Changing potency by spontaneous fusion
Abstract
Recent reports have suggested that mammalian stem cells residing in one tissue may have the capacity to produce differentiated cell types for other tissues and organs 1-9. Here we define a mechanism by which progenitor cells of the central nervous system can give rise to non-neural derivatives. Cells taken from mouse brain were co-cultured with pluripotent embryonic stem cells. Following selection for a transgenic marker carried only by the brain cells, undifferentiated stem cells are recovered in which the brain cell genome has undergone epigenetic reprogramming. However, these cells also carry a transgenic marker and chromosomes derived from the embryonic stem cells. Therefore the altered phenotype does not arise by direct conversion of brain to embryonic stem cell but rather through spontaneous generation of hybrid cells. The tetraploid hybrids exhibit full pluripotent character, including multilineage contribution to chimaeras. We propose that transdetermination consequent to cell fusion 10 could underlie many observations otherwise attributed to an intrinsic plasticity of tissue stem cells 9.
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There is an absence of transplant-to-host cell fusion events.
“indicating the absence of transplant-to-host cell fusion events”
From Xenotransplanted human cortical neurons reveal species-specific development and functional integration into mouse visual circuits (2019) · cites this paper as Ying et al., 2002
The discussion (page not identified in the index) reports spontaneous fusion between embryonic stem cells and brain cells in co-culture and advises checking both donor and host markers. The blastocyst-injection passage describes contributions from hybrids formed before injection; it does not establish whether transplanted cells fused with host cells. A search for transplant-to-host fusion found no passage establishing its absence. (LLM, conf=0.74)
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Cites
Bone marrow cells regenerate infarcted myocardium
Orlic, D., Kajstura, J., Chimenti, S., Jakoniuk, I., Anderson, S. M., Li, B., Pickel, J. M., McKay, R. D. G., Nadal‐Ginard, B., Bodine, D. M., et al. (2001) · Nature · doi:10.1038/35070587 · Cited by 5,149 · see citing works
Niwa, H., Miyazaki, J., & Smith, A. G. (2000) · Nature Genetics · doi:10.1038/74199 · Cited by 3,904 · see citing works
Self-citationNichols, J., Zevnik, B., Anastassiadis, K., Niwa, H., Klewe-Nebenius, D., Chambers, I., Schöler, H. R., & Smith, A. G. (1998) · Cell · doi:10.1016/s0092-8674(00)81769-9 · Cited by 3,394 · see citing works
Self-citationMuscle Regeneration by Bone Marrow-Derived Myogenic Progenitors
Ferrari, G., Cusella, G., Angelis, D., Coletta, M., Paolucci, E., Stornaiuolo, A., Cossu, G., & Mavilio, F. (1998) · Science · doi:10.1126/science.279.5356.1528 · Cited by 2,721 · see citing works
Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell
Krause, D. S., Theise, N. D., Collector, M. I., Henegariu, O., Hwang, S., Gardner, R. L., Neutzel, S., & Sharkis, S. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00328-2 · Cited by 2,661 · see citing works
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
Lagasse, E., Connors, H., Al-Dhalimy, M., Reitsma, M., Dohse, M., Osborne, L., Wang, X., Finegold, M., Weissman, I. L., & Grompe, M. (2000) · Nature Medicine · doi:10.1038/81326 · Cited by 2,314 · see citing works
Doetschman, T., Eistetter, H. R., Katz, M., Schmidt, W., & Kemler, R. (1985) · Development · doi:10.1242/dev.87.1.27 · Cited by 1,962 · see citing works
Turning Blood into Brain: Cells Bearing Neuronal Antigens Generated in Vivo from Bone Marrow
Mezey, É., Chandross, K. J., Harta, G., Maki, R. A., & McKercher, S. R. (2000) · Science · doi:10.1126/science.290.5497.1779 · Cited by 1,822 · see citing works
From Marrow to Brain: Expression of Neuronal Phenotypes in Adult Mice
Brazelton, T. R., Rossi, F. M. V., Keshet, G. I., & Blau, H. M. (2000) · Science · doi:10.1126/science.290.5497.1775 · Cited by 1,676 · see citing works
