The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells
Open accessAbstract
Evidence is presented that bone marrow (BM) in addition to CD45positive hematopoietic stem cells contains a rare population of heterogenous CD45negative nonhematopoietic tissue committed stem cells (TCSC). These nonhematopoietic TCSC (i) are enriched in population of CXCR4+ CD34+ AC133+ lin− CD45− and CXCR4+ Sca-1+ lin− CD45− in humans and mice, respectively, (ii) display several markers of pluripotent stem cells (PSC) and (iii) as we envision are deposited in BM early in development. Thus, since BM contains versatile nonhematopoietic stem cells, previous studies on plasticity trans-dedifferentiation of BM-derived hematopoietic stem cells (HSC) that did not include proper controls to exclude this possibility could lead to wrong interpretations. Therefore, in this spotlight review we present this alternative explanation of ‘plasticity’ of BM-derived stem cells based on the assumption that BM stem cells are heterogenous. We also discuss a potential relationship of TCSC/PSC identified by us with other BM-derived CD45negative nonhematopoietic stem cells that were recently identified by other investigators (eg MSC, MAPC, USSC and MIAMI cells). Finally, we discuss perspectives and pitfalls in potential application of these cells in regenerative medicine.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Changing potency by spontaneous fusion
Ying, Q.-L., Nichols, J., Evans, E. P., & Smith, A. G. (2002) · Nature · doi:10.1038/nature729 · Cited by 1,494
Liver from bone marrow in humans
Theise, N. D., Nimmakayalu, M., Gardner, R., Illei, P. B., Morgan, G., Teperman, L., Henegariu, O., & Krause, D. S. (2000) · Hepatology · doi:10.1053/jhep.2000.9124 · Cited by 1,210
Cited by
Conese, M., Piro, D., Carbone, A., Castellani, S., & Di Gioia, S. (2014) · The Scientific World Journal · doi:10.1155/2014/859817 · Cited by 28
Metadata
- Authors
- Kucia, M., Reca, R., Jala, V. R., Dawn, B., Ratajczak, J., & Ratajczak, M. Z.
- Venue
- Leukemia
- Published
- 2005-05-19
- Volume
- 19
- Issue
- 7
- Pages
- 1118-1127
- ISSN
- 0887-6924 (ISSN-L)
- 1476-5551
- OpenAlex
- W2032847865
- Cited by
- 195
- References
- 2
- FWCI
- 14.10
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells. https://app.cochat.ai/papers/10.1038/sj.leu.2403796
- The paper
- Kucia, M., Reca, R., Jala, V. R., Dawn, B., Ratajczak, J., & Ratajczak, M. Z. (2005). Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells. Leukemia. https://doi.org/10.1038/sj.leu.2403796
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
