Cited by 176NF-κB Signaling PathwaysDNA Repair MechanismsEffects of Radiation Exposure

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The ATM protein is required for sustained activation of NF-κB following DNA damage

Piret, Bernard, Schoonbroodt, Sonia, Piette, Jacques·1999·Oncogene

DOI 10.1038/sj.onc.1202541

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Abstract

Cells lacking an intact ATM gene are hypersensitive to ionizing radiation and show multiple defects in the cell cycle-coupled checkpoints. DNA damage usually triggers cell cycle arrest through, among other things, the activation of p53. Another DNA-damage responsive factor is NF-kappaB. It is activated by various stress situations, including oxidative stress, and by DNA-damaging compounds such as topoisomerase poisons. We found that cells from Ataxia Telangiectasia patients exhibit a defect in NF-kappaB activation in response to treatment with camptothecin, a topoisomerase I poison. In AT cells, this activation is shortened or suppressed, compared to that observed in normal cells. Ectopic expression of the ATM protein in AT cells increases the activation of NF-kappaB in response to camptothecin. MO59J glioblastoma cells that do not express the DNA-PK catalytic subunit respond normally to camptothecin. These results support the hypothesis that NF-kappaB is a DNA damage-responsive transcription factor and that its activation pathway by DNA damage shares some components with the one leading to p53 activation.

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THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
Baldwin, A. S. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.649 · Cited by 5,882
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
DNA Repair and Mutagenesis
Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683
Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF‐kappa B transcription factor and HIV‐1.
Schreck, R., RIEBER, P., & Baeuerle, P. A. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07761.x · Cited by 3,793
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047
A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase
Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., et al. (1995) · Science · doi:10.1126/science.7792600 · Cited by 2,785
TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB
Wang, C.-Y., Mayo, M. W., & Baldwin, A. S. (1996) · Science · doi:10.1126/science.274.5288.784 · Cited by 2,586
Suppression of TNF-α-Induced Apoptosis by NF-κB
Antwerp, D. J. V., Martin, S. J., Kafri, T., Green, D. R., & Verma, I. M. (1996) · Science · doi:10.1126/science.274.5288.787 · Cited by 2,581
DNA repair and mutagenesis
Bootsma, D., & Hoeijmakers, J. H. J. (1996) · Trends in Genetics · doi:10.1016/0168-9525(96)81408-9 · Cited by 2,285
A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E., & Karin, M. (1997) · Nature · doi:10.1038/41493 · Cited by 2,125
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
Shieh, S.-Y., Ikeda, M., Taya, Y., & Prives, C. (1997) · Cell · doi:10.1016/s0092-8674(00)80416-x · Cited by 2,100
Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53
Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science · doi:10.1126/science.281.5383.1677 · Cited by 2,042
Antioxidant and redox regulation of gene transcription
Sen, C. K., & Packer, L. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.7.8635688 · Cited by 1,972
Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death
Liu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81375-6 · Cited by 1,937
DNA TOPOISOMERASES
Wang, J. C. (1996) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.65.070196.003223 · Cited by 1,838
Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage
Banin, S., Moyal, L., Shieh, S.-Y., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y., et al. (1998) · Science · doi:10.1126/science.281.5383.1674 · Cited by 1,797
p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
Dulić, V., Kaufmann, W. K., Wilson, S. J., Tisty, T. D., Lees, E., Harper, J. W., Elledge, S. J., & Reed, S. I. (1994) · Cell · doi:10.1016/0092-8674(94)90379-4 · Cited by 1,465
Signal transduction through NF-κB
May, M. J., & Ghosh, S. (1998) · Immunology Today · doi:10.1016/s0167-5699(97)01197-3 · Cited by 1,098
Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control
Chu, Z.-L., McKinsey, T. A., Liu, L., Gentry, J. J., Malim, M. H., & Ballard, D. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.19.10057 · Cited by 872
Redox Regulation of NF-kappa B Activation
Flohé, L., Brigelius‐Flohé, R., Saliou, C., Traber, M. G., & Packer, L. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00501-1 · Cited by 859
Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
Bose, R., Verheij, M., Haimovitz‐Friedman, A., Scotto, K. W., FUKS, Z. Y., & Kolesnick, R. (1995) · Cell · doi:10.1016/0092-8674(95)90429-8 · Cited by 827
Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis
Santana, M., Peña, L. A., Haimovitz‐Friedman, A., Martin, S. J., Green, D. R., McLoughlin, M., Cordon‐Cardo, C., Schuchman, E. H., FUKS, Z. Y., & Kolesnick, R. (1996) · Cell · doi:10.1016/s0092-8674(00)80091-4 · Cited by 798
Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?