Genetic variants and strains of the laboratory mouse
(1990) · Choice Reviews Online · doi:10.5860/choice.28-1324 · Cited by 1,492 · see citing works
Turning Brain into Blood: A Hematopoietic Fate Adopted by Adult Neural Stem Cells in Vivo
Bjornson, C. R. R., Rietze, R. L., Reynolds, B. A., Magli, M. C., & Vescovi, A. L. (1999) · Science · doi:10.1126/science.283.5401.534 · Cited by 1,412 · see citing works
Embryonic Stem Cells Express Neuronal Properties in Vitro
Bain, G., Kitchens, D. L., Yao, M., Huettner, J. E., & Gottlieb, D. I. (1995) · Developmental Biology · doi:10.1006/dbio.1995.1085 · Cited by 1,168 · see citing works
Generalized Potential of Adult Neural Stem Cells
Clarke, D. L., Johansson, C. B., Wilbertz, J. H., Veress, B., Nilsson, E. D., Karlström, H., Lendahl, U., & Frisén, J. (2000) · Science · doi:10.1126/science.288.5471.1660 · Cited by 1,057 · see citing works
The Evolving Concept of a Stem Cell
Blau, H. M., Brazelton, T. R., & Weimann, J. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00409-3 · Cited by 1,044 · see citing works
Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells
Tada, M., Takahama, Y., Abe, K., Nakatsuji, N., & Tada, T. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00459-6 · Cited by 891 · see citing works
Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells
Yeom, Y. I., Fuhrmann, G., Ovitt, C. E., Brehm, A., Ohbo, K., Groß, M., Hübner, K., & Schöler, H. R. (1996) · Development · doi:10.1242/dev.122.3.881 · Cited by 864 · see citing works
Embryonic stem cells alone are able to support fetal development in the mouse
Nagy, A., Gócza, E., Díaz-Bautista, E., Prideaux, V. R., Iványi, E., Markkula, M., & Rossant, J. (1990) · Development · doi:10.1242/dev.110.3.815 · Cited by 781 · see citing works
Genetic variants and strains of the Laboratory mouse
(1996) · doi:10.1093/oso/9780198548690.001.0001 · Cited by 504 · see citing works
Skeletal myogenic potential of human and mouse neural stem cells
Galli, R., Borello, U., Gritti, A., Minasi, M. G., Bjornson, C. R. R., Coletta, M., Mora, M., Angelis, M. G. C. D., Fiocco, R., Cossu, G., et al. (2000) · Nature Neuroscience · doi:10.1038/79924 · Cited by 483 · see citing works
Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.
Mountford, P. S., Zevnik, B., Düwel, A., Nichols, J., Li, M., Dani, C., Robertson, M., Chambers, I., & Smith, A. G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.10.4303 · Cited by 312 · see citing works
Self-citationCulture and differentiation of embryonic stem cells
Smith, A. G. (1991) · Methods in Cell Science · doi:10.1007/bf01666137 · Cited by 265 · see citing works
Self-citationHybridization of Somatic Cells
Ephrussi, B. (2015) · Princeton University Press eBooks · doi:10.1515/9781400868223 · Cited by 255 · see citing works
Marshak, D. R., Gardner, R. L., & Gottlieb, D. J. (2001) · Medical Entomology and Zoology · Cited by 218 · see citing works
Internal ribosome entry sites and dicistronic RNAs in mammalian transgenesis
Mountford, P. S., & Smith, A. G. (1995) · Trends in Genetics · doi:10.1016/s0168-9525(00)89040-x · Cited by 171 · see citing works
Self-citationLupton, S. D., Brunton, L. L., Kalberg, V. A., & Overell, R. W. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.6.3374-3378.1991 · Cited by 164 · see citing works
Multi-lineage ‘stem’ cells in the mammalian embryo
Gardner, R. L., & Beddington, R. S. P. (1988) · Journal of Cell Science · doi:10.1242/jcs.1988.supplement_10.2 · Cited by 153 · see citing works
“Hybrid” Type Cells in Combined Cultures of Two Different Mammalian Cell Strains
Barski, G., Sorieul, S., & Cornefert, F. (1961) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/26.5.1269 · Cited by 138 · see citing works
Pratt, T., Sharp, L., Nichols, J., Price, D. J., & Mason, J. O. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9935 · Cited by 121 · see citing works
Self-citationLupton, S. D., Brunton, L. L., Kalberg, V. A., & Overell, R. W. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.6.3374 · Cited by 111 · see citing works
