CoChat
Sign Up
Cited by 158Neuropeptides and Animal PhysiologyStress Responses and CortisolTreatment of Major Depression

The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.

Substance P receptor antagonist and clomipramine prevent stress-induced alterations in cerebral metabolites, cytogenesis in the dentate gyrus and hippocampal volume

van der Hart, M G C, Czéh, B, de Biurrun, G, Michaelis, T, Watanabe, T, Natt, O, Frahm, J, Fuchs, E·2002·Molecular Psychiatry
DOI 10.1038/sj.mp.4001130
Open this paper in CoChat — free account

Abstract

The neuropeptide substance P and its receptor, the neurokinin 1 receptor (NK(1)R) have been proposed as possible targets for new antidepressant therapies. The present study investigated the effect of the NK(1)R antagonist L-760,735 and the tricyclic antidepressant clomipramine in the chronic psychosocial stress paradigm of adult male tree shrews. Animals were subjected to a 7-day period of psychosocial stress before the onset of daily oral administration of L-760,735 (10 mg kg(-1) day(-1)) or clomipramine (50 mg kg(-1) day(-1)). The psychosocial stress continued throughout the treatment period of 28 days. Brain metabolite concentrations were determined in vivo by proton magnetic resonance spectroscopy. Cell proliferation in the dentate gyrus and hippocampal volume were measured post mortem. Stress significantly decreased in vivo concentrations of N-acetyl-aspartate (-14%), creatine and phosphocreatine (-15%) and choline-containing compounds (-15%). The proliferation rate of the granule precursor cells in the dentate gyrus was reduced (-45%), and hippocampal volume was decreased (-14%). The stress-induced changes of brain metabolites, hippocampal volume and dentate cytogenesis rate were prevented by concomitant drug administration. Elevated myo-inositol concentrations after both treatments hint to an astrocytic enhancement. These results suggest that-despite a different pharmacological profile-the NK(1)R antagonist L-760,735, a member of a novel class of antidepressant drugs, has comparable neurobiological efficacy to tricyclic antidepressants such as clomipramine.

Overview

Integrity signals

Registry

Crossref · 10.1038/sj.mp.4001130

Cites

61 of 61 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Cited by

Sorted by citations

See all 158

Related

See all

Metadata

Authors
van der Hart, M. G. C., Czéh, B., de Biurrun, G., Michaelis, T., Watanabe, T., Natt, O., Frahm, J., & Fuchs, E.
Affiliations
  • German Primate Center (DE)
  • Max Planck Society (DE)
Corresponding author
Fuchs, E
ORCID
Venue
Molecular Psychiatry
Publisher
Springer Science and Business Media LLC
Published
2002-10-01
Volume
7
Issue
9
Pages
933-941
ISSN
  • 1359-4184 (ISSN-L)
  • 1476-5578
DOI
10.1038/sj.mp.4001130
OpenAlex
W2065495488
Cited by
158
References
61
Citations by year
2025: 1 · 2024: 4 · 2023: 1 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 6 · 2015: 7 · 2014: 3 · 2013: 4 · 2012: 10
FWCI
5.35
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Molecular Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords
substance P, neurokinin-1 receptor, clomipramine, chronic psychosocial stress, antidepressants, brain metabolites, N-acetylaspartate, creatine, phosphocreatine, choline-containing compounds, myo-inositol, dentate gyrus, hippocampal volume, granule cell proliferation, astrocytes, tree shrew
MeSH terms
Animals, Antidepressive Agents, Tricyclic, Body Weight, Brain Chemistry, Cell Division, Chronic Disease, Clomipramine, Major Depressive Disorder, Disease Models, Animal, Male, Magnetic Resonance Spectroscopy, Stress, Psychological, Tupaiidae, Dentate Gyrus, Neurokinin-1 Receptor Antagonists

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review