Motor Stimulant Effects of Ethanol Injected into the Substantia Nigra Pars Reticulata: Importance of Catalase-Mediated Metabolism and the Role of Acetaldehyde
Abstract
A series of experiments was conducted to investigate the locomotor effects of local injections of ethanol and the ethanol metabolite, acetaldehyde, into substantia nigra pars reticulata (SNr). Infusions of ethanol into SNr resulted in a dose-related increase in locomotor activity, with maximal effects at a dose of 1.4 micromol. Ethanol injected into a control site dorsal to substantia nigra failed to stimulate locomotion, and another inactive site was identified in brainstem areas posterior to substantia nigra. The locomotor effects of intranigral ethanol (1.4 micromol) were reduced by coadministration of 10 mg/kg sodium azide, a catalase inhibitor that acts to reduce the metabolism of ethanol into acetaldehyde in the brain. SNr infusions of acetaldehyde, which is the first metabolite of ethanol, also increased locomotion. Taken together, these results indicate that SNr is one of the sites at which ethanol and acetaldehyde may be acting to induce locomotor activity. These results are consistent with the hypothesis that acetaldehyde is a centrally active metabolite of ethanol, and provide further support for the idea that catalase activity is a critical step in the regulation of ethanol-induced motor activity. These studies have implications for understanding the brain mechanisms involved in mediating the ascending limb of the biphasic dose-response curve for the effect of ethanol on locomotor activity.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Catalase may have a limited role in ethanol metabolism in certain brain regions, except for aminergic neurons, where it is present in high concentrations.
“However, catalase may have a limited role in ethanol metabolism in certain brain regions, except for aminergic neurons, where it is present in high concentrations134,148–150.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [149]
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
(1975) · Journal of AOAC INTERNATIONAL · doi:10.1093/jaoac/58.5.1085 · Cited by 20,078 · see citing works
Beaton, A. E., & Keppel, G. (1975) · American Educational Research Journal · doi:10.2307/1162588 · Cited by 5,857 · see citing works
A stereotaxic atlas of the rat brain
Pellegrino, L. J., & Cushman, A. J. (1967) · Plenum Press eBooks · Cited by 4,688 · see citing works
Paxinos, G. (1985) · Cited by 3,715 · see citing works
Design and Analysis: A Researcher's Handbook
Morgan, J. (2005) · Technometrics · doi:10.1198/tech.2005.s329 · Cited by 2,365 · see citing works
Aebi, H. E. (1974) · Elsevier eBooks · doi:10.1016/b978-0-12-091302-2.50032-3 · Cited by 2,075 · see citing works
Impérato, A., & Chiara, G. D. (1986) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23929-5 · Cited by 858 · see citing works
Parkinson’s Disease and Movement Disorders
Tn, M., & Bhattacharyya, K. (2005) · Jaypee Brothers Medical Publishers (P) Ltd. eBooks · doi:10.5005/jp/books/10587 · Cited by 804 · see citing works
Parkinson's Disease and Movement Disorders
Kieburtz, K. D. (1994) · Archives of Neurology · doi:10.1001/archneur.1994.00540220013003 · Cited by 617 · see citing works
The role of GABAA receptors in the acute and chronic effects of ethanol
Grobin, A., Matthews, D. B., Devaud, L., & Morrow, A. (1998) · Psychopharmacology · doi:10.1007/s002130050685 · Cited by 498 · see citing works
Design and analysis a researcher's handbook
Keppel, G., & Wickens, T. D. (2004) · Cited by 486 · see citing works
Alcohol tolerance and dependence
Rigter, H., & Crabbe, J. C. (1980) · Elsevier eBooks · Cited by 420 · see citing works
Kissin, B., & Begleiter, H. (1983) · Springer eBooks · doi:10.1007/978-1-4613-3518-4 · Cited by 380 · see citing works
Pohorecky, L. A. (1977) · Biobehavioral Reviews · doi:10.1016/0147-7552(77)90025-0 · Cited by 368 · see citing works
Wichmann, T., Bergman, H., Starr, P. A., DeLong, M. R., Watts, R. L., & Subramanian, T. (1999) · Experimental Brain Research · doi:10.1007/s002210050696 · Cited by 297 · see citing works
Scheel‐Krüger, J., Arnt, J., & Magelund, G. (1977) · Neuroscience Letters · doi:10.1016/0304-3940(77)90183-5 · Cited by 279 · see citing works
THE ROLE OF ACETALDEHYDE IN THE ACTIONS OF ETHANOL
Eckfeldt, J. H., Takio, K., Mope, L., & Yonetani, T. (1975) · Cited by 251 · see citing works
Neurochemical Bases of Locomotion and Ethanol Stimulant Effects
