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Differential interaction and activation of Rho family GTPases by p210bcr-abl and p190bcr-abl

Harnois, Thomas, Constantin, Bruno, Rioux, Agnès, Grenioux, Eddy, Kitzis, Alain, Bourmeyster, Nicolas·2003·Oncogene
DOI 10.1038/sj.onc.1206626
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Abstract

The p210(bcr-abl) and p190(bcr-abl) fusion proteins, respectively responsible for chronic myelogenous leukemia and acute lymphoblastic leukemia, present deregulated tyrosine kinase activity and abnormal localization. The Dbl homology domain of Bcr, activating Rho GTPases, is present in p210(bcr-abl), but absent in p190(bcr-abl). We investigated the interaction of Bcr-Abl chimeras and Rho proteins by coimmunoprecipitation, pull-down experiments and GEF activity measurement. RhoA, Rac1 and Cdc42 interact in vivo with p210(bcr-abl) only. Moreover, the three types of GTPases are activated in vitro and in vivo by p210(bcr-abl). Nevertheless, Rac1 and Cdc42, but not RhoA, are activated by p190(bcr-abl) in vitro and in vivo. Part of this GEF activity of p190(bcr-abl) is probably attributable to p95(vav), which is complexed with both p190(bcr-abl) and p210(bcr-abl) in an activated form. p160(bcr), also in complex with Bcr-Abl, presents no GEF activity in p190(bcr-abl)-expressing cells. These results suggest that differential activation of Rho proteins should play a major role in Bcr-Abl-induced leukemogenesis.

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Research works printed but not linked: 50

