The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.
Hydrodynamic Gene Delivery: Its Principles and Applications
Open accessAbstract
Efficient and safe methods for delivering genetic materials into cells must be developed before the clinical potential of gene therapy can be fully realized. Recently, hydrodynamic gene delivery using a rapid injection of a relatively large volume of DNA solution has opened up a new avenue for gene therapy studies in vivo. This method is superior to the existing delivery systems because of its simplicity, efficiency, and versatility. Wide success in applying hydrodynamic principles to delivery of DNA, RNA, proteins, and synthetic compounds, into the cells in various tissues of small animals, has inspired the recent attempts at establishing a hydrodynamic procedure for clinical use. In this review, we provide an overview of the theory and practice of hydrodynamic gene delivery so as to aid researchers for the use of this method in their pre-clinical and translational gene therapy studies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Metabolic Basis of Sexual Dimorphism in PKU Mice After Genome-targeted PAH Gene Therapy
Chen, L., Thung, S. N., & Woo, S. L. C. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300137 · Cited by 12
RetractedHydrodynamics-based transfection in animals by systemic administration of plasmid DNA
Liu, F., Song, Y. K., & Liu, D. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300947 · Cited by 1,727
Self-citationRNA interference targeting Fas protects mice from fulminant hepatitis
Song, E., Lee, S.-K., Wang, J., Ince, N., Ouyang, N., Min, J., Chen, J., Shankar, P., & Lieberman, J. (2003) · Nature Medicine · doi:10.1038/nm828 · Cited by 1,110
RNA interference in adult mice
McCaffrey, A. P., Meuse, L., Pham, T.-T. T., Conklin, D. S., Hannon, G. J., & Kay, M. A. (2002) · Nature · doi:10.1038/418038a · Cited by 1,059
Zhang, G., Budker, V., & Wolff, J. A. (1999) · Human Gene Therapy · doi:10.1089/10430349950017734 · Cited by 944
Morphological classifications of vertebrate blood capillaries
Bennett, H. S., Luft, J. H., & Hampton, J. C. (1959) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1959.196.2.381 · Cited by 635
Inhibition of hepatitis B virus in mice by RNA interference
McCaffrey, A. P., Nakai, H., Pandey, K., Huang, Z., Salazar, F. H., Xu, H., Wieland, S. F., Marion, P. L., & Kay, M. A. (2003) · Nature Biotechnology · doi:10.1038/nbt824 · Cited by 607
In vivo activity of nuclease-resistant siRNAs
LAYZER, J. M., MCCAFFREY, A. P., TANNER, A. K., HUANG, Z., KAY, M. A., & SULLENGER, B. A. (2004) · RNA · doi:10.1261/rna.5239604 · Cited by 580
Efficient delivery of siRNA for inhibition of gene expression in postnatal mice
Lewis, D. L., Hagstrom, J. E., Loomis, A. G., Wolff, J. A., & Herweijer, H. (2002) · Nature Genetics · doi:10.1038/ng944 · Cited by 546
Chen, Z.-Y., He, C.-Y., Ehrhardt, A., & Kay, M. A. (2003) · Molecular Therapy · doi:10.1016/s1525-0016(03)00168-0 · Cited by 462
Cited by
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
Komor, A. C., Badran, A. H., & Liu, D. R. (2017) · Cell · doi:10.1016/j.cell.2016.10.044 · Cited by 1,013
Self-citationMicrobubbles in ultrasound-triggered drug and gene delivery
Hernot, S., & Klibanov, A. L. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.005 · Cited by 990
Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts
Stewart, M. P., Langer, R., & Jensen, K. F. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00678 · Cited by 747
Nonviral Gene Delivery: Principle, Limitations, and Recent Progress
Al-Dosari, M. S., & Gao, X. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9143-y · Cited by 706
Delivery strategies of the CRISPR-Cas9 gene-editing system for therapeutic applications
Liu, C., Zhang, L., Liu, H., & Cheng, K. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.09.012 · Cited by 607
Metadata
- Authors
- Suda, T., & Liu, D.
- Venue
- Molecular Therapy
- Publisher
- Elsevier BV
- Published
- 2007-12
- Volume
- 15
- Issue
- 12
- Pages
- 2063-2069
- ISSN
- 1525-0016 (ISSN-L)
- OpenAlex
- W2034629713
- Cited by
- 347
- References
- 108
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Hydrodynamic Gene Delivery: Its Principles and Applications. https://app.cochat.ai/papers/10.1038/sj.mt.6300314
- The paper
- Suda, T., & Liu, D. (2007). Hydrodynamic Gene Delivery: Its Principles and Applications. Molecular Therapy. https://doi.org/10.1038/sj.mt.6300314
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
