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Cited by 276Neurotransmitter Receptor Influence on BehaviorGenetic Associations and EpidemiologyBipolar Disorder and Treatment

The DOI matches its Crossref record; 72 of the 77 references it cites were found in a registry or an index.

A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders

Anguelova, M, Benkelfat, C, Turecki, G·2003·Molecular Psychiatry
DOI 10.1038/sj.mp.4001328
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Abstract

The different 5-HT (serotonin) receptors including the serotonin transporter (5-HTT) are candidate genes for affective disorders such as major depressive disorder (MDD) and bipolar disorder (BD). They have been investigated in a number of allelic association studies where the individual results have been inconsistent, and therefore, definite conclusions are difficult to make. Systematic reviews using meta-analytical techniques are a reliable method for objectively and reproducibly assessing individual studies and generating combined result. This study aimed at reviewing published studies investigating the association between affective disorders (MDD and BD) and variation at genes coding for serotonin receptors and the serotonin transporter. We performed National Library of Medicine database searches to identify potential studies. More than 430 articles were reviewed and 86 studies met the inclusion criteria for participation in our review. Of these, 41 studies investigated 45 different 5-HT receptor variants and 45 studies investigated at least one of two commonly studied 5-HTT polymorphisms in MDD. Many studies investigated the association between MDD and BD with the 5-HT2A 102 T/C, the 5-HTT promoter 44 bp insertion/deletion and the intron 2 VNTR polymorphisms, and thus, these could be pooled using meta-analytic techniques. The overall odds ratio (OR) for the combined individual results was significant for BD and the two 5-HTT polymorphisms: Mantel-Haenszel weighted OR=1.14, CI: 1.03-1.26, P=0.015 for the promoter locus (N=3467) and Mantel-Haenszel Weighted odds ratio OR=1.18, CI: 1.05-1.32, P=0.004 for the VNTR locus (N=3620). However, sensitivity analysis indicated that, in each case, the overall positive association could be mostly attributed to the large effect of one individual study. Therefore, these results suggest that, although promising, further studies are required to assess appropriately the evidence suggesting an association between BD and 5-HTT.

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Research works printed but not linked: 5

  1. Furlong RA, Ho L, Walsh C, Rubinsztein JS, Jain S, Paykel ES et al. Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders. Am J Med Genet 1998; 81: 58–63. · DOI
  2. Massat I, Souery D, Lipp O, Blairy S, Papadimitriou G, Dikeos D et al. A European multicenter association study of HTR2A receptor polymorphism in bipolar affective disorder. Am J Med Genet 2000; 96: 136–140. · DOI
  3. Vogt IR, Shimron A, Neidt H, Erdmann J, Cichon S, Schulze TG et al. Investigation of the human serotonin 6 [5-HT6] receptor gene in bipolar affective disorder and schizophrenia. Am J Med Genet 2000; 96: 217–221. · DOI
  4. Saleem Q, Ganesh S, Vijaykumar M, Reddy YC, Brahmachari SK, Jain S . Association analysis of 5HT transporter gene in bipolar disorder in the Indian population. Am J Med Genet 2000; 96: 170–172. · DOI
  5. Ho LW, Furlong RA, Rubinsztein JS, Walsh C, Paykel ES, Rubinsztein DC . Genetic associations with clinical characteristics in bipolar affective disorder and recurrent unipolar depressive disorder. Am J Med Genet 2000; 96: 36–42. · DOI

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Metadata

Authors
Anguelova, M., Benkelfat, C., & Turecki, G.
Affiliations
  • Douglas Mental Health University Institute (CA)
  • McGill University Health Centre (CA)
Corresponding author
Turecki, G
ORCID
Turecki, G
Venue
Molecular Psychiatry
Publisher
Springer Science and Business Media LLC
Published
2003-06-01
Volume
8
Issue
6
Pages
574-591
ISSN
  • 1359-4184 (ISSN-L)
  • 1476-5578
DOI
10.1038/sj.mp.4001328
OpenAlex
W1997688244
Cited by
276
References
77
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 6 · 2020: 8 · 2019: 6 · 2018: 9 · 2017: 6 · 2016: 14 · 2015: 16 · 2014: 12 · 2013: 13 · 2012: 19
FWCI
2.10
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Molecular Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Foundation for Suicide Prevention
  • Canadian Institutes of Health Research
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Keywords
serotonin receptors, serotonin transporter, 5-HTT polymorphism, 5-HT2A receptor, promoter polymorphism, major depressive disorder, bipolar disorder, mood disorders, candidate genes, genetic association
MeSH terms
Carrier Proteins, Humans, Membrane Glycoproteins, Nerve Tissue Proteins, Receptors, Serotonin, Mood Disorders, Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins

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