Substance P receptor antagonist and clomipramine prevent stress-induced alterations in cerebral metabolites, cytogenesis in the dentate gyrus and hippocampal volume

Estimation of metabolite concentrations from localized in vivo proton NMR spectra

Provencher, S. W. (1993) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910300604 · Cited by 3,659

Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus

Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111

Causal Relationship Between Stressful Life Events and the Onset of Major Depression

Kendler, K. S., Karkowski, L. M., & Prescott, C. A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.6.837 · Cited by 2,566

A molecular and cellular theory of depression

Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129

STRESS AND HIPPOCAMPAL PLASTICITY

McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087

Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders

Sapolsky, R. M. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.925 · Cited by 2,016

Hippocampal atrophy in recurrent major depression

Sheline, Y. I., Wang, P. W., Gado, M. H., Csernansky, J. G., & Vannier, M. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.3908 · Cited by 1,932

Hippocampal Volume Reduction in Major Depression

Bremner, J. D., Narayan, M., Anderson, E. R., Staib, L. H., Miller, H. L., & Charney, D. S. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.115 · Cited by 1,670

Neurogenesis in the Dentate Gyrus of the Adult Tree Shrew Is Regulated by Psychosocial Stress and NMDA Receptor Activation

Gould, E., McEwen, B. S., Tanapat, P., Galea, L. A. M., & Fuchs, E. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02492.1997 · Cited by 1,496

The cellular neurobiology of depression

Manji, H. K., Drevets, W. C., & Charney, D. S. (2001) · Nature Medicine · doi:10.1038/87865 · Cited by 1,182

Risk and Resilience in an Acute Stress Paradigm: Evidence From Salivary Cortisol and Time-Frequency Analysis of the Reward Positivity

Ethridge, P., Ali, N., Racine, S. E., Pruessner, J. C., & Weinberg, A. (2020) · Clinical Psychological Science · doi:10.1177/2167702620917463 · Cited by 32

NK1receptor antagonists under investigation for the treatment of affective disorders

Czéh, B., Fuchs, E., & Simon, M. (2006) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.15.5.479 · Cited by 31

Treatment-Specific Hippocampal Subfield Volume Changes With Antidepressant Medication or Cognitive-Behavior Therapy in Treatment-Naive Depression

Tai, H.-H., Cha, J., Vedaei, F., Dunlop, B. W., Craighead, W. E., Mayberg, H. S., & Choi, K. S. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.718539 · Cited by 30

Chronic psychosocial stress in tree shrews: effect of the substance P (NK1 receptor) antagonist L-760735 and clomipramine on endocrine and behavioral parameters

van der Hart, M. G. C., de Biurrun, G., Czéh, B., Rupniak, N. M. J., den Boer, J. A., & Fuchs, E. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2260-0 · Cited by 30

Aggressive behavior: Implications of dominance and subordination for the study of mental disorders

Arregi, A., Azpiroz, A., Fano, E., & Garmendia, L. (2006) · Aggression and Violent Behavior · doi:10.1016/j.avb.2006.01.005 · Cited by 30

Unpredictable chronic mild stress in mice

Surget, A., & Belzung, C. (2008) · ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) · Cited by 26

Neurogenesis and Neuroenhancement in the Pathophysiology and Treatment of Bipolar Disorder

Schloesser, R. J., Chen, G., & Manji, H. K. (2006) · International review of neurobiology · doi:10.1016/s0074-7742(06)77005-2 · Cited by 23

Altered Glial Plasticity in Animal Models for Mood Disorders

Czéh, B., Fuchs, E., & Flügge, G. (2013) · Current Drug Targets · doi:10.2174/1389450111314110005 · Cited by 23

Metabolic changes in 37 newly diagnosed Wilson's disease patients assessed by magnetic resonance spectroscopy

Tarnacka, B., Szeszkowski, W., Gołębiowski, M., & Członkowska, A. (2009) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2009.02.007 · Cited by 21

SONU20176289, a compound combining partial dopamine D2 receptor agonism with specific serotonin reuptake inhibitor activity, affects neuroplasticity in an animal model for depression

Michael-Titus, A. T., Albert, M., Michael, G. J., Michaelis, T., Watanabe, T., Frahm, J., Pudovkina, O. L., van der Hart, M. G. C., Hesselink, M. B., Fuchs, E., et al. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.09.006 · Cited by 19

