Cited by 582Venous Thromboembolism Diagnosis and ManagementBlood Coagulation and Thrombosis MechanismsInflammatory Biomarkers in Disease Prognosis

The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.

The Hypercoagulable State of Malignancy: Pathogenesis and Current Debate

Open access

Caine, Graham J, Stonelake, Paul S, Lip, Gregory Y H, Kehoe, Sean T·2002·Neoplasia

DOI 10.1038/sj.neo.7900263PMC PMC1550339

Open this paper in CoChat — free account

Abstract

A hypercoagulable or prothrombotic state of malignancy occurs due to the ability of tumor cells to activate the coagulation system. It has been estimated that hypercoagulation accounts for a significant percentage of mortality and morbidity in cancer patients. Prothrombotic factors in cancer include the ability of tumor cells to produce and secrete procoagulant/fibrinolytic substances and inflammatory cytokines, and the physical interaction between tumor cell and blood (monocytes, platelets, neutrophils) or vascular cells. Other mechanisms of thrombus promotion in malignancy include nonspecific factors such as the generation of acute phase reactants and necrosis (i.e., inflammation), abnormal protein metabolism (i.e., paraproteinemia), and hemodynamic compromise (i.e., stasis). In addition, anticancer therapy (i.e., surgery/chemotherapy/hormone therapy) may significantly increase the risk of thromboembolic events by similar mechanisms, e.g., procoagulant release, endothelial damage, or stimulation of tissue factor production by host cells. However, not all of the mechanisms for the production of a hypercoagulable state of cancer are entirely understood. In this review, we attempt to describe what is currently accepted about the pathophysiology of the hypercoagulable state of cancer. We also discuss whether or not to screen patients with idiopathic deep venous thrombosis for an underlying malignancy, and whether this would be beneficial to patients. It is hoped that a better understanding of these mechanisms will ultimately lead to the development of more targeted treatment to prevent thromboembolic complications in cancer patients. It is also hoped that antithrombotic strategies may also have a positive effect on the process of tumor growth and dissemination.

Integrity signals

Registry

Crossref · 10.1038/sj.neo.7900263

Cites

128 of 128 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Prevention of Venous Thromboembolism
Geerts, W. H., Heit, J. A., Clagett, G. P., Pineo, G. F., Colwell, C. W., Anderson, F. A., & Wheeler, H. B. (2001) · CHEST Journal · doi:10.1378/chest.119.1_suppl.132s · Cited by 4,368
Prognosis of Cancers Associated with Venous Thromboembolism
Sørensen, H. T., Mellemkjær, L., Olsen, J. H., & Baron, J. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200012213432504 · Cited by 1,628
A Randomized Clinical Trial Evaluating Tamoxifen in the Treatment of Patients with Node-Negative Breast Cancer Who Have Estrogen-Receptor–Positive Tumors
Fisher, B., Costantino, J., Redmond, C. K., POISSON, R., Bowman, D., Couture, J., Dimitrov, N. V., Wolmark, N., Wickerham, D. L., Fisher, E. R., et al. (1989) · New England Journal of Medicine · doi:10.1056/nejm198902233200802 · Cited by 1,466
Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1.
Bevilacqua, M. P., Pober, J. S., Majeau, G. R., Fiers, W. C., Cotran, R. S., & Gimbrone, M. A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.12.4533 · Cited by 1,059
Rates of Initial and Recurrent Thromboembolic Disease Among Patients with Malignancy Versus Those without Malignancy: Risk Analysis Using Medicare Claims Data
Levitan, N. I., Dowlati, A., Remick, S. C., Tahsildar, H. I., Sivinski, L. D., Beyth, R. J., & Rimm, A. A. (1999) · Medicine · doi:10.1097/00005792-199909000-00001 · Cited by 891
Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration.
Clauss, M. A., Gerlach, M. L., Gerlach, H., Brett, J., Wang, F., Familletti, P. C., Pan, Y.-C. E., Olander, J. V., Connolly, D. T., & Stern, D. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.6.1535 · Cited by 831
Subcutaneous Low-Molecular-Weight Heparin Compared with Continuous Intravenous Heparin in the Treatment of Proximal-Vein Thrombosis
Hull, R. D., Raskob, G. E., Pineo, G. F., Green, D., Trowbridge, A. A., Elliott, C. G., Lerner, R. G., Hall, J. H., Sparling, T. G., Brettell, H. R., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199204093261502 · Cited by 689
Activation of blood coagulation in cancer: Trousseau's syndrome revisited
Rickles, F., & Edwards, R. (1983) · Blood · doi:10.1182/blood.v62.1.14.bloodjournal62114 · Cited by 680
Deep-Vein Thrombosis and the Incidence of Subsequent Symptomatic Cancer
Prandoni, P., Lensing, A. W. A., Buller, H. R., Cogo, A., Prins, M. H., Cattelan, A. M., Cuppini, S., Noventa, F., & ten Cate, J. W. (1992) · New England Journal of Medicine · doi:10.1056/nejm199210153271604 · Cited by 671
Angiogenesis Inhibition and Tumor Regression Caused by Heparin or a Heparin Fragment in the Presence of Cortisone
Folkman, J., Langer, R., Linhardt, R. J., Haudenschild, C. C., & Taylor, S. (1983) · Science · doi:10.1126/science.6192498 · Cited by 619

Flagged first, then by citations

Show all 125 references

Sorted by citations

Items 101–200 of 582

Risk and Prognosis of Cancer After Lower Limb Arterial Thrombosis
Sundbøll, J., Veres, K., Horváth–Puhó, E., Adelborg, K., & Sørensen, H. T. (2018) · Circulation · doi:10.1161/circulationaha.117.032617 · Cited by 44
Risk of Ischemic and Hemorrhagic Strokes in Occult and Manifest Cancers
Andersen, K. K., & Olsen, T. S. (2018) · Stroke · doi:10.1161/strokeaha.118.021373 · Cited by 44
Systematic review update of observational studies further supports aspirin role in cancer treatment: Time to share evidence and decision-making with patients?
Elwood, P. C., Pickering, J. E., Morgan, G., Galante, J., Weightman, A. L., Morris, D., Longley, M. J., Mason, M. D., Adams, R., Dolwani, S., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0203957 · Cited by 43
Hypercoagulability in patients with haematological neoplasia: No apparent initiation by tissue factor
Iversen, P. O., Østenstad, B., Iversen, N., Holme, P. A., Sandset, P. M., & Negaard, H. F. S. (2008) · Thrombosis and Haemostasis · doi:10.1160/th07-09-0541 · Cited by 42
Influence of a history of cancer on long-term cardiovascular outcomes after coronary stent implantation (an Observation from Coronary Revascularization Demonstrating Outcome Study-Kyoto Registry Cohort-2)
Nakatsuma, K., Shiomi, H., Morimoto, T., Watanabe, H., Nakagawa, Y., Furukawa, Y., Kadota, K., Andò, K., Ono, K., Shizuta, S., et al. (2018) · European Heart Journal - Quality of Care and Clinical Outcomes · doi:10.1093/ehjqcco/qcy014 · Cited by 42
The potential role of platelets in the consensus molecular subtypes of colorectal cancer
Lam, M. S., Roszik, J., Marie, P. K., Davis, J. S., Morris, J. S., Kopetz, S., & Menter, D. G. (2017) · Cancer and Metastasis Reviews · doi:10.1007/s10555-017-9678-9 · Cited by 41
Acute Coronary Syndrome Management in Cancer Patients
Al‐Hawwas, M., Tsitlakidou, D., Gupta, N., Iliescu, C., Çilingiroğlu, M., & Marmagkiolis, K. (2018) · Current Oncology Reports · doi:10.1007/s11912-018-0724-8 · Cited by 41
Risk of venous thromboembolism in patients undergoing cancer surgery and options for thromboprophylaxis
Bergqvist, D. (2007) · Journal of Surgical Oncology · doi:10.1002/jso.20625 · Cited by 41
Breaking down tumor thrombus: Current strategies for medical management
Tathireddy, H., Rice, D., Martens, K. L., Shivakumar, S., & Shatzel, J. J. (2023) · Thrombosis Research · doi:10.1016/j.thromres.2023.09.004 · Cited by 40
Targeting Tissue Factor for Immunotherapy of Triple-Negative Breast Cancer Using a Second-Generation ICON
Hu, Z., Shen, R. Z., Campbell, A. R., McMichael, E. L., Yu, L., Ramaswamy, B., London, C. A., Xu, T., & Carson, W. E. (2018) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-17-0343 · Cited by 40
Circulating fibrinogen to pre‐albumin ratio is a promising biomarker for diagnosis of colorectal cancer
Sun, F., Tan, Y., Gao, Q., Li, S., Zhang, J., Chen, Q., Jiang, Y., Zhang, L., Ying, H., & Wang, X. (2018) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.22635 · Cited by 40
Thromboprophylaxis with low‐molecular‐weight heparin in medical patients with cancer
Lyman, G. H. (2009) · Cancer · doi:10.1002/cncr.24665 · Cited by 40
The role of coagulome in the tumor immune microenvironment
Wahab, R., Hasan, M. M., Azam, Z., Grippo, P. J., & Al-Hilal, T. A. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115027 · Cited by 43
Prognostic and predictive value of plasma D-dimer in advanced non-small cell lung cancer patients undergoing first-line chemotherapy
Ge, L., Li, J., Bao, Q., Chen, P., Jiang, Q., & Zhu, L. (2014) · Clinical & Translational Oncology · doi:10.1007/s12094-014-1198-2 · Cited by 39
Proteases: Pivot Points in Functional Proteomics
Verhamme, I. M., Leonard, S. E., & Perkins, R. C. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8814-3_20 · Cited by 39
Bleeding with vascular endothelial growth factor tyrosine kinase inhibitor: A network meta-analysis
Das, A., Mahapatra, S., Bandyopadhyay, D., Samanta, S., Chakraborty, S., Philpotts, L. L., Jahangir, E., & Roy, B. (2020) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2020.103186 · Cited by 37
Effect of Pharmacologic Prophylaxis on Venous Thromboembolism After Radical Prostatectomy: The PREVENTER Randomized Clinical Trial
Patel, H. D., Faisal, F. A., Trock, B. J., Joice, G. A., Schwen, Z. R., Pierorazio, P. M., Johnson, M. H., Bivalacqua, T. J., Han, M., Gorin, M. A., et al. (2020) · European Urology · doi:10.1016/j.eururo.2020.05.001 · Cited by 37
Thromboembolic Events Associated with Bevacizumab plus Chemotherapy for Patients with Colorectal Cancer: A Meta-Analysis of Randomized Controlled Trials.
Alahmari, A. K., Almalki, Z. S., Alahmari, A. K., & Guo, J. J. (2016) · Europe PMC (PubMed Central) · Cited by 37
Tryptophan metabolism along the kynurenine and serotonin pathways reveals substantial differences in colon and rectal cancer
Crotti, S., D’Angelo, E., Bedin, C., Fassan, M., Pucciarelli, S., Nitti, D., Bertazzo, A., & Agostini, M. (2017) · Metabolomics · doi:10.1007/s11306-017-1288-6 · Cited by 35
The Long-Term Effect of Cancer on Incident Stroke: A Nationwide Population-Based Cohort Study in Korea
Jang, H.-S., Choi, J., Shin, J., Chung, J., Bang, O. Y., Kim, G., Seo, W., & Lee, J. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00052 · Cited by 35
Cancer and stroke: What do we know and where do we go?
Lun, R., Siegal, D. M., Ramsay, T., & Dowlatshahi, D. D. (2022) · Thrombosis Research · doi:10.1016/j.thromres.2022.09.014 · Cited by 35
The Effect of Low Molecular Weight Heparin Thromboprophylaxis on Bleeding Complications After Gastric Cancer Surgery
Jeong, O., Ryu, S. Y., Park, Y. K., & Kim, Y. J. (2010) · Annals of Surgical Oncology · doi:10.1245/s10434-010-1032-1 · Cited by 35
Stroke Rate Increases Around the Time of Cancer Diagnosis
Wei, Y., Chen, K., Wu, C.-L., Lee, T.-W., Liu, C.-H., Shyu, Y., & Lin, C. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00579 · Cited by 34
Peripheral blood cell ratios as prognostic factors in canine diffuse large B‐cell lymphoma treated with CHOP protocol
Henriques, J. J. G. P., Felisberto, R., Constantino‐Casas, F., Cabeçadas, J., & Dobson, J. M. (2020) · Veterinary and Comparative Oncology · doi:10.1111/vco.12668 · Cited by 34
Management of Acute Coronary Syndrome in Cancer Patients: It’s High Time We Dealt with It
Lucà, F., Parrini, I., Abrignani, M. G., Rao, C. M., Piccioni, L., Fusco, S. A. D., Ceravolo, R., Bisceglia, I., Riccio, C., Gelsomino, S., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11071792 · Cited by 34
Biomolecular markers of cancer-associated thromboembolism
Hanna, D. L., White, R. H. R., & Wun, T. (2013) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2013.02.008 · Cited by 34
Circulating levels of coagulation and inflammation markers and cancer risks: individual participant analysis of data from three long-term cohorts
Silva, I. D. S., Stavola, B. L. D., Pizzi, C., & Meade, T. W. (2010) · International Journal of Epidemiology · doi:10.1093/ije/dyq012 · Cited by 34
Safety of lone thrombus aspiration without concomitant coronary stenting in selected patients with acute myocardial infarction
Escaned, J., Pinto, M. E., Gorgadze, T., Gonzalo, N., Armengol, F., Hernández, R., Jiménez‐Quevedo, P., Nuñez-Gil, I. J., Pérez-Vizcayno, M. J., Alfonso, F., et al. (2013) · EuroIntervention · doi:10.4244/eijv8i10a178 · Cited by 32
Combined Use of the Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios as a Prognostic Predictor in Patients with Operable Soft Tissue Sarcoma
Liang, Y., Wang, W., Li, J., Guan, Y., Que, Y., Xiao, W., Zhang, X., & Zhou, Z. (2018) · Journal of Cancer · doi:10.7150/jca.24871 · Cited by 32
High prevalence and risk factors of thromboembolism in stage IV melanoma
Sparsa, A., Durox, H., Doffoël-Hantz, V., Munyangango, E. M., Bédane, C., Cendras, J., Gantois, C., Boulinguez, S., & Bonnetblanc, J. (2010) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2010.03795.x · Cited by 32
Increased acquired activated protein C resistance in unselected patients with hematological malignancies
Negaard, H. F. S., Iversen, P. O., Østenstad, B., Mowinckel, M., & Sandset, P. M. (2008) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2008.03060.x · Cited by 32
EVIDENCE-BASED REVIEW OF THE ROLE OF APROTININ IN BLOOD CONSERVATION DURING ORTHOPAEDIC SURGERY
Kokoszka, A., Kuflik, P. L., Bitan, F. D., Casden, A. M., & Neuwirth, M. G. (2005) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200505000-00029 · Cited by 32
Unprovoked venous thromboembolism and subsequent cancer risk: a population‐based cohort study
Sun, L. ‐., Chung, W.-T., Lin, C., Liang, J., & Kao, C. ‐. (2016) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13251 · Cited by 31
A novel oncotherapy strategy: Direct thrombin inhibitors suppress progression, dissemination and spontaneous metastasis in non‐small cell lung cancer
Zhao, B., Wu, M., Hu, Z., Wang, T., Yu, J., Ma, Y., Wang, Q., Zhang, Y., Chen, D., Li, T., et al. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15384 · Cited by 30
Lung Cancer as a Leading Cause among Paraneoplastic Non-Bacterial Thrombotic Endocarditis: A Meta-Analysis of Individual Patients’ Data
Rahouma, M., Khairallah, S. M., Dabsha, A., Elkharbotly, I. A. M. H., Baudo, M., Ismail, A., Korani, O. M., Hossny, M. H., Dimagli, A., Girardi, L. N., et al. (2023) · Cancers · doi:10.3390/cancers15061848 · Cited by 30
Venous thromboembolism and cancer risk
Sandén, P., Svensson, P. J., & Själander, A. (2016) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-016-1411-y · Cited by 30
Risk of thrombosis in women with malignancies undergoing ovarian stimulation for fertility preservation
Somigliana, E., Peccatori, F. A., Filippi, F., Martinelli, F., Raspagliesi, F., & Martinelli, I. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu035 · Cited by 29
Venous Thromboembolism in Patients Diagnosed With Lung Cancer
Salla, E., Dimakakos, E. P., Tsagkouli, S., Giozos, I., Charpidou, A., Kainis, E., & Syrigos, K. N. (2015) · Angiology · doi:10.1177/0003319715614945 · Cited by 28
Efficacy and safety of apixaban for primary prevention of thromboembolism in patients with cancer and a central venous catheter: A subgroup analysis of the AVERT Trial
Brandt, W., Brown, C., Wang, T., Tagalakis, V., Shivakumar, S., Ciuffini, L., Mallick, R., Wells, P. S., & Carrier, M. (2022) · Thrombosis Research · doi:10.1016/j.thromres.2022.05.014 · Cited by 27
Association of atrial fibrillation and various cancer subtypes
Khan, M. Z., Gupta, A., Patel, K., Abraham, A., Franklin, S. M., Kim, D. Y., Patel, K., Hussian, I., Zarak, M. S., Figueredo, V. M., et al. (2021) · Journal of Arrhythmia · doi:10.1002/joa3.12589 · Cited by 26
Predictors of Survival in Patients With Ischemic Stroke and Active Cancer: A Prospective, Multicenter, Observational Study
Gon, Y., Sakaguchi, M., Yamagami, H., Abe, S., Hashimoto, H., Ohara, N., Takahashi, D., Abe, Y., Takahashi, T., Kitano, T., et al. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.123.029618 · Cited by 26
Role of Adipose Tissue in Metabolic System Disorders
Rezaee, F. (2013) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.s13-008 · Cited by 30
Protease-activated receptor-1 (PAR1) promotes epithelial-endothelial transition through Twist1 in hepatocellular carcinoma
Xiao, T., Zhang, Q., Zong, S., Zhong, W., Qin, Y., Bi, Z., Chen, S., Liu, H., Wei, J., Zhou, B., et al. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0858-4 · Cited by 26
C-Reactive Protein Predicts Risk of Venous Thromboembolism in Pediatric Musculoskeletal Infection
Amaro, E. J., Marvi, T. K., Posey, S. L., Benvenuti, M. A., An, T. J., Dale, K. M., Lovejoy, S. A., Martus, J. E., Johnson, M. E., Mencio, G. A., et al. (2018) · Journal of Pediatric Orthopaedics · doi:10.1097/bpo.0000000000001256 · Cited by 26
Tissue factor is regulated by epidermal growth factor in normal and malignant human endometrial epithelial cells
Kato, S., Pinto, M. P., Carvajal, A., Espinoza, N., Monso, C., Bravo, L., Villalón, M., Cuello, M. A., Quest, A. F. G., Suenaga, A., et al. (2005) · Thrombosis and Haemostasis · doi:10.1160/th05-01-0066 · Cited by 26
Meta-analysis of Outcomes Following Aneurysm Repair in Patients with Synchronous Intra-abdominal Malignancy
Kumar, K., Dattani, N., Asaad, O. M., Bown, M. J., Sayers, R. D., & Saratzis, A. N. (2016) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2016.07.084 · Cited by 25
Venous thromboembolic events in lymphoma patients: Actual relationships between epidemiology, mechanisms, clinical profile and treatment
Antic, D. A., Jelicic, J., Vuković, V., Nikolovski, S. S., & Mihaljević, B. (2017) · Blood Reviews · doi:10.1016/j.blre.2017.10.002 · Cited by 25
Thromboembolic prophylaxis in neurosurgical practice: a systematic review
Zhang, Z., Cai, H., & Vleggeert-Lankamp, C. L. A. (2023) · Acta Neurochirurgica · doi:10.1007/s00701-023-05792-3 · Cited by 24
Latest Innovations in the Treatment of Venous Disease
Attaran, R. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7040077 · Cited by 24
Fibrinogen/albumin ratio as a promising predictor of platinum response and survival in ovarian clear cell carcinoma
Chen, W., Shan, B., Zhou, S., Yang, H., & Ye, S. (2022) · BMC Cancer · doi:10.1186/s12885-022-09204-0 · Cited by 24
A Review of Hereditary and Acquired Coagulation Disorders in the Aetiology of Ischaemic Stroke
de Lau, L. M. L., Leebeek, F. W. G., de Maat, M. P. M., Koudstaal, P. J., & Dippel, D. W. J. (2010) · International Journal of Stroke · doi:10.1111/j.1747-4949.2010.00468.x · Cited by 24
The Incidence of Pulmonary Embolism and Associated FDG-PET Findings in IV Contrast-Enhanced PET/CT
Flavell, R. R., Behr, S. C., Brunsing, R. L., Naeger, D. M., & Pampaloni, M. H. (2014) · Academic Radiology · doi:10.1016/j.acra.2014.02.013 · Cited by 23
Outcome of incidentally diagnosed pulmonary embolism in patients with malignancy
den Exter, P. L., Jiménez, D., Kroft, L. J. M., & Huisman, M. V. (2012) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e3283553914 · Cited by 23
Risk Factors, Biomarkers, Etiology, Outcome and Prognosis of Ischemic Stroke in Cancer Patients
Sorgun, M. H., Kuzu, M., Özer, İ. Ş., Yılmaz, V., Ulukan, Ç., Çotur, H., Tezcan, S., Rzayev, S., Rawandi, A., Bakırarar, B., et al. (2018) · Europe PMC (PubMed Central) · doi:10.22034/apjcp.2018.19.3.649 · Cited by 23
Incidence and prevalence of venous thromboembolism in chronic liver disease: A systematic review and meta-analysis
Subhani, M., Sheth, A., Ahmed, J., Wijayasiri, P., Gardezi, S. A., Enki, D. G., Morling, J. R., Aithal, G. P., Ryder, S. D., & Aravinthan, A. D. (2022) · Thrombosis Research · doi:10.1016/j.thromres.2022.05.004 · Cited by 23
Nervous System-Systemic Crosstalk in SARS-CoV-2/COVID-19: A Unique Dyshomeostasis Syndrome
Anand, H., Ende, V., Singh, G. K., Qureshi, I., Duong, T. Q., & Mehler, M. F. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.727060 · Cited by 22
Microangiopathic Hemolytic Anemia as the First Manifestation of Metastatic Signet Ring Cell Carcinoma of Unknown Origin: A Case Report and Review of Literature
Shin, S.-Y., Park, H., Chae, S. W., & Woo, H. (2011) · Annals of Laboratory Medicine · doi:10.3343/kjlm.2011.31.3.157 · Cited by 22
Quantitative Proteomic Approach Targeted to Fibrinogen β Chain in Tissue Gastric Carcinoma
Repetto, O., Maiero, S., Magris, R., Miolo, G., Cozzi, M. R., Steffan, A., Canzonieri, V., Cannizzaro, R., & Re, V. D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030759 · Cited by 22
Pancreatoblastoma: A Rare Tumor Still Evolving in Clinical Presentation and Histology
Balasundaram, C., Luthra, M., Chavalitdhamrong, D., Chow, J., Khan, H., & Endres, P. (2012) · PubMed · doi:10.6092/1590-8577/661 · Cited by 21
The risk of arterial thromboembolic events after cancer diagnosis
Navi, B. B., Howard, G., Howard, V. J., Zhao, H., Judd, S. E., Elkind, M. S. V., Iadecola, C., DeAngelis, L. M., Kamel, H., Okin, P. M., et al. (2019) · Research and Practice in Thrombosis and Haemostasis · doi:10.1002/rth2.12223 · Cited by 21
Venous Thromboembolism and Cancer
Bergqvist, D., Caprini, J. A., Dotsenko, O., Kakkar, A. K., Mishra, R. G., & Wakefield, T. W. (2007) · Current Problems in Surgery · doi:10.1067/j.cpsurg.2007.01.004 · Cited by 21
Chlorogenic Acid‐Conjugated Nanoparticles Suppression of Platelet Activation and Disruption to Tumor Vascular Barriers for Enhancing Drug Penetration in Tumor
Ke, Y., Ma, Z., Ye, H., Guan, X., Xiang, Z., Xia, Y. Q., & Shi, Q. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202202205 · Cited by 20
Microvascular Free Tissue Transfer in Patients with Hematological Disorders
zkan, M., Chen, H., Mardini, S., Cigna, E., Hao, S., Hung, K.-F., & Chen, H.-S. (2006) · Plastic & Reconstructive Surgery · doi:10.1097/01.prs.0000232371.69606.61 · Cited by 20
Trends in Hospitalization and Mortality of Venous Thromboembolism in Hospitalized Patients With Colon Cancer and Their Outcomes: US Perspective
Devani, K., Patil, N. T., Simons-Linares, C. R., Patel, N., Jaiswal, P., Patel, P., Patel, S. D., Savani, C., Sajnani, K. P., Young, M., et al. (2016) · Clinical Colorectal Cancer · doi:10.1016/j.clcc.2016.09.006 · Cited by 20
Incidence of cancer-associated thromboembolism in Japanese gastric and colorectal cancer patients receiving chemotherapy: a single-institutional retrospective cohort analysis (Sapporo CAT study)
Oba, A., Nakamura, M., Sakamaki, K., Murai, T., Matsuda, C., Itaya, K., Sone, T., Yagisawa, M., Koike, Y., Endo, A., et al. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-028563 · Cited by 20
Perioperative hyperfibrinolysis – physiology and pathophysiology
Marinho, D. S. (2020) · Brazilian Journal of Anesthesiology (English Edition) · doi:10.1016/j.bjane.2020.12.007 · Cited by 20
Differential contribution of tissue factor and Factor XII to thrombin generation triggered by breast and pancreatic cancer cells
