The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A Novel Cell-penetrating Peptide, M918, for Efficient Delivery of Proteins and Peptide Nucleic Acids
Open accessAbstract
Cell-penetrating peptides (CPPs) have attracted increasing attention in the past decade as a result of their high potential to convey various, otherwise impermeable, bioactive agents across cellular plasma membranes. Albeit different CPPs have proven potent in delivery of different cargoes, there is generally a correlation between high efficacy and cytotoxicity for these peptides. Hence, it is of great importance to find new, non-toxic CPPs with more widespread delivery properties. We present a novel CPP, M918, that efficiently translocates various cells in a non-toxic fashion. In line with most other CPPs, the peptide is internalized mainly via endocytosis, and in particular macropinocytosis, but independent of glycosaminoglycans on the cell surface. In addition, in a splice correction assay using antisense peptide nucleic acid (PNA) conjugated via a disulphide bridge to M918 (M918-PNA), we observed a dose-dependent increase in correct splicing, exceeding the effect of other CPPs. Our data demonstrate that M918 is a novel CPP that can be used to translocate different cargoes inside various cells efficiently.
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Cites
Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide
Nielsen, P. E., Egholm, M., Berg, R. H., & Buchardt, O. (1991) · Science · doi:10.1126/science.1962210 · Cited by 3,332
Wadia, J. S., Stan, R. V., & Dowdy, S. F. (2004) · Nature Medicine · doi:10.1038/nm996 · Cited by 1,647
Progress in antisense technology
Crooke, S. T. (2004) · Annual Review of Medicine · doi:10.1146/annurev.med.55.091902.104408 · Cited by 417 · cited 1×
“The main techniques to knock down the expression of proteins include the use of antisense oligonucleotides (asONs) and small interfering RNAs”
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Cited by
Cell-Penetrating Peptides: Design, Synthesis, and Applications
Copolovici, D. M., Langel, K., Eriste, E., & Langel, Ü. (2014) · ACS Nano · doi:10.1021/nn4057269 · Cited by 963
Self-citationSecondary structure of cell-penetrating peptides controls membrane interaction and insertion
Eiríksdóttir, E., Konate, K., Langel, Ü., Divita, G., & Deshayes, S. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.03.005 · Cited by 323
Self-citationHerce, H. D., Garcia, A. E., Litt, J., Kane, R. S., Martin, P., Enrique, N., Rebolledo, A., & Milesi, V. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2009.05.066 · Cited by 305
Metadata
- Authors
- El-Andaloussi, S., Johansson, H. J., Holm, T., & Langel, Ü.
- Venue
- Molecular Therapy
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 15
- Issue
- 10
- Pages
- 1820-1826
- ISSN
- 1525-0016 (ISSN-L)
- OpenAlex
- W2080971086
- Cited by
- 170
- References
- 3
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- El-Andaloussi, S., Johansson, H. J., Holm, T., & Langel, Ü. (2007). A Novel Cell-penetrating Peptide, M918, for Efficient Delivery of Proteins and Peptide Nucleic Acids. Molecular Therapy. https://doi.org/10.1038/sj.mt.6300255
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