Karyological Demonstration of Hybridization of Mammalian Cells in vitro
Sorieul, S., & Ephrussi, B. (1961) · Nature · doi:10.1038/190653b0 · Cited by 70 · see citing works
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RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow
Jiang, Y., Jahagirdar, B., Reinhardt, R. L., Schwartz, R. E., Keene, C. D., Ortiz-Gonzalez, X. R., Reyes, M., Lenvik, T. R., Lund, T. C., Blackstad, M., et al. (2002) · Nature · doi:10.1038/nature00870 · Cited by 5,523 · see citing works
RetractedSHED: Stem cells from human exfoliated deciduous teeth
Miura, M., Gronthos, S., Zhao, M., Lu, B., Fisher, L. W., Robey, P. G., & Shi, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0937635100 · Cited by 3,007 · see citing works
Ying, Q.-L., Nichols, J., Chambers, I., & Smith, A. G. (2003) · Cell · doi:10.1016/s0092-8674(03)00847-x · Cited by 2,114 · see citing works
Self-citationChromatin modification and epigenetic reprogramming in mammalian development
Li, E. (2002) · Nature Reviews Genetics · doi:10.1038/nrg887 · Cited by 1,900 · see citing works
Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium
Balsam, L. B., Wagers, A. J., Christensen, J. L., Kofidis, T., Weissman, I. L., & Robbins, R. C. (2004) · Nature · doi:10.1038/nature02460 · Cited by 1,737 · see citing works
Directed differentiation of embryonic stem cells into motor neurons.
Wichterle, H., Lieberam, I., Porter, J. A., & Jessell, T. (2002) · Cell · doi:10.1016/s0092-8674(02)00835-8 · Cited by 1,792 · see citing works
"Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells
Ramalho‐Santos, M., Yoon, S., Matsuzaki, Y., Mulligan, R. C., & Melton, D. A. (2002) · Science · doi:10.1126/science.1072530 · Cited by 1,711 · see citing works
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
Álvarez‐Dolado, M., Pardal, R., García‐Verdugo, J. M., Fike, J. R., Lee, H. O., Pfeffer, K., Lois, C., Morrison, S. J., & Álvarez-Buylla, A. (2003) · Nature · doi:10.1038/nature02069 · Cited by 1,617 · see citing works
Cell fusion is the principal source of bone-marrow-derived hepatocytes
Wang, X., Willenbring, H., Akkari, Y. M. N., Torimaru, Y., Foster, M., Al-Dhalimy, M., Lagasse, E., Finegold, M. J., Olson, S. B., & Grompe, M. (2003) · Nature · doi:10.1038/nature01531 · Cited by 1,569 · see citing works
Mangi, A. A., Noiseux, N., Kong, D., He, H., Rezvani, M., Ingwall, J. S., & Dzau, V. J. (2003) · Nature Medicine · doi:10.1038/nm912 · Cited by 1,510 · see citing works
Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture
Ying, Q.-L., Stavridis, M., Griffiths, D., Li, M., & Smith, A. (2003) · Nature Biotechnology · doi:10.1038/nbt780 · Cited by 1,504 · see citing works
Self-citationLittle Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells
Wagers, A. J., Sherwood, R. I., Christensen, J. L., & Weissman, I. L. (2002) · Science · doi:10.1126/science.1074807 · Cited by 1,460 · see citing works
Ortiz, L. A., Gambelli, F., McBride, C., Gaupp, D., Baddoo, M., Kaminski, N., & Phinney, D. G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432929100 · Cited by 1,448 · see citing works
Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming
Jaenisch, R., & Young, R. A. (2008) · Cell · doi:10.1016/j.cell.2008.01.015 · Cited by 1,408 · see citing works
Transplanted bone marrow regenerates liver by cell fusion
Vassilopoulos, G., Wang, P.-R., & Russell, D. W. (2003) · Nature · doi:10.1038/nature01539 · Cited by 1,282 · see citing works
Plasticity of Adult Stem Cells
Wagers, A. J., & Weissman, I. L. (2004) · Cell · doi:10.1016/s0092-8674(04)00208-9 · Cited by 1,248 · see citing works
Neural Tissue Engineering: Strategies for Repair and Regeneration
Schmidt, C. E., & Leach, J. B. (2003) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.5.011303.120731 · Cited by 1,236 · see citing works
Autologous mesenchymal stem cell transplantation in stroke patients
Bang, O. Y., Lee, J. S., Lee, P. H., & Lee, G. (2005) · Annals of Neurology · doi:10.1002/ana.20501 · Cited by 1,101 · see citing works
Retinal repair by transplantation of photoreceptor precursors
