Cited by 335Coffee research and impactsNeurotransmitter Receptor Influence on BehaviorAdenosine and Purinergic Signaling

The DOI matches its Crossref record; 48 of the 50 references it cites were found in a registry or an index.

Association Between A2a Receptor Gene Polymorphisms and Caffeine-Induced Anxiety

Alsene, Karen, Deckert, Jürgen, Sand, Philipp, de Wit, Harriet·2003·Neuropsychopharmacology

DOI 10.1038/sj.npp.1300232

Open this paper in CoChat — free account

Abstract

The adenosine receptor system, which mediates the psychoactive effects of caffeine, is also thought to be involved in the regulation of anxiety. In this study, we examined the association between variations in anxiogenic responses to caffeine and polymorphisms in the A1 and A2a adenosine receptor genes. Healthy, infrequent caffeine users (N=94) recorded their subjective mood states following a 150 mg oral dose of caffeine freebase or placebo in a double-blind study. We found a significant association between self-reported anxiety after caffeine administration and two linked polymorphisms on the A2a receptor gene, the 1976C>T and 2592C>Tins polymorphisms. Individuals with the 1976T/T and the 2592Tins/Tins genotypes reported greater increases in anxiety after caffeine administration than the other genotypic groups. The study shows that an adenosine receptor gene polymorphism that has been associated with Panic Disorder is also associated with anxiogenic responses to an acute dose of caffeine.

Integrity signals

Registry

Crossref · 10.1038/sj.npp.1300232

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Profile of mood states
McNair, D. M. (1992) · Medical Entomology and Zoology · Cited by 2,527
Mutation nomenclature extensions and suggestions to describe complex mutations: A discussion
den Dunnen, J. T., & Antonarakis, S. E. (2000) · Human Mutation · doi:10.1002/(sici)1098-1004(200001)15:1 · Cited by 1,757
The Measurement and Appraisal of Adult Intelligence (4th ed.).
Wechsler, D. (1958) · doi:10.1037/11167-000 · Cited by 1,683
A Shortened Version of the Profile of Mood States
Shacham, S. (1983) · Journal of Personality Assessment · doi:10.1207/s15327752jpa4703_14 · Cited by 1,231 · cited 7×
“Genetic variation in caffeine-induced anxiety K Alsene et al segment overlap at a pairwise score cutoff of 60.”
BackgroundInfluential
A workbench for multiple alignment construction and analysis
Schuler, G. D., Altschul, S. F., & Lipman, D. J. (1991) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.340090304 · Cited by 985
Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man
Martin, W. R., Sloan, J. W., SAPIRA, J. D., & Jasinski, D. R. (1971) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1971122part1245 · Cited by 945
Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor
Ledent, C. A., Vaugeois, J., Schiffmann, S. N., Pedrazzini, T., Yacoubi, M. E., Vanderhaeghen, J. J., Costentin, J., Heath, J. K., Vassart, G., & Parmentier, M. (1997) · Nature · doi:10.1038/41771 · Cited by 918
Structure and function of adenosine receptors and their genes
Fredholm, B. B., Arslan, G., Halldner, L., Kull, B., Schulte, G., & Wasserman, W. W. (2000) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002100000313 · Cited by 583
Research advances in alcohol and drug problems
Stephenson, J. P. (1975) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(75)90081-1 · Cited by 575
Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A 1 receptor
Johansson, B. A., Halldner, L., Dunwiddie, T. V., Masino, S. A., Poelchen, W., Giménez‐Llort, L., Escorihuela, R. M., Fernández‐Teruel, A., Wiesenfeld‐Hallin, Z., Xu, X.-J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161292398 · Cited by 506

Show all 50 references

Research works printed but not linked: 2

American Psychiatric Association (2000). Diagnostic and Statistical Manual of Mental Disorders, 4th Edition Text Revised. American Psychiatric Association: Washington, DC.
Deckert J, Kuhlenbäumer G, Weiß K, Schirmacher A, Ringelstein EB, Arolt V et al (2001). Chromosome 22q11.2 as a candidate gene locus: association of the more active COMT-allele with panic disorder. Am J Med Genet 105: 570.

