CoChat
Sign Up
Cited by 137Eating Disorders and BehaviorsNeurotransmitter Receptor Influence on BehaviorGenetic Associations and Epidemiology

The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.

Association of Multiple DRD2 Polymorphisms with Anorexia Nervosa

Open access
Bergen, Andrew W, Yeager, Meredith, Welch, Robert A, Haque, Kashif, Ganjei, J Kelly, van den Bree, Marianne B M, Mazzanti, Chiara, Nardi, Irma, Fichter, Manfred M, Halmi, Katherine A, Kaplan, Allan S, Strober, Michael, Treasure, Janet, Woodside, D Blake, Bulik, Cynthia M, Bacanu, Silviu-Alin, Devlin, Bernie, Berrettini, Wade H, Goldman, David, Kaye, Walter H·2005·Neuropsychopharmacology
DOI 10.1038/sj.npp.1300719
Open this paper in CoChat — free accountOpen PDF

Abstract

To investigate whether the dopaminergic system plays a role in the etiology of anorexia nervosa (AN) via the dopamine D2 receptor, we investigated association and transmission disequilibrium at seven single-nucleotide polymorphisms (SNPs) spanning about 75 kbp of the gene DRD2. We studied 191 probands with a DSM-IV diagnosis of AN, 457 parents and affected relatives with a DSM-IV eating disorder diagnosis, and 98 unrelated, female, normal weight controls. The -141 C/- insertion/deletion (-141 Indel), previously shown to affect DRD2 transcription efficiency, and multiple exon seven polymorphisms, one of which has previously been shown to affect DRD2 transcript stability, exhibited statistically significant association with diagnosis in haplotype transmission disequilibrium and in haplotype case : control analyses. Significant linkage disequilibrium between the -141 Indel and two exon seven SNPs (939Y and 957Y) was observed over a distance of >50 kbp in the AN probands but not in the controls. Genetically transmitted variation in D2 dopamine receptor expression mediated by functional polymorphisms affecting transcription and translation efficiency may play a role in vulnerability to AN.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/sj.npp.1300719

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 53 references

1 of the 53 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

  1. Elston RC (2001). S.A.G.E. Statistical Analysis for Genetic Epidemiology. MetroHealth Campus, Case Western Reserve University: Cleveland.
  2. First MB, Gibbon M, Spitzer RL, Williams JB (1996). User's guide for the structured clinical interview for DSM IV axis I disorders-research version SCID-I, version 2.0. Biometrics Research, New York Stat Psychiatric Institute: New York.
  3. Schneider S, Roessli D, Excoffier L (2000). Arlequin Ver. 2.000: A Software for Population Genetic Analysis. Genetics and Biometry Laboratory, University of Geneva: Switzerland. http://anthro.unige.ch/alrequin .

Cited by

Sorted by citations

Items 101–137 of 137

Related

See all

Metadata

Authors
Bergen, A. W., Yeager, M., Welch, R. A., Haque, K., Ganjei, J. K., van den Bree, M. B. M., Mazzanti, C., Nardi, I., Fichter, M. M., Halmi, K. A., Kaplan, A. S., Strober, M., Treasure, J., Woodside, D. B., Bulik, C. M., Bacanu, S.-A., Devlin, B., Berrettini, W. H., Goldman, D., & Kaye, W. H.
Affiliations
  • National Institutes of Health (US)
  • Tissue Gene (United States) (US)
  • Cancer Research UK (GB)
  • University of Pisa (IT)
  • Schön Klinik Roseneck (DE)
  • Cornell University (US)
  • University Health Network (CA)
  • University of California, Los Angeles (US)
  • King's College London (GB)
  • University of North Carolina at Chapel Hill (US)
  • University of Pittsburgh (US)
  • University of Pennsylvania Health System (US)
  • National Institute on Alcohol Abuse and Alcoholism (US)
Corresponding author
Bergen, Andrew W
ORCID
Venue
Neuropsychopharmacology
Publisher
Springer Science and Business Media LLC
Published
2005-05-25
Volume
30
Issue
9
Pages
1703-1710
ISSN
  • 0893-133X (ISSN-L)
  • 1740-634X
DOI
10.1038/sj.npp.1300719
OpenAlex
W2111445266
Cited by
137
References
53
Citations by year
2025: 1 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 2 · 2018: 8 · 2017: 4 · 2016: 8 · 2015: 10 · 2014: 7 · 2013: 7 · 2012: 10
FWCI
8.09
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
  • ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion)
  • INFM-OAR (INFN Catania) (submittedVersion, other-oa)
  • Zenodo (CERN European Organization for Nuclear Research) (cc-by)
Funders
  • U.S. Department of Health and Human Services
  • Louis and Harold Price Foundation
  • National Alliance for Research on Schizophrenia and Depression
  • Australian Government
  • European Commission (644690)
  • National Institutes of Health
  • National Institute of Mental Health (MH 57881)
  • National Center for Research Resources (RR-03655, P41RR003655)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
anorexia nervosa, DRD2, dopamine D2 receptor, single nucleotide polymorphisms, linkage disequilibrium, dopaminergic system, genetic susceptibility, eating disorders, transcription efficiency, transcript stability
MeSH terms
Adolescent, Adult, Aged, Anorexia Nervosa, Exons, Female, Genotype, Humans, Male, Middle Aged, Linkage Disequilibrium, Chi-Square Distribution, Receptors, Dopamine D2, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review