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Molecular and cellular mechanisms of action of angiotensin II (AT1) receptors in vascular smooth muscle.
Abstract
Angiotensin is an important regulator of blood pressure and exerts both pressor actions and influences growth in the cardiovascular system via the AT1 receptor. This review describes a number of signalling mechanisms involved in vasoconstriction and growth in response to AT1 receptor activation in vascular smooth muscle.
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“Angiotensin II exerts vasoconstrictor effect (Hughes, 1998).”
From Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease (2021) · cites this paper as Hughes, 1998
Citations
Cited by
Beamish, J. A., He, P., Kottke-Marchant, K., & Marchant, R. E. (2010) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2009.0630 · Cited by 383
“The AT1 receptor mediates changes in intracellular calcium that are a major determinant of SMC contraction.(76) Ang-II may stimulate SMC proliferation(83,84) or stimulate hypertrophy without proliferation.”
Angiotensin receptors: distribution, signalling and function
DINH, D. T., FRAUMAN, A. G., JOHNSTON, C. I., & FABIANI, M. E. (2001) · Clinical Science · doi:10.1042/cs1000481 · Cited by 268
Elmarasi, M., Elmakaty, I., Elsayed, B., Elsayed, A., Zein, J. A., Boudaka, A., & Eid, A. H. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31200 · Cited by 169
“While AT1 is primarily implicated inVSMC contraction (Hughes, 1998; Yu et al., 2012), a characteristic of differentiated phenotype, AT2 is known to promote proliferation or hypertrophy of these cells (Chow & Allen, 2016; Lemarié & Schiffrin, 2010; Nguyen Dinh Cat & Touyz, 2011; Ruiz ‐ Ortega et…”
BackgroundTouyz, R. M., He, G., Wu, X., Park, J. B., Mabrouk, M. E., & Schiffrin, E. L. (2001) · Hypertension · doi:10.1161/01.hyp.38.1.56 · Cited by 105
Regulatory mechanisms of atrial fibrotic remodeling in atrial fibrillation
Lin, C., & Pan, C. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7408-8 · Cited by 100
Mettu, P. S., Wielgus, A. R., Ong, S. S. Y., & Cousins, S. W. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.04.006 · Cited by 93
Signal transduction systems and atrial fibrillation
Goette, A. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00521-1 · Cited by 84
Touyz, R. M., He, G., Mabrouk, M. E., et al. (2001) · Journal of Hypertension · doi:10.1097/00004872-200103001-00006 · Cited by 77
Dinh, D. T., Frauman, A. G., Sourial, M., CASLEY, D. J., Johnston, C. I., & Fabiani, M. E. (2001) · Endocrinology · doi:10.1210/endo.142.3.8020 · Cited by 57
Eicosanoid blood vessel regulation in physiological and pathological states
Imig, J. D. (2020) · Clinical Science · doi:10.1042/cs20191209 · Cited by 63
Angiotensin signaling and receptor types in teleost fish
Russell, M. J., Klemmer, A. M., & Olson, K. R. (2001) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/s1095-6433(00)00296-8 · Cited by 56
Angiotensin II Induces Phenotype-Dependent Apoptosis in Vascular Smooth Muscle Cells
Bascands, J., Girolami, J., Troly, M., Escargueil‐Blanc, I., Nazzal, D., Salvayre, R., & Blaes, N. (2001) · Hypertension · doi:10.1161/hy1201.096540 · Cited by 56
Nonchannel drug targets in atrial fibrillation
Goette, A., & Lendeckel, U. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.01.001 · Cited by 39
Direct Inhibition of Renin as a Cardiovascular Pharmacotherapy
Sepehrdad, R., Frishman, W. H., Stier, C. T., & Sica, D. A. (2007) · Cardiology in Review · doi:10.1097/crd.0b013e318093e43a · Cited by 34
“Ang-II stimulation of AT1 receptors in blood vessels also promotes the release of endothelin, causing vasoconstriction and thus increasing BP.(27,28) Ang II has several other direct and indirect effects mediated through the AT1 receptor that lead to an increase in intravascular volume, sodium retention, and BP.”
BackgroundGuo, D., Tardif, V., Ghelima, K., Chan, J. S. D., Ingelfinger, J. R., Chen, X.-M., & Chénier, I. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401544200 · Cited by 32
Angiotensin II Dilates Bovine Adrenal Cortical Arterioles: Role of Endothelial Nitric Oxide
Gauthier, K. M., Zhang, D. X., Edwards, E. M., Holmes, B. B., & Campbell, W. B. (2005) · Endocrinology · doi:10.1210/en.2005-0129 · Cited by 22
Kutumova, E., Kiselev, I., Sharipov, R., Lifshits, G., & Kolpakov, F. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.746300 · Cited by 16
“• Vascular Smooth Muscle Angiotensin II exerts vasoconstrictor effect (Hughes, 1998).”
BackgroundConsortium of Southeastern Hypertension Control
Harris, R. C., & Sica, D. A. (1999) · The American Journal of the Medical Sciences · doi:10.1097/00000441-199912000-00004 · Cited by 16
Potential Mechanisms and Physiologic Actions of Intracellular Angiotensin II
Sica, D. A., & Harris, R. C. (1999) · The American Journal of the Medical Sciences · doi:10.1016/s0002-9629(15)40662-7 · Cited by 14
Yu, J., Prado, G. N., Taylor, L., Pal‐Ghosh, R., & POLGAR, P. R. (2002) · International Immunopharmacology · doi:10.1016/s1567-5769(02)00177-7 · Cited by 11
AT 1-signalling in vascular smooth muscle
Hughes, A. D. (2000) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.3317/jraas.2000.014 · Cited by 9
Self-citationBoerman, E. M., Sen, S., Shaw, R. L., et al. (2018) · Microcirculation · doi:10.1111/micc.12452 · Cited by 8
Goette, A., Röcken, C., Nepple, K., & Lendeckel, U. (2003) · Springer eBooks · doi:10.1007/978-1-4419-9082-2_9 · Cited by 8
Guo, D., Tardif, V., Chénier, I., Chan, J. S. D., Ingelfinger, J. R., Chen, X. M., & Inagami, T. (2006) · Journal of Cardiothoracic-Renal Research · doi:10.1016/j.jccr.2005.12.005
Tadevosyan, A. (2009) · Papyrus : Institutional Repository (Université de Montréal) · doi:10.71781/26826
Metadata
- Authors
- Hughes, A.
- Venue
- Journal of Human Hypertension
- Published
- 1998-05-01
- Volume
- 12
- Issue
- 5
- Pages
- 275-281
- ISSN
- 0950-9240 (ISSN-L)
- 1476-5527
- OpenAlex
- W1963495404
- Cited by
- 29
- References
- 0
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2012: 2
- Type
- other
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- www.springer.com/tdm (vor)
- Locations
- Journal of Human Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- angiotensin II, angiotensin II type 1 receptor, vascular smooth muscle, vasoconstriction, cell growth, signalling mechanisms, blood pressure regulation, hypertension
- MeSH terms
- Angiotensin II, Animals, Cells, Cultured, Humans, Hypertension, Ion Channels, Muscle, Smooth, Vascular, Type C Phospholipases, Protein Kinase C, Receptors, Angiotensin, Vasoconstriction, Signal Transduction, Receptor, Angiotensin, Type 2, Receptor, Angiotensin, Type 1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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