CoChat
Sign Up
Cited by 335Coffee research and impactsNeurotransmitter Receptor Influence on BehaviorAdenosine and Purinergic Signaling

The DOI matches its Crossref record; 48 of the 50 references it cites were found in a registry or an index.

Association Between A2a Receptor Gene Polymorphisms and Caffeine-Induced Anxiety

Alsene, Karen, Deckert, Jürgen, Sand, Philipp, de Wit, Harriet·2003·Neuropsychopharmacology
DOI 10.1038/sj.npp.1300232
Open this paper in CoChat — free account

Abstract

The adenosine receptor system, which mediates the psychoactive effects of caffeine, is also thought to be involved in the regulation of anxiety. In this study, we examined the association between variations in anxiogenic responses to caffeine and polymorphisms in the A1 and A2a adenosine receptor genes. Healthy, infrequent caffeine users (N=94) recorded their subjective mood states following a 150 mg oral dose of caffeine freebase or placebo in a double-blind study. We found a significant association between self-reported anxiety after caffeine administration and two linked polymorphisms on the A2a receptor gene, the 1976C>T and 2592C>Tins polymorphisms. Individuals with the 1976T/T and the 2592Tins/Tins genotypes reported greater increases in anxiety after caffeine administration than the other genotypic groups. The study shows that an adenosine receptor gene polymorphism that has been associated with Panic Disorder is also associated with anxiogenic responses to an acute dose of caffeine.

Overview

Integrity signals

Registry

Crossref · 10.1038/sj.npp.1300232

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 50 references

Research works printed but not linked: 2

  1. American Psychiatric Association (2000). Diagnostic and Statistical Manual of Mental Disorders, 4th Edition Text Revised. American Psychiatric Association: Washington, DC.
  2. Deckert J, Kuhlenbäumer G, Weiß K, Schirmacher A, Ringelstein EB, Arolt V et al (2001). Chromosome 22q11.2 as a candidate gene locus: association of the more active COMT-allele with panic disorder. Am J Med Genet 105: 570.

Cited by

Sorted by citations

Items 301–335 of 335

Related

See all

Metadata

Authors
Alsene, K., Deckert, J., Sand, P., & de Wit, H.
Affiliations
  • University of Chicago (US)
  • University of Münster (DE)
  • University of Würzburg (DE)
ORCID
Venue
Neuropsychopharmacology
Publisher
Springer Science and Business Media LLC
Published
2003-05-14
Volume
28
Issue
9
Pages
1694-1702
ISSN
  • 0893-133X (ISSN-L)
  • 1740-634X
DOI
10.1038/sj.npp.1300232
OpenAlex
W2043153453
Cited by
334
References
50
Citations by year
2026: 12 · 2025: 6 · 2024: 10 · 2023: 12 · 2022: 8 · 2021: 13 · 2020: 13 · 2019: 18 · 2018: 18 · 2017: 16 · 2016: 19 · 2015: 9 · 2014: 21 · 2013: 11 · 2012: 21
FWCI
6.86
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Drug Abuse (DA 02812, R01DA002812)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
Keywords
caffeine, anxiety, adenosine A2A receptor, adenosine A1 receptor, genetic polymorphism, subjective mood, panic disorder, genetic susceptibility
MeSH terms
Adult, Central Nervous System Stimulants, Animals, Anxiety, Caffeine, Cysteine, Double-Blind Method, Female, Genotype, Humans, Hybrid Vigor, Male, Neuropsychological Tests, Pain Measurement, Personality Inventory, Polymorphism, Genetic, Threonine, Time Factors, Genetic Variation, Sequence Analysis, DNA, Receptors, Purinergic P1, Tandem Repeat Sequences, Receptor, Adenosine A2A

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review