MacLaren, R. E., Pearson, R. A., MacNeil, A., Douglas, R. H., Salt, T. E., Akimoto, M., Swaroop, A., Sowden, J. C., & Ali, R. R. (2006) · Nature · doi:10.1038/nature05161 · Cited by 1,099 · see citing works
Nygren, J., Jovinge, S. V., Breitbach, M., Säwén, P., Roell, W., Hescheler, J., Taneera, J., Fleischmann, B. K., & Jacobsen, S. E. W. (2004) · Nature Medicine · doi:10.1038/nm1040 · Cited by 1,036 · see citing works
Biology of Hematopoietic Stem Cells and Progenitors: Implications for Clinical Application
Kondo, M., Wagers, A. J., Manz, M. G., Prohaska, S. S., Scherer, D. C., Beilhack, G. F., Shizuru, J. A., & Weissman, I. L. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141007 · Cited by 992 · see citing works
Characterization and Enrichment of Cardiomyocytes Derived From Human Embryonic Stem Cells
Xu, C., Police, S., Rao, N., & Carpenter, M. K. (2002) · Circulation Research · doi:10.1161/01.res.0000035254.80718.91 · Cited by 902 · see citing works
Plasticity of marrow-derived stem cells
Herzog, E. L., Chai, L., & Krause, D. S. (2003) · Blood · doi:10.1182/blood-2003-05-1664 · Cited by 841 · see citing works
Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition
Silva, J., Barrandon, O., Nichols, J., Kawaguchi, J., Theunissen, T. W., & Smith, A. G. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060253 · Cited by 810 · see citing works
Self-citationLaBarge, M. A., & Blau, H. M. (2002) · Cell · doi:10.1016/s0092-8674(02)01078-4 · Cited by 798 · see citing works
Adult Stem Cells for Tissue Repair — A New Therapeutic Concept?
Korbling, M. J., & Estrov, Z. E. (2003) · New England Journal of Medicine · doi:10.1056/nejmra022361 · Cited by 798 · see citing works
Ianus, A., Holz, G. G., Theise, N. D., & Hussain, M. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16502 · Cited by 773 · see citing works
Klf4 reverts developmentally programmed restriction of ground state pluripotency
Guo, G., Yang, J. P., Nichols, J., Hall, J., Eyres, I., Mansfield, W. M., & Smith, A. G. (2009) · Development · doi:10.1242/dev.030957 · Cited by 767 · see citing works
Self-citationDifferentiation of Pluripotent Embryonic Stem Cells Into Cardiomyocytes
Boheler, K. R., Czyż, J., Tweedie, D., Yang, H., Anisimov, S. V., & Wobus, A. M. (2002) · Circulation Research · doi:10.1161/01.res.0000027865.61704.32 · Cited by 737 · see citing works
Kretzschmar, K., & Watt, F. M. (2012) · Cell · doi:10.1016/j.cell.2012.01.002 · Cited by 719 · see citing works
Kucia, M., Reca, R., Campbell, F. R., Zuba‐Surma, E. K., Majka, M., Ratajczak, J., & Ratajczak, M. Z. (2006) · Leukemia · doi:10.1038/sj.leu.2404171 · Cited by 698 · see citing works
D’Ippolito, G., Diabira, S., Howard, G. A., Meneï, P., Roos, B. A., & Schiller, P. C. (2004) · Journal of Cell Science · doi:10.1242/jcs.01103 · Cited by 665 · see citing works
Regulatory networks in embryo-derived pluripotent stem cells
Boiani, M., & Schöler, H. R. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1744 · Cited by 660 · see citing works
Senescence impairs successful reprogramming to pluripotent stem cells
Banito, A., Rashid, S. T., Acosta, J. C., Li, S., Pereira, C. F., Geti, I., Pinho, S., Silva, J. C., Azuara, V., Walsh, M., et al. (2009) · Genes & Development · doi:10.1101/gad.1811609 · Cited by 642 · see citing works
Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane
Bari, C. D., Dell’Accio, F., Vandenabeele, F., Vermeesch, J. R., Raymackers, J., & Luyten, F. P. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200212064 · Cited by 642 · see citing works
Stem cell origin of cancer and differentiation therapy
Sell, S. (2004) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2004.04.007 · Cited by 638 · see citing works
Sato, Y., Araki, H., Kato, J., Nakamura, K., Kawano, Y., Kobune, M., Sato, T., Miyanishi, K., Takayama, T., Takahashi, M., et al. (2005) · Blood · doi:10.1182/blood-2005-02-0572 · Cited by 610 · see citing works
The origin of the cancer stem cell: current controversies and new insights
Bjerkvig, R., Tysnes, B. B., Aboody, K. S., Najbauer, J., & Terzis, A. J. A. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1740 · Cited by 595 · see citing works
Myogenic Regulatory Factors and the Specification of Muscle Progenitors in Vertebrate Embryos
Pownall, M. E., Gustafsson, M. K., & Emerson, C. P. (2002) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.18.012502.105758 · Cited by 578 · see citing works
Transplanted bone marrow generates new neurons in human brains
Mezey, É., Key, S., Vogelsang, G. B., Szalayova, I., Lange, G. D., & Crain, B. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0336479100 · Cited by 567 · see citing works
Roh, J. D., Sawh-Martinez, R., Brennan, M. P., Jay, S. M., Devine, L., Rao, D. A., Yi, T., Mirensky, T. L., Nalbandian, A., Udelsman, B., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911465107 · Cited by 559 · see citing works
Hematopoietic stem cells convert into liver cells within days without fusion
Jang, Y.-Y., Collector, M. I., Baylin, S. B., Diehl, A. M., & Sharkis, S. J. (2004) · Nature Cell Biology · doi:10.1038/ncb1132 · Cited by 554 · see citing works
Badorff, C., Brandes, R. P., Popp, R., Rupp, S., Urbich, C., Aicher, A., Fleming, I., Busse, R., Zeiher, A. M., & Dimmeler, S. (2003) · Circulation · doi:10.1161/01.cir.0000051460.85800.bb · Cited by 531 · see citing works
Nagaya, N., Fujii, T., Iwase, T., Ohgushi, H., Itoh, T., Uematsu, M., Yamagishi, M., Mori, H., Kangawa, K., & Kitamura, S. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01071.2003 · Cited by 519 · see citing works
Chd1 regulates open chromatin and pluripotency of embryonic stem cells
Gaspar‐Maia, A., Alajem, A., Polesso, F., Sridharan, R., Mason, M. J., Heidersbach, A. J., Ramalho‐Santos, J., McManus, M. T., Plath, K., Meshorer, E., et al. (2009) · Nature · doi:10.1038/nature08212 · Cited by 509 · see citing works
Spees, J. L., Olson, S. D., Ylöstalo, J., Lynch, P. J., Smith, J. R., Perry, A. S., Peister, A., Wang, M. Y., & Prockop, D. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437997100 · Cited by 510 · see citing works
Myocyte Death, Growth, and Regeneration in Cardiac Hypertrophy and Failure
Nadal‐Ginard, B., Kajstura, J., Leri, A., & Anversa, P. (2003) · Circulation Research · doi:10.1161/01.res.0000053618.86362.df · Cited by 501 · see citing works
Direct Conversion of Fibroblasts into Stably Expandable Neural Stem Cells
Thier, M. C., Wörsdörfer, P., Lakes, Y. B., Gorris, R., Herms, S., Opitz, T., Seiferling, D., Quandel, T., Hoffmann, P., Nöthen, M. M., et al. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.03.003 · Cited by 485 · see citing works
Xue, T., Cho, H. C., Akar, F. G., Tsang, S.-Y., Jones, S. P., Marbán, E., Tomaselli, G. F., & Li, R. A. (2005) · Circulation · doi:10.1161/01.cir.0000151313.18547.a2 · Cited by 480 · see citing works
Stem cell differentiation requires a paracrine pathway in the heart
Behfar, A., Zingman, L. V., Hodgson, D. M., Rauzier, J., Kane, G. C., Terzic, A., & Pucéat, M. (2002) · The FASEB Journal · doi:10.1096/fj.02-0072com · Cited by 477 · see citing works
Cardiomyocyte Cell Cycle Regulation
Pasumarthi, K. B. S., & Field, L. J. (2002) · Circulation Research · doi:10.1161/01.res.0000020201.44772.67 · Cited by 469 · see citing works
A human peripheral blood monocyte-derived subset acts as pluripotent stem cells
Zhao, Y. L., Glesne, D. A., & Huberman, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0536882100 · Cited by 458 · see citing works
Pluripotent stem cells from the adult mouse inner ear
Li, H., Liu, H., & Heller, S. (2003) · Nature Medicine · doi:10.1038/nm925 · Cited by 463 · see citing works
The post‐natal heart contains a myocardial stem cell population
Hierlihy, A. M., Seale, P., Lobe, C. G., Rudnicki, M. A., & Megeney, L. A. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03477-4 · Cited by 452 · see citing works
Cardiac Stem Cells and Mechanisms of Myocardial Regeneration
Leri, A., Kajstura, J., & Anversa, P. (2005) · Physiological Reviews · doi:10.1152/physrev.00013.2005 · Cited by 445 · see citing works
Mesenchymal stem cells: isolation, in vitro expansion and characterization.
Nardi, N., & Meirelles, L. D. S. (2006) · Handbook of experimental pharmacology · doi:10.1007/3-540-31265-x_11 · Cited by 274 · see citing works
Tepper, O. M., Capla, J. M., Galiano, R. D., Ceradini, D. J., Callaghan, M. J., Kleinman, M. E., & Gurtner, G. C. (2004) · Blood · doi:10.1182/blood-2004-03-1051 · Cited by 446 · see citing works
Ji, J. F., He, B. P., Dheen, S. T., & Tay, S. S. W. (2004) · Stem Cells · doi:10.1634/stemcells.22-3-415 · Cited by 443 · see citing works
Side effects of retroviral gene transfer into hematopoietic stem cells
Baum, C., Düllmann, J., Li, Z., Fehse, B., Meyer, J., Williams, D. A., & Kalle, C. V. (2003) · Blood · doi:10.1182/blood-2002-07-2314 · Cited by 431 · see citing works
Contribution of transplanted bone marrow cells to Purkinje neurons in human adult brains
Weimann, J. M., Charlton, C. A., Brazelton, T. R., Hackman, R. C., & Blau, H. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337659100 · Cited by 429 · see citing works
Isolation and characterization of multipotent human periodontal ligament stem cells
Gay, I., Chen, S., & MacDougall, M. J. (2007) · Orthodontics and Craniofacial Research · doi:10.1111/j.1601-6343.2007.00399.x · Cited by 420 · see citing works
One strategy for cell and gene therapy: Harnessing the power of adult stem cells to repair tissues
Prockop, D. J., Gregory, C. A., & Spees, J. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834138100 · Cited by 416 · see citing works
Citrullination regulates pluripotency and histone H1 binding to chromatin
Christophorou, M. A., Castelo‐Branco, G., Halley‐Stott, R. P., Oliveira, C. S., Loos, R., Radzisheuskaya, A., Mowen, K. A., Bertone, P., Silva, J., Zernicka‐Goetz, M., et al. (2014) · Nature · doi:10.1038/nature12942 · Cited by 409 · see citing works
Ridder, K., Keller, S., Dams, M., Rupp, A.-K., Schlaudraff, J., Del Turco, D., Starmann, J., Macas, J., Karpova, D., Devraj, K., et al. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001874 · Cited by 412 · see citing works
Lin, F., Cordes, K. R., Li, L., Hood, L., Couser, W. G., Shankland, S. J., & Igarashi, P. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000061595.28546.a0 · Cited by 409 · see citing works
Lack of a Fusion Requirement for Development of Bone Marrow-Derived Epithelia
Harris, R. G., Herzog, E. L., Bruscia, E. M., Grove, J. E., Arnam, J. S. V., & Krause, D. S. (2004) · Science · doi:10.1126/science.1098925 · Cited by 407 · see citing works
Transdifferentiation potential of human mesenchymal stem cells derived from bone marrow
Song, L., & Tuan, R. S. (2004) · The FASEB Journal · doi:10.1096/fj.03-1100fje · Cited by 395 · see citing works
A genome-wide RNAi screen identifies a new transcriptional module required for self-renewalPreprint
Hu, G., Kim, J., Xu, Q., Leng, Y., Orkin, S. H., & Elledge, S. J. (2009) · Genes & Development · doi:10.1101/gad.1769609 · Cited by 393 · see citing works
Damaged epithelia regenerated by bone marrow–derived cells in the human gastrointestinal tract
Okamoto, R., Yajima, T., Yamazaki, M., Kanai∥, T., Mukai, M., Okamoto, S., Ikeda, Y., Hibi∥, T., Inazawa, J., & Watanabe, M. (2002) · Nature Medicine · doi:10.1038/nm755 · Cited by 382 · see citing works
Gliosis and brain remodeling after treatment of stroke in rats with marrow stromal cells
Li, Y., Chen, J., Zhang, C. L., Wang, L., Lu, D., Katakowski, M., Gao, Q., Shen, L., Zhang, J., Lü, M., et al. (2004) · Glia · doi:10.1002/glia.20126 · Cited by 381 · see citing works
BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury
Lu, P., JONES, L., & Tuszynski, M. H. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.09.018 · Cited by 375 · see citing works
The NuRD component Mbd3 is required for pluripotency of embryonic stem cells
Kaji, K., Caballero, I. M., MacLeod, R., Nichols, J., Wilson, V. A., & Hendrich, B. (2006) · Nature Cell Biology · doi:10.1038/ncb1372 · Cited by 375 · see citing works
Self-citationMikkola, H. K. A., Klintman, J., Yang, H., Hock, H., Schlaeger, T. M., Fujiwara, Y., & Orkin, S. H. (2003) · Nature · doi:10.1038/nature01345 · Cited by 371 · see citing works
Galli, R., Gritti, A., Bonfanti, L., & Vescovi, A. L. (2003) · Circulation Research · doi:10.1161/01.res.0000065580.02404.f4 · Cited by 370 · see citing works
Akashi, K., He, X., Chen, J., Iwasaki, H., Niu, C. S., Steenhard, B. M., Zhang, J., Haug, J., & Li, L. (2002) · Blood · doi:10.1182/blood-2002-06-1780 · Cited by 368 · see citing works
Plasticity of Bone Marrow–Derived Stem Cells
Grove, J. E., Bruscia, E. M., & Krause, D. S. (2004) · Stem Cells · doi:10.1634/stemcells.22-4-487 · Cited by 368 · see citing works
Neuhuber, B., Gallo, G., Howard, L., Kostura, L., Mackay, A. M., & Fischer, I. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20147 · Cited by 365 · see citing works
Wutz, A. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3035 · Cited by 361 · see citing works
Kang, S. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00089-x · Cited by 362 · see citing works
Tissue engineering: current state and perspectives
Lavik, E., & Langer, R. (2004) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-004-1580-z · Cited by 359 · see citing works
Cell fusion-independent differentiation of neural stem cells to the endothelial lineage
Wurmser, A. E., Nakashima, K., Summers, R. G., Toni, N., D’Amour, K. A., Lie, D. C., & Gage, F. H. (2004) · Nature · doi:10.1038/nature02604 · Cited by 358 · see citing works
Islet Regeneration During the Reversal of Autoimmune Diabetes in NOD Mice
Kodama, S., Kühtreiber, W. M., Fujimura, S., Dale, E. A., & Faustman, D. L. (2003) · Science · doi:10.1126/science.1088949 · Cited by 356 · see citing works
A Heterogeneous Expression Pattern for Nanog in Embryonic Stem Cells
Singh, A. M., Hamazaki, T., Hankowski, K. E., & Terada, N. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0126 · Cited by 353 · see citing works
Nanog promotes transfer of pluripotency after cell fusion
Silva, J., Chambers, I., Pollard, S. M., & Smith, A. G. (2006) · Nature · doi:10.1038/nature04914 · Cited by 351 · see citing works
Self-citationNeuroectodermal differentiation from mouse multipotent adult progenitor cells
Jiang, Y., Henderson, D., Blackstad, M., Chen, A., Miller, R. F., & Verfaillie, C. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834196100 · Cited by 349 · see citing works
Adult stem cells: assessing the case for pluripotency
Verfaillie, C. M. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02386-3 · Cited by 344 · see citing works
Biological implications of cell fusion
Ogle, B. M., Cascalho, M., & Platt, J. L. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1678 · Cited by 343 · see citing works
Kurozumi, K., Nakamura, K., Tamiya, T., Kawano, Y., Kobune, M., Hirai, S., Uchida, H., Sasaki, K., Ito, Y., Kato, K., et al. (2003) · Molecular Therapy · doi:10.1016/j.ymthe.2003.10.012 · Cited by 340 · see citing works
Shizuru, J. A., Negrin, R. S., & Weissman, I. L. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.54.101601.152334 · Cited by 337 · see citing works
A chemical approach to stem-cell biology and regenerative medicine
Xu, Y., Shi, Y., & Ding, S. (2008) · Nature · doi:10.1038/nature07042 · Cited by 335 · see citing works
Stem Cells for Myocardial Regeneration
Orlic, D., Hill, J. M., & Arai, A. E. (2002) · Circulation Research · doi:10.1161/01.res.0000046045.00846.b0 · Cited by 335 · see citing works
Stem cells in the skin: waste not, Wnt notPreprint
Alonso, L. C., & Fuchs, E. V. (2003) · Genes & Development · doi:10.1101/gad.1086903 · Cited by 336 · see citing works
Feldman, A. L., Arber, D. A., Pittaluga, S., Martı́nez, A., Burke, J. S., Raffeld, M. A., Camós, M., Warnke, R. A., & Jaffe, E. S. (2008) · Blood · doi:10.1182/blood-2007-11-124792 · Cited by 333 · see citing works
Cryopreservation of Human Stem Cells for Clinical Application: A Review
Hunt, C. J. (2011) · Transfusion Medicine and Hemotherapy · doi:10.1159/000326623 · Cited by 331 · see citing works
Defined Conditions for Neural Commitment and Differentiation
Ying, Q., & Smith, A. G. (2003) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(03)65023-8 · Cited by 328 · see citing works
Self-citationRatajczak, M. Z., Kucia, M., Reca, R., Majka, M., Janowska‐Wieczorek, A., & Ratajczak, J. (2003) · Leukemia · doi:10.1038/sj.leu.2403184 · Cited by 330 · see citing works
Deng, J. V., Petersen, B. E., Steindler, D. A., Jorgensen, M., & Laywell, E. D. (2005) · Stem Cells · doi:10.1634/stemcells.2005-0370 · Cited by 328 · see citing works
Updates on stem cells and their applications in regenerative medicine
Bajada, S., Mazakova, I., Richardson, J. B., & Ashammakhi, N. A. (2008) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.83 · Cited by 326 · see citing works
Therapeutic angiogenesis in cardiovascular disease
Simons, M., & Ware, J. A. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1226 · Cited by 325 · see citing works
Nuclear Transplantation, Embryonic Stem Cells, and the Potential for Cell Therapy
Hochedlinger, K., & Jaenisch, R. (2003) · New England Journal of Medicine · doi:10.1056/nejmra035397 · Cited by 322 · see citing works
- Authors
- Ying, Q.-L., Nichols, J., Evans, E. P., & Smith, A. G.
- Affiliations
- University of Edinburgh (GB)
- University of Oxford (GB)
- Corresponding author
- Smith, Austin G.
- Venue
- Nature
- Published
- 2002-03-13
- Volume
- 416
- Issue
- 6880
- Pages
- 545-548
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2109794889
- Cited by
- 1,494
- References
- 30
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 10 · 2021: 9 · 2020: 12 · 2019: 8 · 2018: 7 · 2017: 26 · 2016: 11 · 2015: 23 · 2014: 34 · 2013: 36 · 2012: 62
- FWCI
- 79.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- ERA (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- transdetermination, cell fusion, stem cell potency, epigenetic reprogramming, tetraploid hybrids, embryonic stem cells, pluripotency, chimerism
- MeSH terms
- Animals, Anti-Bacterial Agents, Antigens, Differentiation, Blastocyst, Brain, Cell Differentiation, Cell Fusion, Cell Line, Cells, Cultured, Chimera, Cinnamates, Drug Resistance, Embryo, Mammalian, Female, Embryonic and Fetal Development, Hybrid Cells, Hygromycin B, Male, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Stem Cells, Coculture Techniques, Mice
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