The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Role of the tumor microenvironment in mediating de novo resistance to drugs and physiological mediators of cell death
Abstract
The emergence of clinical drug resistance continues to be an obstacle for the successful treatment of cancer. Our current understanding of mechanisms associated with drug resistance has been ascertained by investigating drug-resistant models created by exposing a parental population to increasing concentrations of a cytotoxic. These unicellular drug-resistant models have been critical in elucidating drug-resistant mechanism and in some cases have aided in the identification of drug targets. However, these models do not address resistance mechanisms that contribute to de novo drug resistance. We propose that specific niches within the tumor microenvironment may provide a sanctuary for subpopulations of tumors cells that affords a survival advantage following initial drug exposure and may facilitate the acquisition of acquired drug resistance. More specifically, we propose that the bone marrow microenvironment is a sanctuary for hema-topoietic cancers. This review will focus on the bone marrow microenvironment and its role in conferring resistance to cytotoxics and physiological mediators of cell death.
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“CAFs comprise the majority of cell types within the TME, and their reciprocal interactions with cancer cells have been well documented (Whiteside, 2008; Hazlehurst et al., 2003; Karnoub et al., 2007).”
From Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism (2016) · cites this paper as Hazlehurst et al., 2003
Citations
Cites
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Self-citationFocal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin.
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Cited by
Sorted by citations
The Different Mechanisms of Cancer Drug Resistance: A Brief Review
Mansoori, B., Mohammadi, A., Davudian, S., Shirjang, S., & Baradaran, B. (2017) · Advanced Pharmaceutical Bulletin · doi:10.15171/apb.2017.041 · Cited by 1,957
Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy
Henke, E., Nandigama, R., & Ergün, S. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00160 · Cited by 1,142
“Experiments in melanoma and sarcoma cells showed that downregulation of the p53 tumor suppressor gene resulted in increased survival following cell detachment and resistance to apoptosis (Lewis et al., 2002; Hazlehurst et al., 2003).”
BackgroundTumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism
Zhao, H., Yang, L., Baddour, J., Achreja, A., Bernard, V., Moss, T., Marini, J. C., Tudawe, T., Seviour, E. G., San Lucas, F. A., et al. (2016) · eLife · doi:10.7554/elife.10250 · Cited by 927
Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents
Sharma, S. V., Haber, D. A., & Settleman, J. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2820 · Cited by 600
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“In addition to elucidating the mechanisms of chemoresistance and the role of CAM-DR in PDAC [4], the 3D model characterized in this study may serve as a high-throughput screening platform for chemotherapeutic drug testing that provides a more reliable prediction of the response to treatment of patients with pancreatic…”
BackgroundInfluential
Metadata
- Authors
- Hazlehurst, L. A., Landowski, T. H., & Dalton, W. S.
- Affiliations
- University of South Florida (US)
- Corresponding author
- Dalton, William S
- Venue
- Oncogene
- Published
- 2003-10-20
- Volume
- 22
- Issue
- 47
- Pages
- 7396-7402
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2041997066
- Cited by
- 203
- References
- 61
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 8 · 2022: 5 · 2021: 6 · 2020: 19 · 2019: 2 · 2018: 3 · 2017: 9 · 2016: 14 · 2015: 9 · 2014: 10 · 2013: 12 · 2012: 18
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Keywords
- tumor microenvironment, acquired drug resistance, bone marrow microenvironment, hematopoietic tumors, cytotoxic drugs, cell death, cancer stem cells, hematopoietic stem cells
- MeSH terms
- Animals, Antineoplastic Agents, Cell Adhesion, DNA Damage, Humans, Neoplasms, Signal Transduction, Integrins, Apoptosis, Drug Resistance, Neoplasm
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