Turecki, Gustavo

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience

Stress Responses and CortisolChild Abuse and Trauma

Cited by 3,531

Suicide and suicidal behaviour

Turecki, G., & Brent, D. A. (2016) · The Lancet

Suicide and Self-Harm StudiesHomicide, Infanticide, and Child Abuse

Cited by 2,338

Analysis of shared heritability in common disorders of the brain

The Brainstorm Consortium, Anttila, V., Bulik-Sullivan, B., Finucane, H. K., Walters, R. K., Bras, J., Duncan, L., Escott-Price, V., Falcone, G. J., Gormley, P., et al. (2018) · Science

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 1,924

Conserved role of intragenic DNA methylation in regulating alternative promoters

Maunakea, A. K., Nagarajan, R. P., Bilenky, M., Ballinger, T. J., D’Souza, C., Fouse, S. D., Johnson, B. E., Hong, C., Nielsen, C., Zhao, Y., et al. (2010) · Nature

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 1,743

Genome-wide association study identifies 30 loci associated with bipolar disorder

eQTLGen Consortium, Stahl, E. A., BIOS Consortium, the Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Breen, G., Forstner, A. J., McQuillin, A., Ripke, S., Trubetskoy, V., Mattheisen, M., et al. (2019) · Nature Genetics

Bipolar Disorder and TreatmentGenetic Associations and Epidemiology

Cited by 1,519

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Mullins, N., Forstner, A. J., O’Connell, K. S., Coombes, B., Coleman, J. R. I., Qiao, Z., Als, T. D., Bigdeli, T. B., Børte, S., Bryois, J., et al. (2021) · Nature Genetics

Bipolar Disorder and TreatmentGenetic Associations and Epidemiology

Cited by 1,517

Suicide risk and prevention during the COVID-19 pandemic

Gunnell, D., Appleby, L., Arensman, E., Hawton, K., John, A., Kapur, N., Khan, M., O'Connor, R. C., Pirkis, J., Appleby, L., et al. (2020) · The Lancet Psychiatry

Suicide and Self-Harm StudiesCOVID-19 and Mental Health

Cited by 1,513

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Lee, P. H., Anttila, V., Won, H., Feng, Y.-C. A., Rosenthal, J., Zhu, Z., Tucker-Drob, E. M., Nivard, M. G., Grotzinger, A. D., Posthuma, D., et al. (2019) · Cell

Genetic Associations and EpidemiologySchizophrenia research and treatment

Cited by 1,381

Suicide and suicide risk

Turecki, G., Brent, D. A., Gunnell, D., O’Connor, R. C., Oquendo, M. A., Pirkis, J., & Stanley, B. H. (2019) · Nature Reviews Disease Primers

Suicide and Self-Harm StudiesHomicide, Infanticide, and Child Abuse

Cited by 1,074

Social stress induces neurovascular pathology promoting depression

Menard, C., Pfau, M. L., Hodes, G. E., Kana, V., Wang, V. X., Bouchard, S., Takahashi, A., Flanigan, M. E., Aleyasin, H., LeClair, K. B., et al. (2017) · Nature Neuroscience

Barrier Structure and Function StudiesTryptophan and brain disorders

Cited by 1,028

Psychiatric diagnoses in 3275 suicides: a meta-analysis

Arsenault-Lapierre, G., Kim, C., & Turecki, G. (2004) · BMC Psychiatry

Suicide and Self-Harm StudiesHomicide, Infanticide, and Child Abuse

Cited by 985

Effects of the social environment and stress on glucocorticoid receptor gene methylation: A systematic review

Turecki, G., & Meaney, M. J. (2016) · Biological Psychiatry

Stress Responses and CortisolEpigenetics and DNA Methylation

Cited by 796

Sex-specific transcriptional signatures in human depression

Labonté, B., Engmann, O., Purushothaman, I., Menard, C., Wang, J., Tan, C., Scarpa, J. R., Moy, G., Loh, Y.-H. E., Cahill, M., et al. (2017) · Nature Medicine

