Matrix Metalloproteinase-Mediated Disruption of Tight Junction Proteins in Cerebral Vessels is Reversed by Synthetic Matrix Metalloproteinase Inhibitor in Focal Ischemia in Rat

The blood-brain barrier/neurovascular unit in health and disease

Hawkins, B. T., & Davis, T. P. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.4 · Cited by 2,661

Occludin: a novel integral membrane protein localizing at tight junctions.

Furuse, M., Hirase, T., Itoh, M., Nagafuchi, A., Yonemura, S., Tsukita, S., & Tsukita, S. (1993) · The Journal of cell biology · doi:10.1083/jcb.123.6.1777 · Cited by 2,580

Multifunctional strands in tight junctions

Tsukita, S., Furuse, M., & Itoh, M. (2001) · Nature reviews. Molecular cell biology · doi:10.1038/35067088 · Cited by 2,578

The blood–brain barrier: an overview

Ballabh, P., Braun, A., & Nedergaard, M. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.12.016 · Cited by 2,276

Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

Furuse, M., Fujita, K., Hiiragi, T., Fujimoto, K., & Tsukita, S. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.7.1539 · Cited by 2,100

Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice

Nitta, T., Hata, M., Gotoh, S., Seo, Y., Sasaki, H., Hashimoto, N., Furuse, M., & Tsukita, S. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302070 · Cited by 1,917

Mechanisms, challenges and opportunities in stroke

Lo, E. H., Dalkara, T., & Moskowitz, M. A. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1106 · Cited by 1,808

Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

Strongin, A. Y., Collier, I. E., Bannikov, G. A., Marmer, B. L., Grant, G. A., & Goldberg, G. I. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.10.5331 · Cited by 1,589

Endothelial Cell-to-Cell Junctions: Molecular Organization and Role in Vascular Homeostasis

Bazzoni, G., & Dejana, E. (2004) · Physiological Reviews · doi:10.1152/physrev.00035.2003 · Cited by 1,384

Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands

Morita, K., Furuse, M., Fujimoto, K., & Tsukita, S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.511 · Cited by 1,126

Endothelial Dysfunction and Hyperhomocysteinemia-Linked Cerebral Small Vessel Disease: Underlying Mechanisms and Treatment Timing

Li, S., Li, G., Luo, X., Huang, Y. Q., Wen, L., & Li, J. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.736309 · Cited by 27

Inhibition of NF-kappaB activation by Pyrrolidine dithiocarbamate partially attenuates hippocampal MMP-9 activation and improves cognitive deficits in streptozotocin-induced diabetic rats

Zhao, Z., Huang, G.-Z., Wang, B., & Zhong, Y. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.10.018 · Cited by 27

Sodium Tanshinone IIA Silate Exerts Microcirculation Protective Effects against Spinal Cord Injury In Vitro and In Vivo

Li, X., Luo, D., Hou, Y., Hou, Y., Chen, S., Zhan, J., Luan, J., Wang, L., & Lin, D. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/3949575 · Cited by 27

Neurolysin substrates bradykinin, neurotensin and substance P enhance brain microvascular permeability in a human in vitro model

Al-Ahmad, A. J., Pervaiz, I., & Karamyan, V. T. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12931 · Cited by 27

Modulation of Tight Junction Proteins in the Perineurium to Facilitate Peripheral Opioid Analgesia

Rittner, H. L., Amasheh, S., Moshourab, R. A., Hackel, D., Yamdeu, R.-S., Mousa, S. A., Fromm, M., Stein, C., & Brack, A. (2012) · Anesthesiology · doi:10.1097/aln.0b013e318256eeeb · Cited by 27

Hemostasis and Alterations of the Central Nervous System

del Zoppo, G. D., Izawa, Y., & Hawkins, B. (2013) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0033-1357490 · Cited by 24

Temporal Profile of Matrix Metalloproteinases and Their Inhibitors in a Human Endothelial Cell Culture Model of Cerebral Ischemia

Reuter, B., Rodemer, C., Grudzenski, S., Couraud, P., Weksler, B. B., Romero, I. A., Meairs, S. P., Bugert, P., Hennerici, M. G., & Fatar, M. (2013) · Cerebrovascular Diseases · doi:10.1159/000350731 · Cited by 27

