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Cited by 125

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Comparison of human mammary epithelial cells immortalized by simian virus 40 T-Antigen or by the telomerase catalytic subunit

Toouli, Christian D, Huschtscha, Lily I, Neumann, Axel A, Noble, Jane R, Colgin, Lorel M, Hukku, Bharati, Reddel, Roger R·2002·Oncogene
DOI 10.1038/sj.onc.1205014
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Abstract

We directly compared two methods of immortalizing human mammary epithelial cells (HMECs). Cells were transfected with an expression plasmid either for hTERT, the catalytic subunit of telomerase, or for the simian virus 40 (SV40) early region genes. Under standard culture conditions, HMECs were not immortalized by hTERT unless they had spontaneously ceased expression of the p16(INK4a) tumor suppressor gene. Untransfected HMECs had low levels of telomerase expression, and immortalization by both methods was associated with an increase in telomerase activity and prevention of telomere shortening. SV40-induced immortalization was accompanied by aberrant differentiation, loss of DNA damage response, karyotypic instability and, in some cases, tumorigenicity. hTERT-immortalized cells had fewer karyotypic changes, but had intact DNA damage responses, and features of normal differentiation. Although SV40-immortalized cells are useful for studies of carcinogenesis, hTERT-immortalized cells retain more properties of normal cells.

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Crossref · 10.1038/sj.onc.1205014

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Citations

Cites

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Metadata

Authors
Toouli, C. D., Huschtscha, L. I., Neumann, A. A., Noble, J. R., Colgin, L. M., Hukku, B., & Reddel, R. R.
Venue
Oncogene
Publisher
Springer Science and Business Media LLC
Published
2002-01-03
Volume
21
Issue
1
Pages
128-139
ISSN
  • 0950-9232
  • 1476-5594
DOI
10.1038/sj.onc.1205014
Cited by
125
References
9
Language
en
Licence

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