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Cited by 96Chronic Kidney Disease and DiabetesBlood Pressure and Hypertension StudiesRenin-Angiotensin System Studies

Long-term effects of ramipril and nitrendipine on albuminuria in hypertensive patients with type II diabetes and impaired renal function

Fogari, R, Zoppi, A, Corradi, L, Mugellini, A, Lazzari, P, Preti, P, Lusardi, P·1999·Journal of Human Hypertension
DOI 10.1038/sj.jhh.1000732
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Abstract

The aim of this study was to compare the effects of ramipril and nitrendipine chronic treatment on urinary albumin excretion (UAE) in hypertensive patients with type II non-insulin-dependent diabetes mellitus (NIDDM) and impaired renal function. A 2-year, prospective, randomised study was conducted on 51 men with a diastolic blood pressure (DBP) > or =95 and 300 and <2000 mg/24 h. After a 3-month preliminary observation period, during which patients began a low-protein, low-sodium diet, and a subsequent 4-week run-in period on placebo, patients were randomly treated with ramipril 5 mg or nitrendipine 20 mg for 2 years. Both drugs similarly reduced BP without affecting glucose homeostasis. In the ramipril group UAE significantly decreased after only 3 months of treatment, whereas in the nitrendipine group a significant although lesser reduction in UAE was observed only after 1 year. During the second year the UAE% change was not statistically different between the two treatments. Serum creatinine and creatinine clearance showed no significant change with both drugs. The progression of renal insufficiency as assessed by the rate of reduction of creatinine clearance over the 2 years of the study was similar in the ramipril and the nitrendipine groups. In conclusion both ramipril and nitrendipine were associated with a decrease in UAE although such a reduction was earlier and more marked with ramipril. The decline of renal function did not differ significantly between the two tre…

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  • Previous studies involving angiotensin-I-converting enzyme inhibitors demonstrated beneficial effects on proteinuria but did not demonstrate the superiority of renin-angiotensin system blockade in slowing progression to end-stage renal disease over nonblockade forms of therapy.

    “Previous studies involving angiotensin-I-converting enzyme inhibitors have demonstrated beneficial effects on proteinuria but have not demonstrated the superiority of blockade of the renin-angiotensin system in slowing the progression to end-stage renal disease over nonblockade forms of therapy. 14-20”

    From Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy (2001) · cites this paper as [18]

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Authors
Fogari, R., Zoppi, A., Corradi, L., Mugellini, A., Lazzari, P., Preti, P., & Lusardi, P.
Affiliations
University of Pavia (IT)
ORCID
Preti, P
Venue
Journal of Human Hypertension
Publisher
Springer Science and Business Media LLC
Published
1999-01-01
Volume
13
Issue
1
Pages
47-53
ISSN
  • 0950-9240 (ISSN-L)
  • 1476-5527
DOI
10.1038/sj.jhh.1000732
OpenAlex
W2032425666
Cited by
96
References
0
Citations by year
2026: 2 · 2025: 1 · 2023: 1 · 2022: 5 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 2
FWCI
6.70
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Human Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Keywords
ramipril, nitrendipine, albuminuria, urinary albumin excretion, hypertension, type 2 diabetes, renal dysfunction, renal insufficiency progression, ACE inhibitors, calcium channel blockers, antihypertensive drug comparison, creatinine clearance
MeSH terms
Aged, Albuminuria, Angiotensin-Converting Enzyme Inhibitors, Calcium Channel Blockers, Creatinine, Diabetes Mellitus, Type 2, Humans, Hypertension, Kidney, Longitudinal Studies, Male, Middle Aged, Nitrendipine, Prospective Studies, Ramipril

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