Blood brain barrier breakdown was found in non-infarcted area after 2-h MCAO

Wang, X., Liu, Y., Sun, Y., Liu, W., & Jin, X. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.02.035 · Cited by 27

Intravenous Administration of Human Amniotic Mesenchymal Stem Cells in the Subacute Phase of Cerebral Infarction in a Mouse Model Ameliorates Neurological Disturbance by Suppressing Blood Brain Barrier Disruption and Apoptosis via Immunomodulation

Yoshida, Y., Takagi, T., Kuramoto, Y., Tatebayashi, K., Shirakawa, M., Yamahara, K., Doe, N., & Yoshimura, S. (2021) · Cell Transplantation · doi:10.1177/09636897211024183 · Cited by 27

Long-term consequences of surgical brain injury - characteristics of the neurovascular unit and formation and demise of the glial scar in a rat model.

Frontczak‐Baniewicz, M., Chrapusta, S. J., & Sulejczak, D. (2011) · PubMed · Cited by 27

Activation of sulfonate ester based matrix metalloproteinase proinhibitors by hydrogen peroxide

Daniel, K. B., Jourden, J. L. M., Negoescu, K. E., & Cohen, S. M. (2010) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-010-0727-x · Cited by 28

Matrix Metalloproteinase-Mediated Neuroinflammation in Vascular Cognitive Impairment of the Binswanger Type

Rosenberg, G. A. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0277-4 · Cited by 27

Neuronal PirB Upregulated in Cerebral Ischemia Acts as an Attractive Theranostic Target for Ischemic Stroke

Wang, J., Zhang, Y., Xia, J., Cai, T., Du, J., Chen, J., Li, P., Shen, Y., Zhang, A., Fu, B., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.007197 · Cited by 26

Pharmacological therapy to cerebral ischemia-reperfusion injury: Focus on saponins

Zeng, M., Zhang, R., Yang, Q., Guo, L., Zhang, X., Yu, B., Gan, J., Yang, Z., Li, H., Wang, Y., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113696 · Cited by 26

Role of microbial dysbiosis in the pathogenesis of Alzheimer's disease

Susmitha, G., & Kumar, R. K. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109478 · Cited by 27

Low-intensity open-field blast exposure effects on neurovascular unit ultrastructure in mice

Li, C., Chen, S., Siedhoff, H. R., Grant, D. G., Liu, P., Balderrama, A., Jackson, M. A., Zuckerman, A., Greenlief, C. M., Kobeissy, F. H., et al. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01636-4 · Cited by 27

The neuroprotective potential of phytochemicals in traumatic brain injury: mechanistic insights and pharmacological implications

Hasan, G. M., Anwar, S., Shamsi, A., Sohal, S. S., & Hassan, M. I. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1330098 · Cited by 26

Minocycline alters expression of inflammatory markers in autonomic brain areas and ventilatory responses induced by acute hypoxia

Silva, T. M., Chaar, L. J. E., Silva, R. C., Takakura, A. C. T., Câmara, N. O. S., Antunes, V. R., & Moreira, T. S. (2018) · Experimental Physiology · doi:10.1113/ep086780 · Cited by 26

Targeting Water in the Brain: Role of Aquaporin-4 in Ischemic Brain Edema

Mamtilahun, M., Tang, G., Zhang, Z., Wang, Y., Tang, Y., & Yang, G. (2019) · Current Drug Targets · doi:10.2174/1389450120666190214115309 · Cited by 26

The effect of high mobility group box-1 protein on cerebral edema, blood-brain barrier, oxidative stress and apoptosis in an experimental traumatic brain injury model

Evran, Ş., Çalış, F., Akkaya, E., Baran, O., Çevik, S., Katar, S., Gürevin, E. G., Hanımoğlu, H., Hatiboğlu, M. A., Armutak, E. İ., et al. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.10.013 · Cited by 26

Maternal Exposure to Di‑ n ‑butyl Phthalate Promotes the Formation of Testicular Tight Junctions through Downregulation of NF-κB/COX-2/PGE2/MMP‑2 in Mouse Offspring

Ma, T., Zhou, Y., Xia, Y., Meng, X., Jin, H., Wang, B., Chen, Y., Qiu, J., Wu, J., Ding, J., et al. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.0c01701 · Cited by 26

Increased activity of Rho kinase contributes to hemoglobin-induced early disruption of the blood-brain barrier in vivo after the occurrence of intracerebral hemorrhage.

Fu, Z., Chen, Y., Qin, F., Yang, S., Deng, X., Ding, R., Feng, L., Li, W., & Zhu, J. (2014) · Europe PMC (PubMed Central) · Cited by 26

Nanomaterial-Based Drug Delivery Systems for Ischemic Stroke

Jiang, C., Zhou, Y., Chen, R., Yang, M., Zhou, H., Tang, Z., Shi, H., & Qin, D. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15122669 · Cited by 25

Dissociation and protection of the neurovascular unit after thrombolysis and reperfusion in ischemic rat brain

Yamashita, T., Kamiya, T., Deguchi, K., Inaba, T., Zhang, H., Shang, J., Miyazaki, K., Ohtsuka, A., Katayama, Y., & Abe, K. (2010) · Okayama Igakkai Zasshi (Journal of Okayama Medical Association) · doi:10.4044/joma.122.195 · Cited by 25

PARP inhibition attenuates early brain injury through NF-κB/MMP-9 pathway in a rat model of subarachnoid hemorrhage

Chen, T., Wang, W., Li, J., Xu, H., Peng, Y., Fan, L., Yan, F., Gu, C., Wang, L., & Chen, G. (2016) · Brain Research · doi:10.1016/j.brainres.2016.05.005 · Cited by 25

Shengui Sansheng Pulvis maintains blood-brain barrier integrity by vasoactive intestinal peptide after ischemic stroke

Xia, Z.-Y., Luo, C., Liu, B., Bian, X.-Q., Yang, L., Pang, A. M., Xu, Y., Tan, H.-M., & Zhao, Y. (2019) · Phytomedicine · doi:10.1016/j.phymed.2019.153158 · Cited by 26

Improvement of autophagy dysfunction as a potential mechanism for environmental enrichment to protect blood-brain barrier in rats with vascular cognitive impairment

Xu, L., Qu, C., Qu, C., Shen, J., Song, H., Li, Y., Li, T., Zheng, J., & Zhang, J. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135437 · Cited by 25

DL-3n-Butylphthalide Improves Blood–Brain Barrier Integrity in Rat After Middle Cerebral Artery Occlusion

Mamtilahun, M., Wei, Z., Qin, C., Wang, Y., Tang, Y., Shen, F., Tian, H., Zhang, Z., & Yang, G. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.610714 · Cited by 25

Blood–Brain Barrier Mechanisms in Stroke and Trauma

Li, W., Cao, F., Takase, H., Arai, K., Lo, E. H., & Lok, J. M. (2020) · Handbook of experimental pharmacology · doi:10.1007/164_2020_426 · Cited by 26

Celastrol protects against early brain injury after subarachnoid hemorrhage in rats through alleviating blood-brain barrier disruption and blocking necroptosis

Xu, H., Cai, Y., Yu, M., Sun, J., Cai, J., Li, J., Qin, B., Ying, G., Chen, T., Shen, Y.-F., et al. (2021) · Aging · doi:10.18632/aging.203221 · Cited by 25

Small Vessel Disease: Ancient Description, Novel Biomarkers

Moretti, R., & Caruso, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073508 · Cited by 25

Marine Natural Products from the Russian Pacific as Sources of Drugs for Neurodegenerative Diseases

Khotimchenko, Y. S., Silachev, D. N., & Katanaev, V. L. (2022) · Marine Drugs · doi:10.3390/md20110708 · Cited by 25

Lutein isolated from Scenedesmus obliquus microalga boosts immunity against cyclophosphamide-induced brain injury in rats

El-Baz, F. K., Salama, A., Ali, S. I., & Elgohary, R. (2022) · Scientific Reports · doi:10.1038/s41598-022-25252-9 · Cited by 25

Accumulation of macromolecules in brain parenchyma in acute phase of cerebral infarction/reperfusion

Ishii, T., Asai, T., Urakami, T., & Oku, N. (2010) · Brain Research · doi:10.1016/j.brainres.2010.01.039 · Cited by 25

A close look at brain dynamics: Cells and vessels seen by in vivo two-photon microscopy

Fumagalli, S., Ortolano, F., & Simoni, M. G. D. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.06.005 · Cited by 27

Late cerebral ischaemia after subarachnoid haemorrhage: Is cerebrovascular receptor upregulation the mechanism behind?

Edvinsson, L. I., & Povlsen, G. K. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02227.x · Cited by 25

Establishment and evaluation of an experimental animal model of high altitude cerebral edema

Guo, P., Luo, H., Fan, Y., Luo, Y., & Zhou, Q. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.05.008 · Cited by 25

Matrix metalloproteinases and small artery remodeling

Martinez‐Lemus, L. A., & Galiñanes, E. L. (2011) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2011.06.002 · Cited by 25

Single nucleotide polymorphisms in the angiogenic and lymphangiogenic pathways are associated with lymphedema caused by Wuchereria bancrofti

Debrah, L. B., Albers, A., Debrah, A. Y., Brockschmidt, F. F., Becker, T., Herold, C., Hofmann, A., Osei-Mensah, J., Mubarik, Y., Fröhlich, H., et al. (2017) · Human Genomics · doi:10.1186/s40246-017-0121-7 · Cited by 25

Panax notoginseng Saponins Ameliorate Leukocyte Adherence and Cerebrovascular Endothelial Barrier Breakdown upon Ischemia-Reperfusion in Mice

Wu, T., Jia, Z., Dong, S., Han, B., Zhang, R., Liang, Y., Zhang, S., & Sun, J. (2019) · Journal of Vascular Research · doi:10.1159/000494935 · Cited by 25

Cryptotanshinone Attenuates Oxygen-Glucose Deprivation/ Recovery-Induced Injury in an in vitro Model of Neurovascular Unit

Zhao, H., Zheng, T., Yang, X., Fan, M., Zhu, L., Liu, S., Wu, L., & Sun, C. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00381 · Cited by 26

Increased matrix metalloproteinases expression in tuberous sclerosis complex: modulation by microRNA 146a and 147bin vitro

Broekaart, D. W. M., van Scheppingen, J., Anink, J. J., Wierts, L., Hof, B. V. H., Jansen, F. E., Spliet, W. G. M., van Rijen, P. C., Kamphuis, W. W., de Vries, H. E., et al. (2019) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12572 · Cited by 25

Proteoglycan 4 Reduces Neuroinflammation and Protects the Blood–Brain Barrier after Traumatic Brain Injury

Bennett, M., Chin, A., Lee, H. J., Cestero, E. M., Strazielle, N., Ghersi‐Egea, J., Threlkeld, S. W., Schmidt, T. A., Richendrfer, H. A., Szmydynger‐Chodobska, J., et al. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2020.7229 · Cited by 25

Blood-brain barrier disruption in the striatum of rats treated with 3-nitropropionic acid

Duran‐Vilaregut, J., del Valle, J., Camins, A., Pallàs, M., Pelegrí, C., & Vilaplana, J. (2008) · NeuroToxicology · doi:10.1016/j.neuro.2008.10.007 · Cited by 27

Microfluidic models of the neurovascular unit: a translational view

Wevers, N. R., & de Vries, H. E. (2023) · Fluids and Barriers of the CNS · doi:10.1186/s12987-023-00490-9 · Cited by 25

Insight into the pathophysiological advances and molecular mechanisms underlying cerebral stroke: current status

Dhapola, R., Medhi, B., & HariKrishnaReddy, D. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09597-0 · Cited by 24

Human severe sepsis cytokine mixture increases β2-integrin-dependent polymorphonuclear leukocyte adhesion to cerebral microvascular endothelial cells in vitro

Blom, C., Deller, B., Fraser, D. D., Patterson, E. K., Martin, C. M., Young, G. B., Liaw, P. C., Yazdan-Ashoori, P., Ortiz, A., Webb, B., et al. (2015) · Critical Care · doi:10.1186/s13054-015-0883-z · Cited by 24

Picroside II protects the blood-brain barrier by inhibiting the oxidative signaling pathway in cerebral ischemia-reperfusion injury

Zhai, L., Liu, M., Wang, T., Zhang, H., Li, S., & Guo, Y. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174414 · Cited by 24

Protection of blood-brain barrier as a potential mechanism for enriched environments to improve cognitive impairment caused by chronic cerebral hypoperfusion

Qu, C., Xu, L., Shen, J., Li, Y., Qu, C., Song, H., & Zhang, J. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112385 · Cited by 25

Nonoptimal bacteria species induce neutrophil-driven inflammation and barrier disruption in the female genital tract

Fujishima, M. C., Yazdanpanah, A., Horne, S., Lamont, A., Lopez, P. G., Zuend, C. F., Birse, K., Taverner, M. K., Greenslade, R., Abou, M., et al. (2023) · Mucosal Immunology · doi:10.1016/j.mucimm.2023.04.001 · Cited by 25

Association of Plasma Claudin-5 with Age and Alzheimer Disease

Tachibana, K., Hirayama, R., Sato, N., Hattori, K., Kato, T., Takeda, H., & Kondoh, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031419 · Cited by 23

Molecular hydrogen in the treatment of acute and chronic neurological conditions: mechanisms of protection and routes of administration

Dohi, K., Satoh, K., Miyamoto, K., Momma, S., Fukuda, K., Higuchi, R., Ohtaki, H., & Banks, W. A. (2017) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.16-87 · Cited by 23

Gestational Hypoxia and Blood-Brain Barrier Permeability: Early Origins of Cerebrovascular Dysfunction Induced by Epigenetic Mechanisms

Herrera, E. A., & González‐Candia, A. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.717550 · Cited by 23

Clarifying the mechanism of apigenin against blood–brain barrier disruption in ischemic stroke using systems pharmacology

Wang, X., Yu, Z., Dong, F., Li, J., Niu, P., Ta, Q., Kan, J., Ma, C., Han, M., Yu, J., et al. (2023) · Molecular Diversity · doi:10.1007/s11030-023-10607-9 · Cited by 23

Carvacrol decreases blood–brain barrier permeability post-diffuse traumatic brain injury in rats

Abbasloo, E., Khaksari, M., Sanjari, M., Kobeissy, F. H., & Thomas, T. C. (2023) · Scientific Reports · doi:10.1038/s41598-023-40915-x · Cited by 23

Blood-brain barrier biomarkers

Zapata-Acevedo, J. F., Mantilla-Galindo, A., Vargas-Sánchez, K., & González-Reyes, R. E. (2024) · Advances in clinical chemistry · doi:10.1016/bs.acc.2024.04.004 · Cited by 23

Molecular pathology of brain edema after severe burns in forensic autopsy cases with special regard to the importance of reference gene selection

Wang, Q., Ishikawa, T., Michiue, T., Zhu, B.-L., Guan, D.-W., & Maeda, H. (2013) · International Journal of Legal Medicine · doi:10.1007/s00414-013-0868-x · Cited by 26

Genome response to tissue plasminogen activator in experimental ischemic stroke

Jickling, G. C., Zhan, X., Ander, B. P., Turner, R. J., Stamova, B. S., Xu, H., Tian, Y., Liu, D., Davis, R. R., Lapchak, P. A., et al. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-254 · Cited by 23

New hypothesis for insulin resistance in hypertension due to receptor cleavage

DeLano, F. A., Zhang, H., Tran, E. D., Zhang, C., & Schmid‐Schönbein, G. W. (2010) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.09.64 · Cited by 23

Increased cerebral expressions of MMPs, CLDN5, OCLN, ZO1 and AQPs are associated with brain edema following fatal heat stroke

Du, Y., Xu, J.-T., Jin, H., Zhao, R., Zhao, D. H., Du, S., Xue, Y., Xie, X., & Wang, Q. (2017) · Scientific Reports · doi:10.1038/s41598-017-01923-w · Cited by 23

Altered Insulin/Insulin-Like Growth Factor Signaling in a Comorbid Rat model of Ischemia and β-Amyloid Toxicity

Amtul, Z., Hill, D. J., Arany, E. J., & Cechetto, D. F. (2018) · Scientific Reports · doi:10.1038/s41598-018-22985-4 · Cited by 23

Limb remote ischemic postconditioning protects integrity of the blood-brain barrier after stroke

Qi, C., Zhang, X., Li, J., Hu, X.-S., Zhou, F., Li, S., Lin, Y.-S., & Qi, W.-Q. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.237122 · Cited by 23

Combining Ceftriaxone with Doxycycline and Daptomycin Reduces Mortality, Neuroinflammation, Brain Damage, and Hearing Loss in Infant Rat Pneumococcal Meningitis

Muri, L., Perny, M., Zemp, J., Grandgirard, D., & Leib, S. L. (2019) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00220-19 · Cited by 23

The Lyme disease bacterium, Borrelia burgdorferi, stimulates an inflammatory response in human choroid plexus epithelial cells

Thompson, D., Sorenson, J., Greenmyer, J. R., Brissette, C. A., & Watt, J. A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0234993 · Cited by 24

The Role of Transient Receptor Potential Channels in Blood-Brain Barrier Dysfunction after Ischemic Stroke

Huang, Q., Wang, X., Lin, X., Zhang, J., You, X., & Shao, A. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110647 · Cited by 23

Mesenchymal Stem Cell Treatment Prevents Post-Stroke Dysregulation of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases

Chelluboina, B., Nalamolu, K. R., Mendez, G. G., Klopfenstein, J. D., Pinson, D. M., Wang, D. Z., & Veeravalli, K. K. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485533 · Cited by 23

MMP-12 knockdown prevents secondary brain damage after ischemic stroke in mice

Arruri, V. K., Chokkalla, A. K., Jeong, S., Chelluboina, B., Mehta, S. L., Veeravalli, K. K., & Vemuganti, R. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105432 · Cited by 23

Is there a role for herpes simplex virus type 1 in multiple sclerosis?

Duarte, L. F., Gatica, S., Castillo, A., Kalergis, A. M., Bueno, S. M., Riedel, C. A., & González, P. A. (2022) · Microbes and Infection · doi:10.1016/j.micinf.2022.105084 · Cited by 24

Optogenetic Activation of Astrocytes Reduces Blood-Brain Barrier Disruption via IL-10 In Stroke

Suo, Q., Deng, L., Chen, T., Wu, S., Qi, L., Liu, Z., He, T., Tian, H.-L., Li, W., Tang, Y., et al. (2023) · Aging and Disease · doi:10.14336/ad.2023.0226 · Cited by 23

Cenicriviroc prevents dysregulation of astrocyte/endothelial cross talk induced by ischemia and HIV-1 via inhibiting the NLRP3 inflammasome and pyroptosis

Fattakhov, N. S., Ngo, A., Torices, S., Joseph, J.-A., Okoro, A., Moore, C., Naranjo, O., Becker, S., & Toborek, M. J. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00600.2023 · Cited by 22

Research progress and challenges of stem cell therapy for ischemic stroke

Cha, Z., Qiao, Y., Lu, Q., Wang, Q., Lu, X., Zhou, H., & Li, T. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1410732 · Cited by 22

Plasma 3‐nitrotyrosine estimates the reperfusion‐induced cerebrovascular stress, whereas matrix metalloproteinases mainly reflect plasma activity: a study in patients treated with thrombolysis or endovascular recanalization

Baş, D. F., Topçuoğlu, M. A., Özdemir, Y., Saatçi, I., Bodur, E., & Dalkara, T. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07952.x · Cited by 23

Inhibition of telomerase activity alters tight junction protein expression and induces transendothelial migration of HIV-1-infected cells

Huang, W., Rha, G. B., Chen, L., Seelbach, M. J., Zhang, B., Andras, I. E., Bruemmer, D., Hennig, B., & Toborek, M. J. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01126.2009 · Cited by 23

Different resuscitation strategies and novel pharmacologic treatment with valproic acid in traumatic brain injury

Dekker, S. E., Nikolian, V. C., Sillesen, M., Bambakidis, T., Schober, P. R., & Alam, H. B. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24125 · Cited by 22

Peripheral Nerve Injury Induces Dynamic Changes of Tight Junction Components

Wang, X., Miao, Y., Ni, J., Wang, Y., Qian, T., Yu, J. J., Liu, Q., Wang, P., & Yi, S. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01519 · Cited by 22

Potential Tear Biomarkers for the Diagnosis of Parkinson’s Disease—A Pilot Study

Acera, A., Gómez‐Esteban, J. C., Murueta‐Goyena, A., Galdós, M., Azkargorta, M., Elortza, F., Ruzafa, N., Ibarrondo, O., Pereiro, X., & Vecino, E. (2022) · Proteomes · doi:10.3390/proteomes10010004 · Cited by 25

Modulation of tight junction proteins in the perineurium for regional pain control

Hackel, D., Brack, A., Fromm, M., & Rittner, H. L. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06499.x · Cited by 22

Matrix metalloproteinases 2 and 9 in the cochlea: expression and activity after aminoglycoside exposition

Setz, C., Brand, Y., Radojevic, V., Hanusek, C., Mullen, P. J., Levano, S., Listyo, A., & Bodmer, D. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.02.043 · Cited by 22

Circulating tight junction proteins mirror blood-brain barrier integrity in leukaemia central nervous system metastasis

Zhu, J.-C., Si, M., Li, Y., Chen, H., Fan, Z., Xie, Q., & Jiao, X. (2016) · Hematological Oncology · doi:10.1002/hon.2289 · Cited by 22

Meprin β: A novel regulator of blood–brain barrier integrity

Gindorf, M., Storck, S. E., Ohler, A., Scharfenberg, F., Becker-Pauly, C., & Pietrzik, C. U. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20905206 · Cited by 21

Role of hydrogen sulfide in subarachnoid hemorrhage

Lu, D., Wang, L., Liu, G., Wang, S., Wang, Y. N., Wu, Y. H., Wang, J., & Sun, X. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13828 · Cited by 21

Alzheimer’s disease is an inherent, natural part of human brain aging: an integrated perspective

Ferrer, I. (2022) · Free Neuropathology · doi:10.17879/freeneuropathology-2022-3806 · Cited by 25

Metalloproteinases and neurodegenerative diseases: pathophysiological and therapeutic perspectives

Rosenberg, G. A. (2015) · Metalloproteinases In Medicine · doi:10.2147/mnm.s68849 · Cited by 21

Beyond cell-cell adhesion

Traweger, A., Toepfer, S., Wagner, R. N., Zweimueller-Mayer, J., Gehwolf, R., Lehner, C., Tempfer, H., Krizbai, I. A., Wilhelm, I., Bauer, H., et al. (2013) · Tissue Barriers · doi:10.4161/tisb.25039 · Cited by 21

Endothelial barrier antigen-immunoreactivity is conversely associated with blood-brain barrier dysfunction after embolic stroke in rats

Pelz, J. O., Härtig, W., Weise, C. M., Hobohm, C., Schneider, D., Krueger, M., Kacza, J., & Michalski, D. (2013) · European Journal of Histochemistry · doi:10.4081/ejh.2013.e38 · Cited by 21

Update on the effects of treatment with recombinant tissue-type plasminogen activator (rt-PA) in acute ischemic stroke

Bonaventura, A., Montecucco, F., & Dallegri, F. (2016) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2016.1227779 · Cited by 22

Electroacupuncture Exerts Neuroprotection through Caveolin-1 Mediated Molecular Pathway in Intracerebral Hemorrhage of Rats

Li, H., Li, Y., Chen, Z., Zhang, X., Zheng, X.-W., Yang, W.-T., Chen, S., & Zheng, G. (2016) · Neural Plasticity · doi:10.1155/2016/7308261 · Cited by 21

Preischemic treadmill exercise improves short-term memory by inhibiting hypoperfusion-induced disruption of blood-brain barrier after bilateral common carotid arteries occlusion

Lee, J. M., Baek, S., Kim, T.-W., Park, H.-S., Park, S.-S., Park, J., Kim, Y., Lee, H.-S., & Shin, M. (2019) · Journal of Exercise Rehabilitation · doi:10.12965/jer.1938274.137 · Cited by 21

Long-term dietary supplementation with plant-derived omega-3 fatty acid improves outcome in experimental ischemic stroke

Bonetti, N. R., Liberale, L., Akhmedov, A. T., Pasterk, L., Gobbato, S., Puspitasari, Y. M., Vukolic, A., Saravi, S. S. S., Coester, B., Horváth, C., et al. (2021) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2021.04.005 · Cited by 22

GANAB and N-Glycans Substrates Are Relevant in Human Physiology, Polycystic Pathology and Multiple Sclerosis: A Review

