Malm, Tarja

Microglia states and nomenclature: A field at its crossroads

Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M.-E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., et al. (2022) · Neuron

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 1,973

Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to β-amyloid deposition in APP/PS1 double transgenic Alzheimer mice

Malm, T. M., Koistinaho, M., Pärepalo, M., Vatanen, T., Ooka, A., Karlsson, S., & Koistinaho, J. (2005) · Neurobiology of Disease

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 301

Early Alzheimer’s disease pathology in human cortex involves transient cell states

Gazestani, V., Kamath, T., Nadaf, N. M., Dougalis, A., Burris, S. J., Rooney, B., Junkkari, A., Vanderburg, C., Pelkonen, A., Gomez-Budia, M., et al. (2023) · Cell

Alzheimer's disease research and treatmentsSingle-cell and spatial transcriptomics

Cited by 209

The viral protein corona directs viral pathogenesis and amyloid aggregation

Ezzat, K., Pernemalm, M., Pålsson, S., Roberts, T. C., Järver, P., Dondalska, A., Bestas, B., Sobkowiak, M. J., Levänen, B., Sköld, M., et al. (2019) · Nature Communications

Alzheimer's disease research and treatmentsNanoparticle-Based Drug Delivery

Cited by 209

PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

Konttinen, H., Cabral-da-Silva, M. E. C., Ohtonen, S., Wojciechowski, S., Shakirzyanova, A., Caligola, S., Giugno, R., Ishchenko, Y., Hernández, D., Fazaludeen, M. F., et al. (2019) · Stem Cell Reports

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 191

Nuclear Receptors License Phagocytosis by Trem2+Myeloid Cells in Mouse Models of Alzheimer's Disease

Savage, J. C., Jay, T., Goduni, E., Quigley, C., Mariani, M. M., Malm, T., Ransohoff, R. M., Lamb, B. T., & Landreth, G. E. (2015) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 154

Stable RNA interference: Comparison of U6 and H1 promoters in endothelial cells and in mouse brain

Mäkinen, P. I., Koponen, J. K., Kärkkäinen, A., Malm, T. M., Pulkkinen, K. H., Koistinaho, J., Turunen, M. P., & Ylä‐Herttuala, S. (2006) · The Journal of Gene Medicine

RNA Interference and Gene DeliveryVirus-based gene therapy research

Cited by 134

Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient mice

Koistinaho, M., Malm, T. M., Kettunen, M. I., Goldsteins, G., Starckx, S., Kauppinen, R. A., Opdenakker, G., & Koistinaho, J. (2005) · Journal of Cerebral Blood Flow & Metabolism

Acute Ischemic Stroke ManagementNeuroprotection in Cerebral Ischemia

Cited by 120

Neuronally-directed effects of RXR activation in a mouse model of Alzheimer’s disease

Mariani, M. M., Malm, T., Lamb, R., Jay, T. R., Neilson, L., Casali, B., Medarametla, L., & Landreth, G. E. (2017) · Scientific Reports

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 98

Neuron-astrocyte transmitophagy is altered in Alzheimer's disease

Lampinen, R., Belaya, I., Saveleva, L., Liddell, J. R., Rait, D., Huuskonen, M. T., Giniatullina, R., Sorvari, A., Soppela, L., Mikhailov, N., et al. (2022) · Neurobiology of Disease

Autophagy in Disease and TherapyAlzheimer's disease research and treatments

Cited by 97

Nuclear receptors in neurodegenerative diseases

Skerrett, R., Malm, T., & Landreth, G. (2014) · Neurobiology of Disease

Alzheimer's disease research and treatmentsNuclear Receptors and Signaling

Cited by 94

The Evolving Biology of Microglia in Alzheimer's Disease

Malm, T. M., Jay, T. R., & Landreth, G. E. (2015) · Neurotherapeutics

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 85

A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke

Maysami, S., Wong, R., Pradillo, J. M., Denes, A., Dhungana, H., Malm, T., Koistinaho, J., Orset, C., Rahman, M., Rubio, M., et al. (2016) · Journal of Cerebral Blood Flow & Metabolism

Neuroinflammation and Neurodegeneration MechanismsAcute Ischemic Stroke Management

Cited by 84

Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer’s disease through inhibition of inflammation

Malm, T., Mariani, M., Donovan, L. J., Neilson, L., & Landreth, G. E. (2015) · Journal of Neuroinflammation

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 77

Glia-Derived Extracellular Vesicles: Role in Central Nervous System Communication in Health and Disease

Pistono, C., Bister, N., Stanová, I., & Malm, T. (2021) · Frontiers in Cell and Developmental Biology

Extracellular vesicles in diseaseNeuroinflammation and Neurodegeneration Mechanisms

Cited by 75

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease

Xia, Z., Prescott, E. E., Urbanek, A., Wareing, H. E., King, M. C., Olerinyova, A., Dakin, H., Leah, T., Barnes, K. A., Matuszyk, M. M., et al. (2024) · Nature Communications

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 67

High Soluble Amyloid‐β42 Predicts Normal Cognition in Amyloid‐Positive Individuals With Alzheimer's Disease‐Causing Mutations

Sturchio, A., (DIAN), T. D. I. A. C., Dwivedi, A. K., Malm, T., Wood, M. J. A., Cilia, R., Sharma, J. S., Hill, E. J., Schneider, L. S., Graff-Radford, N. R., et al. (2022) · Journal of Alzheimer's Disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 57

Emerging Role of miR-21-5p in Neuron–Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer’s Disease

Garcia, G., Pinto, S., Ferreira, S., Lopes, D., Serrador, M. J., Fernandes, A., Vaz, A. R., Mendonça, A. D., Edenhofer, F., Malm, T., et al. (2022) · Cells

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 55

ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling

Scoyni, F., Sitnikova, V., Giudice, L., Korhonen, P., Trevisan, D. M., Hernandez de Sande, A., Gomez-Budia, M., Giniatullina, R., Ugidos, I. F., Dhungana, H., et al. (2024) · Cell Reports

Circular RNAs in diseasesMicroRNA in disease regulation

Cited by 27

Modeling neuroinflammatory interactions between microglia and astrocytes in a human iPSC-based coculture platform

Tujula, I., Hyvärinen, T., Lotila, J., Rogal, J., Voulgaris, D., Sukki, L., Tornberg, K., Korpela, K., Jäntti, H., Malm, T., et al. (2025) · Cell Communication and Signaling

Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and Treatments

Cited by 22

Brain environment and Alzheimer's disease mutations affect the survival, migration and differentiation of neural progenitor cells

Karkkainen, V., Magga, J., Koistinaho, J., & Malm, T. (2012) · Current Alzheimer Research

Neurogenesis and neuroplasticity mechanismsAlzheimer's disease research and treatments

Cited by 16

The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions

Takalo, M., Jeskanen, H., Rolova, T., Kervinen, I., Hellén, M., Heikkinen, S., Koivisto, H., Jokivarsi, K., Müller, S. A., Koivumäki, E.-M., et al. (2025) · Journal of Neuroinflammation

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 15

Mitochondrial Function in Alzheimer’s Disease: Focus on Astrocytes

Lampinen, R., Belaya, I., Boccuni, I., Malm, T., & Kanninen, K. M. (2018) · Astrocyte - Physiology and Pathology

Mitochondrial Function and PathologyAlzheimer's disease research and treatments

Cited by 8

Elevated Brain Tissue miR-223-3p After Ischemic Stroke Reflects Immune Infiltration Rather Than Intrinsic Upregulation

Korvenlaita, N., Gómez-Budia, M., Pistono, C., Scoyni, F., Jäntti, H., Ohtonen, S., Fazaludeen, M. F., de Sande, A. H., Bouvy-Liivrand, M., Heinäniemi, M., et al. (2026) · Cellular and Molecular Neurobiology

Neuroinflammation and Neurodegeneration MechanismsMicroRNA in disease regulation

Cited by 0