Aberrantly expressed c‐Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF‐κB

The hallmarks of cancer

Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219 · see citing works

A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group [see comments]

Harris, N. L., Jaffe, E., Stein, H., Pm, B., Jk, C., Cleary, M. L., Delsol, G., Peeters, C., Falini, B., & Gatter, K. C. (1994) · Blood · doi:10.1182/blood.v84.5.1361.1361 · Cited by 6,312 · see citing works

Mammalian MAP kinase signalling cascades

Chang, L., & Karin, M. (2001) · Nature · doi:10.1038/35065000 · Cited by 5,118 · see citing works

Phosphorylation meets ubiquitination: the control of NF-κB activity

Karin, M., & Ben-Neriah, Y. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.621 · Cited by 4,766 · see citing works

AP-1 function and regulation

Karin, M., Liu, Z.-G., & Zandi, E. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80068-3 · Cited by 2,904 · see citing works

CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs

Förster, R., Schubel, A., Breitfeld, D., Kremmer, E., Renner‐Müller, I., Wolf, E., & Lipp, M. (1999) · Cell · doi:10.1016/s0092-8674(00)80059-8 · Cited by 2,348 · see citing works

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

Angel, P., Hattori, K., Smeal, T., & Karin, M. (1988) · Cell · doi:10.1016/0092-8674(88)90143-2 · Cited by 1,239 · see citing works

Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation

Yamaoka, S., Courtois, G., Chable-Bessia, C., Whiteside, S. T., Weil, R., Agou, F., Kirk, H., Kay, R. J., & Israël, A. (1998) · Cell · doi:10.1016/s0092-8674(00)81466-x · Cited by 1,077 · see citing works

NF-κB Function in Growth Control: Regulation of Cyclin D1 Expression and G 0 /G 1 -to-S-Phase Transition

Hinz, M., Krappmann, D., Eichten, A., Heder, A., Scheidereit, C., & Strauss, M. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2690 · Cited by 788 · see citing works

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.

Bargou, R. C., Emmerich, F., Krappmann, D., Bommert, K., Mapara, M. Y., Arnold, W., Royer, H., Grinstein, E., Greiner, A., Scheidereit, C., et al. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119849 · Cited by 757 · see citing works

c‐Jun regulates cell cycle progression and apoptosis by distinct mechanisms

Wisdom, R., Johnson, R. S., & Moore, C. (1999) · The EMBO Journal · doi:10.1093/emboj/18.1.188 · Cited by 687 · see citing works

Induction of proto-oncogene JUN/AP-1 by serum and TPA

Lamph, W. W., Wamsley, P., Sassone‐Corsi, P., & Verma, I. M. (1988) · Nature · doi:10.1038/334629a0 · Cited by 658 · see citing works

Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease

Dürkop, H., Latza, U., Hummel, M., Eitelbach, F., Seed, B., & Stein, H. (1992) · Cell · doi:10.1016/0092-8674(92)90180-k · Cited by 643 · see citing works

Cross‐coupling of the NF‐kappa B p65 and Fos/Jun transcription factors produces potentiated biological function.

Stein, B., Baldwin, A. S., Ballard, D. W., Greene, W. C., Angel, P. E., & Herrlich, P. A. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06066.x · Cited by 630 · see citing works

ATF‐2 is preferentially activated by stress‐activated protein kinases to mediate c‐jun induction in response to genotoxic agents.

van Dam, H., Wilhelm, D., Herr, I., Steffen, A., Herrlich, P. A., & Angel, P. E. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07168.x · Cited by 598 · see citing works

Control of cell cycle progression by c-Jun is p53 dependentPreprint

Schreiber, M., Kolbus, A., Piu, F., Szabowski, A., Möhle-Steinlein, U., Tian, J., Karin, M., Angel, P., & Wagner, E. F. (1999) · Genes & Development · doi:10.1101/gad.13.5.607 · Cited by 576 · see citing works

Diverse functions of JNK signaling and c-Jun in stress response and apoptosis

Leppä, S., & Bohmann, D. (1999) · Oncogene · doi:10.1038/sj.onc.1203173 · Cited by 522 · see citing works

c-Jun and JunB Antagonistically Control Cytokine-Regulated Mesenchymal–Epidermal Interaction in Skin

Szabowski, A., Maas‐Szabowski, N., Andrecht, S., Kolbus, A., Schorpp‐Kistner, M., Fusenig, N. E., & Angel, P. E. (2000) · Cell · doi:10.1016/s0092-8674(00)00178-1 · Cited by 423 · see citing works

Cell cycle‐dependent variations in c‐Jun and JunB phosphorylation: a role in the control of cyclin D1 expression

Bakiri, L., Lallemand, D., Bossy‐Wetzel, E., & Yaniv, M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.9.2056 · Cited by 399 · see citing works

Regulation of IL‐4 expression by the transcription factor JunB during T helper cell differentiation

Li, B., Tournier, C., Davis, R. J., & Flavell, R. A. (1999) · The EMBO Journal · doi:10.1093/emboj/18.2.420 · Cited by 362 · see citing works

The mammalian Jun proteins: redundancy and specificity

Mechta‐Grigoriou, F., Gerald, D., & Yaniv, M. (2001) · Oncogene · doi:10.1038/sj.onc.1204381 · Cited by 340 · see citing works

Epstein–Barr virus latent membrane protein‐1 triggers AP‐1 activity via the c‐Jun N‐terminal kinase cascade

Kieser, A., Kilger, E., Gires, O., Ueffing, M., Kölch, W., & Hammerschmidt, W. (1997) · The EMBO Journal · doi:10.1093/emboj/16.21.6478 · Cited by 319 · see citing works

Inducible regulatory elements in the human cyclin D1 promoter.

Herber, B., Truss, M., Beato, M., & Müller, R. (1994) · PubMed · Cited by 309 · see citing works

High-level nuclear NF-kappa B and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells

Bargou, R., Leng, C., Krappmann, D., Emmerich, F., Mapara, M., Bommert, K., Royer, H., Scheidereit, C., & Dörken, B. (1996) · Blood · doi:10.1182/blood.v87.10.4340.bloodjournal87104340 · Cited by 308 · see citing works

A Dominant Negative to Activation Protein-1 (AP1) That Abolishes DNA Binding and Inhibits Oncogenesis

Olive, M., Krylov, D. Y., Echlin, D. R., Gardner, K. L., Taparowsky, E. J., & Vinson, C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18586 · Cited by 284 · see citing works

Molecular mechanisms of constitutive NF-κB/Rel activation in Hodgkin/Reed-Sternberg cells

Krappmann, D., Emmerich, F., Kordes, U., Scharschmidt, E., Dörken, B., & Scheidereit, C. (1999) · Oncogene · doi:10.1038/sj.onc.1202351 · Cited by 271 · see citing works

Constitutive NF-κB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells

Hinz, M., Löser, P., Mathas, S., Krappmann, D., Dörken, B., & Scheidereit, C. (2001) · Blood · doi:10.1182/blood.v97.9.2798 · Cited by 259 · see citing works

Chronic Myeloid Leukemia with Increased Granulocyte Progenitors in Mice Lacking JunB Expression in the Myeloid Lineage

Passegue, E. A., Jochum, W., Schorpp‐Kistner, M., Möhle-Steinlein, U., & Wagner, E. F. (2001) · Cell · doi:10.1016/s0092-8674(01)00188-x · Cited by 236 · see citing works

A Network of Mitogen-Activated Protein Kinases Links G Protein-Coupled Receptors to the c- jun Promoter: a Role for c-Jun NH 2 -Terminal Kinase, p38s, and Extracellular Signal-Regulated Kinase 5

Marinissen, M. J., Chiariello, M., Pallante, M., & Gutkind, J. S. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4289 · Cited by 209 · see citing works

Anti-CD20- and B-cell receptor-mediated apoptosis: evidence for shared intracellular signaling pathways.

Mathas, S., Rickers, A., Bommert, K., Dörken, B., & Mapara, M. Y. (2000) · PubMed · Cited by 155 · see citing works

Novel NEMO/IκB Kinase and NF-κB Target Genes at the Pre-B to Immature B Cell Transition

Li, J., Peet, G. W., Balzarano, D., Li, X., Massa, P. T., Barton, R. W., & Marcu, K. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100846200 · Cited by 153 · see citing works

ETS1, NFκB and AP1 synergistically transactivate the human GM – CSF promoter

Thomas, R. S., Tymms, M. J., McKinlay, L. H., Shannon, M. F., Seth, A. K., & Kola, I. (1997) · Oncogene · doi:10.1038/sj.onc.1201125 · Cited by 145 · see citing works

ULTRAVIOLET‐RADIATION INDUCED c‐jun GENE TRANSCRIPTION: TWO AP‐1 LIKE BINDING SITES MEDIATE THE RESPONSE

Stein, B., Angel, P. E., van Dam, H., Ponta, H., Herrlich, P. A., van der Eb, A. J., & Rahmsdorf, H. J. (1992) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1992.tb04255.x · Cited by 127 · see citing works

Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs

Höpken, U. E., Foss, H., Meyer, D., Hinz, M., Leder, K., Stein, H., & Lipp, M. (2002) · Blood · doi:10.1182/blood.v99.4.1109 · Cited by 120 · see citing works

The Molecular and Cellular Origins of Hodgkin's Disease

Staudt, L. M. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.2.207 · Cited by 115 · see citing works

Functional Analysis of the Human Cyclin D2 and Cyclin D3 Promoters

Brooks, A. R., Shiffman, D., Chan, C. S., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.15.9090 · Cited by 114 · see citing works

UV-Induced Stabilization of c-fos and Other Short-Lived mRNAs

Blattner, C., Kannouche, P. L., Litfin, M., Bender, K., Rahmsdorf, H. J., Angulo, J. F., & Herrlich, P. A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.10.3616-3625.2000 · Cited by 109 · see citing works

Cloning of Human and Mouse EBI1, a Lymphoid-Specific G-Protein-Coupled Receptor Encoded on Human Chromosome 17q12-q21.2

Schweickart, V. L., Raport, C. J., Godiska, R., et al. (1994) · Genomics · doi:10.1006/geno.1994.1553 · Cited by 97 · see citing works

Constitutive activation of transcription factor AP-1 in primary adult T-cell leukemia cells.

Mori, N., Fujii, M., Iwai, K., Ikeda, S., Yamasaki, Y., Hata, T., Yamada, Y., Tanaka, Y., Tomonaga, M., & Yamamoto, N. (2000) · PubMed · doi:10.1182/blood.v95.12.3915 · Cited by 91 · see citing works

Stress‐activated protein kinases are negatively regulated by cell density

Lallemand, D., Ham, J., Garbay, S., Bakiri, L., Traincard, F., Jeannequin, O., Pfarr, C. M., & Yaniv, M. (1998) · The EMBO Journal · doi:10.1093/emboj/17.19.5615 · Cited by 91 · see citing works

Constitutively activated JNK is associated with HTLV-1 mediated tumorigenesis.

Xu, X., Heidenreich, O. T., Kitajima, I., et al. (1996) · PubMed · Cited by 90 · see citing works

Transcriptional activation of the Hepatocyte Growth Factor receptor (c-met) gene by its ligand (Hepatocyte Growth Factor) is mediated through AP-1

Seol, D., Chen, Q., & Zarnegar, R. (2000) · Oncogene · doi:10.1038/sj.onc.1203404 · Cited by 87 · see citing works

Expression of the c-met proto-oncogene and its ligand, hepatocyte growth factor, in Hodgkin disease

Teofili, L., Febo, A. L. D., Pierconti, F., et al. (2001) · Blood · doi:10.1182/blood.v97.4.1063 · Cited by 79 · see citing works

Tumor cell growth fraction in Hodgkin's disease.

Gerdes, J., Unnik, J. A. M. V., Pileri, S. A., Schwarting, R., Unnik, J. A. M. V., & Stein, H. (1987) · PubMed Central · Cited by 75 · see citing works

Epstein–Barr virus in Hodgkin’s disease

Chapman, A. L. N., & Rickinson, A. B. (1998) · Annals of Oncology · doi:10.1093/annonc/9.suppl_5.s5 · Cited by 49 · see citing works

Expression of cyclin D2 and D3 in lymphoid lesions

Teramoto, N., Tamm, K. P., Székely, L., Polack, A., Yoshino, T., Akagi, T., & Klein, G. (1999) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19990517)81:4 · Cited by 42 · see citing works

High-dose therapy followed by stem cell transplantation in partial response after first-line induction therapy for aggressive non-Hodgkin’s lymphoma

Haïoun, C., Lepage, É., Gisselbrecht, C., et al. (1998) · Annals of Oncology · doi:10.1093/annonc/9.suppl_1.s5 · Cited by 18 · see citing works

Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression

Lecker, S. H., Jagoe, R. T., Gilbert, A., Gomes, M., Baracos, V., Bailey, J., Price, S. R., Mitch, W. E., & Goldberg, A. L. (2004) · The FASEB Journal · doi:10.1096/fj.03-0610com · Cited by 1,539 · see citing works

Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma

Lamprecht, B., Walter, K., Kreher, S., Kumar, R., Hummel, M., Lenze, D., Köchert, K., Bouhlel, M. A., Richter, J., Soler, E., et al. (2010) · Nature Medicine · doi:10.1038/nm.2129 · Cited by 376 · see citing works

Cyr61 Expression Confers Resistance to Apoptosis in Breast Cancer MCF-7 Cells by a Mechanism of NF-κB-dependent XIAP Up-Regulation

Lin, M.-T., Chang, C.-C., Chen, S.-T., Chang, H.-L., Su, J.-L., Chau, Y.-P., & Kuo, M.-L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402305200 · Cited by 194 · see citing works

Cell signaling and transcription factor activation by asbestos in lung injury and disease

Shukla, A., Ramos-Nino, M., & Mossman, B. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00315-1 · Cited by 87 · see citing works

Co-targeting SRC overcomes resistance to BRAF inhibitors in colorectal cancer

Rubio-Cuesta, B., Carretero-Puche, C., Llamas, P., Sarmentero, J., Gil-Calderon, B., Lens-Pardo, A., Antón-Pascual, B., Rubio-González, E., Cámara-Jurado, M., Salamanca, J., et al. (2025) · British Journal of Cancer · doi:10.1038/s41416-025-03058-6 · Cited by 7 · see citing works

Protein kinase p-JNK is correlated with the activation of AP-1 and its associated Jun family proteins in hepatocellular carcinoma

Guo, L., Guo, Y., Xiao, S., & Shi, X. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.03.019 · Cited by 40 · see citing works

Transient Induction of C–Jun During Hepatic Regeneration

Alcorn, J. A., Feitelberg, S. P., & Brenner, D. A. (1990) · Hepatology · doi:10.1002/hep.1840110602 · Cited by 86 · see citing works

Expression of junB is markedly stimulated by glycyrrhizin in a human hepatoma cell line

Koike (2011) · Oncology Reports · doi:10.3892/or.2011.1137 · Cited by 9 · see citing works

Stepwise Transformation of Rat Embryo Fibroblasts: c-Jun, JunB, or JunD Can Cooperate with Ras for Focus Formation, but a c-Jun-Containing Heterodimer Is Required for Immortalization

Vandel, L., Montreau, N., Vial, E., Pfarr, C. M., Binétruy, B., & Castellazzi, M. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.1881 · Cited by 56 · see citing works

E1A dependent up-regulation of c-jun/AP-1 activity

Kitabayashi, I., Chiu, R., Gachelin, G., & Yokoyama, K. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.3.649 · Cited by 40 · see citing works