De Masi, R., & Orlando, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137373 · Cited by 20

Contributions of Drug Transporters to Blood-Brain Barriers

Liu, L., & Liu, X. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-7647-4_9 · Cited by 21

Contribution of blood-brain barrier-related blood-borne factors for Alzheimer’s disease vs. vascular dementia diagnosis: A pilot study

Gong, M., & Jia, J. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.949129 · Cited by 20

Antioxidation activity of molecular hydrogen via protoheme catalysis in vivo: an insight from ab initio calculations

Kim, S.-A., Jong, Y.-C., Kang, M.-S., & Yu, C. (2022) · Journal of Molecular Modeling · doi:10.1007/s00894-022-05264-y · Cited by 20

Regional contribution of vascular dysfunction in white matter dementia: clinical and neuropathological insights

Pansieri, J., Hadley, G., Lockhart, A., Pisa, M., & DeLuca, G. C. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1199491 · Cited by 21

Influence of the brain‑gut axis on neuroinflammation in cerebral ischemia‑reperfusion injury (Review)

Zhang, Y., Yang, H., Hou, S., Xia, Y., & Wang, Y. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5354 · Cited by 23

Adjudin protects blood–brain barrier integrity and attenuates neuroinflammation following intracerebral hemorrhage in mice

Su, Q., Su, C., Zhang, Y., Guo, Y., Liu, Y., Liu, Y., Yong, V. W., & Xue, M. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111962 · Cited by 20

Hopping the Hurdle: Strategies to Enhance the Molecular Delivery to the Brain through the Blood–Brain Barrier

Cogill, S. A., Lee, J.-H., Jeon, M., Kim, D.-G., & Chang, Y. (2024) · Cells · doi:10.3390/cells13100789 · Cited by 20

Ischemic Postconditioning Decreases Cerebral Edema and Brain Blood Barrier Disruption Caused by Relief of Carotid Stenosis in a Rat Model of Cerebral Hypoperfusion

Yang, F., Zhang, X., Sun, Y., Wang, B., Zhou, C., Luo, Y., & Ge, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057869 · Cited by 20

Brain Edema and Disorders of Cerebrospinal Fluid Circulation

Rosenberg, G. A. (2008) · Elsevier eBooks · doi:10.1016/b978-0-7506-7525-3.50101-1 · Cited by 20

Protective effects of angiopoietin-like 4 on the blood-brain barrier in acute ischemic stroke treated with thrombolysis in mice

Zhang, B., Xu, X., Chu, X., Yu, X., & Zhao, Y. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.03.001 · Cited by 20

Vasogenic edema due to tight junction disruption by matrix metalloproteinases in cerebral ischemia

Rosenberg, G. A., & Yang, Y. R. (2007) · Neurosurgical FOCUS · doi:10.3171/foc.2007.22.5.5 · Cited by 358

Relationship of gelatinases-tight junction proteins and blood-brain barrier permeability in the early stage of cerebral ischemia and reperfusion.

Xin, H., Liang, W., Mang, J., Lin, L., Guo, N., Zhang, F., & Xu, Z. (2012) · PubMed Central · doi:10.3969/j.issn.1673-5374.2012.31.001 · Cited by 11

Matrix Metalloproteinases and TIMPs Are Associated With Blood-Brain Barrier Opening After Reperfusion in Rat Brain

Rosenberg, G. A., Estrada, E. Y., & Dencoff, J. E. (1998) · Stroke · doi:10.1161/01.str.29.10.2189 · Cited by 861

Early Inhibition of MMP Activity in Ischemic Rat Brain Promotes Expression of Tight Junction Proteins and Angiogenesis During Recovery

Yang, Y., Thompson, J. F., Taheri, S., Salayandia, V. M., McAvoy, T. A., Hill, J. W., Yang, Y., Estrada, E. Y., & Rosenberg, G. A. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.56 · Cited by 147

Early appearance of activated matrix metalloproteinase-9 and blood–brain barrier disruption in mice after focal cerebral ischemia and reperfusion

Fujimura, M., Gasche, Y., Morita‐Fujimura, Y., Massengale, J. L., 川瀬, 誠., & Chan, P. H. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01843-0 · Cited by 339