -aspartate Neurotoxicity by Inhibiting Microglia
Tikka, T., & Koıstınaho, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7527 · Cited by 539
Targeting leukocyte MMPs and transmigration
Brundula, V., Rewcastle, N. B., Metz, L. M., Bernard, C. C. A., & Yong, V. W. (2002) · Brain · doi:10.1093/brain/awf133 · Cited by 427
Proteolytic Cascade Enzymes Increase in Focal Cerebral Ischemia in Rat
Rosenberg, G. A., Navratil, M., Barone, F. C., & Feuerstein, G. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199605000-00002 · Cited by 403
Early Appearance of Activated Matrix Metalloproteinase-9 after Focal Cerebral Ischemia in Mice: A Possible Role in Blood—Brain Barrier Dysfunction
Gasche, Y. G., Fujimura, M., Morita‐Fujimura, Y., Copin, J., 川瀬, 誠., Massengale, J. L., & Chan, P. H. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199909000-00010 · Cited by 400
Early appearance of activated matrix metalloproteinase-9 and blood–brain barrier disruption in mice after focal cerebral ischemia and reperfusion
Fujimura, M., Gasche, Y., Morita‐Fujimura, Y., Massengale, J. L., 川瀬, 誠., & Chan, P. H. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01843-0 · Cited by 339
Increased gelatinase A (MMP-2) and gelatinase B (MMP-9) activities in human brain after focal ischemia
Clark, A. W., Krekoski, C. A., Bou, S.-S., Chapman, K. R., & Edwards, D. R. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00859-8 · Cited by 328
Focal Cerebral Ischemia Induces Active Proteases That Degrade Microvascular Matrix
Fukuda, S., Fini, C. A., Mabuchi, T., Koziol, J. A., Eggleston, L. L., & del Zoppo, G. J. (2004) · Stroke · doi:10.1161/01.str.0000119383.76447.05 · Cited by 277
Resistance of young gelatinase B–deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions
Dubois, B., Masure, S., Hurtenbach, U., Paemen, L. R., Heremans, H., van den Oord, J., Sciot, R., Meinhardt, T., Hämmerling, G. J., Opdenakker, G., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6886 · Cited by 262
Self-citation
Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion-reperfusion in rats
Xu, L., Fagan, S. C., Waller, J. L., Edwards, D. J., Borlongan, C. V., Zheng, J., Hill, W., Feuerstein, G., & Hess, D. C. (2004) · BMC Neurology · doi:10.1186/1471-2377-4-7 · Cited by 172
Differences in Vulnerability to Permanent Focal Cerebral Ischemia Among 3 Common Mouse Strains
Majid, A., He, Y. Y., Gidday, J. M., Kaplan, S. S., Gonzales, E. R., Park, T. S., Fenstermacher, J. D., Wei, L., Choi, D. W., & Hsu, C. Y. (2000) · Stroke · doi:10.1161/01.str.31.11.2707 · Cited by 164
β-Amyloid precursor protein transgenic mice that harbor diffuse Aβ deposits but do not form plaques show increased ischemic vulnerability: Role of inflammation
Koistinaho, M., Kettunen, M. I., Goldsteins, G., Keinänen, R., Salminen, A., Ort, M., Bures, J., Liu, D., Kauppinen, R. A., Higgins, L. S., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032670899 · Cited by 159
Self-citation
Matrix metalloproteinase 2 gene knockout has no effect on acute brain injury after focal ischemia
Asahi, M., Sumii, T., Fini, M. E., Itohara, S., & Lo, E. H. (2001) · Neuroreport · doi:10.1097/00001756-200109170-00050 · Cited by 158
Activation Systems for Latent Matrix Metalloproteinase-2 are Upregulated Immediately after Focal Cerebral Ischemia
Chang, D., Hosomi, N., Lucero, J. D., Heo, J. H., Abumiya, T., Mazar, A. P., & del Zoppo, G. J. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000091765.61714.30 · Cited by 136
Minocycline prevents neurotoxicity induced by cerebrospinal fluid from patients with motor neurone disease
Tikka, T., Vartiainen, N. E., Goldsteins, G., Oja, S. S., Andersen, P. M., Marklund, S. L., & Koıstınaho, J. (2002) · Brain · doi:10.1093/brain/awf068 · Cited by 136
Self-citation
The gelatinase inhibitory activity of tetracyclines and chemically modified tetracycline analogues as measured by a novel microtiter assay for inhibitors
Paemen, L. R., Martens, E., Norga, K., Masure, S., Roets, E., Hoogmartens, J., & Opdenakker, G. (1996) · Biochemical Pharmacology · doi:10.1016/0006-2952(96)00168-2 · Cited by 107
Self-citation
Treatment of epigallocatechin‐3‐gallate inhibits matrix metalloproteinases‐2 and ‐9 via inhibition of activation of mitogen‐activated protein kinases, c‐jun and NF‐κB in human prostate carcinoma DU‐145 cells
Vayalil, P. K., & Katiyar, S. K. (2003) · The Prostate · doi:10.1002/pros.10352 · Cited by 96
Effects of minocycline alone and in combination with mild hypothermia in embolic stroke
Wang, C. X., Yang, T., & Shuaib, A. M. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04045-3 · Cited by 84
Functional sites of chemically modified tetracyclines: inhibition of the oxidative activation of human neutrophil and chicken osteoclast pro-matrix metalloproteinases.
Sorsa, T. A., Ramamurthy, N. S., Vernillo, A., Zhang, X., Konttinen, Y. T., Rifkin, B. R., & Golub, L. M. (1998) · PubMed · Cited by 63
Temporal characteristics of the protective effect of aminoguanidine on cerebral ischemic damage
Zhang, F., & Iadecola, C. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00557-5 · Cited by 57
Soluble Fractalkine Prevents Monocyte Chemoattractant Protein-1-Induced Monocyte Migration via Inhibition of Stress-Activated Protein Kinase 2/p38 and Matrix Metalloproteinase Activities
Vitale, S., Schmid‐Alliana, A., Breuil, V., Pomeranz, M., Millet, M.-A., Rossi, B., & Schmid‐Antomarchi, H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.1.585 · Cited by 54
Modulation of phorbol ester—induced regulation of matrix metalloproteinases and tissue inhibitors of metalloproteinases by SB203580, a specific inhibitor of p38 mitogen-activated protein kinase
Park, M. J., Park, I., Hur, J.-H., Kim, M., Lee, H.-C., Woo, S., Lee, K.-H., Rhee, C., Hong, S., & Lee, S. (2002) · Journal of neurosurgery · doi:10.3171/jns.2002.97.1.0112 · Cited by 41
Neutralizing antibodies in gene-defective hosts
Opdenakker, G., den Steen, P. E. V., Laureys, G., Hunninck, K., & Arnold, B. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(02)00037-6 · Cited by 17
Self-citation