Phillips, T. J., & Shent, E. H. (1996) · International review of neurobiology · doi:10.1016/s0074-7742(08)60669-8 · Cited by 208 · see citing works
Waller, M. B., Murphy, J. M., McBride, W. J., Lumeng, L., & Li, T. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90567-8 · Cited by 201 · see citing works
Ethanol metabolism in rat brain homogenates by a catalase-H2O2 system
Aragón, C. M. G., Rogan, F., & Amit, Z. (1992) · Biochemical Pharmacology · doi:10.1016/0006-2952(92)90042-h · Cited by 183 · see citing works
Ericson, M., Molander, A., Löf, E., Engel, J. A., & Söderpalm, B. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01564-4 · Cited by 169 · see citing works
An evaluation of the locomotor stimulating action of ethanol in rats and mice
Frye, G. D., & Breese, G. R. (1981) · Psychopharmacology · doi:10.1007/bf00435856 · Cited by 169 · see citing works
Acetaldehyde Increases Dopaminergic Neuronal Activity in the VTA
Foddai, M., Dosia, G., Spiga, S., & Diana, M. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300326 · Cited by 164 · see citing works
Enzymatic Production of Acetaldehyde from Ethanol in Rat Brain Tissue
Gill, K. J., Menez, J. F., Lucas, D., & Deitrich, R. A. (1992) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1992.tb01892.x · Cited by 163 · see citing works
Role of acetaldehyde in the actions of ethanol on the brain — A review
Hunt, W. A. (1996) · Alcohol · doi:10.1016/0741-8329(95)02026-8 · Cited by 162 · see citing works
Crabbe, J. C., Johnson, N. A., Gry, D. K., Kosobud, A., & Young, E. R. (1982) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077898 · Cited by 162 · see citing works
The distribution and metabolism of acetaldehyde in rats during ethanol oxidation—I
Eriksson, C. J. P., & Sippel, H. W. (1977) · Biochemical Pharmacology · doi:10.1016/0006-2952(77)90310-0 · Cited by 160 · see citing works
Mereu, G., & Gessa, G. L. (1985) · Brain Research · doi:10.1016/0006-8993(85)91249-1 · Cited by 154 · see citing works
Criswell, H. E., Simson, P. E., Duncan, G. E., McCown, T. J., Herbert, J. S., Morrow, A. L., & Breese, G. R. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39547-9 · Cited by 152 · see citing works
Quertemont, É., Tambour, S., & Tirelli, E. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.03.003 · Cited by 148 · see citing works
Rodd, Z. A., Meléndez, R. I., Zaffaroni, A., D, A. G. M., McBride, W. J., & Li, T. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00733-x · Cited by 145 · see citing works
The excitatory effect of ethanol: Absence in rats, no tolerance and increased sensitivity in mice
Masur, J., Formigoni, M. L. O. D. S., & Zwicker, A. P. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90175-9 · Cited by 143 · see citing works
Rodd, Z. A., Bell, R. L., Zhang, Y., Murphy, J. M., D, A. G. M., Zaffaroni, A., Li, T., & McBride, W. J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300561 · Cited by 141 · see citing works
Cellular and behavioral neurobiology of alcohol: receptor-mediated neuronal processes.
Grant, K. A., & Dm, L. (1995) · PubMed · Cited by 139 · see citing works
The acetaldehyde content in rat brain during ethanol metabolism
Sippel, H. W. (1974) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1974.tb04380.x · Cited by 134 · see citing works
Catalase Mediates Acetaldehyde Formation from Ethanol in Fetal and Neonatal Rat Brain
Hamby‐Mason, R., Chen, J. J., Schenker, S., Perez, A., & Henderson, G. I. (1997) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1997.tb04255.x · Cited by 132 · see citing works
Ethanol Oxidation by Rat Brain in Vivo
Cohen, G., Sinet, P. M., & Heikkila, R. E. (1980) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1980.tb04833.x · Cited by 130 · see citing works
Regional Distribution of Catalase in the Adult Rat Brain
Brannan, T. S., Maker, H. S., & Raes, I. (1981) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1981.tb02411.x · Cited by 129 · see citing works
Intraventricular self-administration of acetaldehyde, but not ethanol, in naive laboratory rats
Brown, Z. W., Amit, Z., & Rockman, G. E. (1979) · Psychopharmacology · doi:10.1007/bf00427509 · Cited by 128 · see citing works
Ethanol metabolism in the brain
Zimatkin, S. M., & Deitrich, R. A. (1997) · Addiction Biology · doi:10.1080/13556219772444 · Cited by 125 · see citing works
The University of North Carolina at Chapel Hill University Libraries (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/tcpt-n430 · Cited by 121 · see citing works
Immunocytochemical localization of catalase in the central nervous system of the rat.
Moreno, S., Mugnaini, E., & Cerù, M. (1995) · Journal of Histochemistry & Cytochemistry · doi:10.1177/43.12.8537642 · Cited by 112 · see citing works
Distribution and Kinetics of Ethanol Metabolism in Rat Brain
Zimatkin, S. M., Liopo, A. V., & Deitrich, R. A. (1998) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb03958.x · Cited by 111 · see citing works
Scheel‐Krüger, J., Magelund, G., & Olianas, M. C. (1981) · PubMed · Cited by 107 · see citing works
Correa, M., Arizzi, M. N., Betz, A. J., Mingote, S., & Salamone, J. D. (2003) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2003.09.013 · Cited by 105 · see citing works
Self-citationConditioned place preference induced by intraventricular infusions of acetaldehyde
Smith, B. R., Amit, Z., & Splawinsky, J. (1984) · Alcohol · doi:10.1016/0741-8329(84)90097-1 · Cited by 101 · see citing works
Bevan, M. D., Smith, A. D., & Bolam, J. P. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00377-6 · Cited by 95 · see citing works
DISTRIBUTION OF CATALASE IN RAT BRAIN: AMINERGIC NEURONS AS POSSIBLE TARGETS FOR ETHANOL EFFECTS
ZIMATKIN, S. M., & LINDROS, K. O. (1996) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a008128 · Cited by 93 · see citing works
The Role of Acetaldehyde in the Actions of Ethanol
Truitt, E. B., & Walsh, M. J. (1971) · Springer eBooks · doi:10.1007/978-1-4615-6525-3_5 · Cited by 90 · see citing works
Microperoxisome distribution in the central nervous system of the rat
McKenna, O. C., Arnold, G., & Holtzman, E. (1976) · Brain Research · doi:10.1016/0006-8993(76)90729-0 · Cited by 86 · see citing works
Voluntary ethanol drinking increases locomotor activity in alcohol-preferring AA rats
Päivärinta, P., & Korpi, E. R. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90289-6 · Cited by 78 · see citing works
Intraventricular self-administration of acetaldehyde and voluntary consumption of ethanol in rats
Brown, Z. W., Amit, Z., & Smith, B. R. (1980) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(80)91487-9 · Cited by 75 · see citing works
SMITH, B. R., Aragón, C. M. G., & Amit, Z. (1997) · Addiction Biology · doi:10.1080/13556219772570 · Cited by 75 · see citing works
Dudek, B. C., & Phillips, T. J. (1990) · Psychopharmacology · doi:10.1007/bf02253724 · Cited by 74 · see citing works
Aragón, C. M. G., & Amit, Z. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90165-p · Cited by 73 · see citing works
Trevitt, J. T., Carlson, B., Correa, M., Keene, A. C., Morales, M., & Salamone, J. D. (2001) · Psychopharmacology · doi:10.1007/s002130100908 · Cited by 71 · see citing works
Self-citationTrevitt, J. T., Carlson, B., Nowend, K. L., & Salamone, J. D. (2001) · Psychopharmacology · doi:10.1007/s002130100708 · Cited by 70 · see citing works
Self-citationCrocker, A. D. (1997) · Reviews in the Neurosciences · doi:10.1515/revneuro.1997.8.1.55 · Cited by 70 · see citing works
Studies on Ethanol‐Brain Catalase Interaction: Evidence for Central Ethanol Oxidation
Aragón, C. M. G., Amit, Z., & Stotland, L. M. (1991) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1991.tb01848.x · Cited by 69 · see citing works
Comparison of excited phases alter sedatives and tranquilizers
Read, G. W., Cutting, W., & Furst, A. (1960) · Psychopharmacology · doi:10.1007/bf00404231 · Cited by 68 · see citing works
Colombo, G., Agabio, R., Lobina, C., Reali, R., Vacca, G., & Gessa, G. L. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00560-3 · Cited by 67 · see citing works
The Role of Acetaldehyde in the Central Effects of Ethanol
Quertemont, É., Grant, K. A., Correa, M., Arizzi, M. N., Salamone, J. D., Tambour, S., Aragón, C. M. G., McBride, W. J., Rodd, Z. A., D, A. G. M., et al. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000156185.39073.d2 · Cited by 66 · see citing works
Self-citationAragón, C. M. G., Spivak, K. J., & Amit, Z. (1989) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1989.tb00293.x · Cited by 64 · see citing works
The Catalase Inhibitor Sodium Azide Reduces Ethanol-Induced Locomotor Activity
Sanchis‐Segura, C., Miquel, M., Correa, M., & Aragón, C. M. G. (1999) · Alcohol · doi:10.1016/s0741-8329(99)00016-6 · Cited by 64 · see citing works
Self-citationWard, R. J., Colantuoni, C., Dahchour, A., Quertemont, É., & de Witte, P. A. M. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00007-5 · Cited by 63 · see citing works
Pastor, R., Sanchis‐Segura, C., & Aragon, C. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1241-9 · Cited by 62 · see citing works
Self-citationIs ethanol a pro-drug? The role of acetaldehyde in the central effects of ethanol
Quertemont, É., & Tambour, S. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.01.001 · Cited by 59 · see citing works
Rodd, Z. A., Bell, R. L., McKinzie, D. L., Webster, A. A., Murphy, J. M., Lumeng, L., Li, T., & McBride, W. J. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000122107.08417.d0 · Cited by 59 · see citing works
Modulation of ethanol-induced motor incoordination by mouse striatal A1 adenosinergic receptor
Dar, M. S. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00552-4 · Cited by 57 · see citing works
Amit, Z., Brown, Z. W., & Rockman, G. E. (1977) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(77)90049-7 · Cited by 56 · see citing works
Cyanamide reduces brain catalase and ethanol-induced locomotor activity: is there a functional link?