Sorted by citations

Items 101–200 of 335

ADORA2A Gene Variation, Caffeine, and Emotional Processing: A Multi-level Interaction on Startle Reflex
Domschke, K., Gajewska, A., Winter, B., Herrmann, M. J., Warrings, B., Mühlberger, A., Wosnitza, K., Glotzbach, E., Conzelmann, A., Dlugos, A. M., et al. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.253 · Cited by 64
Human behavioral pharmacology, past, present, and future: symposium presented at the 50th annual meeting of the Behavioral Pharmacology Society
Comer, S. D., Bickel, W. K., Yi, R., de Wit, H., Higgins, S. T., Wenger, G. R., Johanson, C., & Kreek, M. J. (2010) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32833bb9f8 · Cited by 60
Association study of A2a adenosine receptor genetic polymorphism in panic disorder
Lam, P., Hong, C., & Tsai, S. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.12.012 · Cited by 60
How to Keep the Brain Awake? The Complex Molecular Pharmacogenetics of Wake Promotion
Hasan, S., Pradervand, S., Ahnaou, A., Drinkenburg, W. H. I. M., Tafti, M., & Franken, P. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.3 · Cited by 58
Performance effects and metabolic consequences of caffeine and caffeinated energy drink consumption on glucose disposal
Shearer, J., & Graham, T. E. (2014) · Nutrition Reviews · doi:10.1111/nure.12124 · Cited by 64
Consumption of dietary caffeine and coffee in physically active populations: physiological interactions
Tunnicliffe, J. M., Erdman, K. A., Reimer, R. A., Lun, V. M. Y., & Shearer, J. (2008) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h08-124 · Cited by 61
P50 sensory gating in panic disorder
Ghisolfi, E. S., Heldt, E., Zanardo, A. P., Júnior, I. M. S., Prokopiuk, A. D. S., Becker, J., Cordioli, A. V., Manfro, G. G., & Lara, D. R. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.02.006 · Cited by 56
The CYP1A2 -163C>A polymorphism does not alter the effects of caffeine on basketball performance
Puente, C., Abián‐Vicén, J., Coso, J. D., Lara, B., & Salinero, J. J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195943 · Cited by 60
Caffeine, mood and mental performance in everyday life
Rogers, P. J. (2007) · Nutrition Bulletin · doi:10.1111/j.1467-3010.2007.00607.x · Cited by 58
Astrocytic adenosine: from synapses to psychiatric disorders
Hines, D. J., & Haydon, P. G. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0594 · Cited by 58
Association of the COMT Met158 allele with trait impulsivity in healthy young adults
Soeiro‐de‐Souza, M. G., Stanford, M. S., Bio, D. S., Machado‐Vieira, R., & Moreno, R. A. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1336 · Cited by 53
Genetic basis of apnoea of prematurity and caffeine treatment response: role of adenosine receptor polymorphisms
Kumral, A., Tüzün, F., Yeşilırmak, D. C., Duman, N., & Özkan, H. (2012) · Acta Paediatrica · doi:10.1111/j.1651-2227.2012.02664.x · Cited by 52
Impact of genetic variations in ADORA2A gene on depression and symptoms: a cross-sectional population-based study
Oliveira, S. M., Ardais, A. P., Bastos, C. R., Gazal, M., Jansen, K., Souza, L. D. D. M., da Silva, R. A., Kaster, M. P., Lara, D. R., & Ghisleni, G. (2018) · Purinergic Signalling · doi:10.1007/s11302-018-9635-2 · Cited by 54
Interindividual variation in anxiety response to amphetamine: Possible role for adenosine A2A receptor gene variants
Hohoff, C., McDonald, J. M., Baune, B. T., Cook, E. H., Deckert, J., & de Wit, H. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30228 · Cited by 50
Novel Players in the Aging Synapse: Impact on Cognition
Temido‐Ferreira, M., Coelho, J. E., Pousinha, P. A., & Lopes, L. V. (2019) · Journal of Caffeine and Adenosine Research · doi:10.1089/caff.2019.0013 · Cited by 57
The Taste of Caffeine
Poole, R. L., & Tordoff, M. G. (2017) · Journal of Caffeine Research · doi:10.1089/jcr.2016.0030 · Cited by 54
Gene-Environment Interaction in Parkinson's Disease: Coffee, ADORA2A, and CYP1A2
Chuang, Y., Lill, C. M., Lee, P., Hansen, J., Lassen, C. F., Bertram, L., Greene, N., Sinsheimer, J. S., & Ritz, B. R. (2016) · Neuroepidemiology · doi:10.1159/000450855 · Cited by 49
The Acute Effect of Various Doses of Caffeine on Power Output and Velocity during the Bench Press Exercise among Athletes Habitually Using Caffeine