Flagged first, then by citations

Research works printed but not linked: 1

Sorsa T, 1998, J Rheumatol, 25, 975

Sorted by citations

Minocycline: Far beyond an Antibiotic
Garrido‐Mesa, N., Zarzuelo, A., & Gálvez, J. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12139 · Cited by 935
Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases
Hu, J., den Steen, P. E. V., Sang, Q. A., & Opdenakker, G. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2308 · Cited by 806
Self-citation
Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): The next decade
Vandooren, J., den Steen, P. E. V., & Opdenakker, G. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.770819 · Cited by 790
Self-citation
The impact of microglial activation on blood-brain barrier in brain diseases
da Fonseca, A. C. C., Matias, D., Garcia, C., Amaral, R., Geraldo, L. H., Freitas, C., & Lima, F. R. S. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00362 · Cited by 572
Microglial Activation in Stroke: Therapeutic Targets
Yenari, M. A., Kauppinen, T. M., & Swanson, R. A. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.07.005 · Cited by 398

See all 120

Authors: Koistinaho, M., Malm, T. M., Kettunen, M. I., Goldsteins, G., Starckx, S., Kauppinen, R. A., Opdenakker, G., & Koistinaho, J.
Affiliations: University of Eastern Finland (FI)
Rega Institute for Medical Research (BE)
Department of Neurobiology, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
Corresponding author: Koistinaho, Milla
ORCID: Malm, Tarja M
Kettunen, Mikko I
Kauppinen, Risto A
Opdenakker, Ghislain
Venue: Journal of Cerebral Blood Flow & Metabolism
Publisher: SAGE Publications
Published: 2005-04
Volume: 25
Issue: 4
Pages: 460-467
ISSN: 0271-678X (ISSN-L)
1559-7016
DOI: 10.1038/sj.jcbfm.9600040
OpenAlex: W2004309874
Cited by: 120
References: 38
Citations by year: 2026: 2 · 2024: 5 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 8 · 2016: 2 · 2015: 10 · 2014: 12 · 2013: 11 · 2012: 7
FWCI: 6.45
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
PubMed (publishedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Keywords: minocycline, doxycycline, tetracycline, MMP-9, MMP-9 knockout mice, permanent cerebral ischemia, middle cerebral artery occlusion, neuroprotection, infarct size, MMP-2, timing of drug administration
MeSH terms: Animals, Anti-Bacterial Agents, Cerebral Cortex, Brain Ischemia, Doxycycline, Male, Mice, Inbred BALB C, Minocycline, Down-Regulation, Mice, Knockout, Infarction, Middle Cerebral Artery, Matrix Metalloproteinase 9, Mice, Matrix Metalloproteinase Inhibitors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Minocycline Protects against Permanent Cerebral Ischemia in Wild Type but Not in Matrix Metalloprotease-9-Deficient Mice

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks