Cited by 245Cell death mechanisms and regulationMitochondrial Function and PathologyRedox biology and oxidative stress

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The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal

Vieira, Helena LA, Belzacq, Anne-Sophie, Haouzi, Delphine, Bernassola, Francesca, Cohen, Isabel, Jacotot, Etienne, Ferri, Karine F, El Hamel, Chahrazed, Bartle, Laura M, Melino, Gerry, Brenner, Catherine, Goldmacher, Victor, Kroemer, Guido·2001·Oncogene

DOI 10.1038/sj.onc.1204575

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Abstract

Nitric oxide (NO), peroxynitrite, and 4-hydroxynonenal (HNE) may be involved in the pathological demise of cells via apoptosis. Apoptosis induced by these agents is inhibited by Bcl-2, suggesting the involvement of mitochondria in the death pathway. In vitro, NO, peroxynitrite and HNE can cause direct permeabilization of mitochondrial membranes, and this effect is inhibited by cyclosporin A, indicating involvement of the permeability transition pore complex (PTPC) in the permeabilization event. NO, peroxynitrite and HNE also permeabilize proteoliposomes containing the adenine nucleotide translocator (ANT), one of the key components of the PTPC, yet have no or little effects on protein-free control liposomes. ANT-dependent, NO-, peroxynitrite- or HNE-induced permeabilization is at least partially inhibited by recombinant Bcl-2 protein, as well as the antioxidants trolox and butylated hydroxytoluene. In vitro, none of the tested agents (NO, peroxynitrite, HNE, and tert-butylhydroperoxide) causes preferential carbonylation HNE adduction, or nitrotyrosylation of ANT. However, all these agents induced ANT to undergo thiol oxidation/derivatization. Peroxynitrite and HNE also caused significant lipid peroxidation, which was antagonized by butylated hydroxytoluene but not by recombinant Bcl-2. Transfection-enforced expression of vMIA, a viral apoptosis inhibitor specifically targeted to ANT, largely reduces the mitochondrial and nuclear signs of apoptosis induced by NO, peroxynitrite and HNE in intact cells. Taken together these data suggest that NO, peroxynitrite, and HNE may directly act on ANT to induce mitochondrial membrane permeabilization and apoptosis.

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Background
Nitric oxide-induced eosinophil apoptosis is dependent on mitochondrial permeability transition (mPT), JNK and oxidative stress: apoptosis is preceded but not mediated by early mPT-dependent JNK activation
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“ANT has been shown to act as a critical target in mitochondrial membrane permeabilization induced by NO and peroxynitrite [30], giving ground for usage of bongkrekic acid as an inhibitor of mPT in this study.”
Background
Computational Insights on the Competing Effects of Nitric Oxide in Regulating Apoptosis
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“Additional mitochondrial targets of peroxynitrite include the adenine nucleotide translocase (Vieira et al., 2001), nicotinamide nucleotide transhydrogenase (Forsmark-Andree et al., 1996), and Complex I, II, and V of the electron transport chain (Radi et al., 1994; Cassina and Radi, 1996; Riobo et…”
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“NO exerts inhibition on mitochondrial permeability transition pore (MPTP) and cytochrome c release (Vieira et al., 2001) and induces expression of cytoprotective genes, such as HSP70 and HO-1 (Kim et al.”
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Background
Neuroprotective effects of the antioxidant action of 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride against ischemic neuronal damage in the brain
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“of ROS in the brain after various insults is respiration dependent, and mitochondria in vitro are sensitive to ROS (31).”
Background
U937 Cell Necrosis Mediated by Peroxynitrite Is Not Caused by Depletion of ATP and Is Prevented by Arachidonate via an ATP-Dependent Mechanism
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“An effect of peroxynitrite on the adenine nucleotide translocator was recently identified in Kroemer’s laboratory (Vieira et al., 2001), and this event, in conjunction with alterations in the redox state (Costantini et al., 1996), may well be involved in the commitment to MPT, critically regulated…”
Background
N1‐(quinolin‐2‐ylmethyl)butane‐1,4‐diamine, a polyamine analogue, attenuated injury in in vitro and in vivo models of cerebral ischemia
Cen, J., Liu, L., He, L., Liu, M., Wang, C., & Ji, B. (2012) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2012.08.008 · Cited by 12
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Role of solute carrier transporters in regulating dendritic cell maturation and function
Shao, L., Yang, M., Sun, T., Xia, H., Du, D., Li, X., & Jie, Z. (2023) · European Journal of Immunology · doi:10.1002/eji.202350385 · Cited by 11
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Reactivity of mitochondrial peroxiredoxins with biological hydroperoxides
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BackgroundSelf-citation
Mitochondrial Regulation of Cell Death
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BackgroundSelf-citation
Interactions among nitric oxide and Bcl‐family proteins after MPP+ exposure of SH‐SY5Y neural cells II: Exogenous NO replicates MPP+ actions
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“, 2001), as well as the conformational state of the mitochondrial permeability transition pore (PTP; Vieira et al., 2001; Reichert et al., 2001) and the nitration of cytochrome c (Cassina et al.”
Background

Authors: Vieira, H. L., Belzacq, A.-S., Haouzi, D., Bernassola, F., Cohen, I., Jacotot, E., Ferri, K. F., El Hamel, C., Bartle, L. M., Melino, G., Brenner, C., Goldmacher, V., & Kroemer, G.
Affiliations: Centre National de la Recherche Scientifique (FR)
Université de Technologie de Compiègne (FR)
University of Rome Tor Vergata (IT)
Corresponding author: Kroemer, Guido
ORCID: Vieira, Helena LA
Haouzi, Delphine
Bernassola, Francesca
Cohen, Isabel
Jacotot, Etienne
Melino, Gerry
Brenner, Catherine
Goldmacher, Victor
Kroemer, Guido
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2001-07-19
Volume: 20
Issue: 32
Pages: 4305-4316
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1204575
OpenAlex: W2005480061
Cited by: 244
References: 67
Citations by year: 2026: 1 · 2025: 1 · 2023: 2 · 2022: 7 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 9 · 2015: 5 · 2014: 7 · 2013: 10 · 2012: 16
FWCI: 6.75
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
Funders: Agence Nationale de la Recherche
Ligue Contre le Cancer
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: adenine nucleotide translocase, nitric oxide, peroxynitrite, 4-hydroxynonenal, apoptosis, mitochondrial permeability transition pore, mitochondrial membrane permeabilization, Bcl-2, lipid peroxidation, thiol oxidation, Trolox, butylated hydroxytoluene, cyclosporine, oxidative stress
MeSH terms: Mitochondrial Permeability Transition Pore, Mitochondrial ADP, ATP Translocases, Aldehydes, Animals, Cell Nucleus, HeLa Cells, Humans, Intracellular Membranes, Ion Channels, Membrane Proteins, Mitochondria, Nitrates, Nitric Oxide, Permeability, Proteins, Proteolipids, Lipid Peroxidation, Oxidants, Apoptosis, Jurkat Cells, Proto-Oncogene Proteins c-bcl-2, Mitochondrial Membrane Transport Proteins, Inhibitor of Apoptosis Proteins, Mice

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The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal

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