Wilk, M., Filip-Stachnik, A., Krzysztofik, M., Maszczyk, A., & Zając, A. (2019) · Nutrients · doi:10.3390/nu11071465 · Cited by 53
A pragmatic, unblinded randomised controlled trial comparing an occupational therapy-led lifestyle approach and routine GP care for panic disorder treatment in primary care
Lambert, R. A., Harvey, I. M., & Poland, F. M. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.08.026 · Cited by 48
Caffeine Intake and Mental Health in College Students
Bertasi, R. A. O., Humeda, Y., Bertasi, T. G. O., Zins, Z., Kimsey, J., & Pujalte, G. G. A. (2021) · Cureus · doi:10.7759/cureus.14313 · Cited by 58
Caffeine and cognitive performance: Persistent methodological challenges in caffeine research
James, J. E. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.05.019 · Cited by 47
Acute effects of brewed cocoa consumption on attention, motivation to perform cognitive work and feelings of anxiety, energy and fatigue: a randomized, placebo-controlled crossover experiment
Boolani, A., Lindheimer, J. B., Loy, B. D., Crozier, S. J., & O’Connor, P. J. (2017) · BMC Nutrition · doi:10.1186/s40795-016-0117-z · Cited by 46
The Role of Adenosine Tone and Adenosine Receptors in Huntington's Disease
Blum, D. L., Chern, Y., Domenici, M. R., Buée, L., Lin, C., Rea, W. P., Ferré, S., & Popoli, P. (2018) · Journal of Caffeine and Adenosine Research · doi:10.1089/caff.2018.0006 · Cited by 48
Orthogonal Activation of the Reengineered A3Adenosine Receptor (Neoceptor) Using Tailored Nucleoside Agonists
Gao, Z., Duong, H. T., Sonina, T., Kim, S., Rompaey, P. V., Calenbergh, S. V., Mamedova, L., Kim, H. O., Kim, M. J., Kim, A. Y., et al. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm050968b · Cited by 45
Affective response to physical activity as an intermediate phenotype
Lee, H., Emerson, J. A., Bohlen, L. C., & Williams, D. M. (2018) · Social Science & Medicine · doi:10.1016/j.socscimed.2018.11.018 · Cited by 45
Cumulative neurobehavioral and physiological effects of chronic caffeine intake: individual differences and implications for the use of caffeinated energy products
Spaeth, A. M., Goel, N., & Dinges, D. F. (2014) · Nutrition Reviews · doi:10.1111/nure.12151 · Cited by 46
Neurobehavioral hazard identification and characterization for caffeine
Turnbull, D., Rodricks, J. V., & Mariano, G. (2015) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2015.12.002 · Cited by 45
Association studies of the adenosine A2a receptor (1976T > C) genetic polymorphism in Parkinson’s disease and schizophrenia
Hong, C.-J., Liu, H.-C., Liu, T.-Y., Liao, D., & Tsai, S. (2005) · Journal of Neural Transmission · doi:10.1007/s00702-005-0286-4 · Cited by 41
Coffee, caffeine‐related genes, and Parkinson's disease: A case–control study
Facheris, M., Schneider, N. K., Lesnick, T. G., de Andrade, M., Cunningham, J. M., Rocca, W. A., & Maraganore, D. M. (2008) · Movement Disorders · doi:10.1002/mds.22247 · Cited by 41
The Development of a Personalised Training Framework: Implementation of Emerging Technologies for Performance
Pickering, C., & Kiely, J. (2019) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk4020025 · Cited by 48
Are low doses of caffeine as ergogenic as higher doses? A critical review highlighting the need for comparison with current best practice in caffeine research
Pickering, C., & Kiely, J. (2019) · Nutrition · doi:10.1016/j.nut.2019.06.016 · Cited by 40
An Adenosine A 2A Receptor Gene Haplotype is Associated with Migraine With Aura
Hohoff, C., Marziniak, M., Lesch, K., Deckert, J., Sommer, C., & Mößner, R. (2007) · Cephalalgia · doi:10.1111/j.1468-2982.2007.01254.x · Cited by 39
Caffeine challenge test and panic disorder: a systematic literature review
Vilarim, M. M., Araújo, D. M. R., & Nardi, A. E. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.83 · Cited by 39
Brain pH Response to Hyperventilation in Panic Disorder: Preliminary Evidence for Altered Acid-Base Regulation
Friedman, S. D., Mathis, C. M., Hayes, C., Renshaw, P. F., & Dager, S. R. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.4.710 · Cited by 39
ADA*2 Allele of the Adenosine Deaminase Gene May Protect against Coronary Artery Disease
