The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Angiotensin receptors: distribution, signalling and function
Abstract
Angiotensin II (Ang II) is a multi-functional hormone that plays a major role in regulating blood pressure and cardiovascular homoeostasis. The actions of Ang II are mediated by at least two receptor subtypes, designated AT1 and AT2. In addition, other angiotensin receptors have been identified which may recognize other angiotensin peptide fragments; however, until now only the AT1 and AT2 receptor have been cloned in animals or humans. Most of the well-described actions of Ang II, such as vasoconstriction, facilitation of sympathetic transmission, stimulation of aldosterone release and promotion of cellular growth are all mediated by the AT1 receptor. Much less is known about the function of the AT2 receptor, but recent studies suggest that it may play a role in mediating anti-proliferation, cellular differentiation, apoptosis and vasodilatation. In this review, we discuss recent advances in our understanding of Ang II receptors, in particular, their distribution, signalling and function.
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Hughes, A. (1998) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1000635 · Cited by 29
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Metadata
- Authors
- DINH, D. T., FRAUMAN, A. G., JOHNSTON, C. I., & FABIANI, M. E.
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 2001-03-27
- Volume
- 100
- Issue
- 5
- Pages
- 481-492
- ISSN
- 0143-5221 (ISSN-L)
- 1470-8736
- OpenAlex
- W2005685765
- Cited by
- 268
- References
- 1
- FWCI
- 9.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- DINH, D. T., FRAUMAN, A. G., JOHNSTON, C. I., & FABIANI, M. E. (2001). Angiotensin receptors: distribution, signalling and function. Clinical Science. https://doi.org/10.1042/cs1000481
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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