Lü, X. (1993) · Cell · doi:10.1016/0092-8674(93)90496-d · Cited by 773
DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product
Hartley, K. O., Gell, D. A., Smith, G. C. M., Zhang, H., Divecha, N., Connelly, M. A., Admon, A., Lees‐Miller, S. P., Anderson, C. W., & Jackson, S. P. (1995) · Cell · doi:10.1016/0092-8674(95)90482-4 · Cited by 745
The p53 Network
Agarwal, M. L., Taylor, W. R., Chernov, M. V., Chernova, O. B., & Stark, G. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.1 · Cited by 725
DNA Damaging Agents Induce Expression of Fas Ligand and Subsequent Apoptosis in T Lymphocytes via the Activation of NF-κB and AP-1
Kasibhatla, S., Brunner, T., Genestier, L., Echeverri, F., Mahboubi, A., & Green, D. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80054-4 · Cited by 721
THE GENETIC DEFECT IN ATAXIA-TELANGIECTASIA
Lavin, M. F., & Shiloh, Y. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.177 · Cited by 642
Components of the Ku‐dependent non‐homologous end‐joining pathway are involved in telomeric length maintenance and telomeric silencing
Boulton, S. J., & Jackson, S. P. (1998) · The EMBO Journal · doi:10.1093/emboj/17.6.1819 · Cited by 641
NF-kappa B activation by ultraviolet light not dependent on a nuclear signal
Devary, Y., Rosette, C., DiDonato, J. A., & Karin, M. (1993) · Science · doi:10.1126/science.8367725 · Cited by 637
Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation
Baskaran, R., Wood, L. D., Whitaker, L. L., Canman, C. E., Morgan, S. E., Xu, Y., Barlow, C., Baltimore, D., Wynshaw-Boris, A. J., Kastan, M. B., et al. (1997) · Nature · doi:10.1038/387516a0 · Cited by 538
Absence of p350 Subunit of DNA-Activated Protein Kinase from a Radiosensitive Human Cell Line
Lees‐Miller, S. P., Godbout, R., Chan, D. W., Weinfeld, M., Day, R. S., Barron, G. M., & Allalunis‐Turner, J. (1995) · Science · doi:10.1126/science.7855602 · Cited by 529
Topoisomerase Poisons: Harnessing the Dark Side of Enzyme Mechanism
Froelich-Ammon, S. J., & Osheroff, N. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.37.21429 · Cited by 504
ATAXIA-TELANGIECTASIA AND THE NIJMEGEN BREAKAGE SYNDROME: Related Disorders But Genes Apart
Shiloh, Y. (1997) · Annual Review of Genetics · doi:10.1146/annurev.genet.31.1.635 · Cited by 482
Interaction between ATM protein and c-Abl in response to DNA damage
Shafman, T. D., Khanna, K. K., Kedar, P. S., Spring, K. J., Kozlov, S., Yen, T. J., Hobson, K., Gatei, M. H., Zhang, N., Watters, D. J., et al. (1997) · Nature · doi:10.1038/387520a0 · Cited by 478
Yeast Ku as a Regulator of Chromosomal DNA End Structure
Gravel, S., Larrivée, M., Labrecque, P., & Wellinger, R. J. (1998) · Science · doi:10.1126/science.280.5364.741 · Cited by 444
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.
Alkalay, I., Yaron, A., Hatzubai, A., Orian, A., Ciechanover, A. J., & Ben‐Neriah, Y. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10599 · Cited by 441
Ionizing radiation induces expression and binding activity of the nuclear factor kappa B.
Brach, M. A., Hass, R., Sherman, M., Gunji, H., Weichselbaum, R. R., & Kufe, D. W. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115354 · Cited by 408
Dual roles of ATM in the cellular response to radiation and in cell growth control.Preprint
Xu, Y., & Baltimore, D. (1996) · Genes & Development · doi:10.1101/gad.10.19.2401 · Cited by 407
p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches
Lee, S., Elenbaas, B., Levine, A. J., & Griffith, J. D. (1995) · Cell · doi:10.1016/s0092-8674(05)80006-6 · Cited by 405
Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway.
Anderson, M. T., Staal, F. J. T., Gitler, C., Herzenberg, L. A., & Herzenberg, L. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.24.11527 · Cited by 401
A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF‐kappa B.
Pahl, H. L., & Baeuerle, P. A. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07256.x · Cited by 390
ATM‐dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post‐translational activation of p53 protein involving poly(ADP‐ribose) polymerase
Vaziri, H., West, M. D., Allsopp, R., Davison, T. S., Wu, Y., Arrowsmith, C. H., Poirier, G. G., & Benchimol, S. (1997) · The EMBO Journal · doi:10.1093/emboj/16.19.6018 · Cited by 384
Daunorubicin‐induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis.
Jaffrézou, J., Levade, T., Bettaı̈eb, A., Andrieu‐Abadie, N., Bezombes, C., Maestre, N., Vermeersch, S., Rousse, A., & Laurent, G. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00599.x · Cited by 369
Three distinct signalling responses by murine fibroblasts to genotoxic stress
Liu, Z.-G., Rajasekaran, B., Lea-Chou, E., Wood, L. D., Chen, Y., Karin, M., & Wang, J. Y. J. (1996) · Nature · doi:10.1038/384273a0 · Cited by 355
Eukaryotic DNA topoisomerases: two forms of type I DNA topoisomerases from HeLa cell nuclei.
Liu, L. F., & Miller, K. G. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.6.3487 · Cited by 351
Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus
Jayaraman, L., & Prives, C. L. (1995) · Cell · doi:10.1016/s0092-8674(05)80007-8 · Cited by 343
Accelerated telomere shortening in ataxia telangiectasia
Metcalfe, J. A., Parkhill, J., Campbell, L. J., Stacey, M. W., Biggs, P., Byrd, P. J., & Taylor, A. M. R. (1996) · Nature Genetics · doi:10.1038/ng0796-350 · Cited by 338
DNA-dependent protein kinase acts upstream of p53 in response to DNA damage
Woo, R. A., McLure, K. G., Lees‐Miller, S. P., Rancourt, D. E., & Lee, P. W. K. (1998) · Nature · doi:10.1038/29343 · Cited by 308
Topoisomerase I inhibitors: Review and update
Rothenberg, M. L. (1997) · Annals of Oncology · doi:10.1023/a:1008270717294 · Cited by 308
Predominance of null mutations in ataxia-telangiectasia
Gilad, S. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.4.433 · Cited by 287
The nuclear tyrosine kinase c-abl negatively regulates cell growth
Sawyers, C. L., McLaughlin, J., Goga, A., Havlik, M., & Witte, O. N. (1994) · Cell · doi:10.1016/0092-8674(94)90240-2 · Cited by 277
Functional interaction between DNA-PK and c-Abl in response to DNA damage
Kharbanda, S. M., Pandey, P., Jin, S., Inoue, S., Bharti, A. K., Yuan, Z.-M., Weichselbaum, R. R., Weaver, D. T., & Kufe, D. W. (1997) · Nature · doi:10.1038/386732a0 · Cited by 251
Recombinant ATM protein complements the cellular A-T phenotype
Ziv, Y., Bar‐Shira, A., Pecker, I., Russell, P. S., Jorgensen, T. J., Tsarfati, I., & Shiloh, Y. (1997) · Oncogene · doi:10.1038/sj.onc.1201319 · Cited by 240
Sequential DNA damage‐independent and ‐dependent activation of NF‐κB by UV
Bender, K., Göttlicher, M., Whiteside, S. T., Rahmsdorf, H. J., & Herrlich, P. (1998) · The EMBO Journal · doi:10.1093/emboj/17.17.5170 · Cited by 223
Role for c-Abl tyrosine kinase in growth arrest response to DNA damage
Yuan, Z.-M., Huang, Y., Whang, Y. E., Sawyers, C. L., Weichselbaum, R. R., Kharbanda, S. M., & Kufe, D. W. (1996) · Nature · doi:10.1038/382272a0 · Cited by 216
Multiple redox regulation in NF-kappaB transcription factor activation.
