The DOI matches its Crossref record; 28 of the 29 references it cites were found in a registry or an index.
HLA and genetic susceptibility to sleepwalking
Abstract
HLA-DQB1 typing was performed in 60 Caucasian subjects with sleepwalking (SW) disorder and their families and 60 ethnically matched subjects without any diagnosed sleep disorder. A total of 21 sleepwalkers (35.0%) were DQB1*0501 positive vs eight (13.3%) controls (P = 0.0056; odds ratio = 3.5, 95% CI = 1.4-8.7). The family data for all HLA subtypes were further assessed for allelic association with SW using the transmission-disequilibrium test. A significant excess transmission was observed for DQB1*05 and *04 alleles in familial cases, strongly suggesting that a DQB1 polymorphic amino acid might be more tightly associated than any single allele. Sequence screening revealed that Ser74 in the second exon shared by all DQB1*05 and *04 was 20 times transmitted against 4 times non-transmitted (P = 0.001) in familial cases of SW. Thus, together with narcolepsy and REM sleep behavior disorder, these findings suggest that specific DQB1 genes are implicated in disorders of motor control during sleep.
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“Indeed, stress [12,123,124], emotional/behavioral problems, and personality traits have been linked to NREM sleep parasomnias [124,125,126,127,128], although the specific pathway and direction of this association remains unclear.”
From Diagnosis and Management of NREM Sleep Parasomnias in Children and Adults (2023) · cites this paper as [123]
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Metadata
- Authors
- Lecendreux, M., Bassetti, C., Dauvilliers, Y., Mayer, G., Neidhart, E., & Tafti, M.
- Affiliations
- Hôpital Robert-Debré (FR)
- University Hospital of Bern (CH)
- University Hospital of Geneva (CH)
- Corresponding author
- Tafti, M
- Venue
- Molecular Psychiatry
- Published
- 2003-01-01
- Volume
- 8
- Issue
- 1
- Pages
- 114-117
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W1966121006
- Cited by
- 193
- References
- 29
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 5 · 2023: 8 · 2022: 20 · 2021: 9 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 10 · 2013: 11 · 2012: 6
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hôpitaux Universitaires de Genève
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- sleepwalking, HLA-DQB1, genetic susceptibility, family transmission, transmission disequilibrium test, sleep disorders, narcolepsy, REM sleep behavior disorder
- MeSH terms
- Adolescent, Adult, Aged, Child, Child, Preschool, Female, Histocompatibility Testing, HLA-DQ Antigens, Humans, Male, Middle Aged, Polymorphism, Restriction Fragment Length, Somnambulism, Linkage Disequilibrium, Genetic Predisposition to Disease, HLA-DQ beta-Chains
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