Safranow, K., Rzeuski, R., Bińczak‐Kuleta, A., Czyżycka, E., Skowronek, J., Jakubowska, K., Wojtarowicz, A., Łoniewska, B., Ciechanowicz, A., Kornacewicz‐Jach, Z., et al. (2007) · Cardiology · doi:10.1159/000099096 · Cited by 38
Genetic Polymorphisms in ADORA2A and CYP1A2 Influence Caffeine’s Effect on Postprandial Glycaemia
Banks, N. F., Tomko, P. M., Colquhoun, R. J., Muddle, T. W. D., Emerson, S. R., & Jenkins, N. D. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-46931-0 · Cited by 44
Genetic Factors in Anxiety Disorders
Domschke, K., & Maron, E. (2013) · Modern trends in psychiatry · doi:10.1159/000351932 · Cited by 42
A caffeine challenge test in panic disorder patients, their healthy first-degree relatives, and healthy controls
Nardi, A. E., Valença, A. M., Nascimento, I., Freire, R. C. R., Veras, A. B., Neto, V. L. D. M., Lopes, F. L., King, A. L. S., Soares‐Filho, G. L., Mezzasalma, M. A., et al. (2007) · Depression and Anxiety · doi:10.1002/da.20354 · Cited by 38
Genetics of caffeine and brain-related outcomes – a systematic review of observational studies and randomized trials
Kapellou, A., King, A., Graham, C., Pilić, L., & Mavrommatis, Y. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuad029 · Cited by 41
Linkage and association studies of anxiety disorders
Hamilton, S. P. (2009) · Depression and Anxiety · doi:10.1002/da.20615 · Cited by 35
Effects of ADORA2A gene variation and caffeine on prepulse inhibition: A multi-level risk model of anxiety
Gajewska, A., Blumenthal, T. D., Winter, B., Herrmann, M. J., Conzelmann, A., Mühlberger, A., Warrings, B., Jacob, C., Arolt, V., Reif, A., et al. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.08.008 · Cited by 36
Association of Adenosine Receptor Gene Polymorphisms and In Vivo Adenosine A1 Receptor Binding in The Human Brain
Hohoff, C., Garibotto, V., Elmenhorst, D., Baffa, A., Kroll, T., Hoffmann, A., Schwarte, K., Zhang, W., Arolt, V., Deckert, J., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.150 · Cited by 36
Human in vivo research on the vascular effects of adenosine
Riksen, N. P., Rongen, G. A. P. J. M., Yellon, D. M., & Smits, P. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.01.053 · Cited by 34
Genetic determinants of cognitive responses to caffeine drinking identified from a double-blind, randomized, controlled trial
Renda, G., Committeri, G., Zimarino, M., Nicola, M. D., Tatasciore, A., Ruggieri, B., Ambrosini, E., Viola, V., Antonucci, I., Stuppia, L., et al. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.03.001 · Cited by 39
A study of the possible association between adenosine A2A receptor gene polymorphisms and attention‐deficit hyperactivity disorder traits
Molero, Y., Gumpert, C., Serlachius, E., Lichtenstein, P., Walum, H., Johansson, D., Anckarsäter, H., Westberg, L., Eriksson, E., & Halldner, L. (2013) · Genes, Brain and Behavior · doi:10.1111/gbb.12015 · Cited by 34
Genetic determinants of liking and intake of coffee and other bitter foods and beverages
Cornelis, M. C., & van Dam, R. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-03153-7 · Cited by 34
The effect of caffeine and stress on auditory hallucinations in a non-clinical sample
Crowe, S. F., Barot, J., Caldow, S., D’Aspromonte, J., Dell’Orso, J., Clemente, A. D., Hanson, K., Kellett, M., Makhlota, S., McIvor, B., et al. (2011) · Personality and Individual Differences · doi:10.1016/j.paid.2010.12.007 · Cited by 34
Behavioral Genetics of Affective and Anxiety Disorders
Domschke, K., & Reif, A. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2011_185 · Cited by 36
Social environment modulates anxiogenic effects of caffeine in zebrafish
Neri, D., Ruberto, T., Mwaffo, V., Bartolini, T., & Porfiri, M. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000415 · Cited by 36
Adenosine A2A Receptors as Biomarkers of Brain Diseases
Moreira-de-Sá, A., Lourenço, V. S., Canas, P. M., & Cunha, R. A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.702581 · Cited by 33
Caffeine modulates P50 auditory sensory gating in healthy subjects
Ghisolfi, E. S., Schuch, A., Júnior, I. M. S., Luersen, G. F., Martins, F. F., Ramos, F. L. P., Becker, J., & Lara, D. R. (2005) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2005.09.001 · Cited by 33
The A2a adenosine receptor modulates the reinforcement efficacy and neurotoxicity of MDMA
Ruiz‐Medina, J., Ledent, C. A., Carretón, O., & Valverde, O. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110389210 · Cited by 33
Adenosine role in brain functions: Pathophysiological influence on Parkinson's disease and other brain disorders
Soliman, A. M., Fathalla, A. M., & Moustafa, A. A. (2018) · Pharmacological Reports · doi:10.1016/j.pharep.2018.02.003 · Cited by 33
Caffeine intake induces an alteration in human neutrophil A2A adenosine receptors
Varani, K., Portaluppi, F., Gessi, S., Merighi, S., Vincenzi, F., Cattabriga, E., Dalpiaz, A., Bortolotti, F., Belardinelli, L., & Borea, P. A. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5312-z · Cited by 33
Sympathetic activity relates to adenosine A2A receptor gene variation in blood-injury phobia
Hohoff, C., Domschke, K., Schwarte, K., Spellmeyer, G., Vögele, C., Hetzel, G., Deckert, J., & Gerlach, A. L. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-008-0089-5 · Cited by 35
Serotonin Transporter Genotype and Acute Subjective Response to Amphetamine
Lott, D. C., Kim, S., Cook, E. H., & de Wit, H. (2006) · American Journal on Addictions · doi:10.1080/10550490600859868 · Cited by 32
Unraveling the genetic underpinnings of sleep deprivation-induced impairments in human cognition
Satterfield, B. C., Stucky, B., Landolt, H., & Dongen, H. P. A. V. (2019) · Progress in brain research · doi:10.1016/bs.pbr.2019.03.026 · Cited by 34
ADORA2A variation and adenosine A1 receptor availability in the human brain with a focus on anxiety-related brain regions: modulation by ADORA1 variation
Hohoff, C., Kroll, T., Zhao, B., Kerkenberg, N., Lang, I., Schwarte, K., Elmenhorst, D., Elmenhorst, E., Aeschbach, D., Zhang, W., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01085-w · Cited by 29
The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population
Kobayashi, H., Ujike, H., Iwata, N., Inada, T., Yamada, M., Sekine, Y., Uchimura, N., Iyo, M., Ozaki, N., Itokawa, M., et al. (2010) · Behavioral and Brain Functions · doi:10.1186/1744-9081-6-50 · Cited by 30
ADORA2A rs5760423 and CYP1A2 rs762551 Polymorphisms as Risk Factors for Parkinson’s Disease
Siokas, V., Aloizou, A.-M., Tsouris, Z., Liampas, I., Liakos, P., Calina, D., Docea, A. O., Tsatsakis, A., Bogdanos, D. P., Hadjigeorgiou, G. M., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030381 · Cited by 29
Striatopallidal adenosine A2A receptor modulation of goal-directed behavior: Homeostatic control with cognitive flexibility
Chen, J., Choi, D., & Cunha, R. A. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109421 · Cited by 29
Protective effects of the novel adenosine derivative WS0701 in a mouse model of posttraumatic stress disorder
Huang, Z., Liu, R., Bai, X., Zhao, G., Song, J.-K., Wu, S., & Du, G. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.143 · Cited by 29
Coffee Intake
Cornelis, M. C. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-398397-8.00012-5 · Cited by 27
Theacrine, a Potent Antidepressant Purine Alkaloid from a Special Chinese Tea, Promotes Adult Hippocampal Neurogenesis in Stressed Mice
Ouyang, S., Zhai, Y.-J., Wu, Y., Xie, G., Wang, G.-E., Mao, Z., Hui-hua, H., Luo, X.-H., Sun, W., Liang, L., et al. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c01514 · Cited by 28
The Effect of Coffee and Caffeine on Mood, Sleep, and Health-Related Quality of Life
Distelberg, B. J., Staack, A., Elsen, K. D., & Sabaté, J. (2017) · Journal of Caffeine Research · doi:10.1089/jcr.2016.0023 · Cited by 31
Synergistic effects between ADORA2A and DRD2 genes on anxiety disorders in children with ADHD
Fraporti, T. T., Contini, V., Tovo‐Rodrigues, L., Recamonde‐Mendoza, M., Rovaris, D. L., Rohde, L. A., Hutz, M. H., Salatino‐Oliveira, A., & Genro, J. P. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.03.021 · Cited by 31
The Genetic Basis of Panic Disorder
Na, H.-R., Kang, E.-H., Lee, J.-H., & Yu, B.-H. (2011) · Journal of Korean Medical Science · doi:10.3346/jkms.2011.26.6.701 · Cited by 27
The association between caffeine consumption and objective sleep variables is dependent on ADORA2A c.1083T>C genotypes