Rousseau, A., Larsen, A. K., Dreden, P. V., Sabbah, M., Elalamy, I., & Gerotziafas, G. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4172 · Cited by 20
The Role of Platelets in Tumor Growth, Metastasis, and Immune Evasion
Li, Z., Riesenberg, B., Metelli, A., Li, A., & Wu, B. X. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813456-6.00030-8 · Cited by 20
When Two Maladies Meet: Disease Burden and Pathophysiology of Stroke in Cancer
Sun, M.-Y., & Bhaskar, S. M. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415769 · Cited by 19
Effectiveness of Platelet Function Analyzer-100 for Laboratory Detection of Anti-Platelet Drug-Induced Platelet Dysfunction
Kweon, O. J., Lim, Y. K., Kim, B., Lee, M., & Kim, H. R. (2018) · Annals of Laboratory Medicine · doi:10.3343/alm.2019.39.1.23 · Cited by 19
YC-1 Prevents Tumor-Associated Tissue Factor Expression and Procoagulant Activity in Hypoxic Conditions by Inhibiting p38/NF-κB Signaling Pathway
Hsieh, K., Wei, C.-K., & Wu, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020244 · Cited by 19
Clinical Course of Cancer Patients With COVID-19: A Retrospective Cohort Study
Alpert, N., Rapp, J. L., Marcellino, B. K., Lieberman‐Cribbin, W., Flores, R. M., & Taioli, E. (2020) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkaa085 · Cited by 19
Feasibility of using hyperosmolar mannitol as a liquid tumor embolization agent.
Feng, L., Kienitz, B. A., Matsumoto, C., Bruce, J. N., Sisti, M. B., Duong, H., & Pile‐Spellman, J. (2005) · PubMed Central · Cited by 19
Aggressive chronic platelet inhibition with prasugrel and increased cancer risks: revising oral antiplatelet regimens?
Serebruany, V. L. (2009) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2009.00710.x · Cited by 19
Real world prescribing practices of apixaban or rivaroxaban lead-in doses for the treatment of venous thromboembolism in hospitalized patients
Williams, M. A., Ahuja, T., Raco, V., Papadopoulos, J., Green, D., Yuriditsky, E., & Arnouk, S. (2022) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-022-02641-5 · Cited by 18
Weekly risk of venous thromboembolism recurrence in patients receiving oral anticoagulants
Laliberté, F., Coleman, C. I., Bookhart, B., Lefèbvre, P., Cloutier, M., Damaraju, C. V., Schein, J. R., & Kaatz, S. (2014) · Current Medical Research and Opinion · doi:10.1185/03007995.2014.915801 · Cited by 18
Superior Vena Cava Obstruction in Hemodialysis Patients: Symptoms, Clinical Presentation and Outcomes Compared to Other Etiologies
Siegel, Y., & Kuker, R. A. (2016) · Therapeutic Apheresis and Dialysis · doi:10.1111/1744-9987.12395 · Cited by 18
D-dimer levels and cerebral infarction in critically ill cancer patients
Ryu, J.-A., Bang, O. Y., & Lee, G.-H. (2017) · BMC Cancer · doi:10.1186/s12885-017-3588-7 · Cited by 18
Cancer risk in stroke survivors followed for up to 10 years in general practices in Germany
Jacob, L., & Kostev, K. (2019) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-019-02855-w · Cited by 18
Anticoagulants for cancer-associated ischemic stroke
Liu, A., & Hsu, J. (2019) · Tzu Chi Medical Journal · doi:10.4103/tcmj.tcmj_55_19 · Cited by 18
Genome-Wide DNA Methylation Signatures Predict the Early Asymptomatic Doxorubicin-Induced Cardiotoxicity in Breast Cancer
Bauer, M., Todorova, V., Stone, A., Carter, W., Plotkin, M. D., Hsu, P.-C., Wei, J. Y., Su, J., & Makhoul, I. (2021) · Cancers · doi:10.3390/cancers13246291 · Cited by 17
Coagulation- and fibrinolysis-related genes for predicting survival and immunotherapy efficacy in colorectal cancer
Ma, Y., Wang, B., He, P., Qi, W., Xiang, L., Maswikiti, E. P., & Chen, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1023908 · Cited by 17
Trends in Venous Thromboembolism Readmission Rates after Ischemic Stroke and Intracerebral Hemorrhage
Shu, L., de Havenon, A., Liberman, A. L., Henninger, N., Goldstein, E., Reznik, M. E., Mahta, A., Al‐Mufti, F., Frontera, J. A., Furie, K. L., et al. (2023) · Journal of Stroke · doi:10.5853/jos.2022.02215 · Cited by 17
Insights into Cancer-Associated Thrombosis Leading Towards Ischemic Stroke
Hansda, S., & Das, H. (2025) · Biology · doi:10.3390/biology14010050 · Cited by 17
D-dimer levels as a prognostic factor for determining oncological outcomes in musculoskeletal sarcoma
Morii, T., Mochizuki, K., Tajima, T., Ichimura, S., & Satomi, K. (2011) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-12-250 · Cited by 17
Early death among head and neck cancer patients
Farnebo, L., Malila, N. K., Mäkitie, A. A., & Laurell, G. F. E. (2016) · Current Opinion in Otolaryngology & Head & Neck Surgery · doi:10.1097/moo.0000000000000236 · Cited by 17
Anticoagulation in combination with antiangiogenesis and chemotherapy for cancer patients: evidence and hypothesis
Wang, J., & Zhu, C. (2016) · OncoTargets and Therapy · doi:10.2147/ott.s103184 · Cited by 17
Timing of Prophylactic Anticoagulation and Its Effect on Thromboembolic Events After Surgery for Metastatic Tumors of the Spine
Ramos, R. D. L. G., Longo, M., Gelfand, Y. J., Echt, M., Kinon, M. D., & Yassari, R. (2018) · Spine · doi:10.1097/brs.0000000000002944 · Cited by 17
Risk of major bleeding associated with concomitant use of anticancer drugs and direct oral anticoagulant in patients with cancer and atrial fibrillation
Wang, C., Wu, V. C., Tu, H., Huang, Y., Chen, S., Chu, P., Wen, M., Huang, H., & Chang, S. (2021) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-021-02570-9 · Cited by 17
Trends in cardiovascular mortality of cancer patients in the US over two decades 1999‐2019
Kobo, O. M., Khattak, S., Lopez‐Mattei, J., Spall, H. G. C. V., Graham, M. M., Cheng, R. K.-H., Osman, M., Sun, L. Y., Ullah, W., Fischman, D. L., et al. (2021) · International Journal of Clinical Practice · doi:10.1111/ijcp.14841 · Cited by 17
Incident Cardiovascular Diseases Among Survivors of High-Risk Stage II–III Colorectal Cancer: A Cluster-Wide Cohort Study
Lee, S. F., Yip, P. L., Vellayappan, B. A., Chee, C. E., Wong, L. C., Wan, E. Y. F., Chan, E. W., Lee, C.-F., Lee, F. A.-S., & Luque-Fernández, M. Á. (2022) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2022.7042 · Cited by 17
Risk for Myocardial Infarction Following 5-Fluorouracil Treatment in Patients With Gastrointestinal Cancer
Shanmuganathan, J. W. D., Kragholm, K. H., Tayal, B., Polcwiartek, C., Poulsen, L. Ø., El‐Galaly, T. C., Fosbøl, E. L., D’Souza, M., Gislason, G., Køber, L., et al. (2021) · JACC CardioOncology · doi:10.1016/j.jaccao.2021.11.001 · Cited by 16
What Proportion of Patients With Musculoskeletal Tumors Demonstrate Thromboelastographic Markers of Hypercoagulability? A Pilot Study
Sabharwal, S., Jalloh, H., Levin, A. S., & Morris, C. D. (2022) · Clinical Orthopaedics and Related Research · doi:10.1097/corr.0000000000002314 · Cited by 16
Net Clinical Benefit of Non-vitamin K Antagonist Oral Anticoagulants for Venous Thromboembolism Prophylaxis in Patients With Cancer: A Systematic Review and Trade-Off Analysis From 9 Randomized Controlled Trials
Yan, Y., Zhang, C., Shen, L., Su, Y.-J., Liu, X., Wang, L., & Gu, Z. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00575 · Cited by 16
Efficacy and safety of primary thromboprophylaxis for the prevention of venous thromboembolism in patients with cancer and a central venous catheter: A systematic review and meta-analysis
Li, A., Brandt, W., Brown, C., Wang, T., Ikesaka, R., Delluc, A., Wells, P. S., & Carrier, M. (2021) · Thrombosis Research · doi:10.1016/j.thromres.2021.10.012 · Cited by 16
Mean platelet volume as a possible biomarker of tumor progression in rectal cancer
Włodarczyk, M., Kasprzyk, J., Sobolewska-Włodarczyk, A., Włodarczyk, J., Tchorzewski, M. T., Dziki, A. J., & Dziki, Ł. A. (2016) · Cancer Biomarkers · doi:10.3233/cbm-160657 · Cited by 15
Venous Thromboembolism Rates After Free Flap Reconstruction of the Head and Neck Region
Bengür, F. B., Saadoun, R., Moroni, E. A., Khan, N. I., Bottegal, M. T., Sridharan, S., Kubik, M. W., & Solari, M. G. (2023) · Annals of Plastic Surgery · doi:10.1097/sap.0000000000003520 · Cited by 15
Clinical outcomes and factors predicting development of venous thromboembolic complications in patients with advanced refractory cancer in a Phase I Clinic: The M. D. Anderson Cancer Center experience
Vemulapalli, S., Chintala, L., Tsimberidou, A. M., Dhillon, N., Lei, X. J., Hong, D. S., & Kurzrock, R. (2009) · American Journal of Hematology · doi:10.1002/ajh.21423 · Cited by 15
Venous Thromboembolism in the Cancer Population: Pathology, Risk, and Prevention
Hawbaker, S. (2012) · Journal of the Advanced Practitioner in Oncology · doi:10.6004/jadpro.2012.3.1.3 · Cited by 15
Increased risk for cancer after stroke at a young age: etiological relevance or incidental finding?
Tanislav, C., Adarkwah, C. C., Jakob, L., & Kostev, K. (2019) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-019-03022-x · Cited by 15

