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Cited by 54

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Richter's and prolymphocytic transformation of chronic lymphocytic leukemia are associated with high mRNA expression of activation-induced cytidine deaminase and aberrant somatic hypermutation

Reiniger, L, Bödör, C, Bognár, Á, Balogh, Z, Csomor, J, Szepesi, Á, Kopper, L, Matolcsy, A·2006·Leukemia
DOI 10.1038/sj.leu.2404183
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Abstract

Chronic lymphocytic leukemia (CLL) is an indolent B-cell non-Hodgkin's lymphoma that may transform into higher-grade lymphoma. The transformation involves an increased number of prolymphocytic cells, termed prolymphocytic transformation (PLT) or the development of diffuse large B-cell lymphoma (DLBL), also referred to as Richter's transformation (RT). To analyze whether activation-induced cytidine deaminase (AID), which is essential for somatic hypermutation (SHM) of normal B-cells, and malfunction of SHM termed aberrant somatic hypermutation (ASHM) are associated with higher-grade transformation of CLL, AID mRNA expression and the mutation pattern of c-MYC, PAX-5 and RhoH genes were analyzed in eight cases of CLL without transformation and in 21 cases that showed RT or PLT. Chronic lymphocytic leukemia cases, which showed no transformation or eventually transformed into higher-grade lymphoma, showed low levels of AID mRNA expression and low frequency of mutations of c-MYC, PAX-5 and RhoH genes. In both RT and PLT, high-levels of AID mRNA expression and high-frequency mutations of c-MYC, PAX-5 and RhoH genes were detected. These results indicate that AID expression and ASHM are associated with higher-grade transformation of CLL and provide further evidences that AID expression and ASHM may be activated during the clonal history of B-cell lymphomas.

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Crossref · 10.1038/sj.leu.2404183

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27 of 27 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 1

  1. Foucar K, Rydell RE . Richter's syndrome in chronic lymphocytic leukemia. Cancer 1980; 46: 118–134. · doi:10.1002/1097-0142(19800701)46:1<118::aid-cncr2820460120>3.0.co;2-j

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Metadata

Authors
Reiniger, L., Bödör, C., Bognár, Á., Balogh, Z., Csomor, J., Szepesi, Á., Kopper, L., & Matolcsy, A.
Venue
Leukemia
Publisher
Springer Science and Business Media LLC
Published
2006-03-16
Volume
20
Issue
6
Pages
1089-1095
ISSN
  • 0887-6924
  • 1476-5551
DOI
10.1038/sj.leu.2404183
Cited by
54
References
27
Language
en
Licence

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