Nunes, R. A., Mazzotti, D. R., Hirotsu, C., Andersen, M. L., Tufik, S. B., & Bittencourt, L. (2016) · Sleep Medicine · doi:10.1016/j.sleep.2016.06.038 · Cited by 27
Polymorphisms in Adenosine Receptor Genes are Associated with Infarct Size in Patients with Ischemic Cardiomyopathy
Tang, Z., Diamond, M. A., Chen, J.-M., Holly, T. A., Bonow, R. O., Dasgupta, A., Hyslop, T., Purzycki, A., Wagner, J. L., McNamara, D. M., et al. (2007) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100331 · Cited by 27
Arousal and the attentional network in panic disorder
Geiger, M. J., Neufang, S., Stein, D. J., & Domschke, K. (2014) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2436 · Cited by 27
Caffeine consumption during pregnancy and ADHD at the age of 11 years: a birth cohort study
Del-Ponte, B., Santos, I., Tovo-Rodrigues, L., Anselmi, L., Munhoz, T. N., & Matijasevich, A. (2016) · BMJ Open · doi:10.1136/bmjopen-2016-012749 · Cited by 23
Affect-Modulated Startle: Interactive Influence of Catechol-O-Methyltransferase Val158Met Genotype and Childhood Trauma
Klauke, B., Winter, B., Gajewska, A., Zwanzger, P., Reif, A., Herrmann, M. J., Dlugos, A. M., Warrings, B., Jacob, C., Mühlberger, A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039709 · Cited by 26
Methodological and metabolic considerations in the study of caffeine-containing energy drinks
Shearer, J. (2014) · Nutrition Reviews · doi:10.1111/nure.12131 · Cited by 26
Modification of caffeine effects on the affect-modulated startle by neuropeptide S receptor gene variation
Domschke, K., Klauke, B., Winter, B., Gajewska, A., Herrmann, M. J., Warrings, B., Mühlberger, A., Wosnitza, K., Dlugos, A. M., Naunin, S., et al. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2678-0 · Cited by 25
Caffeine consumption during early pregnancy impairs oviductal embryo transport, embryonic development and uterine receptivity in mice†
Qian, J., Zhang, Y., Qu, Y., Zhang, L., Shi, J., Zhang, X., Liu, S., Kim, B. H., Hwang, S. J., Zhou, T., et al. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy155 · Cited by 26
Adenosine A2A Receptors in the Rat Prelimbic Medial Prefrontal Cortex Control Delay-Based Cost-Benefit Decision Making
Leffa, D. T., Pandolfo, P., Gonçalves, N., Machado, N. J., de Souza, C. M., Real, J. I., Silva, A. C., Silva, H. B. L., Köfalvi, A., Cunha, R. A., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00475 · Cited by 25
Effect of Coffee in Lipopolysaccharide-Induced Indoleamine 2,3-Dioxygenase Activation and Depressive-like Behavior in Mice
Hall, S., Arora, D. S., Anoopkumar‐Dukie, S., & Grant, G. D. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b03568 · Cited by 23
The complexity of coffee and its impact on metabolism
Zhang, H., & Speakman, J. R. (2024) · Journal of Endocrinology · doi:10.1530/joe-24-0075 · Cited by 23
Treadmill running frequency on anxiety and hippocampal adenosine receptors density in adult and middle-aged rats
da Costa, M. S., Ardais, A. P., Fioreze, G. T., Mioranzza, S., Botton, P. H. S., Portela, L. V., Souza, D. O., & Porciúncula, L. O. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.10.015 · Cited by 22
Caffeine Increases Tear Volume Depending on Polymorphisms within the Adenosine A2a Receptor Gene and Cytochrome P450 1A2
Arita, R., Yanagi, Y., Honda, N., Maeda, S., Maeda, K., Kuchiba, A., Yamaguchi, T., Yanagihara, Y., Suzuki, H., & Amano, S. (2012) · Ophthalmology · doi:10.1016/j.ophtha.2011.11.033 · Cited by 22
Moving towards Specific Nutrigenetic Recommendation Algorithms: Caffeine, Genetic Variation and Cardiovascular Risk
Caterina, R. D., & El‐Sohemy, A. (2016) · Lifestyle Genomics · doi:10.1159/000446801 · Cited by 22
Influence of genetic polymorphisms and habitual caffeine intake on the changes in blood pressure, pulse rate, and calculation speed after caffeine intake: A prospective, double blind, randomized trial in healthy volunteers
Yoshihara, T., Zaitsu, M., Shiraishi, F., Arima, H., Takahashi‐Yanaga, F., Arioka, M., Kajioka, S., & Sasaguri, T. (2019) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2019.01.006 · Cited by 21
How does caffeine influence memory? Drug, experimental, and demographic factors
Zhang, R.-C., & Madan, C. R. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.033 · Cited by 23