Sanchis‐Segura, C., Miquel, M., Correa, M., & Aragón, C. M. G. (1999) · Psychopharmacology · doi:10.1007/s002130050980 · Cited by 55 · see citing works
Self-citationRodd, Z. A., McKinzie, D. L., Meléndez, R. I., Berry, N. S., Murphy, J. M., & McBride, W. J. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1300-2 · Cited by 54 · see citing works
A multi-demensional examination of the positive reinforcing properties of acetaldehyde
Amit, Z., & Smith, B. R. (1985) · Alcohol · doi:10.1016/0741-8329(85)90077-1 · Cited by 53 · see citing works
Reddy, B. V., Boyadjieva, N. I., & Sarkar, D. K. (1995) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1995.tb01512.x · Cited by 53 · see citing works
Brain ethanol concentrations and ethanol discrimination in rats: effects of dose and time
Quertemont, É., Green, H. L., & Grant, K. A. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1437-7 · Cited by 51 · see citing works
Brain catalase activity is highly correlated with ethanol-induced locomotor activity in mice
Correa, M., Sanchis‐Segura, C., & Aragón, C. M. G. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00511-x · Cited by 50 · see citing works
Self-citationEthanol-induced motor activity in normal and acatalasemic mice
Aragón, C. M. G., Pesold, C., & Amit, Z. (1992) · Alcohol · doi:10.1016/0741-8329(92)90055-f · Cited by 50 · see citing works
Myers, R. D., & Wl, V. (1969) · PubMed · Cited by 48 · see citing works
Characterization of the Production of Acetaldehyde by Astrocytes in Culture after Ethanol Exposure
Eysseric, H., Gonthier, B., Soubeyran, A., Bessard, G., Saxod, R., & Barret, L. G. (1997) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1997.tb04247.x · Cited by 47 · see citing works
Arizzi, M. N., Correa, M., Betz, A. J., Wisniecki, A., & Salamone, J. D. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00158-x · Cited by 46 · see citing works
Self-citationCorrea, M., Arizzi, M. N., Betz, A. J., Mingote, S., & Salamone, J. D. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1557-0 · Cited by 46 · see citing works
Self-citationBrain Ethanol Levels After Voluntary Ethanol Drinking in AA and Wistar Rats
Nurmi, M., Kiianmaa, K., & Sinclair, J. D. (1999) · Alcohol · doi:10.1016/s0741-8329(99)00022-1 · Cited by 46 · see citing works
Correa, M., Miquel, M., Sanchis‐Segura, C., & Aragón, C. M. G. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04186.x · Cited by 46 · see citing works
Self-citationBrown, Z. W., Amit, Z., Smith, B. R., & Rockman, G. E. (1978) · Neuropharmacology · doi:10.1016/0028-3908(78)90134-x · Cited by 45 · see citing works
Gingras, M. A., & Cools, A. R. (1996) · Psychopharmacology · doi:10.1007/bf02247337 · Cited by 45 · see citing works
Effects of Chronic Lead Administration on Ethanol-Induced Locomotor and Brain Catalase Activity
Correa, M., Miquel, M., Sanchis‐Segura, C., & Aragón, C. M. G. (1999) · Alcohol · doi:10.1016/s0741-8329(99)00023-3 · Cited by 44 · see citing works
Self-citationLead Acetate Potentiates Brain Catalase Activity and Enhances Ethanol-Induced Locomotion in Mice
Correa, M., Miquel, M., & Aragón, C. M. G. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00204-5 · Cited by 43 · see citing works
Self-citationJamal, M., Ameno, K., Kumihashi, M., Ameno, S., Kubota, T., Wang, W., & Ijiri, I. (2003) · Journal of Chromatography B · doi:10.1016/j.jchromb.2003.09.015 · Cited by 41 · see citing works
Comparison of acetaldehyde and ethanol: Depression of motor activity in mice
Holtzman, S. G., & Schneider, F. H. (1974) · Life Sciences · doi:10.1016/0024-3205(74)90432-9 · Cited by 40 · see citing works
Carlson, B. B., Wisniecki, A., & Salamone, J. D. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1247-3 · Cited by 39 · see citing works
Self-citationFinn, M., Mayorga, A. J., Conlan, A., & Salamone, J. D. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00087-0 · Cited by 38 · see citing works
Self-citationCorrea, M., Sanchis‐Segura, C., Pastor, R., & Aragón, C. M. G. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.03.033 · Cited by 38 · see citing works
Self-citationMayorga, A. J., Trevitt, J. T., Conlan, A., Gianutsos, G., & Salamone, J. D. (1999) · Psychopharmacology · doi:10.1007/s002130050921 · Cited by 37 · see citing works
Self-citationSanchis‐Segura, C., Correa, M., & Aragón, C. M. G. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00183-2 · Cited by 36 · see citing works
Self-citationCorrea, M., Roig, A., & Aragón, C. M. G. (2004) · Life Sciences · doi:10.1016/j.lfs.2003.08.042 · Cited by 34 · see citing works
Self-citationEffects of naloxone and buprenorphine on intravenous acetaldehyde self-injection in rats
Myers, W. D., Ng, K. T., & Singer, G. (1984) · Physiology & Behavior · doi:10.1016/0031-9384(84)90168-9 · Cited by 34 · see citing works
Daily injections of cyanamide enhance both ethanol-induced locomotion and brain catalase activity
Sanchis‐Segura, C., Miquel, M., Correa, M., & Aragón, C. M. G. (1999) · Behavioural Pharmacology · doi:10.1097/00008877-199909000-00004 · Cited by 34 · see citing works
Self-citationCatalase inhibition in the Arcuate nucleus blocks ethanol effects on the locomotor activity of rats
Sanchis‐Segura, C., Correa, M., Miquel, M., & Aragón, C. M. G. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.11.025 · Cited by 30 · see citing works
Self-citationCrankshaw, D. L., Briggs, J. E., Olszewski, P. K., Shi, Q., Grace, M. K., Billington, C. J., & Levine, A. S. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00111-2 · Cited by 30 · see citing works
Demarest, K., Hitzemann, B. A., Mahjubi, E., McCaughran, J. A., & HITZEMANN, R. J. (1998) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb03946.x · Cited by 29 · see citing works
Phillips, T. J., Shen, E., McKinnon, C. S., Burkhart‐Kasch, S., Lessov, C. N., & Palmer, A. A. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02580.x · Cited by 29 · see citing works
Dar, M. S. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02684.x · Cited by 29 · see citing works
Potentiation of ethanol toxicity by cyanamide in relation to acetaldehyde accumulation
Hillbom, M., Sarviharju, M., & Lindros, K. O. (1983) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(83)90186-2 · Cited by 27 · see citing works
Carlson, B. B., Behrstock, S. P., Tobin, A. J., & Salamone, J. D. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00218-5 · Cited by 24 · see citing works
Self-citationBrain aldehyde dehydrogenase: Adaptive increase following prolonged ethanol administration in rats
Amir, S. (1978) · Neuropharmacology · doi:10.1016/0028-3908(78)90051-5 · Cited by 24 · see citing works
Opposite effects of acute versus chronic naltrexone administration on ethanol-induced locomotion
Sanchis‐Segura, C., Pastor, R., & Aragón, C. M. G. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.11.003 · Cited by 24 · see citing works
Spivak, K. J., Aragón, C. M. G., & Amit, Z. (1987) · PubMed · Cited by 24 · see citing works
Effect of acetaldehyde on acute tolerance and ethanol consumption in drinker and nondrinker rats.
Tampier, L., & Quintanilla, M. E. (2002) · Journal of Studies on Alcohol · doi:10.15288/jsa.2002.63.257 · Cited by 23 · see citing works
Correa, M., Mingote, S., Betz, A. J., Wisniecki, A., & Salamone, J. D. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00117-9 · Cited by 23 · see citing works
Self-citationLittle, H. J. (2000) · Addiction · doi:10.1046/j.1360-0443.2000.951217512.x · Cited by 21 · see citing works
Antagonism of ethanol effects by Ro 15‐4513: An electrophysiological analysis
Marrosu, F., Carcangiu, G., Passino, N., Aramo, S., & Mereu, G. (1989) · Synapse · doi:10.1002/syn.890030203 · Cited by 21 · see citing works
Does Acetaldehyde Mediate Ethanol Action in the Central Nervous System?
Mascia, M. P., Maiya, R., Borghese, C. M., Lobo, I. A., Hara, K., Yamakura, T., Gong, D., & Beckstead, M. J. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02163.x · Cited by 20 · see citing works
Role of Acetaldehyde in the Discriminative Stimulus Effects of Ethanol
Quertemont, É., & Grant, K. A. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1097/00000374-200206000-00010 · Cited by 19 · see citing works
Criswell, H. E., McCown, T. J., Ming, Z., Mueller, R. A., & Breese, G. R. (1999) · PubMed · Cited by 19 · see citing works
Reduced behavioral responses to intranigral muscimol following chronic ethanol
Gonzalez, L. P., & Czachura, J. F. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90023-1 · Cited by 18 · see citing works
Aragón, C. M. G., & Amit, Z. (1985) · Alcohol · doi:10.1016/0741-8329(85)90075-8 · Cited by 18 · see citing works
Nicotinamide Adenine Dinucleotide and the Metabolism of Ethanol and Acetaldehyde
Majchrowicz, E., Bercaw, B. L., Cole, W. M., & Gregory, D. H. (1967) · Quarterly Journal of Studies on Alcohol · doi:10.15288/qjsa.1967.28.213 · Cited by 17 · see citing works
Role of Acetaldehyde in the Discriminative Stimulus Effects of Ethanol
Quertemont, É., & Grant, K. A. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02609.x · Cited by 17 · see citing works
Kuriyama, K., Ohkuma, S., Tomono, S., & Hirouchi, M. (1987) · PubMed · Cited by 16 · see citing works
ACETALDEHYDE-INDUCED ALTERATIONS IN METABOLISM OF MONOAMINES IN MOUSE BRAIN
Hashimoto, T., UEHA, T., KURIYAMA, T., Katsura, M., & KURIYAMA, K. (1989) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a044889 · Cited by 15 · see citing works
Criswell, H. E., McCown, T. J., Ming, Z., Mueller, R. A., & Breese, G. R. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35209-7 · Cited by 12 · see citing works
Diana, M., Pistis, M., Muntoni, A., & Gessa, G. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90574-2 · Cited by 11 · see citing works
Abraini, J. H., Kriem, B., & Rostain, J. (1999) · Neuroscience Research · doi:10.1016/s0168-0102(99)00095-4 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Rungratanawanich, W., Qu, Y., Wang, X., Essa, M. M., & Song, B.-J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00561-7 · Cited by 411 · see citing works
Piecing together the puzzle of acetaldehyde as a neuroactive agent
Correa, M., Salamone, J. D., Segovia, K. N., Pardo, M., Longoni, R., Spina, L., Peana, A. T., Vinci, S., & Acquas, E. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.07.009 · Cited by 118 · see citing works
Self-citationAcetaldehyde mediates alcohol activation of the mesolimbic dopamine system
Melis, M., Enrico, P., Peana, A. T., & Diana, M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05887.x · Cited by 107 · see citing works
Role of acetaldehyde in mediating the pharmacological and behavioral effects of alcohol.
Quertemont, É., & Didone, V. (2006) · PubMed Central · Cited by 87 · see citing works
Pautassi, R. M., Nizhnikov, M. E., & Spear, N. E. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.03.008 · Cited by 68 · see citing works
Melis, M., Diana, M., Enrico, P., Marinelli, M., & Brodie, M. S. (2009) · Alcohol · doi:10.1016/j.alcohol.2009.05.004 · Cited by 63 · see citing works
Font, L., Aragón, C. M. G., & Miquel, M. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.03.020 · Cited by 62 · see citing works
Acetaldehyde sequestering prevents ethanol-induced stimulation of mesolimbic dopamine transmission
Enrico, P., Sirca, D., Mereu, M., Peana, A. T., Lintas, A., Golosio, A., & Diana, M. (2008) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.10.010 · Cited by 59 · see citing works
Correa, M., Manrique, H. M., Font, L., Escrig, M. A., & Aragón, C. M. G. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1219-3 · Cited by 59 · see citing works
Self-citationMystic Acetaldehyde: The Never-Ending Story on Alcoholism
Peana, A. T., Sánchez-Catalán, M. J., Hipólito, L., Rosas, M., Porru, S., Bennardini, F., Romualdi, P., Caputi, F. F., Candeletti, S., Polache, A., et al. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00081 · Cited by 57 · see citing works
Hipólito, L., Sánchez-Catalán, M. J., Zornoza, T., Polache, A., & Granero, L. M. (2010) · Psychopharmacology · doi:10.1007/s00213-009-1751-9 · Cited by 49 · see citing works
Sánchez-Catalán, M. J., Hipólito, L., Zornoza, T., Polache, A., & Granero, L. M. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1495-6 · Cited by 48 · see citing works
Tambour, S., Didone, V., Tirelli, E., & Quertemont, É. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.05.010 · Cited by 47 · see citing works
Crucial Role of Acetaldehyde in Alcohol Activation of the Mesolimbic Dopamine System
Diana, M., Peana, A. T., Sirca, D., Lintas, A., Melis, M., & Enrico, P. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1432.009 · Cited by 43 · see citing works
Stimulant and motivational effects of alcohol: Lessons from rodent and primate models
Brabant, C., Guarnieri, D. J., & Quertemont, É. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.03.006 · Cited by 38 · see citing works
Spina, L., Longoni, R., Vinci, S., Ibba, F., Peana, A. T., Muggironi, G., Spiga, S., & Acquas, E. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01129.x · Cited by 37 · see citing works
Martí‐Prats, L., Sánchez-Catalán, M. J., Hipólito, L., Orrico‐Sánchez, A., Zornoza, T., Polache, A., & Granero, L. M. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.07.081 · Cited by 32 · see citing works
Pastor, R., & Aragón, C. M. G. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e328315ecd7 · Cited by 31 · see citing works
Martí‐Prats, L., Sánchez-Catalán, M. J., Orrico‐Sánchez, A., Zornoza, T., Polache, A., & Granero, L. M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.047 · Cited by 31 · see citing works
Pardo, M., Betz, A. J., Miguel, N. S., López‐Cruz, L., Salamone, J. D., & Correa, M. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00081 · Cited by 29 · see citing works
Self-citationFont, L., Luján, M. Á., & Pastor, R. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00093 · Cited by 26 · see citing works
Acetaldehyde Oral Self‐Administration: Evidence from the Operant‐Conflict Paradigm
Cacace, S., Plescia, F., Barberi, I., & Cannizzaro, C. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01725.x · Cited by 26 · see citing works
Ledesma, J. C., & Aragón, C. M. G. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2831-9 · Cited by 25 · see citing works
Plescia, F., Brancato, A., Marino, R. A. M., & Cannizzaro, C. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00064 · Cited by 25 · see citing works
Induction of brain cytochrome P450 2E1 boosts the locomotor-stimulating effects of ethanol in mice
Ledesma, J. C., Miquel, M., Pascual, M., Guerri, C., & Aragón, C. M. G. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.05.018 · Cited by 23 · see citing works
Acetaldehyde elicits ERK phosphorylation in the rat nucleus accumbens and extended amygdala
Vinci, S., Ibba, F., Longoni, R., Spina, L., Spiga, S., & Acquas, E. (2010) · Synapse · doi:10.1002/syn.20811 · Cited by 23 · see citing works
Fernández, E., Koek, W., Ran, Q., Gerhardt, G. A., France, C. P., & Strong, R. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00200.x · Cited by 23 · see citing works
McLaughlin, P. J., Chuck, T. L., Arizzi, M. N., Salamone, J. D., & Correa, M. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.01.002 · Cited by 22 · see citing works
Self-citationInfusions of acetaldehyde into the arcuate nucleus of the hypothalamus induce motor activity in rats
Correa, M., Arizzi, M. N., & Salamone, J. D. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.12.013 · Cited by 21 · see citing works
Self-citationLedesma, J. C., Baliño, P., & Aragón, C. M. G. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12253 · Cited by 20 · see citing works
The H2O2 scavenger ebselen decreases ethanol-induced locomotor stimulation in mice
Ledesma, J. C., Font, L., & Aragón, C. M. G. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2011.12.003 · Cited by 18 · see citing works
The role of acetaldehyde in ethanol reinforcement assessed by Pavlovian conditioning in newborn rats
March, S. M., Abate, P., Spear, N. E., & Molina, J. C. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2920-9 · Cited by 18 · see citing works
Analytical methodologies for the stereoselective determination of fluoxetine: An overview
Hancu, G., Cârcu‐Dobrin, M., Budău, M., & Rusu, A. (2017) · Biomedical Chromatography · doi:10.1002/bmc.4040 · Cited by 16 · see citing works
Sanz‐Martin, A., Guevara, M. Á., Amezcua, C., Santana, G., & González, M. H. (2011) · Appetite · doi:10.1016/j.appet.2011.04.004 · Cited by 16 · see citing works
Sánchez‐Zavaleta, R., Ávalos‐Fuentes, J. A., González‐Hernández, A. V., Recillas‐Morales, S., Paz‐Bermúdez, F. J., Leyva‐Gómez, G., Cortés, H., & Florán, B. (2022) · Synapse · doi:10.1002/syn.22246 · Cited by 13 · see citing works
Tambour, S., Closon, C., Tirelli, E., & Quertemont, É. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282f158ca · Cited by 13 · see citing works
Martí‐Prats, L., Orrico‐Sánchez, A., Polache, A., & Granero, L. M. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115598337 · Cited by 12 · see citing works
Acetaldehyde involvement in ethanol's postabsortive effects during early ontogeny
March, S. M., Abate, P., & Molina, J. C. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00070 · Cited by 12 · see citing works
Segovia, K. N., Vontell, R., López‐Cruz, L., Salamone, J. D., & Correa, M. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00048 · Cited by 11 · see citing works
Self-citationAlcohol, aging, and the gut microbiome: Intersections of immunity, barrier dysfunction, and disease
Melamed, E., Rungratanawanich, W., Liangpunsakul, S., Maki, K. A., McCullough, R. L., & Llorente, C. (2025) · Alcohol · doi:10.1016/j.alcohol.2025.07.001 · Cited by 11 · see citing works
Orrico‐Sánchez, A., Martí‐Prats, L., Cano-Cebrián, M. J., Granero, L. M., Polache, A., & Zornoza, T. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00037 · Cited by 10 · see citing works
Local iron deficiency in the substantia nigra directly contributes to hyperlocomotion phenotypes
Wang, Z., Huang, Y., Zhou, Z., Huang, J. A., He, Y., & Qiu, P. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105693 · Cited by 9 · see citing works
The MAO-A inhibitor clorgyline reduces ethanol-induced locomotion and its volitional intake in mice
Ledesma, J. C., Escrig, M. A., Pastor, R., & Aragón, C. M. G. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.11.012 · Cited by 9 · see citing works
March, S. M., Cullere, M., Abate, P., Hernández, J. I., Spear, N. E., & Molina, J. C. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00069 · Cited by 8 · see citing works
Díaz-Ruano, S., López-Pérez, A. E., Girón, R., Pérez-García, I., Martı́n, M. I., & Abalo, R. (2019) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm18202 · Cited by 7 · see citing works
Porru, S., López‐Cruz, L., Carratalá‐Ros, C., Salamone, J. D., Acquas, E., & Correa, M. (2021) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14553 · Cited by 7 · see citing works
Self-citationCuitavi, J., Campos‐Jurado, Y., Lorente, J. D., Andrés‐Herrera, P., Ferrís-Vilar, V., Polache, A., & Hipólito, L. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173845 · Cited by 6 · see citing works
Biochemical and Behavioral Consequences of Ethanol Intake in a Mouse Model of Metabolic Syndrome
Baliño, P., Romero‐Cano, R., & Muriach, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020807 · Cited by 6 · see citing works
Jain, N., Smirnovs, M., Strojeva, S., Murovska, M., & Skuja, S. (2021) · Biomedicines · doi:10.3390/biomedicines9091216 · Cited by 6 · see citing works
Acetaldehyde as the first hit of addictive behaviour
Cavallaro, A., Lavanco, G., Cannizzaro, C., Brancato, A., Majo, D. D., Giammanco, M., Martines, F., Miccichè, I., & Plescia, F. (2016) · Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale · doi:10.4081/jbr.2016.6206 · Cited by 3 · see citing works
D’aloisio, G., Acevedo, M. B., Angulo-Alcalde, A., Trujillo, V., & Molina, J. C. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.1031115 · Cited by 2 · see citing works
Gonzalez, H. C., Misare, K. R., Glorioso, K. E., Delaney, J. R., Becker, H. C., Lopez, M. F., Mulholland, P. J., & Hartman, J. H. (2025) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.70188 · Cited by 2 · see citing works
Neural Circuitries and Alcohol Use Disorder: Cutting Corners in the Cycle
Doyle, M. A., Taylor, A., & Winder, D. G. (2023) · Current topics in behavioral neurosciences · doi:10.1007/7854_2023_454 · Cited by 2 · see citing works
Soto, M. T. D., & Miranda, J. M. C. (2020) · REVISTA BIOMÉDICA · doi:10.32776/revbiomed.v31i2.722 · Cited by 2 · see citing works
Alcohol as Prodrug of Salsolinol
Bassareo, V., Maccioni, R., Migheli, R., Peana, A. T., Caboni, P., & Acquas, E. (2022) · Springer eBooks · doi:10.1007/978-3-030-67928-6_52-1 · Cited by 1 · see citing works
Moncayo, L. V., Adu-Gyamfi, F., Mohiuddin, A. K., Cruz, M., Dahman, A.-R., Akbar, Z., Kidd, S. K., Siddiqi, A., Khan, A. M., Chiang, K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.02.673579 · Cited by 1 · see citing works
Implicación de la monoamino oxidasa en conductas inducidas por etanol
Ayuso, M. Á. E. (2016) · doi:10.6035/11610.2016.159812
Alcohol as Prodrug of Salsolinol
Bassareo, V., Maccioni, R., Migheli, R., Peana, A. T., Caboni, P., & Acquas, E. (2022) · Springer eBooks · doi:10.1007/978-3-030-92392-1_52
- Authors
- Arizzi-LaFrance, M. N., Correa, M., Aragon, C. M. G., & Salamone, J. D.
- Affiliations
- Universitat Jaume I (ES)
- University of Connecticut (US)
- Venue
- Neuropsychopharmacology
- Published
- 2005-08-17
- Volume
- 31
- Issue
- 5
- Pages
- 997-1008
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2054532827
- Cited by
- 59
- References
- 124
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 4 · 2020: 1 · 2019: 1 · 2017: 4 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 9 · 2012: 4
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- ethanol, acetaldehyde, substantia nigra pars reticulata, locomotor activity, catalase, alcohol metabolism, sodium azide, biphasic dose-response, brainstem
- MeSH terms
- Acetaldehyde, Ethanol, Animals, Catalase, Central Nervous System Depressants, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Interactions, Enzyme Inhibitors, Male, Motor Activity, Movement, Substantia Nigra, Rats, Sprague-Dawley, Sodium Azide, Alcohol-Induced Disorders, Nervous System, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