Creatine transporter knockout mice (Slc6a8) show increases in serotonin-related proteins and are resilient to learned helplessness

Abdulla, Z. I., Pennington, J. L., Gutierrez, A., & Skelton, M. R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112254 · Cited by 19

Dépression et neuroplasticité : implication des systèmes sérotoninergiques

Daszuta, A., Banasr, M., Soumier, A., Héry, M., & Mocaër, E. (2005) · Therapies · doi:10.2515/therapie:2005066 · Cited by 19

Topical formulations of Aprepitant are safe and effective in relieving pain and inflammation, and drive neural regeneration

Bonelli, F., Demirsoy, İ. H., Vitar, R. M. L., Fonteyne, P., & Ferrari, G. (2023) · The Ocular Surface · doi:10.1016/j.jtos.2023.09.004 · Cited by 16

Study of neurometabolic and behavioral alterations in rodent model of mild traumatic brain injury: a pilot study

Singh, K., Trivedi, R., Haridas, S., Manda, K., & Khushu, S. (2016) · NMR in Biomedicine · doi:10.1002/nbm.3627 · Cited by 16

Adult mammalian neurogenesis and motivated behaviors

Jorgensen, C. (2018) · Integrative Zoology · doi:10.1111/1749-4877.12335 · Cited by 17

Evidencia científica de los aspectos psicológicos en la fibromialgia. Posibilidades de intervención

García-Bardón, V. D. F., Castel-Bernal, B., & Fuentes, J. V. (2006) · Reumatología Clínica · doi:10.1016/s1699-258x(06)73081-9 · Cited by 15

Contrasting effects of opposite- versus same-sex housing on hormones, behavior and neurogenesis in a eusocial mammal

Peragine, D. E., Yousuf, Y., Fu, Y., Swift‐Gallant, A., Ginzberg, K., & Holmes, M. M. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.03.005 · Cited by 14

Social defeat and subsequent isolation housing affect behavior as well as cell proliferation and cell survival in the brains of male greater long-tailed hamsters

Pan, Y., Li, M., Lieberwirth, C., Wang, Z., & Zhang, Z. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.056 · Cited by 11

Changes in Hippocampal Metabolites After Effective Treatment for Fibromyalgia

Wood, P. B., Ledbetter, C. R., & Patterson, J. C. (2009) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e3181af129e · Cited by 11

Tree shrews at the German Primate Center

Fuchs, E. (2015) · Primate Biology · doi:10.5194/pb-2-111-2015 · Cited by 11

Correlation between MR-spectroscopic rat hippocampal choline levels and phospholipase A2

Sartorius, A., Schloss, P. D., Vollmayr, B., Ende, G., Neumann‐Haefelin, C., Hoehn, M., & Henn, F. A. (2006) · The World Journal of Biological Psychiatry · doi:10.1080/15622970600946446 · Cited by 10

Chronic therapy with citalopram decreases regional cerebral glucose utilization in OBX, and not sham-operated, rats: an autoradiographic study

Skelin, I., Sato, H., Kovačević, T., & Dikšić, M. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1659-4 · Cited by 8

The Impact of Ethologically Relevant Stressors on Adult Mammalian Neurogenesis

Jorgensen, C., Taylor, J. A., & Barton, T. (2019) · Brain Sciences · doi:10.3390/brainsci9070158 · Cited by 7

Proton Magnetic Resonance Spectroscopy as a Monitoring Tool for Electroconvulsive Therapy Effects on the Brain

Sartorius, A., Henn, F. A., & Ende, G. (2005) · Current Psychiatry Reviews · doi:10.2174/157340006775101445 · Cited by 7

Voxel-based NK1 Receptor Occupancy Measurements with [18F]SPA-RQ and Positron Emission Tomography: A Procedure for Assessing Errors from Image Reconstruction and Physiological Modeling

Wallius, E., Nyman, M. J., Oikonen, V., Hietala, J. A., & Ruotsalainen, U. (2007) · Molecular Imaging and Biology · doi:10.1007/s11307-007-0096-1 · Cited by 6

Dehydroepiandrosterone increases the number and dendrite maturation of doublecortin cells in the dentate gyrus of middle age male Wistar rats exposed to chronic mild stress