  1. Adamson P, Paterson HF and Hall A . (1992). J. Cell Biol., 119, 617–627. · DOI
  2. Aghazadeh B, Lowry WE, Huang X-Y and Rosen MK . (2000). Cell., 102, 625–633. · DOI
  3. Bassermann F, Jahn T, Miething C, Seipel P, Bai RY, Coutinho S, Tybulewicz VL, Peschel C and Duyster J . (2002). J. Biol. Chem., 277, 12437–12445. · DOI · Paper page
  4. Bazzoni G, Carlesso N, Griffin JD and Hemler ME . (1996). J. Clin. Invest., 98, 521–528. · DOI
  5. Burstein ES, Hesterberg DJ, Gutkind JS, Brann MR, Currier EA and Messier TL . (1998). Oncogene, 17, 1617–1623. · DOI
  6. Chuang T-H, Xu X, Kaartinen V, Heisterkamp N, Groffen J and Bokoch G . (1995). Proc. Natl. Acad. Sci. USA, 92, 10282–10286. · DOI
  7. Clark SS, McLaughlin J, Timmons M, Pendergast AM, Ben-Neriah Y, Dow LW, Crist G, Rovera W, Smith SD and Witte ON . (1988). Science, 239, 775–777. · DOI
  8. Daley GQ and Baltimore D . (1988). Proc. Natl. Acad. Sci. USA, 85, 9312–9316. · DOI
  9. Daley GQ, Van Etten RA and Baltimore D . (1990). Science, 247, 824–830. · DOI · Paper page
  10. Das B, Shu X, Day GJ, Han J, Krishna UM, Falck JR and Broeck D . (2000). J. Biol. Chem., 275, 15074–15081. · DOI
  11. Druker B, Okuda K, Matulonis U, Salgia R, Roberts T and Griffin JD . (1992). Blood, 79, 2215–2220. · DOI
  12. Eda M, Yonemura S, Kato T, Watanabe N, Ishizaki T, Madaule P and Narumiya S . (2001). J. Cell Sci., 114, 3273–3284. · DOI
  13. Han J, Das B, Wie W, Van Aelst L, Mosteller RD, Kosravi-Far R, Westwick JK, Der CJ and Broeck D . (1997). Mol. Cell. Biol., 17, 1346–1353. · DOI
  14. Hansen MD and Nelson WJ . (2001). Curr. Biol., 11, 356–360. · DOI
  15. Hart M, Eva A, Evans T, Aaronson SA and Cerione RA . (1991). Nature, 354, 311–315. · DOI
  16. Hoshino M, Sone M, Fukata M, Kuroda S, Kaibuchi K, Nabeshima Y and Hama C . (1999). J. Biol. Chem., 274, 17837–17844. · DOI
  17. Ilaria Jr RL and Van Etten RA . (1996). J. Biol. Chem., 271, 31704–31710. · DOI
  18. Laëmmli UK and Favre M . (1973). J. Mol. Biol., 80, 575–599. · DOI
  19. Li S, Ilaria Jr RL, Million RP, Daley GQ and Van Etten RA . (1999). J. Exp. Med., 189, 1399–1412. · DOI
  20. Lipp é R, Miaczynska M, Rybin V, Runge A and Zerial M . (2001). Mol. Biol. Cell., 12, 2219–2228. · DOI
  21. Lugo TG, Pendergast A-M, Muller AJ and Witte ON . (1990). Science, 247, 1079–1082. · DOI
  22. Matsuguchi T, Inborn RC, Carlesso N, Xu G, Druker B and Griffin JD . (1995). EMBO J., 14, 257–265. · DOI
  23. McWhirter JR, Gallasso DL and Wang JYJ . (1993). Mol. Cell. Biol., 13, 7587–7595. · DOI
  24. McWhirter JR and Wang JYJ . (1993). EMBO J., 12, 1533–1546. · DOI
  25. Missy K, Van Poucke V, Raynal P, Viala C, Mauco G, Plantavid M, Chap H and Payrastre B . (1998). J. Biol. Chem., 273, 30279–30286. · DOI
  26. Nakashima S and Nozawa Y . (1999). Chem. Phys. Lipids, 98, 153–164. · DOI
  27. Nishida K, Kaziro Y and Satoh T . (1999). Oncogene, 18, 407–415. · DOI
  28. Nobes CD and Hall A . (1999). J. Cell Biol., 144, 1235–1244. · DOI
  29. Ohguchi K, Nakashima S, Tan Z, Banno Y, Dohi S and Nozawa Y . (1997). J. Biol. Chem., 272, 1990–1996. · DOI
  30. Olson MF, Pasteris NG, Gorski JL and Hall A . (1996). Curr. Biol., 6, 1628–1633. · DOI
  31. Olson MF, Paterson HF and Marshall CJ . (1998). Nature, 394, 295–298. · DOI
  32. Pear W, Nolan GP, Scott ML and Baltimore D . (1993). Proc. Natl. Acad. Sci. USA, 90, 8392–8396. · DOI
  33. Puil L, Liu J, Gish G, Mbamalu G, Bowtell D, Pelicci PG, Arlinghaus R and Pawson T . (1994). EMBO J., 13, 764–773. · DOI
  34. Qiu R-G, Chen J, Kirn D, McCormick F and Symons M . (1995). Nature, 374, 457–459. · DOI
  35. Quackenbush RC, Reuther GW, Miller JP, Courtney KD, Pear WS and Pendergast AM . (2000). Blood, 95, 2913–2921. · DOI
  36. Roig J, Tuazon PT, Zipfel PA, Pendergast AM and Traugh JA . (2000). Proc. Natl. Acad. Sci. USA, 97, 14346–14351. · DOI
  37. Rudolph MG, Linnemann T, Grunewald P, Wittinghofer A, Vetter IR and Herrmann C . (2001). J. Biol. Chem., 276, 23914–23921. · DOI
  38. Salgia R, Li J-L, Ewaniuk DS, Pear W, Pisick E, Burky SA, Ernst T, Sattler M, Chen LB and Griffin JD . (1997). J. Clin. Invest., 100, 46–57. · DOI · Paper page
  39. Sander EE, ten Klooster JP, van Delft S, van der Kammen RA and Collard JG . (1999). J. Cell Biol., 147, 1009–1021. · DOI
  40. Sander EE, van Delft S, ten Klooster JP, Reid T, van der Kammen RA, Michiels F and Collard JG . (1998). J. Cell Biol., 143, 1385–1398. · DOI
  41. Skorski T, Kanakaraj P, Nieborowska-skorska M, Ratajczak MZ, Wen SC, Zon G, Gewirtz AM, Perussia B and Calabretta B . (1995). Blood, 86, 726–736. · DOI
  42. Skorski T, Wlodarski P, Daheron L, Salomon P, Nieborowska-Skorska M, Majewski M, Wazik M and Calabretta B . (1998). Proc. Natl. Acad. Sci. USA, 95, 11858–11862. · DOI · Paper page
  43. Skourides PA, Perera SA and Ren R . (1999). Oncogene, 18, 1165–1176. · DOI
  44. Tapon N and Hall A . (1997). Curr. Opin. Cell Biol., 9, 86–92. · DOI
  45. Tolias KF, Cantley LC and Carpenter CL . (1995). J. Biol. Chem., 270, 17656–17659. · DOI
  46. Van Etten RA . (1999). Trends Cell Biol., 9, 179–186. · DOI
  47. Verfaillie CM, Hurley R, Lundell BI, Zao C and Bahtia R . (1995). Acta Haematol., 97, 40–52. · DOI
  48. Voncken JW, van Shaick H, Kaartinen V, Deemer K, Coates T, Landing B, Pattengale P, Dorseuil O, Bokoch GM, Groffen J and Heisterkamp N . (1995). Cell, 80, 719–728. · DOI
  49. Wu Y, Ma G, Lu D, Lin F, Xu HJ, Liu J and Arlinghaus RB . (1999). Oncogene, 18, 4416–4424. · DOI
  50. Zhu X, Boman AL, Kuai J, Ciepak W and Kahn RA . (2000). J. Biol. Chem., 275, 13465–13475. · DOI

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Metadata

Authors
Harnois, T., Constantin, B., Rioux, A., Grenioux, E., Kitzis, A., & Bourmeyster, N.
Venue
Oncogene
Publisher
Springer Science and Business Media LLC
Published
2003-09-25
Volume
22
Issue
41
Pages
6445-6454
ISSN
  • 0950-9232
  • 1476-5594
DOI
10.1038/sj.onc.1206626
Cited by
58
References
1
Language
en
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