Treatment of Major DepressionStress Responses and Cortisol

Cited by 748

Risk Factors for Suicide Completion in Major Depression: A Case-Control Study of Impulsive and Aggressive Behaviors in Men

Dumais, A., Lesage, A. D., Alda, M., Rouleau, G., Dumont, M., Chawky, N., Roy, M., Mann, J. J., Benkelfat, C., & Turecki, G. (2005) · American Journal of Psychiatry

Suicide and Self-Harm StudiesHomicide, Infanticide, and Child Abuse

Cited by 583

Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides

Torres-Platas, S. G., Cruceanu, C., Chen, G. G., Turecki, G., & Mechawar, N. (2014) · Brain, Behavior, and Immunity

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 545

Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons

Nagy, C., Maitra, M., Tanti, A., Suderman, M., Théroux, J.-F., Davoli, M. A., Perlman, K., Yerko, V., Wang, Y. C., Tripathy, S. J., et al. (2020) · Nature Neuroscience

Treatment of Major DepressionSingle-cell and spatial transcriptomics

Cited by 532

Single-nucleus RNA sequencing shows convergent evidence from different cell types for altered synaptic plasticity in major depressive disorder

Nagy, C., Maitra, M., Tanti, A., Suderman, M., Théroux, J.-F., Mechawar, N., Ragoussis, J., & Turecki, G. (2018) · Nature Neuroscience

Treatment of Major DepressionSingle-cell and spatial transcriptomics

Cited by 523

Genome-wide epigenetic regulation by early-life trauma

Labonté, B., Suderman, M., Maussion, G., Navaro, L., Yerko, V., Mahar, I., Bureau, A., Mechawar, N., Szyf, M., Meaney, M. J., et al. (2012) · Archives of General Psychiatry

Epigenetics and DNA MethylationChild Abuse and Trauma

Cited by 488

A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior

Anguelova, M., Benkelfat, C., & Turecki, G. (2003) · Molecular Psychiatry

Suicide and Self-Harm StudiesNeurotransmitter Receptor Influence on Behavior

Cited by 421

Definition, Assessment, and Staging of Treatment—Resistant Refractory Major Depression: A Review of Current Concepts and Methods

Berlim, M. T., & Turecki, G. (2007) · The Canadian Journal of Psychiatry

Treatment of Major DepressionElectroconvulsive Therapy Studies

Cited by 412

Sex differences in nucleus accumbens transcriptome profiles associated with susceptibility versus resilience to subchronic variable stress

Hodes, G. E., Pfau, M. L., Purushothaman, I., Ahn, H. F., Golden, S. A., Christoffel, D. J., Magida, J., Brancato, A., Takahashi, A., Flanigan, M. E., et al. (2015) · The Journal of Neuroscience

Stress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Cited by 395

Global Brain Gene Expression Analysis Links Glutamatergic and GABAergic Alterations to Suicide and Major Depression

Sequeira, A., Mamdani, F., Ernst, C., Vawter, M. P., Bunney, W. E., Lebel, V., Rehal, S., Klempan, T., Gratton, A., Benkelfat, C., et al. (2009) · PLoS ONE

Treatment of Major DepressionSuicide and Self-Harm Studies

Cited by 388

Molecular adaptations of the blood–brain barrier promote stress resilience vs. depression

Dudek, K. A., Dion-Albert, L., Lebel, M., LeClair, K., Labrecque, S., Tuck, E., Ferrer Perez, C., Golden, S. A., Tamminga, C., Turecki, G., et al. (2020) · Proceedings of the National Academy of Sciences

Barrier Structure and Function StudiesStress Responses and Cortisol

Cited by 361

Epigenetic Mechanisms for the Early Environmental Regulation of Hippocampal Glucocorticoid Receptor Gene Expression in Rodents and Humans

Zhang, T. Y., Labonté, B., Wen, X. L., Turecki, G., & Meaney, M. J. (2013) · Neuropsychopharmacology

Stress Responses and CortisolEpigenetics and DNA Methylation

Cited by 347