The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Impoverished Rearing Environment Alters Metabotropic Glutamate Receptor Expression and Function in the Prefrontal Cortex
Abstract
Rearing rats in impoverished (IC) and enriched (EC) environmental conditions alters synaptic plasticity and cognitive processes. Metabotropic glutamate receptors (mGluRs) are known to play a key role in synaptic and behavioral plasticity. In the present study, the effect of rearing conditions on the expression of mGluR proteins in the prefrontal cortex (PFC) was assessed by immunoblotting. A significant difference in the content of prefrontal mGluR1 and mGluR5 (ie group I) and mGluR2/3 (ie group II) was observed between IC and EC rats. To functionally characterize this difference, in vivo microdialysis was used to verify differences in mGluR regulation of extracellular glutamate in the PFC. The results indicate that the capacity of group I and II mGluRs to elevate extracellular glutamate levels was significantly blunted in the PFC of IC rats compared to either EC subjects, or rats reared in normal environmental conditions (ie NIH standards). Group II mGluR receptors regulate performance in a forced T-maze spatial memory task that involves the PFC, and IC rats demonstrated deficits in this task relative to EC rats. These data suggest that reduced mGluR transmission in the PFC produced by impoverished, relative to enriched, rearing environments may contribute to cognitive deficits.
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“In general, factors that lead to enhanced excitation can cause alterations in mGluR2 transmission and cause cognitive deficits (Melendez et al. 2004; Pozzi et al. 2011).”
From Short- and Long-Term Consequences of Nicotine Exposure during Adolescence for Prefrontal Cortex Neuronal Network Function (2012) · cites this paper as Melendez et al. 2004
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From Phenomenology to Strong Biologism and Epigenetics in Psychiatry
THURBER, S. D., & Sheehan, W. (2016) · Springer eBooks · doi:10.1007/978-1-4939-2528-5_26
(2022) · Revista Española de Drogodependencias · doi:10.54108/10010
Alaiz-Noya, M., Miozzo, F., Fuentes-Ramos, M., Machnicka, M. A., Kurowska, M., Herrera, M. L., del Blanco, B., Niñerola, S., Bustos-Martínez, I., Wilczyński, B., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.11.637399
Bouamrane, L. (2015) · theses.fr (ABES) · doi:10.70675/00597159za953z4221z95b8z57a6c1d48c8e
Metadata
- Authors
- Melendez, R. I., Lee Gregory, M., Bardo, M. T., & Kalivas, P. W.
- Affiliations
- University of Kentucky (US)
- Medical University of South Carolina (US)
- Corresponding author
- Kalivas, Peter W
- Venue
- Neuropsychopharmacology
- Published
- 2004-06-09
- Volume
- 29
- Issue
- 11
- Pages
- 1980-1987
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2332377175
- Cited by
- 104
- References
- 40
- Citations by year
- 2025: 2 · 2024: 2 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 9 · 2015: 10 · 2014: 7 · 2013: 4 · 2012: 6
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5f30mh070194-02)
- National Institute of Mental Health (R01MH040817, MH070194, MH-40817)
- National Institute on Drug Abuse (DA07288)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- environmental enrichment, metabotropic glutamate receptors, prefrontal cortex, mGluR1, mGluR5, mGluR2/3, extracellular glutamate, synaptic plasticity, spatial memory, cognitive impairment
- MeSH terms
- Animals, Environment, Gene Expression Regulation, Male, Social Isolation, Rats, Sprague-Dawley, Prefrontal Cortex, Receptors, Metabotropic Glutamate, Rats
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