The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Early steroid treatment improves the recovery of renal function in patients with drug-induced acute interstitial nephritis
Open accessAbstract
The role of steroid treatment in drug-induced acute interstitial nephritis (DI-AIN) is controversial. We performed a multicenter retrospective study to determine the influence of steroids in 61 patients with biopsy-proven DI-AIN, 52 of whom were treated with steroids. The responsible drugs were antibiotics (56%), non-steroidal anti-inflammatory drugs (37%) or other drugs. The final serum creatinine was significantly lower in treated patients while almost half of untreated patients remained on chronic dialysis. Among treated patients, over half showed a complete recovery of baseline renal function, whereas the rest remained in renal failure. There were no significant initial differences between these two subgroups in terms of duration or dosage of steroids. After withdrawal of the presumed causative drug, we found that when steroid treatment was delayed (by an average of 34 days) renal function did not return to baseline levels compared to those who received steroid treatment within the first 2 weeks after withdrawal of the offending agent. We found a significant correlation between the delay in steroid treatment and the final serum creatinine. Renal biopsies, including three patients who underwent a second biopsy, showed a progression of interstitial fibrosis related to the delay in steroid treatment. Our study shows that steroids should be started promptly after diagnosis of DI-AIN to avoid subsequent interstitial fibrosis and an incomplete recovery of renal function.
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“during the case of an antibiotic-related AIN, clinicians may require the use of alternative antibiotic drugs along with the application of an immunosuppressant [3, 6, 16, 17]”
From The diagnosis of acute interstitial nephritis caused by infection versus antibiotic-induced interstitial nephritis: a narrative review (2024) · cites this paper as [17]
Citations
Cites
Acute interstitial nephritis: clinical features and response to corticosteroid therapy
Clarkson, M. R. (2004) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfh485 · Cited by 343
Bhaumik, S. K., Kher, V., Arora, P., Rai, P. K., Singhal, M., Gupta, A., Pandey, R., & Sharma, R. K. (1996) · Renal Failure · doi:10.3109/08860229609052779 · Cited by 67
Acute renal failure in patients with drug-induced acute interstitial nephritis
Koselj, M., Kveder, R., Bren, A. F., & Rott, T. (1993) · Renal Failure · doi:10.3109/08860229309065575 · Cited by 48
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Brahmer, J. R., Abu-Sbeih, H., Ascierto, P. A., Brufsky, J., Cappelli, L. C., Cortazar, F. B., Gerber, D. E., Hamad, L., Hansen, E., Johnson, D. B., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-002435 · Cited by 917
Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors
Cortazar, F. B., Marrone, K. A., Troxell, M. L., Ralto, K. M., Hoenig, M. P., Brahmer, J. R., Le, D. T., Lipson, E. J., Glezerman, I. G., Wolchok, J. D., et al. (2016) · Kidney International · doi:10.1016/j.kint.2016.04.008 · Cited by 666
“The efficacy of glucocorticoids in the treatment of AIN remains controversial due to conflicting observational studies and the absence of a randomized trial.(17,18) In our cohort, 9 of 10 patients with CPI-induced AIN treated with glucocorticoids had complete or partial recovery of renal function, whereas neither of t…”
BackgroundThompson, J. A., Schneider, B. J., Brahmer, J., Andrews, S., Armand, P., Bhatia, S., Budde, L. E., Costa, L., Davies, M., Dunnington, D., et al. (2019) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2019.0013 · Cited by 570
Praga, M., & González, E. (2010) · Kidney International · doi:10.1038/ki.2010.89 · Cited by 507
Self-citationClinical features and outcomes of immune checkpoint inhibitor-associated AKI: a multicenter study
Cortazar, F. B., Kibbelaar, Z. A., Glezerman, I. G., Abudayyeh, A., Mamlouk, O., Motwani, S. S., Murakami, N., Herrmann, S. M., Manohar, S., Shirali, A. C., et al. (2020) · Journal of the American Society of Nephrology · doi:10.1681/asn.2019070676 · Cited by 407
Metadata
- Authors
- González, E., Gutiérrez, E., Galeano, C., Chevia, C., de Sequera, P., Bernis, C., Parra, E. G., Delgado, R., Sanz, M., Ortiz, M., Goicoechea, M., Quereda, C., Olea, T., Bouarich, H., Hernández, Y., Segovia, B., & Praga, M.
- Affiliations
- Hospital Universitario 12 De Octubre (ES)
- Hospital Universitario Ramón y Cajal (ES)
- Hospital Universitario La Paz (ES)
- Hospital Universitario de La Princesa (ES)
- Hospital Ruber Internacional (ES)
- Hospital Universitario de Getafe (ES)
- Hospital Universitario Severo Ochoa (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Corresponding author
- Praga, M.
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 73
- Issue
- 8
- Pages
- 940-946
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W2128802116
- Cited by
- 466
- References
- 0
- Citations by year
- 2026: 19 · 2025: 26 · 2024: 32 · 2023: 23 · 2022: 32 · 2021: 34 · 2020: 30 · 2019: 38 · 2018: 27 · 2017: 28 · 2016: 23 · 2015: 28 · 2014: 23 · 2013: 18 · 2012: 23
- FWCI
- 16.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Nephrology › Nephrotoxicity and Medicinal Plants
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Keywords
- drug-induced acute interstitial nephritis, corticosteroid therapy, renal function recovery, interstitial fibrosis, nonsteroidal anti-inflammatory drugs, serum creatinine, dialysis dependence, renal biopsy
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Anti-Inflammatory Agents, Non-Steroidal, Biopsy, Creatinine, Drug Administration Schedule, Female, Humans, Kidney, Male, Middle Aged, Nephritis, Interstitial, Retrospective Studies, Steroids
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