Caffeine, mood and cognition
Rogers, P. J., & Smith, J. E. (2011) · Elsevier eBooks · doi:10.1533/9780857092922.2.251 · Cited by 22
Synthesis and in vivo Evaluation of Fluorine‐18 and Iodine‐123 Pyrazolo[4,3‐e]‐1,2,4‐triazolo[1,5‐c]pyrimidine Derivatives as PET and SPECT Radiotracers for Mapping A2A Receptors
Vala, C., Morley, T. J., Zhang, X., Papin, C., Tavares, A., Lee, H. S., Constantinescu, C. C., Barret, O., Carroll, V. M., Baldwin, R. M., et al. (2016) · ChemMedChem · doi:10.1002/cmdc.201600219 · Cited by 21
Methylxanthines and Sleep
Porkka‐Heiskanen, T. (2010) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-13443-2_12 · Cited by 21
Preference for caffeine appears earlier in non-anxious than in anxious mice
Vautrin, S., Pelloux, Y., & Costentin, J. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.05.071 · Cited by 21
Augmented hyperaemia and reduced tissue injury in response to ischaemia in subjects with the 34C > T variant of the AMPD1 gene
Riksen, N. P., Franke, B., Oyen, W. J. G., Borm, G. F., van den Broek, P., Boerman, O. C., Smits, P., & Rongen, G. A. P. J. M. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm032 · Cited by 20
ADORA2A genotype modulates interoceptive and exteroceptive processing in a fronto-insular network
Geiger, M. J., Domschke, K., Homola, G. A., Schulz, S. M., Nowak, J., Akhrif, A., Pauli, P., Deckert, J., & Neufang, S. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.05.007 · Cited by 22
Differential effects of ADORA2A gene variations in pre-attentive visual sensory memory subprocesses
Beste, C., Stock, A., Vanessa Ness, A., Epplen, J. T., & Arning, L. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.12.004 · Cited by 20
Caffeine challenge and breath-holding duration in patients with panic disorder
Masdrakis, V. G., Markianos, M., Vaidakis, N., Papakostas, Y. G., & Oulis, P. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.10.002 · Cited by 20
Caffeine intake in pregnancy: relationship between internal intake and effect on birth weight
Partosch, F., Mielke, H., Stahlmann, R., & Gundert-Remy, U. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2015.11.005 · Cited by 19
Categorical complexities of Plasmodium falciparum malaria in individuals is associated with genetic variations in ADORA2A and GRK5 genes
Gupta, H., Jain, A., Saadi, A. V., Vasudevan, T. G., Hande, M., D’Souza, S. C., Ghosh, S. K., Umakanth, S., & Satyamoorthy, K. (2015) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2015.06.010 · Cited by 19
Cost-effectiveness analysis of an occupational therapy-led lifestyle approach and routine general practitioner’s care for panic disorder
Lambert, R. A., Lorgelly, P. K., Harvey, I. M., & Poland, F. M. (2009) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-009-0114-5 · Cited by 19
Panic disorder
Hoppe, L. J., Ipser, J., Gorman, J. M., & Stein, D. J. (2012) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52002-9.00020-6 · Cited by 19
Impact of adenosine A2a receptor polymorphism rs5751876 on platelet reactivity in ticagrelor treated patients
Nardin, M., Verdoia, M., Pergolini, P., Rolla, R., Barbieri, L., Marino, P. N., Bellomo, G., Kedhi, E., Suryapranata, H., Carriero, A., et al. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2017.12.035 · Cited by 19
Arterial Pressure and Heart Rate Increase during REM Sleep in Adenosine A2A-Receptor Knockout Mice, but not in Wild-Type Mice
Sakata, M., Séi, H., Eguchi, N., Morita, Y., & Urade, Y. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300727 · Cited by 17
Gene-Coffee Interactions and Health
Cornelis, M. C. (2014) · Current Nutrition Reports · doi:10.1007/s13668-014-0087-1 · Cited by 17
Association between ADORA2A gene polymorphisms and schizophrenia in the North Chinese Han population
Miao, J., Liu, L., Yan, C., Zhu, X., Fan, M., Yu, P., Ji, K., Huang, Y., Wang, Y., & Zhu, G. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s205014 · Cited by 17
The 1976C>T polymorphism in the adenosine A2A receptor gene does not affect the vasodilator response to adenosine in humans in vivo
Riksen, N. P., Franke, B., van den Broek, P., Smits, P., & Rongen, G. A. P. J. M. (2007) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e32803fb78f · Cited by 16