Piette, J. G., Piret, B., Bonizzi, G., Schoonbroodt, S., Merville, M., Legrand-Poels, S., & Bours, V. (1997) · PubMed · Cited by 212
Self-citation
Beta-lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: a p53-independent response.
Planchon, S. M., Wuerzberger‐Davis, S. M., Frydman, B., Witiak, D. T., Hutson, P. R., Church, D. R., Wilding, G., & Boothman, D. A. (1995) · PubMed · Cited by 202
The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation.
Reed, M. J., Woelker, B., Wang, P., Wang, Y., Anderson, M. E., & Tegtmeyer, P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9455 · Cited by 187
Genetic complementation analysis of ataxia telangiectasia and Nijmegen breakage syndrome: a survey of 50 patients
Jaspers, N. G. J., Gatti, R. A., Baan, C. C., Linssen, P. C. M., & Bootsma, D. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000132673 · Cited by 178
Inhibition of apoptosis by antioxidants in the human HL-60 leukemia cell line
Verhaegen, S., McGowan, A. J., Brophy, A. R., Fernandes, R. S., & Cotter, T. G. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00233-p · Cited by 177
Reactive Oxygen Intermediates Are Involved in the Induction of CD95 Ligand mRNA Expression by Cytostatic Drugs in Hepatoma Cells
Hug, H., Strand, S., Grambihler, A., Galle, J., Hack, V., Stremmel, W., Krammer, P. H., & Galle, P. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.45.28191 · Cited by 177
Free radicals and anticancer drug resistance: Oxygen free radicals in the mechanisms of drug cytotoxicity and resistance by certain tumors
Sinha, B. K., & Mimnaugh, E. G. (1990) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(90)90155-c · Cited by 173
Correction of Radiation Sensitivity in Ataxia Telangiectasia Cells by a Truncated IκB-α
Jung, M., Zhang, Y., Lee, S., & Dritschilo, A. (1995) · Science · doi:10.1126/science.7777860 · Cited by 171
Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells
Pandita, T. K., Pathak, S., & Geard, C. R. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000134069 · Cited by 166
Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family
Hoekstra, M. F. (1997) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(97)80125-6 · Cited by 160
Mechanisms of cell killing by drugs that trap covalent complexes between DNA topoisomerases and DNA.
Nitiss, J. L., & Wang, J. C. (1996) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09537-9 · Cited by 145
Protein-tyrosine Phosphatase Inhibitors Block Tumor Necrosis Factor-dependent Activation of the Nuclear Transcription Factor NF-kB
Singh, S., & Aggarwal, B. B. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.18.10631 · Cited by 124
Domain Organization of IκBα and Sites of Interaction with NF-κB p65
Jaffray, E., Wood, K. M., & Hay, R. T. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.4.2166 · Cited by 121
Topoisomerase poisons activate the transcription factor NF-kappaB in ACH-2 and CEM cells
Piret, B. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.21.4242 · Cited by 121
Self-citation
IκBα Overexpression in Human Breast Carcinoma MCF7 Cells Inhibits Nuclear Factor-κB Activation but Not Tumor Necrosis Factor-α-induced Apoptosis
Cai, Z., Körner, M., Tarantino, N., & Chouaı̈b, S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.1.96 · Cited by 119
UV-induced transcription from the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and UV-induced secretion of an extracellular factor that induces HIV-1 transcription in nonirradiated cells
Stein, B., Krämer, M., Rahmsdorf, H. J., Ponta, H., & Herrlich, P. A. (1989) · Journal of Virology · doi:10.1128/jvi.63.11.4540-4544.1989 · Cited by 116
The DNA-dependent protein kinase, DNA-PK: 10 years and no ends in sight
Lees‐Miller, S. P. (1996) · Biochemistry and Cell Biology · doi:10.1139/o96-054 · Cited by 115
The DNA-Dependent Protein Kinase Participates in the Activation of NFκB Following DNA Damage
Basu, S., Rosenzweig, K. R., Youmell, M., & Price, B. D. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8741 · Cited by 113
Inhibitors of ADP-Ribosylation Impair Inducible Nitric Oxide Synthase Gene Transcription through Inhibition of NF Kappa B Activation
Page, C. L., Sancéau, J., Drapier, J., & Wietzerbin, J. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8113 · Cited by 108
Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype
Zhang, N., Chen, P., Khanna, K. K., Scott, S. P., Gatei, M. H., Kozlov, S., Watters, D. J., Spring, K. J., Yen, T. J., & Lavin, M. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.8021 · Cited by 104
Influence of ATM function on telomere metabolism
Smilenov, L. B., Morgan, S. E., Sawant, S. G., Kastan, M. B., & Pandita, T. K. (1997) · Oncogene · doi:10.1038/sj.onc.1201449 · Cited by 92
DNA strand breaks produced by oxidative stress in mammalian cells exhibit 3′-phosphoglycolate termini
Bertoncini, C. R. A., & Mene, R. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.15.2995 · Cited by 88
A high frequency of distinct ATM gene mutations in ataxia-telangiectasia.
Wright, J. A., Teraoka, S. N., Önengüt, S., Tolun, A., Gatti, R. A., Ochs, H. D., & CONCANNON, P. J. (1996) · PubMed Central · Cited by 81
Induction of the WAF1/CIP1 protein and apoptosis in human T-cell leukemia virus type I-transformed lymphocytes after treatment with adriamycin by using a p53-independent pathway.
Gartenhaus, R. B., Wang, P., & Hoffmann, P. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.1.265 · Cited by 78
ATM gene product phosphorylates I kappa B-alpha.
Jung, M., Kondratyev, A. D., Lee, S. A., Dimtchev, A., & Dritschilo, A. (1997) · PubMed · Cited by 76
DNA-Dependent Protein Kinase Phosphorylation of IκBα and IκBβ Regulates NF-κB DNA Binding Properties
Liu, L., Kwak, Y.-T., Bex, F., Garcı́a-Martı́nez, L. F., Li, X., Meek, K., Lane, W. S., & Gaynor, R. B. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4221 · Cited by 71
Transcription Factor NF-κB Is Activated by Photosensitization Generating Oxidative DNA Damages
Legrand-Poels, S., Bours, V., Piret, B., Pflaum, M., Epe, B., Rentier, B., & Piette, J. G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.12.6925 · Cited by 70
Self-citation
Induction of p21 Mediated by Reactive Oxygen Species Formed during the Metabolism of Aziridinylbenzoquinones by HCT116 Cells
Qiu, X., Forman, H. J., Schönthal, A. H., & Cadenas, E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.50.31915 · Cited by 70
Expression cloning of multiple human cDNAs that complement the phenotypic defects of ataxia-telangiectasia group D fibroblasts.
Meyn, M. S., Lu-Kuo, J. M., & Herzing, L. B. K. (1993) · PubMed · Cited by 68
Reduced telomere length in ataxia-telangiectasia fibroblasts
Xia, S. J., Shammas, M. A., & Reis, R. J. S. (1996) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(96)00015-8 · Cited by 62
Requirements for p53 and the ATM gene product in the regulation of G1/S and S phase checkpoints
Xie, G., Habbersett, R. C., Jia, Y., Peterson, S., Lehnert, B. E., Bradbury, E. M., & D'Anna, J. A. (1998) · Oncogene · doi:10.1038/sj.onc.1201793 · Cited by 61
Damage to DNA by UV light and activation of transcription factors
Sachsenmaier, C., Radler‐Pohl, A., Müller, A., Herrlich, P. A., & Rahmsdorf, H. J. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)90446-4 · Cited by 55
High-frequency transformation of human repair-deficient cell lines by an Epstein-Barr virus-based cDNA expression vector
Peterson, C. A., & Legerski, R. J. (1991) · Gene · doi:10.1016/0378-1119(91)90328-9 · Cited by 55
Impaired Regulation of Nuclear Factor-κB Results in Apoptosis Induced by Gamma Radiation
Jung, M., Zhang, Y., Dimtchev, A., & Dritschilo, A. (1998) · Radiation Research · doi:10.2307/3579906 · Cited by 51
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Self-citation
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Sorted by citations

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Background
Non-canonical activation of the DNA sensing adaptor STING by ATM and IFI16 mediates NF-κB signaling after nuclear DNA damage
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“…(PMA) Fl uo re sc en ce (x 10 00 rf u) O (legend on next page) 746 Molecular Cell 71, 745–760, September 6, 2018 involves the DNA damage kinase ataxia telangiectasia mutated (ATM) and the enzyme poly(ADP-ribose) polymerase 1 (PARP-1) (Hinz et al., 2010; Piret et al., 1999; Stilmann et al., 2009).”
Background
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See all 176

Authors: Piret, B., Schoonbroodt, S., & Piette, J.
Affiliations: University of Liège (BE)
ORCID: Schoonbroodt, Sonia
Piette, Jacques
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 1999-04-01
Volume: 18
Issue: 13
Pages: 2261-2271
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1202541
OpenAlex: W2316716290
Cited by: 176
References: 96
Citations by year: 2025: 4 · 2024: 5 · 2023: 2 · 2022: 6 · 2021: 4 · 2020: 5 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 10 · 2015: 11 · 2014: 2 · 2013: 5 · 2012: 9
FWCI: 3.21
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Keywords: ATM protein, NF-κB activation, DNA damage response, camptothecin, topoisomerase I poisons, ataxia telangiectasia, p53, cell cycle checkpoints, radiosensitivity, DNA-dependent protein kinase, transcription factors
MeSH terms: NF-KappaB Inhibitor alpha, Adolescent, Age Factors, Antineoplastic Agents, Phytogenic, Ataxia Telangiectasia, Brain Neoplasms, Camptothecin, Cells, Cultured, Child, Child, Preschool, DNA Damage, DNA-Binding Proteins, Enzyme Inhibitors, Fibroblasts, Gene Expression Regulation, Glioblastoma, Humans, Leupeptins, Nuclear Proteins, Phosphoric Monoester Hydrolases, Protease Inhibitors, Proteins, Radiation Tolerance, Recombinant Fusion Proteins, Transcription, Genetic, Tumor Cells, Cultured, Tumor Necrosis Factor-alpha, Tumor Suppressor Protein p53, NF-kappa B, Protein Serine-Threonine Kinases, Cell Cycle Proteins, I-kappa B Proteins, Tumor Suppressor Proteins, DNA-Activated Protein Kinase, Topoisomerase I Inhibitors, Ataxia Telangiectasia Mutated Proteins

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The ATM protein is required for sustained activation of NF-κB following DNA damage

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