Diverse functions of JNK signaling and c-Jun in stress response and apoptosis
Abstract
c-Jun/AP-1 activation has been implicated in various, often opposing cellular responses. For example, although there is considerable evidence that c-Jun activation can be a positive step in the events leading a cell towards apoptosis, there are also many reports stating the opposite: that under certain circumstances c-Jun can inhibit apoptosis and promote proliferation or differentiation instead - and that these responses are important for normal mammalian development. It is clear that the effects of c-Jun on cellular responses depend strongly on the cell type and the context of other regulatory influences that the cell is receiving. This review focuses on recent developments in understanding how activation of JNK and c-Jun contributes to different cellular responses.
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The reduction in these seven inflammatory markers provides suggestive evidence for senolytic target engagement in peripheral blood cells in this pilot study.
“with our results indicating downregulation of pathways involved in inflammation and cell fate decisions [105,106] to provide suggestive evidence for senolytic target engagement in peripheral blood cells in this pilot study.”
From Evaluation of exploratory fluid biomarkers from a phase 1 senolytic trial in mild Alzheimer's disease (2025) · cites this paper as [106]
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- Authors
- Leppä, S., & Bohmann, D.
- Affiliations
- University of Helsinki (FI)
- European Molecular Biology Laboratory (DE)
- Venue
- Oncogene
- Published
- 1999-11-01
- Volume
- 18
- Issue
- 45
- Pages
- 6158-6162
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2001617515
- Cited by
- 522
- References
- 2
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 11 · 2023: 11 · 2022: 13 · 2021: 9 · 2020: 11 · 2019: 9 · 2018: 10 · 2017: 12 · 2016: 19 · 2015: 17 · 2014: 19 · 2013: 18 · 2012: 17
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- JNK signaling, c-Jun, AP-1, stress response, apoptosis, cell proliferation, cell differentiation, cell type-specific responses, mammalian development
- MeSH terms
- Animals, Cell Differentiation, Cell Division, Cell Survival, Humans, Signal Transduction, Proto-Oncogene Proteins c-jun, Apoptosis, Mitogen-Activated Protein Kinase Kinases, JNK Mitogen-Activated Protein Kinases, MAP Kinase Kinase 4
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