Herrera‐Perez, J. J., Martı́nez-Mota, L., Jiménez-Rubio, G., Ortiz-López, L. I., Cabrera-Muñoz, E. A., Galindo-Sevilla, N., Zambrano, E., Hernández‐Luis, F., Ramírez-Rodríguez, G. B., & Flores‐Ramos, M. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.01.007 · Cited by 7

Looking Beyond the Monoamine Hypothesis

den Boer, J. A. (2006) · European Neurological Review · doi:10.17925/enr.2006.00.01.1d · Cited by 5

Visualization and Quantification of Neurokinin-1 (NK1) Receptors in the Human Brain

Hietala, J. A., Nyman, M. J., Eskola, O., Laakso, A., Grönroos, T. J., Oikonen, V., Bergman, J., Haaparanta‐Solin, M., Forsback, S. J., Marjamäki, P., et al. (2005) · Molecular Imaging and Biology · doi:10.1007/s11307-005-0001-8 · Cited by 5

Depressionen: Eine Störung der Neuroplastizität?

Fuchs, E., & Flügge, G. (2005) · psychoneuro · doi:10.1055/s-2005-870081 · Cited by 5

Neurotrophic Factors in Etiology and Treatment of Mood Disorders

Duman, R. S. (2007) · Wiley eBooks · doi:10.1002/9780470101001.hcn019 · Cited by 5

New pieces for the substance P puzzle

Linnman, C. (2013) · Pain · doi:10.1016/j.pain.2013.04.020 · Cited by 4

Preclinical approaches to examine novel concepts of the pathophysiology of depressive disorders: lessons learned from tree shrews

Fuchs, E., Czéh, B., & Flügge, G. (2005) · Drug Development Research · doi:10.1002/ddr.20032 · Cited by 4

Adult neurogenesis in rodents and primates: functional implications

(2005) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(05)80038-0 · Cited by 3

Adult Neurogenesis and Social Behavior: A Reciprocal Relationship

Jorgensen, C., & Wang, Z. (2024) · Masterclass in neuroendocrinology · doi:10.1007/978-3-031-51112-7_6 · Cited by 2

Stereoselective and region-specific induction of immediate early gene expression in rat parietal cortex by blockade of neurokinin 1 receptors

Serres, F., Sartori, S. B., Halton, A., Pei, Q., Rochat, C., Singewald, N., Sharp, T., & Millan, M. J. (2006) · Journal of Psychopharmacology · doi:10.1177/0269881105059327 · Cited by 2

Depresyon ve Nöroplastisite

Mete, L. (2007) · Cited by 2

Neurotrophins and neuronal plasticity in the action of antidepressants and morphine

Sairanen, M. (2007) · Työväentutkimus Vuosikirja · Cited by 2

Neural plasticity and the promise of novel pharmacotherapies for depression. Commentary on Fuchs et al., Examining novel concepts of the pathophysiology of depression in the chronic psychosocial stress paradigm in tree shrews

Rupniak, N. M. J. (2004) · Behavioural Pharmacology · doi:10.1097/00008877-200409000-00009 · Cited by 2

Brain TrkB neurotrophin receptor as a target for antidepressant treatments

Rantamäki, T. (2006) · Työväentutkimus Vuosikirja · Cited by 2

Modulation von Peptidrezeptoren

Tracik, F. M., Lieb, K., Bauer, M., & Ströhle, A. (2005) · Springer eBooks · doi:10.1007/3-540-28049-9_38 · Cited by 1

Therapeutic Potential of Tachykinin Receptor Antagonists in Depression and Anxiety Disorders

Rupniak, N. M. J. (2004) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-18891-6_11 · Cited by 1

Depression

Nakagawa, S., & Duman, R. S. (2011) · Springer eBooks · doi:10.1007/978-4-431-53945-2_5 · Cited by 1

Serotonin Modulates the Maturation of the Medial Prefrontal Cortex and Hippocampus: Relevance to the Etiology of Emotional and Cognitive Behaviors

Rebello, T. J. (2012) · doi:10.7916/d8bv7pq3 · Cited by 1

Risk and resilience in an acute stress paradigm: Evidence from salivary cortisol and time-frequency analysis of the reward positivityPreprint

Ethridge, P., Ali, N., Racine, S. E., Pruessner, J. C., & Weinberg, A. (2020) · doi:10.31234/osf.io/2qkp5 · Cited by 1

Imaging Chronic Pain and Inflammation : Positron Emission Tomography Studies of Whiplash Associated Disorder

Linnman, C. (2008) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 1

Caractérisation pré-clinique d’un effet de type antidépresseur de la 3β methoxyprégnénolone (MAP4343), un dérivé de la pregnénolone ayant pour cible potentielle le système microtubulaire

Parésys, L. (2015) · theses.fr (ABES) · doi:10.70675/cb3a1f33z6c64z4692z91cez73d3c9db9fec

Wilson’s Disease in Brain Magnetic Resonance Spectroscopy

Tarnacka, B. (2012) · InTech eBooks · doi:10.5772/33585

Identification of Genes in the Dorsal Raphe Nucleus Regulated by Chronic Stress and Citalopram

Abumaria, N. (2006) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-3175

Neurotransmitter und Modulatoren

Hevers, W., Lüddens, H., Schloss, P. D., Keck, M. E., Landgraf, R., Rupprecht, R., & Lutz, B. (2008) · Springer eBooks · doi:10.1007/978-3-540-68748-1_10

Antidepressant Treatment and Hippocampal Neurogenesis: Monoamine and Stress Hypotheses of Depression Converge

Dranovsky, A., & Hen, R. (2007) · Wiley eBooks · doi:10.1002/9780470101001.hcn020

Localized Proton Magnetic Resonance Spectroscopy of Mouse Brain In Vivo at High Magnetic Field Strength

Tafresh, A. A. (2014) · doi:10.53846/goediss-4709

Peptide

Keck, M. E., & Landgraf, R. (2011) · Springer eBooks · doi:10.1007/978-3-642-19844-1_19

Towards changes in microRNA expression associated with increases and decreases in adult rat hippocampal neurogenesis

Chyurlia, L. (2011) · Carleton University's Institutional Repository (MacOdrum Library, Carleton University) · doi:10.22215/etd/2011-09435

Substance P receptor antagonists for major depressive disorder

Rupniak, N. M. J., & Kramer, M. S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-22194-1.00005-7

Creatine – Creatine Phosphate System in Healthy Persons and in Patients with Mental Disorders

Burbaeva, G. S., Бокша, И. С., Savushkina, O. K., Prokhorova, T. A., Терешкина, Е. Б., & Vorobyeva, E. A. (2025) · Psikhiatriya · doi:10.30629/2618-6667-2024-22-5-94-106

Etude de l'implication fonctionnelle de la neurogénèse hippocampique dans la pathophysiologie et le traitement de la dépression

Surget, A. (2008) · theses.fr (ABES) · doi:10.70675/65cd9b5fz7735z4180zb8d6z7ae3b7cbefff

Implication du BDNF dans l'étiopathogenèse et le traitement des troubles anxio-dépressifs : aspects précliniques.

Ibargüen-Vargas, Y. (2008) · theses.fr (ABES) · doi:10.70675/2d73c017z46fcz4c35z8397zb504072e069a

Chronic psychosocial stress in tree shrews: effect of the substance P (NK1 receptor) antagonist L-760735 and clomipramine on endocrine and behavioral parameters

van der Hart, M. G. C., de Biurrun, G., Czéh, B., Rupniak, N. M. J., den Boer, J. A., & Fuchs, E. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2260-0 · Cited by 30

Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine

Czéh, B., Michaelis, T., Watanabe, T., Frahm, J., de Biurrun, G., van Kampen, M., Bartolomucci, A., & Fuchs, E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211427898 · Cited by 1,114

Examining SLV-323, a novel NK1 receptor antagonist, in a chronic psychosocial stress model for depression

Czéh, B., Pudovkina, O., van der Hart, M. G. C., Simon, M., Heilbronner, U., Michaelis, T., Watanabe, T., Frahm, J., & Fuchs, E. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2184-8 · Cited by 33

Chronic administration of clomipramine prevents the increase in serotonin and noradrenaline induced by chronic stress

Adell, A., García-Marquez, C., Armario, A., & Gelp�, E. (1989) · Psychopharmacology · doi:10.1007/bf00634447 · Cited by 28

Examining novel concepts of the pathophysiology of depression in the chronic psychosocial stress paradigm in tree shrews

Fuchs, E., h, B. C., & gge, G. F. (2004) · Behavioural Pharmacology · doi:10.1097/00008877-200409000-00003 · Cited by 70