Authors: Caine, G. J., Stonelake, P. S., Lip, G. Y. H., & Kehoe, S. T.
Affiliations: Birmingham City Hospital (GB)
Birmingham Women's Hospital (GB)
ORCID: Lip, Gregory Y H
Kehoe, Sean T
Venue: Neoplasia
Publisher: Elsevier BV
Published: 2002
Volume: 4
Issue: 6
Pages: 465-473
ISSN: 1476-5586 (ISSN-L)
1522-8002
DOI: 10.1038/sj.neo.7900263
PMC: PMC1550339
OpenAlex: W2120304210
Cited by: 576
References: 125
Citations by year: 2026: 25 · 2025: 45 · 2024: 30 · 2023: 48 · 2022: 43 · 2021: 36 · 2020: 35 · 2019: 47 · 2018: 49 · 2017: 28 · 2016: 27 · 2015: 25 · 2014: 26 · 2013: 13 · 2012: 7
FWCI: 5.03
Type: journal article
Language: en
Open access: gold
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neoplasia (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Topics: Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Keywords: cancer-associated thrombosis, hypercoagulability, procoagulant factors, fibrinolysis, inflammatory cytokines, tissue factor, antithrombotic therapy, venous thromboembolism
MeSH terms: Antineoplastic Agents, Blood Coagulation, Blood Coagulation Factors, Cell Communication, Humans, Neoplasms, Cytokines, Thrombophilia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Hypercoagulable State of Malignancy: Pathogenesis and Current Debate

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks