Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

p53, the cellular gatekeeper for growth and division

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Wortmannin Inactivates Phosphoinositide 3-Kinase by Covalent Modification of Lys-802, a Residue Involved in the Phosphate Transfer Reaction

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PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

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THE GENETIC DEFECT IN ATAXIA-TELANGIECTASIA

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The consensus motif for phosphorylation by cyclin D1‐Cdk4 is different from that for phosphorylation by cyclin A/E‐Cdk2.

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The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species

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Dual roles of ATM in the cellular response to radiation and in cell growth control.Preprint

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Foundations in Cancer Research p53 and ATM: Cell Cycle, Cell Death, and Cancer

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Predominance of null mutations in ataxia-telangiectasia

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The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.Preprint

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Genotype-Phenotype Relationships in Ataxia-Telangiectasia and Variants

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Recombinant ATM protein complements the cellular A-T phenotype

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Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms

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p53 Is Phosphorylated by CDK7-Cyclin H in a p36MAT1-Dependent Manner

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The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage

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Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

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Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints

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The DNA damage response: putting checkpoints in perspective

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ATM and related protein kinases: safeguarding genome integrity

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The first 30 years of p53: growing ever more complex.

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Cell cycle checkpoint signaling through the ATM and ATR kinases

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ATR: an essential regulator of genome integrity

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The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

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Chk1 is an essential kinase that is regulated by Atr and required for the G ₂ /M DNA damage checkpoint

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

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Post-translational modification of p53 in tumorigenesis

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BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

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DNA damage activates p53 through a phosphorylation–acetylation cascade

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The multiple mechanisms that regulate p53 activity and cell fate

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ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1

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ATM Activation by Oxidative Stress

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p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2

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Requirement of the MRN complex for ATM activation by DNA damage

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A role for ATR in the DNA damage-induced phosphorylation of p53

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Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

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Regulation of p53 in response to DNA damage

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The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

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A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

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Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

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Integration of interferon-α/β signalling to p53 responses in tumour suppression and antiviral defence

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The Fanconi anaemia/BRCA pathway

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Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members

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Chk2/hCds1 functions as a DNA damage checkpoint in G₁by stabilizing p53

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

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The many substrates and functions of ATM.

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Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53

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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

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Acetylation of p53 Activates Transcription through Recruitment of Coactivators/Histone Acetyltransferases

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The complexity of p53 stabilization and activation

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Non-canonical activation of the DNA sensing adaptor STING by ATM and IFI16 mediates NF-κB signaling after nuclear DNA damage

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USP10 Regulates p53 Localization and Stability by Deubiquitinating p53

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MDM2 — master regulator of the p53 tumor suppressor protein

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Signaling to p53

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ATM and ATR: networking cellular responses to DNA damage

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Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage.

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Coping with stress: multiple ways to activate p53

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Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

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p53 and E2f: partners in life and death

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ATM-dependent phosphorylation of nibrin in response to radiation exposure

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Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

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CHK2 kinase in the DNA damage response and beyond

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Regulation of p53 function and stability by phosphorylation.

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Recurrent Initiation: A Mechanism for Triggering p53 Pulses in Response to DNA Damage

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DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis

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Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in <i>Xenopus</i> egg extracts

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Pot1 Deficiency Initiates DNA Damage Checkpoint Activation and Aberrant Homologous Recombination at Telomeres

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Recombinational DNA repair and human disease

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PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

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Cellular zinc metabolism and zinc signaling: From biological functions to diseases and therapeutic targets

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Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

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The controlling role of ATM in homologous recombinational repair of DNA damage

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AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

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The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks

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ATM: Genome stability, neuronal development, and cancer cross paths

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Damage-mediated Phosphorylation of Human p53 Threonine 18 through a Cascade Mediated by a Casein 1-like Kinase

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Caffeine inhibits the checkpoint kinase ATM

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Functional Human Telomeres Are Recognized as DNA Damage in G2 of the Cell Cycle

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Nuclear Retention of ATM at Sites of DNA Double Strand Breaks

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Radiation-induced Assembly of Rad51 and Rad52 Recombination Complex Requires ATM and c-Abl

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ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

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Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation

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A Role for Proapoptotic BID in the DNA-Damage Response

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UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, γ-H2AX formation, and Mre11 relocalization

Limoli, C. L., Giedzinski, E., Bonner, W. M., & Cleaver, J. E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231611798 · Cited by 210 · see citing works

Utilization of Oriented Peptide Libraries to Identify Substrate Motifs Selected by ATM

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Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

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The ATM protein is required for sustained activation of NF-κB following DNA damage

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The role of ubiquitin modification in the regulation of p53

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Protein kinases and transcription factors activation in response to UV-radiation of skin: implications for carcinogenesis

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ATM activates p53 by regulating MDM2 oligomerization and E3 processivity

Cheng, Q., Chen, L., Li, Z., Lane, W. S., & Chen, J. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.294 · Cited by 165 · see citing works

Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex

Adams, K. E., Medhurst, A. L., Dart, D. A., & Lakin, N. D. (2006) · Oncogene · doi:10.1038/sj.onc.1209426 · Cited by 164 · see citing works

Phosphorylation of Serine 18 Regulates Distinct p53 Functions in Mice

Sluss, H. K., Armata, H., Gallant, J., & Jones, S. N. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.3.976-984.2004 · Cited by 152 · see citing works

Another fork in the road—life or death decisions by the tumour suppressor p53

Carvajal, L. A., & Manfredi, J. J. (2013) · The EMBO Reports · doi:10.1038/embor.2013.25 · Cited by 149 · see citing works

p53 accumulates but is functionally impaired when DNA synthesis is blocked

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Therapeutics targeting p53-MDM2 interaction to induce cancer cell death

Koo, N., Sharma, A. K., & Narayan, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095005 · Cited by 153 · see citing works

Accumulation of Cytoplasmic DNA Due to ATM Deficiency Activates the Microglial Viral Response System with Neurotoxic Consequences

Song, X., Ma, F., & Herrup, K. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.0774-19.2019 · Cited by 133 · see citing works

Cell Type- and Promoter-specific Roles of Ser18 Phosphorylation in Regulating p53 Responses

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DNA Damage-Induced Phosphorylation of MdmX at Serine 367 Activates p53 by Targeting MdmX for Mdm2-Dependent Degradation

Okamoto, K., Kashima, K., Pereg, Y., Ishida, M., Yamazaki, S., Nota, A., Teunisse, A., Migliorini, D., Kitabayashi, I., Marine, J.-C., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.21.9608-9620.2005 · Cited by 129 · see citing works

Ionizing radiation induces long-term senescence in endothelial cells through mitochondrial respiratory complex II dysfunction and superoxide generation

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The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans

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Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23

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Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest

Girard, P.-M., Riballo, E., Begg, A. C., Waugh, A., & Jeggo, P. A. (2002) · Oncogene · doi:10.1038/sj.onc.1205596 · Cited by 123 · see citing works

Distinct mechanisms act in concert to mediate cell cycle arrest

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The Cyclooxygenase-2–Prostaglandin E2 Pathway Maintains Senescence of Chronic Obstructive Pulmonary Disease Fibroblasts

Dagouassat, M., Gagliolo, J.-M., Chrusciel, S., Bourin, M.-C., Duprez, C., Caramelle, P., Boyer, L., Hue, S., Stern, J.-B., Validire, P., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201208-1361oc · Cited by 120 · see citing works

ATM protein kinase: the linchpin of cellular defenses to stress

Bhatti, S., Kozlov, S., Farooqi, A. A., Naqi, A., Lavin, M., & Khanna, K. K. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0683-9 · Cited by 116 · see citing works

p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosis

Kawase, T., Ichikawa, H., Ohta, T., Nozaki, N., Tashiro, F., Ohki, R., & Taya, Y. (2008) · Oncogene · doi:10.1038/onc.2008.32 · Cited by 105 · see citing works

Mutation of Mouse p53 Ser23 and the Response to DNA Damage

Wu, Z., Earle, J., Saito, S., Anderson, C. W., Appella, E., & Xu, Y. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.8.2441-2449.2002 · Cited by 103 · see citing works

Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion

Khan, S. H., Moritsugu, J., & Wahl, G. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3266 · Cited by 103 · see citing works

The Pathogenesis of Ataxia-Telangiectasia

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Questioning the Role of Checkpoint Kinase 2 in the p53 DNA Damage Response

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Activation of p53 by Oxidative Stress Involves Platelet-derived Growth Factor-β Receptor-mediated Ataxia Telangiectasia Mutated (ATM) Kinase Activation

Chen, K., Albano, A., Ho, A., & Keaney, J. F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304423200 · Cited by 95 · see citing works

Differential Roles of ATM- and Chk2-Mediated Phosphorylations of Hdmx in Response to DNA Damage

Pereg, Y., Lam, S., Teunisse, A., Biton, S., Meulmeester, E., Mittelman, L., Buscemi, G., Okamoto, K., Taya, Y., Shiloh, Y., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00562-06 · Cited by 93 · see citing works

MDM2 and MDMX can interact differently with ARF and members of the p53 family

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Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export

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Regulation of MDMX Expression by Mitogenic Signaling

Gilkes, D. M., Pan, Y., Coppola, D., Yeatman, T., Reuther, G. W., & Chen, J. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01633-07 · Cited by 82 · see citing works

New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress

Chen, B. P. C., Li, M., & Asaithamby, A. (2012) · Cancer Letters · doi:10.1016/j.canlet.2011.12.004 · Cited by 84 · see citing works

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The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes quiescent but not proliferating MG-63 human osteosarcoma cells to radiation

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Diagnostics of ataxia-telangiectasia by an express test based on the indirect immunofluorescence method

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The DNA Damage Response Kinases DNA-dependent Protein Kinase (DNA-PK) and Ataxia Telangiectasia Mutated (ATM) Are Stimulated by Bulky Adduct-containing DNA

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