Cytokines, p38 MAP kinase and the pathophysiology of depression
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Elevated plasma proinflammatory cytokine levels have been observed in diagnosed MDD patients who attempted suicide, had suicidal ideation, or had geriatric depression, suggesting a positive association between inflammatory mechanisms and different depressive disorder subsets.
“studies have also shown elevated plasma levels of proinflammatory cytokines in diagnosed MDD patients who had attempted suicide, with suicidal ideation, and geriatric depression suggesting that inflammatory mechanisms may be positively associated with different subsets of depressive disorders (Miller et al., 2006;O'Donavan et al., 2013;Sublette et al., 2011).”
From A Review of the Relationship between Proinflammatory Cytokines and Major Depressive Disorder (2014) · cites this paper as Miller et al., 2006
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Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009 · see citing works
Self-citationGene regulation and DNA damage in the ageing human brain
Lu, T., Pan, Y., Kao, S.-Y., Li, C., Kohane, I., Chan, J., & Yankner, B. A. (2004) · Nature · doi:10.1038/nature02661 · Cited by 1,874 · see citing works
Cytokine Production and Treatment Response in Major Depressive Disorder
Lanquillon, S. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00134-7 · Cited by 735 · see citing works
Cytokines and psychopathology: Lessons from interferon-α
Capuron, L., & Miller, A. H. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.009 · Cited by 562 · see citing works
Self-citationCapuron, L., Ravaud, A., Neveu, P. J., Miller, A. H., Maes, M., & Dantzer, R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000995 · Cited by 473 · see citing works
Self-citationWang, X., Wu, H., & Miller, A. H. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001339 · Cited by 128 · see citing works
Self-citationWon, J., Lee, J.-K., & Suh, H. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00047-x · Cited by 25 · see citing works
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The HPA axis in major depression: classical theories and new developments
Pariante, C. M., & Lightman, S. L. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.06.006 · Cited by 2,009 · see citing works
A Review of the Relationship between Proinflammatory Cytokines and Major Depressive Disorder
Young, J. J., Bruno, D., & Pomara, N. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.07.032 · Cited by 422 · see citing works
Khairova, R. A., Machado-Vieira, R., Du, J., & Manji, H. K. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709009924 · Cited by 350 · see citing works
Anisman, H. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0902 · Cited by 292 · see citing works
Nettis, M. A., Lombardo, G., Hastings, C., Zajkowska, Z., Mariani, N., Nikkheslat, N., Worrell, C., Enache, D., McLaughlin, A., Kose, M., et al. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-020-00948-6 · Cited by 235 · see citing works
Voinov, B., Richie, W. D., & Bailey, R. K. (2013) · The Primary Care Companion For CNS Disorders · doi:10.4088/pcc.12r01468 · Cited by 98 · see citing works
- Authors
- Miller, A. H., & Raison, C. L.
- Affiliations
- Emory University (US)
- Corresponding author
- Miller, Andrew H
- Venue
- Neuropsychopharmacology
- Published
- 2006-09-18
- Volume
- 31
- Issue
- 10
- Pages
- 2089-2090
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2068474941
- Cited by
- 39
- References
- 7
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 2 · 2016: 3 · 2014: 5 · 2013: 2 · 2012: 1
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- depression, inflammatory cytokines, p38 MAPK, innate immunity, neuroinflammation, stress-induced inflammation, sympathetic nervous system, chemokines, acute phase proteins, adhesion molecules
- MeSH terms
- Depression, Humans, Cytokines, p38 Mitogen-Activated Protein Kinases
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