Authors: Alsene, K., Deckert, J., Sand, P., & de Wit, H.
Affiliations: University of Chicago (US)
University of Münster (DE)
University of Würzburg (DE)
ORCID: Deckert, Jürgen
Sand, Philipp
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2003-05-14
Volume: 28
Issue: 9
Pages: 1694-1702
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/sj.npp.1300232
OpenAlex: W2043153453
Cited by: 334
References: 50
Citations by year: 2026: 12 · 2025: 6 · 2024: 10 · 2023: 12 · 2022: 8 · 2021: 13 · 2020: 13 · 2019: 18 · 2018: 18 · 2017: 16 · 2016: 19 · 2015: 9 · 2014: 21 · 2013: 11 · 2012: 21
FWCI: 6.86
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Drug Abuse (DA 02812, R01DA002812)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
Keywords: caffeine, anxiety, adenosine A2A receptor, adenosine A1 receptor, genetic polymorphism, subjective mood, panic disorder, genetic susceptibility
MeSH terms: Adult, Central Nervous System Stimulants, Animals, Anxiety, Caffeine, Cysteine, Double-Blind Method, Female, Genotype, Humans, Hybrid Vigor, Male, Neuropsychological Tests, Pain Measurement, Personality Inventory, Polymorphism, Genetic, Threonine, Time Factors, Genetic Variation, Sequence Analysis, DNA, Receptors, Purinergic P1, Tandem Repeat Sequences, Receptor, Adenosine A2A

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Association Between A2a Receptor Gene Polymorphisms and Caffeine-Induced Anxiety

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks